In this episode of the Aging Science podcast, we engage in a thought-provoking conversation with Prof. Joao Pedro De Magalhaes (@jpsenescence). Our dialogue covers a wide array of subjects, including the philosophical and scientific aspects of aging research, the potential of transhumanism, and the intriguing concept of cryonics. We delve into the repurposing of drugs for longevity, the phenomenon of inflammaging, and the promising potential of cellular reprogramming. We also discuss the challenges and opportunities in the field of aging research, the future of biogerontology, and the exciting developments in the Genomics of Ageing and Rejuvenation Lab.