In this installment of The VitaDAO Aging Science Podcast, we embark on a journey through the complex terrain of human genetics and aging with Dr. Joris Deelen. Broadcasting from the dynamic setting of the ARDD conference in Copenhagen, we dive into a rich and enlightening conversation about the limitations and revelations of using mice as model organisms in aging research. Dr. Deelen, a renowned researcher in the field of genetic longevity, brings his extensive knowledge and unique perspective to our discussion.

Together, we explore the intriguing discrepancies between human genetic data and mouse models, shedding light on what these differences mean for our understanding of aging. Dr. Deelen shares his insights from his groundbreaking work at the Max Planck Institute for Biology of Ageing, particularly his research on genetic variants linked to human longevity. We delve into the nuances of GWAS studies, the mystery of missing heritability in aging, and the fascinating case of ApoE in longevity research.

This episode is a treasure trove for anyone interested in the genetic underpinnings of aging, the potential of human genetic studies to unravel the secrets of longevity, and the future directions of aging research. Tune in to gain a deeper understanding of how genetics shapes our journey through life and the exciting possibilities that lie ahead in the quest for extended healthspan and lifespan.