Join our upcoming retreat in January 2026: https://www.siimland.co/retreat
Timestamps:Introduction (00:00)Discussion on longevity clinics and testing (01:52)Essential health tests and biomarkers (05:45)Improving VO2 Max and cardiovascular health (11:28)Blood tests and metabolic health (16:42)Hormone tests and longevity (21:35)Microbiome tests and toxicity (26:55)Microplastics and environmental toxicity (32:14)Food sensitivity testing (39:01)NAD testing and energy metabolism (41:50)Comprehensive health retreat (49:29)
Dr. Joy Kong Youtube channel: https://www.siimland.co/retreat
Dr. Mark Tarnopolsky is a Professor and Division Head of Neuromuscular and Neurometabolic Disorders in the Department of Pediatrics at McMaster University. He completed a PhD in Cell Biology and Metabolism in 2001.
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:00:00 Intro00:25 What are mitochondria03:55 Mitochondria in aging and longevity06:00 Oxidative stress, inflammation, and longevity09:30 Antioxidants and benefits of exercise12:40 Bon Charge sponsorship13:30 Who should take antioxidants21:30 Mark’s antioxidant cocktail study24:30 Why is exercise the best thing for your mitochondria30:35 How endurance training shapes the mitochondria35:10 High intensity interval training36:50 Role of mitochondria in muscle loss42:00 Nutrition for mitochondrial health46:50 Supplements for mitochondrial health53:35 Stimulating mitophagy
Dr Mark Tarnopolsky research page: https://scholar.google.com/citations?user=4jhi_KkAAAAJ&hl=en
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:00:00 Intro00:48 The genetics of a 117-year-old woman08:16 Resilience, immunity and longevity14:33 Muscle building genetics19:33 FOXO3 and stress resilience24:53 FOXO3 gene editing32:08 Can telomere lengthening be harmful to some individuals38:58 IGF-1 and growth hormone and longevity50:08 Genetically short sleepers54:38 What you should know about your longevity genes
First podcast with Tyler about genetics and supplements: https://youtu.be/9GLbTEYewUs
Tyler Panzner channel: https://www.youtube.com/@drtylerpanzner
Timestamps
0:00 – Introduction
4:12 – Humans adapt, and that changes the rules
9:58 – Diet diversity, sensitivities, and n of 1
16:51 – Assess first: biomarkers that predict disease risk
18:27 – Fixing sleep, movement, diet, environment
22:47 – Caution on rapamycin, metformin, methylene blue
25:54 – FOXO3 stem-cell study and what it means
37:15 – Mindset and willpower as real enhancers
41:44 – TMG, astaxanthin, melatonin, creatine
47:09 – VO2 max priorities and performance trade-offs
48:51 – Balancing fitness with joy and purpose
53:18 – Biomarkers mediate risk more than labels
1:01:00 – 2030–2040: what is realistic
1:04:02 – Immortality probabilities and living well now
Julian Issa video podcast: https://youtu.be/vV8yMVGLG6Y?si=XiLxOx0bSSM-xT-v
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Timestamps:
00:00 Does exercise increase inflammation
03:03 Melatonin megadosing research
04:23 NOVOS vs Blueprint VS DoNotAge
07:44 Hidden things that contribute to my health
12:14 Bon Charge sponsorship
13:05 How to improve night shift work
15:40 Supplements to take before the sauna
17:15 Does caffeine age the brain
19:34 Can you make up for lost sleep
20:40 Thoughts on Urolithin A
23:14 Doing too much for longevity
27:59 How to stop waking up at 3AM
30:57 How much sodium do I consume
33:20 Do sleep supplements blunt natural sleep
37:07 Inflammation in longevity
41:23 Importance of good relationship with food
Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025
Timestamps:00:00 Intro00:14 Taurine01:19 Apigenin01:55 Resveratrol03:20 Rapamycin04:55 Metformin06:11 Calcium AKG07:30 Melatonin08:16 SIRT609:05 NAC09:43 NMN, NR, Niacinamide11:10 Niacin13:58 Glycine15:16 Spermidine16:44 Omega-3s17:40 Creatine18:48 Pterostilbene19:19 Magnesium20:16 Vitamin K220:45 Sulforaphane21:34 Curcumin22:08 Methylated B vitamins22:33 Glutathione24:08 Lithium24:55 Lutein & Zeaxanthin25:30 Vitamin C26:29 Ergothioneine27:23 Methylene blue28:46 Multivitamin29:37 Aged garlic extract30:22 Astaxanthin31:06 TMG31:50 Ginger32:15 CoQ1032:53 PQQ33:24 Chondroitin33:45 MSM32:25 Glucosamine34:54 Conclusion
100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA
Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/
Chris Dancy is called 'the most connected man on Earth' because of his pioneering use of technology in everyday life and health optimization.
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Timestamps:00:00 Intro00:23 Why Chris is the most connected man on earth03:38 How Chris used technology to lose weight and get healthy08:43 How technology changes the human experience in the future10:43 Best tools 16:28 The technology Renaissance period20:43 Bon Charge sponsorship21:38 Implants24:18 Hacking time33:28 Meditation and mindfulness36:48 Does time go by faster if you’re stuck in daily routines47:38 How Chris’ perception of time has changed as he got older52:43 Will virtual reality extend perception of lifespan59:03 How to make technology better for your health
Chris Dancy website: https://www.chrisdancy.com/
Josh Witteldorf is a PhD in physics who pivoted to researching aging and investigated the evolutionary reasons for aging and human lifespan. He's written the book Cracking the Aging Code.
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:00:00 Intro00:30 How Josh, as a physicist, got into aging research04:35 Why aging is an evolutionary program13:50 Why humans die and age20:45 Bon Charge sponsorship21:35 Why did aging evolve as an adaptation24:40 Species that are biologically immortal30:25 Shocking way group selection selects for aging and death33:55 How predator-prey relations select for aging43:15 Can humans control our own evolution48:15 A long-term human calorie restriction experiment in Biosphere 252:50 Insulin’s effects on aging 55:20 mTOR and aging57:15 Can you deprogram aging and extend lifespan01:10:00 Gene editing01:15:15 Josh’s predictions for the future
Josh Mitteldorf blog: https://scienceblog.com/joshmitteldorf/
Josh's book Cracking the Aging Code: https://amzn.to/4mFmC6m
Start rewinding your biological clock: https://www.siimland.co/course
Get my free bloodwork cheat sheet: https://www.siimland.co/bloodwork-cheat-sheet
Timestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion
100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA
Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who researches sleep, circadian rhythms, and time-restricted eating
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:00:00 Intro01:05 Circadian clock dysfunction and hallmarks of aging10:35 How the circadian clocks affect aging and lifespan17:00 Bon Charge sponsorship17:55 Why clock dysfunction contributes to aging24:50 What causes circadian clock dysfunction30:00 NAD metabolism and clock function31:30 Calorie restriction and meal timing36:00 Night owls vs morning larks39:35 Shift work42:18 Melatonin supplementation46:00 Clock enhancing nutraceuticals49:10 Should you supplement melatonin at old age59:45 Morning cortisol circadian rhythm01:04:50 Sunlight and UV & infrared light exposure01:09:05 How to keep your circadian clock system working well during aging
Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd
Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/
Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUU
Longevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:
00:00 Intro00:22 Dr Robbins background in longevity research01:57 What is cell senescence07:52 Benefits of senescent cells early in life09:07 Does eliminating senescent cells increase lifespan14:50 How to eliminate senescent cells17:35 Most researched senolytics22:15 Can you reverse the age of senescent cells24:00 Immune system and aging26:20 Rapamycin29:20 Practical tips to reduce your senescent cell burden33:50 Are GLP-1 receptor agonists anti-aging drugs36:55 Should people take senolytics41:05 Gene therapies for senescent cells50:45 What things need to be focused on for breakthroughs in longevity research
Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Masonic Institute on the Biology of Aging and Metabolism (MIBAM) and the Medical Discovery Team on the Biology of Aging at the University of Minnesota. Paul Robbins Research lab: https://robbins.umn.edu/
Full routine to go from average to top 1% health: https://youtu.be/dHfhTQSBAfg
➡ Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Start rewinding your biological clock: https://www.siimland.co/course
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Timestamps:00:00 Intro00:20 Greg and Siim's background06:35 Our opinion on what’s the best diet12:50 What is most important: how much you eat, what you eat, when you eat18:15 Bon Charge sponsorship19:05 How important is the timing of when you eat42:30 Best diet for top 1% longevity, top 1% athletics and general wellbeing53:00 How to structure your calories, protein, carbs and fats01:07:15 Better and worse forms of protein, carbs and fats01:30:20 Low protein vs high protein for longevity02:09:25 Low carb vs plant-based diet02:10:00 Diet tribalism on social media02:33:00 Final words
Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUU
Longevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ
Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd
Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/
Physionic Instagram: https://www.instagram.com/physionic_phd/
Physionic YouTube channel: https://www.youtube.com/@PhysionicStart rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.
Get your free personalized health review: https://www.siimland.co/review
Timestamps:00:00 Intro01:10 Summary of our biomarker differences02:30 Fitness markers09:45 Body composition markers14:45 Inflammation and immune markers19:30 Metabolic health markers24:15 Cardiovascular markers36:30 Kidney markers43:45 Liver markers47:00 Hormone markers53:20 Experimental longevity tests56:45 PhenoAge biological age test01:01:40 RecapMy Evidence-Based Longevity Routine: https://youtu.be/4xkRcfeGDooStart rewinding your biological clock: https://www.siimland.co/course
Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025
Timestamps:00:00 Intro00:16 Ca-AKG01:00 NAD Boosters02:54 Senolytics03:53 Glycine and trimethylglycine04:54 Glucosamine sulfate05:25 Taurine05:48 MSM and chondroitin sulfate06:18 Turmeric06:50 Ashwagandha07:52 Citrulline08:02 Thiamine08:40 Chromium09:14 Melatonin09:44 Theanine10:00 Rhodiola rosea10:24 Vitamin C11:01 Methylated B vitamins11:20 Ginger11:37 Sulforaphane11:52 Resveratrol and pterostilbene13:15 Rapamycin14:16 Metformin15:25 Spermidine and wheat germ16:50 Multivitamin17:40 Vitamin E tocotrienols18:10 Methylene blue18:49 Nicotine19:30 Lutein & zeaxanthin & lycopene20:41 Beta-carotene21:40 Molecular hydrogen22:10 Cocoa flavanols22:27 Spirulina22:58 Berberine23:25 Creatine24:14 Vitamin E tocopherol24:27 Aspirin25:35 Vitamin D326:45 Magnesium27:38 Collagen peptides28:10 Glutathione28:47 Vitamin K29:09 Carnosine29:36 Whey protein29:56 Amino acids31:09 Glutamine31:40 Psyllium husk32:08 Caffeine33:33 Aged garlic extract34:01 Ergothioneine34:46 Red yeast rice extract35:39 Tongkat ali36:06 DHEA36:40 Lithium37:52 Omega-338:18 SIRT638:41 NAC39:19 CoQ1040:01 PQQ40:32 Hyaluronic acid41:02 Boron41:20 Inositol41:30 Electrolytes42:35 Zinc43:08 Ginseng43:19 Shilajit43:44 Gingko biloba44:09 EGCG44:42 Tribulus terrestris45:15 Turkesterone45:45 MCT oil47:00 Iron47:40 GHK-Cu48:55 Iodine50:01 Calcium50:31 Beta-alanine51:09 HMB51:41 Saffron52:25 Probiotics and prebiotics53:45 Nattokinase54:32 Digestive enzymes55:11 Astaxanthin
Top 15 Evidence-Based Supplements: https://youtu.be/jrozJ6oMEjo
Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/
Timestamps:
00:00 Intro01:10 New research in cancer04:35 Circadian rhythms and chemotherapy07:55 Does living close to golf courts increase Parkinson’s and cancer risk11:35 Does glyphosate increase cancer risk13:40 Do you need to worry about cancer if you’re young17:20 Why cancer rates are rising in younger people21:00 Join my Skool community 22:10 Can stress and negative emotions cause cancer27:40 What does it feel to have cancer in the early stages30:35 How much exercise to reduce cancer risk35:15 Should you filter your tap water36:30 Difference between a benign tumor and cancerous tumor40:15 Can the body get rid of cancer on its own42:10 Should you avoid milk and cheese45:25 Processed meat and cured meats47:15 Why can some people live years with cancer49:00 Cancer risk from everyday household items51:35 Can you reverse damage from smoking and alcohol in the context of cancer54:15 Specific biomarkers for cancer risk56:15 Any supplements that have cancer preventive effectsDr Joe Zundell YouTube channel: https://www.youtube.com/@dr.joezundell
Dr Joe Zundell Instagram: https://www.instagram.com/dr.joezundell/Start rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:
00:00 Intro
00:35 Why exercise and physical activity matters
05:05 What exercises does to your health
12:15 Bon Charge Sponsorship
13:05 Dangers of sedentary behavior
14:00 Why exercise improves health
20:25 Why you need to build a reserve
23:35 Physionic’s current workout routine
27:25 Greg’s current workout routine
30:05 Siim’s current workout routine
32:55 Cardio vs weights – which one is better
47:25 How much exercise is too much
55:10 Exercise and respiratory tract infections
56:30 Arterial plaque in ultraendurance athletes
01:06:25 How much moderate and vigorous exercise isbeneficial
01:07:50 How long do athletes live
01:14:45 Is too much resistance training harmful to you
01:22:40 Protein intake and mortality
01:27:15 Strength vs muscle vs power
01:44:50 Physionic’s dumbest workout mistakes
01:46:05 Greg’s dumbest workout mistakes
01:49:00 Siim’s dumbest workout mistakes
01:51:15 Youthspan Society Ad
01:52:25 Why is VO2 max such a strong predictor of longevity
02:06:40 Zone 2 cardio vs HIIT cardio
02:16:00 Walking
02:22:00 Balance and mobility
02:31:40 Only one exercise we could do for the rest of ourlife
02:35:45 Final thoughts
Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/Physionic Instagram: https://www.instagram.com/physionic_phd/ Physionic YouTube channel: https://www.youtube.com/@Physionic
Join Youthspan Society community: https://www.skool.com/youthspan-society-9710/about
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Timestamps:
00:00 Intro
00:35 Is Detox a Scam
05:20 How the body detoxifies itself
16:18 Bon Charge sponsorship
17:10 How to support daily detoxification pathways
30:45 Mineral waters and mineral baths
37:10 Do binders like clay and charcoal work
41:10 Are there supplements that support detox
45:55 Therapeutic detox therapies
47:45 Fix your gut before detoxing
55:45 Organic food, grass-fed, and water filters
01:03:25 Protocol for mold illness
01:18:18 Protocol for heavy metal toxicity
01:23:25 Protocol for microplastics
01:29:45 Anil’s new book
Dr Anil Bajnath Instagram: https://www.instagram.com/dranilbajnath/
Order my new book: https://www.amazon.com/dp/B0CW1B2XM1
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Timestamps:
Kristi Storoschuk Instagram: https://www.instagram.com/krististoroschuk/
Roundtable discussion with Dr. Greg Potter ( @gregpotterphd ) and Dr Nicolas Verhoeve ( @Physionic )
Timestamps:
00:00 Intro00:28 What supplements and/or pharmaceuticals we would give people05:58 Underrated longevity supplements08:35 Underrated medications13:40 The stupidest things we've done for health24:00 Omega-3 fatty acids (fish oil, algal oil) and longevity26:20 Vitamin D and longevity29:40 Do multivitamins affect longevity?34:45 Factors to consider when selecting longevity supplements50:50 The importance of when you take longevity supplements01:01:30 Supplement interactions with genetics, medications and lifestyle01:03:50 Longevity supplements and drugs that interfere with responses to exercise01:18:38 NAD+ -boosting supplements: effects on NAD+ and biomarkers of health and ageing01:34:00 Is resveratrol or pterostilbene good for longevity?01:39:40 Trigonelline and ergothioneine as alternative ways of raising NAD+01:41:30 Trace lithium as a longevity supplement01:44:20 (Calcium) AKG as a longevity supplement01:49:10 Glycine and glyNAC as longevity supplements02:04:20 Taurine as a longevity supplement02:09:35 Some longevity supplements might benefit vegans and vegetarians more02:13:35 Ergothioneine as a longevity supplement02:22:00 Might ergothioneine be a more effective way to increase NAD+?02:26:25 Astaxanthin as a longevity supplement02:31:05 Fatty15 and urolithin A02:35:50 The promise of nobiletin as a clock-enhancing supplementGreg Potter YouTube channel: https://www.youtube.com/@gregpotterphd Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/Physionic Instagram: https://www.instagram.com/physionic_phd/ Physionic YouTube channel: https://www.youtube.com/@Physionic➡ Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/
Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/
Timestamps:
CJ's YouTube channel: https://www.youtube.com/@shiftwithcj795 Top 15 supplements to take: https://www.youtube.com/watch?v=jrozJ6oMEjo&ab_channel=SiimLand