In the upcoming episode of The Science of Aging Podcast, we dive deep into the critical questions surrounding mouse models in aging research with our special guest, Dr. Dan Ehninger from the German Center for Neurodegenerative Diseases (DZNE) in Bonn. Dr. Ehninger, a visionary in the field of biogerontology, brings to the table his controversial and thought-provoking perspectives on the limitations and potential pitfalls of relying on mouse models for understanding human aging. We'll dissect the intricacies of rapamycin and caloric restriction studies, the debate over the mouse model's relevance to human aging, and innovative approaches to designing more effective mouse studies. This episode is a journey into the foundational challenges of aging science, highlighting the need for robust, translational research strategies. Join us for a riveting discussion that promises to enlighten, challenge, and inspire our understanding of the path forward in aging research.