阿茲海默症臨床試驗長年處於高失敗率、低回報的泥沼。本集邀請你從科學的根本重新審視：透過整合基因體、蛋白體、代謝體等多體學資料，科學家如何重建疾病機制地圖，並意外發現可重定位的癌症藥物組合，有望為退化性神經疾病注入新曙光。
Alzheimer’s trials have long suffered from high failure rates. In this deep-dive episode of XioTalks, we explore how multi-omics is reshaping our understanding of disease pathways—and how it’s leading researchers to unexpected therapeutic combinations, including repurposed oncology drugs.
-📝https://doi.org/10.1016/j.cell.2025.06.035-
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你沒聽錯，威而鋼真的有可能成為抗癌幫手！本集我們揭開這項令人驚訝的研究發現：威而鋼可以活化樹突細胞、調節免疫反應，甚至強化免疫療法的效果。從熟悉的藥物到前沿研究，讓我們一起重新認識它的第二人生！
Viagra vs. Cancer? This Time It’s Not a JokeYes—you read that right. Recent studies show that sildenafil (Viagra) mayenhance immune responses by boosting dendritic cell activity. In this episode,we unpack the unexpected science behind this repurposed drug and explore itssurprising potential in cancer therapy.
📝https://doi.org/10.1038/s41586-025-09202-9
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TBAL 台灣活性脂質股份有限公司
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小時候擦破皮會自動癒合，但為什麼我們不能長出一隻新手指？原來，哺乳動物體內真的有「再生開關」，只是演化中被關掉了。本集用生活化語言帶你認識最新研究成果，解釋為何科學家相信，我們或許能再次「學會再生」。
Why Can’t We Regrow? A Genetic Switch Might Be the Key
Why can kids heal scrapes but not regrow limbs? Turns out mammals carry the genetic machinery for regeneration—it’s just switched off. In this episode, we explain the fascinating science behind a recent discovery that could one day change how we recover from injuries.
📝https://www.science.org/doi/10.1126/science.adp0176-
📣【TBAL展場限定・破盤優惠】
只在 2025 亞洲生技大展！
Nightingale 全方位血液代謝體檢測
🔬一次解析250+項健康指標
📌 原價 NT$8,000
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🎤【TBAL 專題演講｜2025 亞洲生技大展】
從多體學檢測到產品應用與代工技術，深入解析未來生技關鍵趨勢 🔬
誠摯邀請您參加由 TBAL 主持的三場專題講座，聚焦科研技術與實務經驗，精準掌握市場新脈動：
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🚩第一場：多體學檢測 (脂質體、蛋白質、代謝體、空間體學)講者：馬文隆 教授時間：7/24(四) 13:00-13:20
🚩第二場：產品開發講者：楊顓丞 博士時間：7/24(四) 15:40-16:00
🚩第三場：代工包覆(核酸包覆、難溶性藥品包覆)、MRT(藥廠經驗)講者：曾堯宣 教授時間：7/25(五) 14:20-14:40
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📍 地點：台北南港展覽館1館 4F L318📆 展期：7/24 – 7/27🎫 名額有限，歡迎提早入席！
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TBAL 台灣活性脂質股份有限公司
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本集深入探討尿液作為代謝體學樣本的研究進展與臨床應用價值。從慢性腎病、代謝症候群到癌症風險評估，尿液中所蘊含的代謝物資訊，正為無創預測工具開啟新契機。探討技術平台、資料解析與未來整合趨勢，適合關注精準醫學的研究與產業界聽眾。This episode explores the evolving role of urine-basedmetabolomics in biomedical research. From kidney disease to metabolic disordersand early cancer detection, urine provides a rich, non-invasive matrix forpredictive biomarker discovery. We delve into its analytical strengths,limitations, and translational potential in precision health.
📝https://research.nightingalehealth.com/blog/urine-metabolite-profiling-from-studies-of-diabetes-patients-to-general-population-cohorts/
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📣【TBAL展場限定・破盤優惠】
只在 2025 亞洲生技大展！
Nightingale 全方位血液代謝體檢測
🔬一次解析250+項健康指標
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⏰ 7/24-7/27
📍台北南港展覽館1館 4樓 L318攤位
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TBAL 台灣活性脂質股份有限公司官網 https://www.t-bal.com/粉絲臉書團 https://www.facebook.com/TBAL2017
YOUTUBE https://www.youtube.com/@Taiwan-BioActive-LipidThe recipient's phone：+886-4-2247-6758Customer service email：t-bal_2@t-bal.com.twFax：04-2217-5362LINE ID：@722hneuu
高血壓、糖尿病、甚至癌症，都不是突然發生的。現在有一種方法叫做代謝體檢測，可以提早發現你身體的風險訊號。本集用簡單語言帶你認識這項新科技，幫助你提早佈局自己的健康未來。
Chronic diseases like diabetes and heart disease often build silently over time. In this episode, we explain how metabolomics can detect subtle changes in your body long before symptoms appear—helping you make smarter health choices today, for a better tomorrow.
📝https://www.nature.com/articles/s41591-022-01980-3
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📣【TBAL展場限定・破盤優惠】
只在 2025 亞洲生技大展！
Nightingale 全方位血液代謝體檢測
🔬一次解析250+項健康指標
📌 原價 NT$8,000
👉 展場價 NT$5000/樣本（不限數量）
👉 大量加碼價 NT$4000/樣本（100樣本以上）
🎯 現場即刻登記，先拿折扣價
⏰ 7/24-7/27
📍台北南港展覽館1館 4樓 L318攤位
TBAL 台灣活性脂質股份有限公司官網 https://www.t-bal.com/粉絲臉書團 https://www.facebook.com/TBAL2017YOUTUBE https://www.youtube.com/@Taiwan-BioActive-Lipid
The recipient's phone：+886-4-2247-6758Customer service email：t-bal_2@t-bal.com.twFax：04-2217-5362LINE ID：@722hneuu
心血管疾病預測仍以膽固醇與血壓為主？其實風險遠不止於此。本集深入探討代謝體學（Metabolomics）如何突破傳統框架，透過數百種代謝物數據描繪更精準的個人健康風險，成為未來預防醫學的重要工具。科學與臨床正在接軌，這場預測革命，正在展開。
Can we go beyond cholesterol to predict heart disease? In this episode, we explore how metabolomics is reshaping cardiovascular risk assessment—leveraging hundreds of metabolic markers to improve accuracy and guide personalized prevention strategies. The future of predictive medicine is already here.
-📝https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-024-00882-0https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5044987
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📣【TBAL展場限定・破盤優惠】
只在 2025 亞洲生技大展！
Nightingale 全方位血液代謝體檢測
🔬一次解析250+項健康指標
📌 原價 NT$8,000
👉 展場價 NT$5000/樣本（不限數量）
👉 大量加碼價 NT$4000/樣本（100樣本以上）
🎯 現場即刻登記，先拿折扣價
⏰ 7/24-7/27
📍台北南港展覽館1館 4樓 L318攤位
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TBAL 台灣活性脂質股份有限公司
粉絲臉書團 https://www.facebook.com/TBAL2017
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The recipient's phone：+886-4-2247-6758
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Significance 研究意義
本研究提出以矽-玻璃製成的 SCALAR ( Silicon Calable ALipid RNP) 微流體晶片，將單一混合單元無縫擴增至 1×、10×、256×，使 mRNA-LNP 產量從 0.1 L /hr 躍升至 17 L /hr，同時保持粒徑 (~70 nm)、封裝效率 (>85 %) 及體內免疫效力一致。
在 COVID-19 疫情中，LNP 配製是疫苗產線瓶頸；該平台證明可在不改變配方參數的情況下，直接由實驗室規模過渡到臨床與商業量產，顯著縮短反應新興病原的時程。
The study introduces a silicon–glass SCALARmicrofluidic platform that parallelizes identical mixing units (1×, 10×, 256×),boosting mRNA-LNP output from 0.1 L /hr to 17 L /hr while preserving particlesize (~70 nm), encapsulation efficiency (>85 %), and in-vivo potency.
During the COVID-19 pandemic, LNPformulation was a production bottleneck; SCALAR enables seamless scale-upwithout re-optimizing formulation parameters, accelerating the response toemerging pathogens.
Importance 關鍵重要性
製程韌性：晶片可耐 >1,000 PSI、高溫滅菌並可重複清洗 (非離子界面活性劑或高壓蒸氣)，克服 PDMS 與 COC 一次性耗材易溶脹或汙染的限制。
產能與成本：256× 晶片每小時可生產約 34,000 劑 (0.5 mL/劑) 疫苗；若採 12-inch 晶圓，可進一步堆疊 >1,000 個混合單元，單片成本估計 < US$100。
品質一致性：自動化壓差驅動與階梯-樹枝流道設計確保各通道流阻均一，實驗顯示 90 % 以上混合長度於三種規格晶片皆無顯著差異。
Process robustness: Silicon–glass chipstolerate >1,000 PSI, autoclaving, and surfactant cleaning, overcomingswelling/leaching issues seen with PDMS or COC disposables.
Throughput & economics: A 256× chipyields ~34 k vaccine doses /hr; scaling to 12-inch wafers (>1,000 units)could drop per-chip cost below US $100.
Product consistency: A ladder-plus-brancharchitecture equalizes flow resistance; fluorescence-dye studies show identical90 % mixing lengths across 1×, 10×, and 256× chips.
Connectivity to other fields 與其他領域之連結
半導體製程 × 生醫製造：利用成熟 MEMS 深反應離子蝕刻與陽極鍵合技術，將「晶圓級量產思維」導入奈米藥物製程，可與晶圓代工、智慧製造 (e.g., inline PAT 感測) 整合。
核酸與細胞治療：平台已成功封裝 siRNA、polyA、CRISPR mRNA 等多種貨載，並適用於 CAR-T 轉染、基因編輯與蛋白替代療法的 LNP 生產。
連續製程與冷鏈革新：SCALAR 可串接透析或切向流過濾，形成連續流產線；若結合端點-需求 (point-of-care) 製造，可降低冷鏈依賴，對資源匱乏地區疫苗供應具策略意義。
Semiconductor–bioprocess convergence: MEMSDRIE and anodic bonding translate wafer-scale manufacturing concepts tonanomedicine, opening collaboration with foundries and smart-factory PATsystems.
Nucleic-acid & cell therapies: The chipformulates siRNA, polyA, CRISPR mRNA, etc., supporting scalable LNP productionfor CAR-T engineering, gene editing, and protein-replacement therapeutics.
Continuous manufacturing & cold-chainrelief: SCALAR can be integrated with inline dialysis or TFF, enablingend-to-end continuous flow and point-of-demand manufacturing that mitigatescold-chain constraints in low-resource settings.-
📣【TBAL展場限定・破盤優惠】
只在 2025 亞洲生技大展！
Nightingale 全方位血液代謝體檢測
🔬一次解析250+項健康指標
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⏰ 7/24-7/27
📍台北南港展覽館1館 4樓 L318攤位
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TBAL 台灣活性脂質股份有限公司
粉絲臉書團 https://www.facebook.com/TBAL2017
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為何有些上皮性卵巢癌細胞能逃過化療？一項發表在《細胞與分子醫學》期刊的研究揭示，一種名為 PEO 的特定脂質分子，特別是透過細胞內 AGPS 酵素合成的這類 PEO，就像為癌細胞穿上了一層「保護罩」。研究人員分析大型資料庫 (如 CCLEC, GDSC) 與實驗室數據，發現甘油磷脂代謝，尤其是 PEO 的含量，與癌細胞對常用化療藥物 紫杉醇 (Paclitaxel) 和 鉑類藥物 (Cisplatin) 的不敏感性有顯著的正相關。透過補充 PEO、抑制 AGPS 等實驗，證實細胞自身合成的 PEO 是導致抗藥性的關鍵因素。本集將深入解析這個「脂質防護罩」的秘密，以及它如何影響癌症治療效果。
Why do some epithelial ovariancancer cells evade chemotherapy? A study published in the journal Cell & Molecular Medicine reveals that a specific lipid molecule called PEO,particularly the type synthesized by the intracellular enzyme AGPS, acts like a "protective shield" for cancer cells. Researchers analyzed large databases (like CCLEC, GDSC) and lab data, finding a significant positivecorrelation between glycerol phospholipid metabolism, especially the level of PEO, and the insensitivity of cancer cells to common chemotherapy drugs like Paclitaxel and Cisplatin. Experiments involving PEO supplementation and AGPS inhibition confirmed that PEO synthesized internally by the cell is a key factor in causing drug resistance. This episode delves into the secret of this "lipid shield" and how it impacts the effectiveness of cancer treatment.-
TBAL 台灣活性脂質股份有限公司
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你可能沒想過，一塊炸雞裡的油脂，竟然可能加快癌細胞的轉移速度？棕櫚酸這個在日常飲食中無所不在的脂肪酸，正被科學家點名為「癌症潛在幫兇」。本集以淺顯方式揭開脂肪與癌細胞的複雜關係，也許會讓你重新審視冰箱裡的食材。
Sounds wild, but it's true—palmitic acid,found in everyday foods, may help cancer cells move faster. This episode unpacksthe science in simple terms, exploring how one common fat could change the waywe think about food, health, and cancer.
📝https://www.nature.com/articles/s43018-023-00513-2
TBAL 台灣活性脂質股份有限公司
粉絲臉書團 https://www.facebook.com/TBAL2017
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油吃多真的會「堵住血管」嗎？還是我們誤會脂肪太久了？
本集帶你釐清不同脂肪（飽和、不飽和、反式脂肪）對心血管代謝的影響，結合最新脂質體學與營養標記分析，提供科學角度的健康建議。從飲食習慣到精準預防，掌握脂肪與代謝風險的關鍵知識，你一定要聽懂！
Is fat clogging your arteries—or have wemisunderstood it all along?In this episode, we explore the complex relationship between dietary fats and cardiovascular metabolism. Learn how different fats (saturated, unsaturated,trans) influence your health, and how lipidomics and nutritional biomarkers are reshaping how we assess risk. From daily habits to future diagnostics, this is your science-based guide to understanding fat and heart health.
📝https://www.nature.com/articles/s41591-024-03124-1
TBAL 台灣活性脂質股份有限公司
粉絲臉書團 https://www.facebook.com/TBAL2017
YOUTUBE https://www.youtube.com/@Taiwan-BioActive-Lipid
The recipient's phone：+886-4-2247-6758
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疫苗技術正在加速演化，mRNA只是開始。這一集聚焦一個被低估的小分子：Mildronate，在新一代脂質體配方中的策略角色。它如何影響劑量設計、安全性與製程效率？這場看不見的藥物遞送革命，或許將重塑疫苗市場版圖。
The mRNA wave was just the beginning. This episode examines how Mildronate—an often-overlooked small molecule—might play a strategic role in next-gen liposomal vaccines. We dive into formulation insights, delivery precision, and clinical implications that could reshape the future of immunization tech.
📝https://pubmed.ncbi.nlm.nih.gov/38798555/
https://pubmed.ncbi.nlm.nih.gov/39151414/
TBAL 台灣活性脂質股份有限公司
官網 https://www.t-bal.com/粉絲臉書團 https://www.facebook.com/TBAL2017YOUTUBE https://www.youtube.com/@Taiwan-BioActive-LipidThe recipient's phone：+886-4-2247-6758Customer service email：t-bal_2@t-bal.com.twFax：04-2217-5362LINE ID：@722hneuu
你知道嗎？細胞釋放出來的「胞外囊泡」（Extracellular Vesicles, EVs），不只是垃圾袋，更可能是下一代藥物傳輸的關鍵武器！
本集將帶你深入了解這項新興技術：如何強化囊泡的載貨能力、提升穩定性與靶向性，並應用於癌症治療、神經疾病、疫苗載體等前沿醫療領域。
從脂質體到EV，藥物運輸的科技革命正在悄悄進行。你準備好迎接這場細胞層級的未來變革了嗎？
Did you know your cells naturally produce nanoscopic vesicles that might carry the next generation of therapies? In this episode, we unpack the science behind Extracellular Vesicles (EVs), how they’re being engineered for better cargo delivery, and why they’re gaining attention as the future of precision drug delivery—from cancer to mRNA vaccines.
Get ready to explore the frontier where cell biology meets medical innovation.
TBAL 台灣活性脂質股份有限公司
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The recipient's phone：+886-4-2247-6758
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Fax：04-2217-5362
LINE ID：@722hneuu
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Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis. J Hepatol. 2015 Jun;62(6):1382-90.
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📌Significance :The significance of this study lies in exploration of potential therapeutic agents for non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, that are increasingly prevalent due to rising obesity rates. The study investigates the effects of cannabinoids, specifically THCV and CBD, for their potential to improve insulin sensitivity and lipid metabolism. This could lead to new pharmacological treatments for NAFLD, as effective therapies.
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📌Importance of lipidology :The effects of THCV and CBD on lipid levels were examined in a variety of in vitro and in vivo systems, with special emphasis on models of hepatosteatosis. Treatment also induced post-translational changes in a variety of proteins such as CREB, PRAS40, AMPKa2 and several STATs indicating increased lipid metabolism and, possibly, mitochondrial activity. They show here that both THCV and CBD reduce intracellular lipid levels in vitro in a model of hepatosteatosis and adipocytes, mobilize zebrafish embryo lipid yolk stores and inhibit hepatosteatosis in obese mice.
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📌Connectivity to other fields :The implications of this study consist of various fields beyond hepatology and metabolic research, including pharmacology, nutrition, and mental health. This highlights the interdisciplinary nature of metabolic research.
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READ MORE
https://pubmed.ncbi.nlm.nih.gov/25595882/
Lipid Profiling
https://www.t-bal.com/art....../group-3wMaXdj7KAt8ziTgHoRYtR
TBAL 台灣活性脂質股份有限公司
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