In this episode of the Aging Science Podcast by VitaDAO, we explore the connection between environmental pollution and longevity with Dr. Dushani Palliyaguru. Delve into the Nrf2 pathway, a critical mechanism for cellular defense, and discover the benefits of sulforaphane from broccoli as a potent Nrf2 activator. Dr. Palliyaguru, a renowned expert in aging and disease prevention, shares her extensive research on how environmental toxins affect health and longevity. Learn about innovative strategies to combat pollution-related health risks and enhance lifespan through nutritional interventions and scientific advancements. Join us for an insightful conversation on promoting longevity in a polluted world.
In this episode of The VitaDAO Aging Science Podcast, we uncover the secretive yet pivotal rapamycin study led by Prof. Adam Salmon. Prof. Salmon, a prominent figure in aging research, shares his insights into AMPK, caloric restriction (CR) mimetics, and multistress resistance in aging. We explore the challenges and promises of invertebrate models and discuss the groundbreaking marmoset study investigating rapamycin's potential to extend lifespan. This episode offers a deep dive into one of the most important ongoing studies in biogerontology, shedding light on the complexities and future directions of aging interventions. Join us to learn more about these crucial advancements in aging research.
In the current episode of The VitaDAO Aging Science Podcast, we dive into the intricate world of rapamycin, caloric restriction, and inflammaging with the distinguished Dr. Arlan Richardson. Dr. Richardson, a pioneer in aging research with a career spanning over five decades, shares his extensive knowledge and groundbreaking insights. We discuss his pioneering work on rapamycin, the complexities of caloric restriction, and the role of chronic inflammation in aging. This episode also touches on the significance of necroptosis, the intriguing connections between senescence and inflammation, and the future of aging interventions. Join us as we explore these vital topics and their implications for human longevity, shedding light on the critical role of preclinical studies in advancing our understanding of aging.
In the current episode of The VitaDAO Aging Science Podcast, we explore the fascinating intersection of entropy, epigenetics, and aging with our esteemed guests, Peter Fedichev, founder of Gero and a trailblazer in longevity research, and Prof. Jan Gruber from Yale-NUS, known for his deep understanding of the physics behind aging. As we navigate through Peter Fedichev's recent paper that sparked heated discussions on the limits of age-reversal, we'll delve into the science of stochastic changes in methylation patterns, the controversial debate around the reversibility of aging, and the impact of entropy on human longevity. This episode will also shine a light on the vital role of VitaDAO in science funding, the challenges faced by PhD students in today's economic climate, and the exciting potential of naked mole rats in aging research.
In the upcoming episode of The Science of Aging Podcast, we dive deep into the critical questions surrounding mouse models in aging research with our special guest, Dr. Dan Ehninger from the German Center for Neurodegenerative Diseases (DZNE) in Bonn. Dr. Ehninger, a visionary in the field of biogerontology, brings to the table his controversial and thought-provoking perspectives on the limitations and potential pitfalls of relying on mouse models for understanding human aging. We'll dissect the intricacies of rapamycin and caloric restriction studies, the debate over the mouse model's relevance to human aging, and innovative approaches to designing more effective mouse studies. This episode is a journey into the foundational challenges of aging science, highlighting the need for robust, translational research strategies. Join us for a riveting discussion that promises to enlighten, challenge, and inspire our understanding of the path forward in aging research.
n this episode of The VitaDAO Aging Science Podcast, we're excited to host Prof. Rudolf Wiesner, an esteemed figure in the field of mitochondrial biology. As a key member of the CECAD Research Center at the University of Cologne, Prof. Wiesner's research has significantly advanced our understanding of mitochondrial dysfunction and its impact on aging. In our conversation, we'll explore his insightful work on mitochondrial DNA deletions, the innovative concept of mitochondria-derived vesicles, and the pivotal role of mitochondria in cellular aging and organ dysfunction. Prof. Wiesner will share his latest findings on the mutation rates in mitochondrial DNA, the intriguing enzyme TWINKLE, and the critical function of the adrenal medulla in mitochondrial quality control. Get ready for a profound discussion that sheds light on the complex relationship between mitochondria and the aging process, offering new perspectives on therapeutic strategies to slow aging and improve healthspan
In this episode of The VitaDAO Aging Science Podcast, we are thrilled to welcome Prof. Björn Schumacher, a leading expert in genome stability and aging. As Director of the Institute for Genome Stability in Ageing and Diseases at the University of Cologne, Prof. Schumacher has pioneered research into how DNA damage influences the aging process and the development of age-related diseases. We'll dive deep into his groundbreaking discovery of novel methods to enhance DNA repair, and how this could revolutionize our approach to extending healthy lifespan. Expect a captivating discussion on the intricacies of DNA repair mechanisms, the role of the DREAM complex, and the potential of new therapies to combat aging at the molecular level. Prepare to be enlightened by Prof. Schumacher's insights on the cutting-edge of aging science
In the upcoming episode of The Science of Aging Podcast, we're set to explore aging research with Dr. Jesse Poganik and Dr. Mahdi Moqri, just before the 2023 Biomarkers of Aging Symposium. Dr. Poganik from Brigham and Women's Hospital and Harvard, and Dr. Moqri, a joint fellow at Harvard and Stanford, will share insights on biomarkers and omics in longevity studies. We'll discuss the importance of biological clocks, functional markers, and the impact of these findings on aging interventions. Tune in for a concise yet deep dive into the future of personalized health and aging research.
In this installment of The VitaDAO Aging Science Podcast, we embark on a journey through the complex terrain of human genetics and aging with Dr. Joris Deelen. Broadcasting from the dynamic setting of the ARDD conference in Copenhagen, we dive into a rich and enlightening conversation about the limitations and revelations of using mice as model organisms in aging research. Dr. Deelen, a renowned researcher in the field of genetic longevity, brings his extensive knowledge and unique perspective to our discussion.
Together, we explore the intriguing discrepancies between human genetic data and mouse models, shedding light on what these differences mean for our understanding of aging. Dr. Deelen shares his insights from his groundbreaking work at the Max Planck Institute for Biology of Ageing, particularly his research on genetic variants linked to human longevity. We delve into the nuances of GWAS studies, the mystery of missing heritability in aging, and the fascinating case of ApoE in longevity research.
This episode is a treasure trove for anyone interested in the genetic underpinnings of aging, the potential of human genetic studies to unravel the secrets of longevity, and the future directions of aging research. Tune in to gain a deeper understanding of how genetics shapes our journey through life and the exciting possibilities that lie ahead in the quest for extended healthspan and lifespan.
In this episode of The VitaDAO Aging Science Podcast, we delve into the intricate dance of time and biology with Dr. David Meyer and Prof. Sarah Voisin. As we broadcast from the vibrant atmosphere of the ARDD conference in Copenhagen, we engage in a thought-provoking dialogue about the ticking of the epigenetic clock and the adaptive changes that come with aging. Dr. Meyer, a bioinformatician with a penchant for genome stability, and Prof. Voisin, an expert at the crossroads of epigenetics and bioinformatics, share their insights on groundbreaking conference presentations and their own pioneering research.
Together, we tackle the pressing issues of sustainability and overpopulation, pondering the role of longevity scientists in these global conversations. Listen in as we dissect stochastic changes during aging, discuss the impact of exercise on epigenetic aging, and consider the nuances of sex differences in biology. This episode is a must-listen for anyone curious about the future of personalized health interventions and the quest for a longer, healthier life.
In this episode of The VitaDAO Aging Science Podcast, we embark on a fascinating journey through the realms of longevity and cellular health with Dr. Arwen Gao. Dr. Gao, a leading authority in the fields of aging research, metabolism, and lysosomal pathways, takes us on a deep dive into the science behind extending lifespan. We'll explore the secrets of C. elegans, the tiny worm with big insights into human aging, and unravel the mysteries of the unfolded protein response (UPR).
Join us as we navigate the complex landscape of scientific discovery, discussing the challenges and triumphs of studying aging, potential breakthroughs, and the future of healthspan. Whether you're a seasoned scientist or new to the world of longevity research, this episode offers a captivating glimpse into the world of aging and the possibilities it holds for a healthier, longer life.
In this episode of The VitaDAO Aging Science Podcast, we delve into the world of age-related eye diseases with Prof. Dorota Skowronska-Krawczyk, a renowned expert in vision and aging. We explore fundamental aging mechanisms, challenges in research, and the potential of senolytics for eye conditions. Prof. Dorota shares insights into the retina's mysteries, the eye's unique immune status, and her groundbreaking work at UC Irvine. Join us as we uncover the intricate ties between vision, aging, and the future of eye health
In this enlightening episode of the Aging Science podcast, we dive deep with Prof. Vera Gorbunova, a trailblazer in the realm of longevity and aging research. Our discussion spans a myriad of fascinating topics, from the mysteries of genome stability and the unique biology of naked mole rats to the promising role of hyaluronan in cancer prevention. We explore the groundbreaking findings on SIRT6 activators like fucoidan, delve into the world of comparative transcriptomics, and unravel the enigma of Peto’s paradox. Prof. Gorbunova's insights into DNA damage, its correlation with aging, and the potential therapeutic applications of her research are truly captivating. We also touch upon her recent project with VitaDAO and the potential future of aging therapies. Join us as we journey through the intricate tapestry of aging science, uncovering the secrets that could reshape our understanding of longevity.
In this episode of the Aging Science podcast, we engage in a thought-provoking conversation with Prof. Joao Pedro De Magalhaes (@jpsenescence). Our dialogue covers a wide array of subjects, including the philosophical and scientific aspects of aging research, the potential of transhumanism, and the intriguing concept of cryonics. We delve into the repurposing of drugs for longevity, the phenomenon of inflammaging, and the promising potential of cellular reprogramming. We also discuss the challenges and opportunities in the field of aging research, the future of biogerontology, and the exciting developments in the Genomics of Ageing and Rejuvenation Lab.
In this episode of the Aging Science podcast, we delve into an insightful discussion with Dr. Heidi Pak (@pak_heidi). Our conversation spans various topics, such as the distinction between fasting and time-restricted feeding, the influence of caloric restriction on different mouse strains, sleep cycles, and the challenges of grad school. We also explore the healthspan vs lifespan debate, the future of nutritional recommendations, and the burgeoning field of circadian rhythms.
In this episode of the Aging Science podcast we talked with Prof. Nir Eynon (@nir_eynon). We touched on many topics, including elite athletes, how COVID affected working culture (for the better), the benefits of tabatas, epigenetic and muscle clocks and how they are affected by exercise, biases in research and the role of meta-analysis.
We had a marvelous conversation with Assoc. Prof. Viktor Korolchuk (@VIKorolchuk) about autophagy, mitochondria, senescence, the importance of modelling, and human desire for radical lifespan extension. Originally from Ukraine where he received his Ph.D., Viktor worked in Cambridge as a postdoctoral fellow and later moved to Newcastle upon Tyne in the beautiful north of the UK to pursue his work on aging.
He has received a grant from VitaDAO to identify novel autophagy activators against aging and lysosomal storage disorders.https://www.vitadao.com/projects/korolchuk-lab
Slowing aging by a couple of percents would save more money than curing any single disease, be it cancer, heart disease, or diabetes. Aging is, in fact, the major risk factor that all these diseases have in common. For this reason, slowing aging becomes the most efficient path to a sustainable and healthy future for humanity.
To get this message out we started The Aging Science podcast. We will bring you interviews and frank conversations with leading experts in the field of longevity, as well as evidence-based health advice to support you on this journey.
This podcast is brought to you by VitaDAO and Kamil Pabis, MSc (the @Aging_Scientist on Twitter).
In this podcast, I (@aging_scientist) had the pleasure of interviewing Asst. Prof Alaattin Kaya (@akay_lab).
We talked about recent breakthroughs in the field, the difficulties of getting funding for risky and novel research, funding agencies, “fishing expeditions”, the importance of overexpression genetic screens in aging research, novel mechanisms of action, and the replication crisis.
In this podcast, I (@aging_scientist) spoke with Dr. Rich Miller about the ins and outs of mouse aging.
The topics we discussed, roughly in this order, included the Interventions Testing Program, rapamycin, mecilizine, and other lifespan-extending drugs. We talked about the importance of genetically heterogenous mouse stocks and the issues with fast-aging progeroid mouse models. We also covered his more recent work on aging rate indicators and the difference between classic biomarkers and aging rate indicators. Finally, we talked about the importance of lifespan research, misuse of the word healthspan, and the emerging use of frailty indices in mice.
VitaDAO and Kamil Pabis, MSc (the @Aging_Scientist on Twitter) bring this podcast to you.