In this wide ranging conversation, Dr. Dean Mitchell sits down with Professor Edward Quadros of SUNY Downstate to explore the critical roles of folate vitamin B9 and vitamin B12 in brain development and lifelong health. We unpack why some children show low cerebrospinal fluid folate despite a normal diet, how autoantibodies to the folate receptor can block folate from reaching the brain, and what the folate receptor antibody test FRAT reveals. Professor Quadros explains the research behind folinic acid leucovorin as a folate enhancer, what clinical studies show in children on the spectrum, and why earlier treatment tends to yield better outcomes. We also look at prenatal folate fortification, the potential value of screening parents, the milk and autoimmunity connection in susceptible kids, and clear up myths around the common MTHFR polymorphism. Finally, we connect B12 status, homocysteine, and the different B12 forms used in practice. If you care about evidence based insights on autism research, neurodevelopment, and smart supplementation, this episode is a must listen.

In this powerful episode, we explore one of the most important—and least understood—medical challenges of our time: how brain injury and aging impact mental health, behavior, and society. Our host is joined by renowned neuropathologist Dr. John Crary, a leading expert on brain diseases at Mount Sinai, to unpack the science and lived reality behind concussions, CTE (chronic traumatic encephalopathy), dementia, and more.Dr. Crary shares his early fascination with neuroanatomy, how pathology reveals the hidden stories inside every brain, and why repetitive mild head trauma—not just big hits—may be the true danger in contact sports and military service. He explains how CTE is diagnosed, why tau tangles are the “smoking gun,” and how the exact location of damage reveals the cause. The conversation digs into why certain brain regions drive memory loss, depression, and even aggression—and why some athletes and veterans develop devastating symptoms at a young age.We also discuss:Sports like football, boxing, and soccer—how risky are they really?The biomechanical “Nestlé Crunch bar” model of brain injuryWhy CTE can only be definitively diagnosed after death (for now)Emerging tools: PET scans, blood tests, MRI biomarkersHow studying athletes may help unlock treatments for Alzheimer’sNew hope in RNA-based therapies and amyloid/tau-targeting drugsWhether recovery is possible after multiple concussions—and when it’s too lateThis episode blends science, medicine, personal stories, and societal urgency. Whether you’re an athlete, parent, physician, or just curious about the brain, this is a must-listen conversation that could change how you think about brain health forever.

What should you do when water damage strikes—whether it’s a burst pipe, a flooded basement, or a slow leak you didn’t notice until it was too late? In this episode, Dr. Mitchell sits down with trusted mold inspector Joseph Reiss to unpack the essentials of mold prevention, testing, and remediation. They cover what to do in the first 24 hours after water damage, why carpets are mold magnets, how to safely contain and remove contaminated materials, and which testing methods actually help identify hidden mold.Joseph also shares insights on flood-proof home design, how to avoid costly mistakes, and what to look for in professionals who truly understand water and mold management. Whether you’re a homeowner, renter, or health-conscious listener, this conversation offers practical steps to protect your home—and your health—from toxic mold.

Adverse drug reactions and allergic responses to medications and vaccines are no longer rare side effects—they’re a growing medical challenge. In this episode, we sit down with Dr. Mariana Castells, Professor of Medicine at Harvard Medical School, Director of the Mastocytosis Center of Excellence, and Director of the Drug Hypersensitivity and Desensitization Center at Brigham and Women’s Hospital.We explore:Why newer medications and targeted therapies carry higher risks of severe reactionsThe difference between drug intolerance, adverse reactions, and true allergiesThe dangers of mislabeling penicillin allergy—and how it affects treatment choicesCutting-edge diagnostic tools like basophil and mast cell activation testingThe role of mast cells, novel receptors, and genetics in multiple drug allergiesStrategies for safer prescribing, testing, and desensitizationWhether you’re a clinician, researcher, or patient who’s experienced a “bad reaction” to medication, this conversation offers clarity on what we know today—and where the science of drug allergy is heading.

What’s it really like to be a medical student in 2025? Host Dr. Mitchell sits down with second-year students Nya Evans and Marco Halabi from Touro College of Osteopathic Medicine for a candid conversation about why they chose medicine, the challenges of medical school today, and how training has evolved since the 1980s. From simulation labs and self-directed learning to the psychological toll of training and the role of AI in the future of medicine, this episode offers a rare first-hand look at how tomorrow’s physicians are being shaped. Both insightful and personal, it’s a reminder that while technology changes, the heart of medicine is still human connection.

Brain fog—a term once absent from the medical lexicon—has become one of the most debilitating and puzzling symptoms of Long COVID. But what exactly is happening inside the body to cause this cognitive impairment? Is it just inflammation, or is there a more complex mechanism at play?In this episode, we sit down with leading immunologist Dr. Terry Harville, Medical Director of the Special Immunology Laboratory at the University of Arkansas for Medical Sciences. Dr. Harville takes us on a deep dive into the unique relationship between the SARS-CoV-2 virus and the human immune system, explaining why this zoonotic virus is so effective at causing long-term neurological issues. This isn't just about forgetfulness; it's a serious medical condition that could be a harbinger of something much worse.If you or someone you know is struggling with the cognitive effects of Long COVID, this episode is an essential listen, packed with scientific insights and actionable treatment strategies from an expert on the front lines.Visit apolloneuro.com and use code: smartmd at checkout to get your hands on the sleep wearable that Dr. Mitchell trusts.Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.com

What if your child’s sudden anxiety, OCD, or tics weren’t behavioral—but biological? In this eye-opening episode, we welcome back Dr. Jill Crista, a leading expert in naturopathic medicine and mold-related illness, to explore a lesser-known but critically important condition: PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections) and its broader counterpart, PANS (Pediatric Acute-onset Neuropsychiatric Syndrome).What if a simple strep throat infection could lead to sudden-onset OCD, anxiety, tics, or even psychosis in children? Dr. Crista breaks down the groundbreaking science behind how infections—and even environmental toxins like mold and glyphosate—can trigger autoimmune attacks on the brain, mimicking psychiatric disorders.Dr. Crista shares her "Core Four" treatment framework and critical cautions (like which "brain-boosting" herbs can actually flare symptoms). Whether you're a parent, clinician, or someone struggling with unexplained neuropsychiatric symptoms, this episode is a must-listen for understanding the body-mind connection in mental health.Visit apolloneuro.com and use code: smartmd at checkout to get your hands on the sleep wearable that Dr. Mitchell trusts.Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.com

Ever looked in the mirror and wondered, What if I tweaked this? You’re not alone. Plastic surgery—once reserved for the rich and famous—is now a reality for everyday people seeking confidence and self-improvement. But how do you know if it’s right for you? And what separates a natural-looking result from a "wind tunnel face"?On this episode, host Dean Mitchell sits down with Dr. Robert Freund, a top Manhattan plastic surgeon, inventor of the Teardrop Breast Lift, and author of Cosmetic Breast Surgery and A More Beautiful You. From their shared high school days to their time at Brown University, Dean and Dr. Freund reunite for a candid conversation about the psychology of plastic surgery, teen procedures, the future of anti-aging and much more!Whether you’re considering a procedure or just fascinated by the intersection of medicine and art, this episode is packed with insider insights, ethical dilemmas, and a few wild stories from Dr. Freund (like the time he spent 16 hours reattaching a model’s fingertip).Visit apolloneuro.com and use code: smartmd at checkout to get your hands on the wearable that Dr. Mitchell trusts.Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comVisit Dr. Mitchell's website here: https://www.mitchellmedicalgroup.com

In this episode of The Smartest Doctor in the room, we welcome back Dr. Kevin Tracey, a pioneering neurosurgeon, scientist, and leading expert in bioelectric medicine—specifically, the healing power of the vagus nerve. Dr. Tracey’s work has proven that electrical stimulation of the vagus nerve can reverse autoimmune conditions without medication, a discovery that could dramatically transform modern medicine.Dr. Tracey also shares insights from his new book, The Great Nerve, which explores the vagus nerve’s role in health, longevity, and holistic healing. Plus, we discuss why he’s a top candidate for a Nobel Prize in medicine.Whether you're a health enthusiast, autoimmune patient, or medical professional, this conversation will change how you think about healing, inflammation, and the mind-body connection.Listen now—and discover how the "great nerve" could be the key to unlocking your body’s natural healing potential.Grab your copy of The Great Nerve on Amazon!Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comVisit Dr. Mitchell's website here: https://www.mitchellmedicalgroup.com

In this episode of The Smartest Doctor in the Room, Dr. Mitchell sits down with renowned nutritionist, chef, and author Mia Rigden to explore her holistic approach to healthy eating for individuals and families. Mia shares her expert insights on balancing nutrition science with the emotional and practical aspects of food, offering actionable tips for sustainable wellness.Mia also opens up about her work with high-profile clients, her bestselling books FoodWise and The Well Journal, and her mission to make nutritious home cooking accessible through her Substack, Between Meals. Whether you're a busy parent, a fitness enthusiast, or just looking to feel better every day, this conversation is packed with science-backed wisdom you won’t want to miss!Visit miarigden.com for more practical insights!Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comVisit Dr. Mitchell's website here: https://www.mitchellmedicalgroup.com

What separates elite athletes from the rest? While we often focus on strength, speed, and skill, one critical factor is frequently overlooked: vision. In this eye-opening episode, we sit down with Dr. Daniel Laby, a leading sports vision ophthalmologist who has worked with the Los Angeles Dodgers, NBA teams, Formula 1 drivers, and Olympic athletes.Whether you’re a pro athlete, a weekend competitor, or just someone who wants to protect and optimize your eyesight, this episode will change how you see the game—literally. Dr. Laby also shares insights from his book, "Eye of the Champion: Unlocking the Power of Sports Vision for Peak Performance," and explains how his work with Usher syndrome patients proves that vision training isn’t just for athletes—it’s for everyone.Tune in to discover how the science of sight can elevate your performance, safety, and quality of life!Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comVisit Dr. Mitchell's website here: https://www.mitchellmedicalgroup.com

In this episode of The Smartest Doctor in the Room, host Dr. Dean Mitchell sits down with Dr. Bruce Farber, Chief of Public Health and Epidemiology at Northwell Health, to dissect the infectious disease threats making headlines—from resurgent measles outbreaks to the looming specter of avian flu. With decades of experience battling HIV, COVID-19, and hospital-acquired infections, Dr. Farber offers a frontline perspective on:The alarming measles surge: Why vaccine hesitancy is fueling preventable outbreaks and who really needs a booster.Bird flu’s pandemic potential: How close are we to human-to-human transmission—and are we prepared?Candida auris & other hospital superbugs: The truth about antibiotic resistance and how to protect yourself during hospital stays.Chronic Lyme & "long COVID" controversies: Why prolonged antibiotics often fail—and what might work instead.Lessons from HIV to COVID: How public health wins (and fails) shape our future.This episode is a must-listen for anyone concerned about the invisible threats in our communities. Tune in for an episode filled with cutting edge insights on modern day medicine, no fear-mongering, just facts.Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comVisit Dr. Mitchell's website here: https://www.mitchellmedicalgroup.com

In this episode of the Smartest Doctor in the Room, host Dr. Dean Mitchell sits down with renowned immunologist and autism researcher Dr. Judy Van der Water from the UC Davis MIND Institute. Together, they dive deep into the groundbreaking research linking maternal immune health, the fetal microbiome, and the rising prevalence of autism spectrum disorders (ASD).Dr. Van der Water shares her pioneering work on gestational immune dysregulation, including the role of maternal autoantibodies (MAR antibodies) in fetal brain development—and why these findings challenge long-held misconceptions about autism’s origins. They also tackle tough questions: Is autism risk determined in utero? How do environmental toxins and epigenetics play a role? And what about vaccines?From early detection strategies to community resources for families, this conversation blends cutting-edge science with practical hope. Whether you’re a parent, clinician, or simply curious about the immune-brain connection, this episode offers invaluable insights into one of medicine’s most urgent mysteries.Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comVisit Dr. Mitchell's website here: https://www.mitchellmedicalgroup.com

In this episode of The Smartest Doctor in the Room, we explore the complex world of gastrointestinal health with leading expert Dr. Rao. The doctors discuss the wide ranging impacts of poor gut health, from digestive issues, to brain fog. They share groundbreaking insights into diagnosis, the role of fungi like Candida, the effects of medications like proton pump inhibitors, and innovative treatment approaches. Dr. Rao and Dr. Mitchell also share their frustrations with the slow speed at which new and proven techniques become widely adopted, and the inflexible attitude towards new discoveries that is all too common in the field. Tune in to hear health advice, industry insights, and everything in between!Need a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comVisit Dr. Mitchell's website here: https://www.mitchellmedicalgroup.com

In this episode of The Smartest Doctor in the Room, we delve into the true essence of effective weight training and holistic wellness with author and four-time world weightlifting champion, Jerzy Gregorek. With a background rooted in resilience, philosophy, and a passion for helping others, Jerzy shares his expert insights on how proper strength training can transform not only your body but also elevate your spirit. Discover practical tips on injury prevention, the importance of flexibility, recovery techniques, and how to cultivate a lifestyle that promotes longevity and mental clarity. Whether you're an athlete, a busy professional, or seeking athletic longevity, Jerzy's wisdom will motivate you to make the hard choices that lead to an easy, fulfilling life. Tune in to learn how to strengthen your body and nurture your soul.Pick Up Jerzy's Book Here: https://thehappybody.com/Check out Dr. Mitchell’s Website: mitchellmedicalgroup.comNeed a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comConnect with ITC Pharmacy at 888-349-5453

In this episode of The Smartest Doctor in the Room, Dr. Mitchell welcomes allergy expert Dr. David Golden Associate Professor at Johns Hopkins to explore the critical topic of anaphylaxis — the most dangerous allergy. They discuss what anaphylaxis really is, how it presents differently in individuals, and the latest advancements in treatment, including the groundbreaking FDA-approved nasal spray as an alternative to injectable epinephrine. Plus, hear insights on allergy testing, immunotherapy options like Xolair, and the evolving protocols in emergency management. Whether you're an allergy sufferer, caregiver, or healthcare professional, this episode provides vital information to help you stay prepared and informed.Check out Dr. Mitchell’s Website: mitchellmedicalgroup.comNeed a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comConnect with ITC Pharmacy at 888-349-5453

In this episode, we dive into the often-misunderstood world of chronic sinusitis, exploring why antibiotics aren't always the answer and uncovering effective, natural, and integrative treatment strategies. Join us as Dr. Linda Dahl, a seasoned ENT specialist with a unique background—from ringside boxing to Broadway—shares her holistic approach to sinus health, the importance of microbiome balance, and when surgery is truly necessary. We also discuss the critical role of allergies, the pitfalls of overprescribing medications, the significance of personalized care, and how holistic practices can help with maternal health. Whether you're a patient or a fellow healthcare professional, this conversation offers valuable insights into managing sinus issues more thoughtfully and effectively. Plus, get a sneak peek into Dr. Dahl's exciting ventures into writing and television!Check out Dr. Mitchell’s Website: mitchellmedicalgroup.comNeed a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comConnect with ITC Pharmacy at 888-349-5453

In this inspiring episode of the "Smartest Doctor in the Room" Dr. Dean Mitchell, celebrates Food Allergy Awareness Month by speaking with a remarkable young advocate, 12-year-old Zacky Muñoz. Along with his mother Priscilla, Zacky shares his personal journey living with food allergies, the challenges he faces, and his passionate fight to improve safety and awareness through the Zacky Fast Act legislation in California. Plus, discover the latest advances in allergy treatments, innovative devices like needle-free epinephrine, and how social media is empowering youth to become advocates. Join us for a heartfelt conversation about resilience, advocacy, and hope for a safer future for children with food allergies.Connect with Zacky and his mission:https://www.zackysuniverse.com/@zackys_universe on Instagramzackys_universe on TikTokCheck out Dr. Mitchell’s Website: mitchellmedicalgroup.comNeed a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comConnect with ITC Pharmacy at 888-349-5453

In this insightful episode, Dr. Mitchell welcomes back renowned mold inspector Joe Reiss to discuss crucial strategies for identifying, addressing, and preventing water damage and mold in your home. From handling water leaks and basement puddles to understanding the complexities of mold species and their health impacts, Joe shares expert tips on source control, environmental assessment, and choosing reputable remediation professionals. Plus, learn how your to care for your home and why indoor air quality is vital for its health, as well as your own. Whether you're a homeowner, renter, or concerned about mold exposure, this episode provides practical advice to help protect your environment and well-being. Listen in to equip yourself with the knowledge to take proactive steps toward a healthier, happier home.Check out Dr. Mitchell’s Website: mitchellmedicalgroup.comNeed a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comConnect with ITC Pharmacy at 888-349-5453

Welcome back to The Smartest Doctor in the Room with Dr. Dean Mictchell. Today on this enlightening episode, he explores the fascinating world of archaeological nutrition with Culinary Archaeologist Lisa Roberts. Discover how ancient food practices, cultural rituals, and traditional diets from the Mediterranean and beyond can offer powerful insights into holistic health, autoimmune conditions, and stress management today. Lisa shares her personal journey from health challenges to becoming a pioneer in blending archaeology, culinary arts, and nutrition — revealing practical tips on nourishing the body, mind, and spirit. Whether you're interested in the science behind the Mediterranean diet, the importance of community and ritual in eating, or how to incorporate ancient wisdom into your modern lifestyle, this episode provides timeless lessons for optimal well-being.Check out Dr. Mitchell’s Website: mitchellmedicalgroup.comNeed a certified mold inspector? Reach out to Joseph ReissPhone Number: 908-451-4592  Email: jprconsultants7929@gmail.comConnect with ITC Pharmacy at 888-349-5453