n this episode of The VitaDAO Aging Science Podcast, we're excited to host Prof. Rudolf Wiesner, an esteemed figure in the field of mitochondrial biology. As a key member of the CECAD Research Center at the University of Cologne, Prof. Wiesner's research has significantly advanced our understanding of mitochondrial dysfunction and its impact on aging. In our conversation, we'll explore his insightful work on mitochondrial DNA deletions, the innovative concept of mitochondria-derived vesicles, and the pivotal role of mitochondria in cellular aging and organ dysfunction. Prof. Wiesner will share his latest findings on the mutation rates in mitochondrial DNA, the intriguing enzyme TWINKLE, and the critical function of the adrenal medulla in mitochondrial quality control. Get ready for a profound discussion that sheds light on the complex relationship between mitochondria and the aging process, offering new perspectives on therapeutic strategies to slow aging and improve healthspan