Cellular resilience & homeostasis is the centre piece of longevity. It is the ability of different branches of our biology to work in synchrony to establish & maintain redox equilibrium.The key driving force of our cellular longevity is mitochondria- the furnace that provides energy currency-ATP to our cells, tissues & organs.While mitochondria efficiently produces ATP in the presence of oxygen via oxidative phosphorylation(OXPHOS), as a part of this energy generation process, free radicals/super oxides are also produced. These superoxides are harmful as they have 3 unpaired electrons. However, our body has an inbuilt mechanism wherein interaction between amino acids, microbiome & cellular environment secretes & influences production of specific antioxidants & enzymes-Superoxide dismutase (SOD), Glutathione, Glutathione peroxidase & Catalase that could travel inside the mitochondria to neutralise these super oxides.The mechanism involves multiple biochemical reactions. Your gut microbiome metabolises specific amino acids- Glutamate, Cysteine & glycine to influence their bioavailability. These amino acids are synthesised into glutathione in cytosol( inside the cells) from where it is transported to mitochondria via specific transporters that allows this negatively charged molecule to pass the inner mitochondrial membrane. The activity of these specific transporter proteins are indirectly influenced by Butyrate(gut microbial metabolites) via its metabolic & epigenetic impacts on cells & mitochondrial health.,Gut microbiome also codes for specific proteins that drive production of Superoxide dismutase. Specific gut microbes could increase the production of SOD via nutritional cooperation. It is important to note that only few antioxidants- SOD, Glutathione can pass the inner mitochondrial membraneInside the mitochondria, SOD with the help of co-factor manganese could convert super oxide into Hydrogen Peroxide(H2O2). Glutathione is oxidised by glutathione peroxidase which converts H2O2 into water, thereby neutralising super oxides. However, if you are deficient in manganese, SOD could partner with iron that could have pro-inflammatory effects & even rust mitochondria. However, when we cross the age of 30 years, our body’s ability to produce these antioxidants reduces & therefore we need exogenous consumption of these antioxidants or their precursors. We also have to make sure that our gut microbiome is balanced & performs beneficial functions to drive the synthesis of SOD & glutathione.Understanding your unique biochemistry & interaction between your gut microbiome & mitochondria is key to promote redox homeostasis.
Know more at: www.genefitletics.com/agegorithm
Citations https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1328324https://pmc.ncbi.nlm.nih.gov/articles/PMC10216031/
Health is not about reductionist biology, not about treating every body organ separately. Unfortunately this has been practice till now!If we experience particular symptoms, we head to our healthcare practitioner & get a series of labs done! Our healthcare practitioner recommend some synthetic compounds, pharmaceutical drug or generic nutrition recommendations to inhibit or suppress particular biochemical functions.Why? Because we trust our healthcare practitioner. Has it helped? Not really? The same disease management strategy has been adopted by new age healthtech companies. The mode of healthcare delivery data collection has changed, complementing blood works with wearables- be it smartwatch,CGM or smart rings. The data collection is the same- healthcare delivery. Be it blood sugar response, HRV or sleep.Unfortunately, the thousands of biochemical reactions are not linear & outcome to millions of interactions happening inside our body. Our body is a complex ecosystem. These new toys( wearables driven markers are the outcome of these millions of interactions. Until you could measure all of these interactions & what specific pathways or molecules are causing abnormal levels of these markers, you cannot derive actionable interventions to regulate that metric.For instance, if your so called toy ring may tell your HRV is low but it fails to decode what specific pathway or molecule caused it.Is it low Butyrate ? low GABA? Elevated LPS? Low nitric oxide? High Uric Acid? Or histamine overproduction?Just by knowing your HRV is low does not translate into interventions that can modulate your heart rate variability.Similarly for sleep, If you disrupted sleep patterns, is it gut derived neurotoxins disrupting the HPA axis causing stress & obstructing sleep? Or its Fluoride consumption that is entering the pineal gland & disrupting melatonin production?Unfortunately, none of these toys could elucidate the underlying cause of dysregulated wearable metrics be it sleep, HRV or blood pressure?But yes, the healthtech VC will be sold by the phrase “ Oh we are collecting healthcare data for the Indian population” & a lot of money will be poured into developing & marketing such wearables . After few years, they may think “ Oh these investments turned sour”.You need to focus not on healthcare delivery but molecular data- that can be collected & mined by combining multiple scientific disciplines including biology, biochemistry, mathematics, bioinformatics, physics, engineering, computer science & more. Just some piece of toy laden with sensors can never measure these molecular & cellular interactions.
We have spent decades avoiding one of the most essential & vital macromolecule-FATS to our own peril.You may hear these fitness folks propagating fats are bad & causing cardiovascular disease referring to an obsolete & obnoxious paper or theory of Ancel keys who claimed in 1958 that it is fat & cholesterol which causes heart disease.Obviously, these folks do not have even an iota of understanding of how human biochemistry works.Years & decades of FAT hate & removing things such butter, ghee or full fat milk( saturated fats) has not helped reduce the incidence of cardiovascular & metabolic diseases. Infact, the incidence of these diseases has increased manifold!What is the reason?We are living under the false assumption that saturated fats are bad & even some folks are even endorsing that seed oils & polyunsaturated fats are not bad!Let us clear this clutter! The number of double bonds in a particular fatty acid determines how it will interact with our cells!While some saturated fats such as C14-myristic acid & C16-Palmitic acid are worst offenders & specifically C16 is said to trigger release of reactive oxygen & nitrogen species & cause cardiovascular disease, it has now been found that some specific odd chain saturated fatty acids such as Pentadecnoic acid(C15) & heptadecanoic acid(C17) as well even chain saturated fatty acid- Stearic Acid(C18) are actually beneficial for our cellular health. Specifically C15 is now called the holy grail of longevity & plays a key role in activating various receptors that reinstates cellular homeostasis, regulates glucose metabolism, reduces cancer cell proliferation, reduces inflammation & even improves cell membrane stability.Just putting all saturated fats in one bucket is a flawed approach & it is important to understand the chemical structure of each saturated fats & interaction with cells, microbiome, receptors & associated biochemical pathways Our today’s talk breaks this myth & discusses, backed by existing research, each of fats in detailKnow more about how you can improve triglyceride levels at:www.genefitletics.com/orahygCitations https://www.nature.com/articles/s41598-020-64960-yhttps://pubmed.ncbi.nlm.nih.gov/33965456/https://pmc.ncbi.nlm.nih.gov/articles/PMC9241382/
Aging is the future not because there is a wave of longevity companies measuring your biological age but assessment of biological age at system biology level gives a comprehensive picture of efficiency of your human & microbial cellular functions.Unfortunately, none of the longevity or so-called fitness companies have model & data in place to measure the cellular functions & specific gene expression & molecular pathways that are causing cellular decay.Some may look at telomere testing or DNA methylation while others may look at plasma level of blood investigations to assess the biological ageIt is important to mention that-Telomere testing does not give a comprehensive view of biology at molecular level & is just one aspect of biological age. None of the telomere tests can actually tell how bad your mitochondria is performing or what specific biomarkers is leading to telomere length shortening-DNA methylation just looks at underexpression or no expression of certain genes, lacking a comprehensive view of human biology-Blood tests never focus on human microbiome functions & just look at certain few blood markers, the outcome of that itself suffers from high standard deviation ~ more than 30%. There are multiple structural issues with no focus on the optimality of quantum biomarkers.-None of these biological age clocks are based on Indian specific molecular data.Departure from these flawed models, we measure biological age based on measurement of cellular functions, focussing on -Cellular Proteostasis -Oxidative stress driven DNA damage-Telomere regulation- Systemic Inflammation-Cellular Senescence -Stem Cell Regenerative signalling-Protein Fermentation-Gut & oral microbiome functional pathways-Cellular stress response-including unfolded protein response-Hypoxia induced stress-Metabolic stress-Mitochondrial Biogenesis-Genotoxic Stress-Antioxidant production markersOur model based on deep learning algorithms has been developed from mining 6 billion of molecular & phenotype metadata sets.Our today’s podcast discusses the science behind aging & how we are bringing a data driven revolution in longevity.
In the year 2022, 1.46 million Indians developed cancer while over 9,00,000 lost their life.65% cancer mortality rate is the biggest cause of concern given that we have so many companies claiming to detect cancer early & number of therapies- radiation, chemo & immunotherapies to kill the tumours.Have you ever wondered why ?We have been stuck in the Dogma that cancer is a genetic disease caused by random genetic mutations while research & evidence has established that cancer is a mitochondria metabolic disease caused by damaged respiration & genetic mutations are downstream effects. Today at our prevent cancer podcast, we invited a special guest & world’s renowned cancer researcher- Dr. Thomas Seyfried. He holds a Ph.D. in Genetics and Biochemistry from the University of Illinois and has a background in neurology.Dr. Seyfried has received numerous awards and honors from various organizations, and he has over 150 peer-reviewed publications. He is also the author of the book "Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer," published in 2012.We discussed in detail on the following-Cancer as a mitochondrial metabolic disease-Why do we not have any solutions for prevention & successful management of cancer?-Why is the somatic mutation theory flawed?-How do cancer cells survive ? -What is cancer cachexia?-How cancer cells fall back on ancient fermentation pathways to proliferate & grow?-What is the origin of metastasis? Role of macrophages in metastatic cancer?-How does standard of care lead to growth of cancer?-Role of inflammatory oncotaxis in malignant cancer?Worth listening to!You can support Dr. Thomas Seyfried in multiple ways:Buy his summary ebook: https://www.cancer-as-a-metabolic-disease.com/summaryebook-purchase-page/Summary book, paperback: https://www.cancer-as-a-metabolic-disease.com/summaryebook-purchase-page/Buy his scientific bookhttps://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920Donate the research directly: https://foundationformetaboliccancertherapies.com/#cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #metabolictherapy
One of the important factors that directly impacts your longevity & biological age is oxidative stress. Oxidative stress is one of the culprits in the onset of various metabolic diseases & even cancer. What exactly is Oxidative Stress? It is a state of imbalance between pro-oxidant & antioxidant activities. Interaction between your biology with the food you eat, environment you live in , toxins or even exercise could lead to production of reactive oxidative species(ROS) which could lead to mitochondria dysfunction, DNA , lipid & protein damage, causing metabolic diseases & even cancer. However our body has defense mechanisms in place. Our body can produce antioxidant glutathione but it needs help from tiny little bugs living in our gut. Gut microbiomes metabolise non-essential amino acids- glutamate, glycine & cysteine & synthesise into glutathione. The glutathione can be oxidised by the help of a specific enzyme called glutathione peroxidase(Gpx). Again certain gut microbes when active could express certain genes that could code for protein that induces production of this enzyme. Once Glutathione is oxidised, it could donate electrons to neutralise ROS. Gut microbiome has a major role to play in maintaining redox balance. Besides, the role of oral microbiome cannot be ruled out as certain oral microbes stimulate production of nitric oxide via nitrate-nitrite pathways that activate certain signalling pathways in the cells that upregulate enzymes that produce glutathione. In addition, nitric oxide influences availability of cysteine that the gut microbiome can use to synthesise glutathione.As such oral & gut microbiomes work together to make sure that glutathione is produced &, oxidised, that can neutralise ROS. However glutathione contains sulphur containing amino acids & a certain gut &/or oral microbiome could synthesise sulphide in H2S. H2s is a potential toxin that could block complex IV of electron transport chain, disrupt production of butyrate(which is needed for stimulating antioxidant activities), disrupt mucus barrier & interfere with metabolic functions The role of the gut microbiome extends beyond Glutathione. Your gut microbes could metabolise various polyphenols, flavonoids, flavonols, ellagic acid & more & synthesize into beneficial compounds that could promote antioxidant activity & neutralise ROS. Therefore it is important to understand your unique biochemistry rather than assuming that your body will produce Glutathione or any other antioxidant at its even as well as if your gut/oral microbes could transform dietary glutathione into harmful toxin H2S which would have cascading effect on your metabolic health.Know more at: www.genefitletics.com/orahyg Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC10216031/ https://pubmed.ncbi.nlm.nih.gov/17157184 https://pmc.ncbi.nlm.nih.gov/articles/PMC10643359/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4631205 https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1328324/full
90% of cancer deaths are attributed to metastasis. What exactly is metastasis ? In simple words it is the spread of cancer cells from the primary tumour sides to different tissues & distant organs. The process involves local invasion, detach from primary site, enter( intravasate) into circulation/blood stream, evade immune attack, enter other tissues /organs & proliferate/form secondary tumour at distant site. While the world is too much focussed on genetic mutations, the process of metastasis is so complex that it is too much to ask for genetic mutations that occur in random fashion. Most of the cancer cells have limited capacity to spread their wings to other sites inside the body. This is where the role of macrophages- the immune cells comes into picture. Macrophages are genetically programmed to go to the site of injury, heal the wound &/or kill that virus or harmful bacteria. These specialised immune cells cannot recognise the tumour cells & start throwing growth factors & cytokines which are stimulatory towards these cancer cells. Macrophages are fusogenic & they fuse with these tumour cells, making them transit from a respiratory energy metabolism state to fermentation stage. Ultimately these macrophages become rogue & start spreading to different parts of the body as they have free passage to different parts of the body due to their inherent nature & task of repair work. In the episode 3 of “ Prevent Cancer Podcast”, we discuss in detail -What causes metastasis? -Why do cancer cells spread to non-random locations? -Why in spite of having similar biochemical phenotype, stem cells may not express systemic metastasis ? Worth listening. Citation : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597235/ Watch our previous episodes: Episode 1- https://youtu.be/OOReAl0b7QQ Listen on Spotify- https://spotifyanchor-web.app.link/e/6WDSc0UxJNb Episode 2- https://youtu.be/_LEhJXladKM Listen on Spotify- https://spotifyanchor-web.app.link/e/cv0EWXUxJNb Check out what Genefitletics is doing in Cancer: www.genefitletics.com/oraonco #cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #cancercell #cancerprogression #tumour
We all know cancer is nothing but uncontrolled cell growth & division. Mitochondria in every cell controls cell cycle. It is a kill switch. When there is mitochondria dysfunction, this kill switch is gone. The cells starts to proliferate & grow. The question arises what differentiates normal cells from cancer cells? It is how cells generate energy. Normal cells generate energy using aerobic respiration. They, in presence of oxygen via oxidative phosphorylation, generate ATP & releases CO2 & water as a byproduct. During this process, they utilize energy sources - carbohydrates & fats to convert into ATP. However mitochondrial dysfunction results in a situation of respiration insufficiency & cells start to divide & grow( become cancerous). These cancer cells can no longer use oxygen efficiently to generate energy. Rather it resorts to ancient fermentation pathways to grow utilizing substrates such as glucose & glutamine via substrate level phosphorylation. As long as people suffering from cancer keep on consuming a lot of glucose, they are enabling cancer cells to proliferate & grow. Unfortunately, we have not seen any healthcare practitioner/oncologist focussing on precision nutrition to starve cancer while nourishing health cells & adoption a nutritional therapeutics approach to stimulate mitochondria biogenesis. In episode 2 of “ Prevent Cancer Podcast”, we discuss the basic difference between normal cells & cancer cells. Know more about how we early detect oral cancer: www.genefitletics.com/oraonco cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation
Cancer has been regarded as a genetic disease caused by genetic mutations driven by somatic mutation theory.
You would be have influx of number of DNA testing or early cancer detection companies claiming they could detect risk/early cancer onset looking at certain genetic mutations, circulating tumor cells or physical examinations
These all are driven by a financial model to make money out of personalized chemo/immuno or radiation therapies irrespective of success of such therapies throwing toxins inside our body.
& then we have some new age VC funded startups setting up dialysis like chains to offer these toxin laden therapies. Unfortunately, none of these companies/healthcare institutions have a clear understanding of how cancer manifests & still treat the human body as black box.
It has now been found that somatic mutation theory(SMT) is a flawed approach & cancer is a mitochondrial metabolic disease(MMT). In a recent research it was discovered there was absence of genes mutations & chromosomal abnormalities in 73 out of 210 cancer cases by sequencing their biological samples(1) while driver gene mutations, said to be responsible for a number of cancers, was found in normal cells which are non cancerous (2).
It has also been found that there exists genomic heterogeneity in different tumor cells which itself makes these targeted therapies sub-optimal & genetic mutations can easily bypass them.
So what causes Cancer ? It is damaged respiration( mitochondria dysfunction) followed by compensatory fermentation(4).
Yes it is mitochondria dysfunction caused by chronic inflammation, carcinogenic toxins, viruses, environmental toxins & more which shuts down the kill switch that controls cell cycle. This leads to cell growth & proliferation triggered by ancient fermentation pathways that ferments glucose & glutamine(3).
In order to break this myth that cancer is a genetic disease & understand the molecular mechanism behind cancer onset, we have started “Prevent Cancer Podcast”
The first episode : What causes cancer ? is live now.
(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712719/
(2) https://pubmed.ncbi.nlm.nih.gov/30467157/
(3)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493566/
(4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467939/
#cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #healthpodcast #cancerpodcast
On the eve of World Heart Day 2024, let us break all myths around onset & progression of cardiovascular disease. Cardiovascular disease is the number one killer globally with no preventative solutions as of now. Most of the #healthcare practitioners & #healthtech companies still blame cholesterol for development of cardiovascular disease while it is a known fact, backed by years of research, that cholesterol does not cause heart disease. In fact cholesterol is one of the essential molecules required for various cellular processes right from maintaining structure, fluidity & integrity of cell membrane, facilitating intracellular signalling including production of nitric oxide. It has also been found that 75% of the people who were hospitalized for heart disease had normal cholesterol levels.Do not blame cholesterol for heart disease. So a question may arise, if cholesterol does not cause heart disease what is the underlying cause of the number one killer globally? What should be measured to evaluate our risk of cardiovascular disease? Should we measure apolipoprotein? Triglycerides ? Today's podcast discusses in detail. We covered the following topic -Cholesterol is not to be blamed for our heart issues - Role of nitric oxide in preventing cardiovascular disease -What causes functional loss of nitric oxide production -Role of oral microbiome in regulating blood pressure -Role of Gut Dysbiosis in elevation of apolipoprotein, triglycerides, VLDL & LDL -How mouth wash & fluoride are connected with increased risk of blood pressure & heart disease. -Why measuring apolipoprotein cannot help you frame a preventative solution for your heart issue. A must listen for everyone, not to be missed! Citations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682969 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164974/ https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1271001/full#B35 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962737/ https://www.sciencedirect.com/science/article/abs/pii/S156757692300869X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290464/ https://pubmed.ncbi.nlm.nih.gov/35893593 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214130 https://pubmed.ncbi.nlm.nih.gov/33914709/ #heartdisease #heartattack #heartdiseaseawareness #hearthealth #metabolichealth #type2diabetes #coronaryarterydisease #cardiology #cardiologist #highbloodpressure #lowbloodpressure #hypertensionawareness #hypertension #cardiovasculardisease#heartcondition #healthhack #heartpalpitations #heartconditions #cholesterol #lowcarbdiet #lowcholesterol #highcholesterol #statin #healthtips
Over the last 4-5 years, we have seen a flurry of gut microbiome DNA testing companies, claiming they have an out of box solution to reverse most chronic diseases! I am afraid this is far away from reality! No doubt, Gut microbiome has a vital role to play in overall physiology but these companies have less than optimal approach on two fronts -These companies do not focus on the system biology approach & fail to study other areas of microbiome including oral, skin, vaginal, scalp, immune system, mitochondria, hormonal health, heavy metals, toxins & more. -Driven by their investor/VC funds philosophy, these companies have adopted primitive DNA sequencing tech to make it an FMCG product/service rather than focussing on bringing scientific breakthroughs. These companies focusses on microbial composition & potential & fail to measure the biochemical functions at molecular level, thereby lacking precision, efficacy & accuracy. A complete departure from this linear outdated model, we at Genefitletics have adopted a system biology approach to -Offer system biology + mathematics platform - Measure the biochemical functions of gut & oral microbiome -Measure mitochondrial functions - collect, process & analyze molecular, longitudinal & clinical data to predict onset of various diseases including type 2 diabetes, cardiovascular diseases, chronic kidney disease & halitosis -Machine learnt models to predict glycemic response to 300 plus foods -Construct data driven precision nutrition & therapeutics interventions to rebalance an individuals’s biology -Collect longitudinal data at regular intervals to train our ML model, assess the efficacy of our interventions & revise the recommendations aligned with changes in individual’s biochemistry -now also offer oral cancer early detect test & associated disease prevention interventions Access to platform is now available for a monthly subscription model starting at Rs.2,500( $ 31) a month More details here: www.genefitletics.com #health #gutmicrobiome #gutmicrobiometest #guthealthtips #guthealthforlife #guthealth #typ2diabetes #obesity #thyroid #hashimoto #hypothyroidism #hypothyroidweightloss #hyperthyroidism #autoimmunedisease #autoimmuneawareness #autism #autismawarness #heartcondition #cardiovasculardisease #cardiovascularrisk #dnatesting #dnatest #dnadiet
Do you know which is the most complex machinery ever made on this planet earth?
Yes , it's the human body!
Our body is a sack of chemicals & biochemical reactions that need to work in synchrony to keep our body in homeostasis. It needs flow of electrons, voltage & current to keep all biological functions moving. Literally everything is connected- what happens in the mouth, spreads everywhere , what happens in mouth influences the functions your gut microbiome performs, what happens in the gut impacts your brain, heart, hormones & more.
What we eat feeds our microbiome which in turn extracts chemical energy for their survival & as a byproduct releases molecules, chemicals & metabolites that impact our overall health.Still when it comes to metabolic health, we are too obsessed with solving /suppressing our blood sugar response without understanding the biochemistry behind. How many CGM companies actually solve for heart health, kidney health or sexual health?
Actually no one! Oh I forgot , a number of these companies track cholesterol levels assuming cholesterol is root cause of heart disease.
Probably, they have forgotten the basics or do not understand how human biology works.
Hard truth for everyone, there is no life without cholesterol- it is synthesized by every cell inside the body & is required for various biochemical processes including producing bile acid, regulating sex hormones, and producing vitamin D.
Since some cells synthesize less than they require while others synthesize in excess, some cells are net exporters while others are net exporters. Therefore cholesterol is transported from one cell to another which needs to be packaged with protein( since cholesterol is not soluble in water) which is referred to as lipoprotein. Cholesterol is packaged with VLDL & LDL & transported to other cells in need. Once the cell utilizes cholesterol, it is transported back via reverse cholesterol transport process.During his process, the liver synthesizes APOA-1 which is released in the bloodstream. The cholesterol moves into APOA-1( made us of 70% HDL) which is transported in liver to perform other cellular processes.
Although some may say we track APOA-1 & APOB-100, the truth is expression of apolipoprotein is regulated /impacted by metabolites secreted by your gut & oral microbiome. Certain metabolites that can impact your LDL production & expression of APOA-1 includes Butyrate, TMAO, Indole Propionic Acid, LPS production, nitric oxide, p-cresol, PAG & more.
Therefore rather than measuring your cholesterol or APOA-1/APOB-100, you should focus on measuring your microbial biochemistry & metabolites secreted by your gut & oral microbiome.
Our video discusses this in detail
Know more at www.genefitletics.com/orahyg
Citations
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1271001/full#B35https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962737/
https://www.sciencedirect.com/science/article/abs/pii/S156757692300869X
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290464/
https://pubmed.ncbi.nlm.nih.gov/35893593/
https://pubmed.ncbi.nlm.nih.gov/33914709/
#heartdisease #heartattack #heartdiseaseawareness #hearthealth #metabolichealth #type2diabetes #coronaryarterydisease #cardiology #cardiologist #highbloodpressure #lowbloodpressure #hypertension
Chronic Kidney Disease is a global health problem. The biggest issue lies in its late diagnosis during the progression of disease. The clinical manifestation & plasma level indications such as eGFR that can indicate kidney health are reduced only at advanced stages of disease development. However the fact is the changes in biology & chemistry at molecular level takes place years before the nitrogenous substances such as urea & creatinine accumulates in the blood. Unfortunately, up till now, we had no models in place to detect the early signs of chronic kidney disease. Even some of the companies are tracking certain vital parameters such as weight monitoring, sleep, water tracking, nutrition & more but these practices are just focussed on managing kidney disease. It is no brainer that increased risk of type 2 diabetes or high blood glucose level could damage blood vessels of kidneys & increase risk /trigger chronic kidney disease. However, research & empirical evidence has now found that functions of oral & gut microbiome have a role to play in early onset of chronic kidney diseases & could be used as early indication & offer preventative solutions -Halitosis(bad breath) via oral microbial metabolites such as oral H2S, ammonia, polyamines & urease pathways is an early sign. -Secretion of gut microbial derived metabolites & uremic toxins such as p-cresol, Indoxyl Sulphate, TMAO & LPS could impact kidney function.High circulatory level of these toxins could lead to oxidative stress. Here comes a very important aspect which is missed by the current healthcare system. Oxidative stress leads to oxidation of certain metals on protein & enzymes, thereby making cells dysfunctional & disrupting nitric oxide. This establishes a clear correlation that chronic kidney disease could increase risk of type 2 diabetes & cardiovascular diseases as well. Our today’s podcast episode discusses this in detail
It has been found that 33% of adult female population suffer from depression, while 1 in 5 men would have this growing mental health issue. Stress is rampant while millions of people deal with dementia & Parkinson's. While there are solution such as drugs & antidepressants to manage these growing mental health conditions, we have not seen any application of science to carve out preventive solution for growing mental health issues. We all know the role of gut microbiome in our brain health via the gut-brain axis. Gut microbes not only produce neurotransmitters but also secrete certain toxic metabolites which could travel to brain & trigger inflammation. But research has now found that the second largest coloniser of microbes in the body- mouth has a vital role to play not only in our oral health but a range of systemic health issues such as type 2 diabetes, heart diseases, arthritis, IBD, colon cancer & more. Improper nutrition & bad oral hygiene could lead to trigger oral microbial dysbiosis which over activates immune response & leads to chronic inflammation. This prolonged inflammation creates a situation of leaky gum which allows certain oral microbes such as streptococcus mutans & P Ginagavalis translocate from mouth into bloodstream & brain where it could secrete toxin metabolites & directly trigger onset & progression of brain health issues such as dementia. Specifically P. Gingivalis could secrete neurotoxic protease-Gingipain which could lead to creation of Amyloid Beta Protein Plague which is associated with dementia. It has also been found that people suffering from Chronic Periodontal disease & also experience neuro inflammation. Besides, Oral microbial dysbiosis is also connected with loss of dopamine production neurons, the hallmark of motor dysfunction & parkinsons disease. Our today’s talk opens pandorabox on oral microbiome- brain health connection. We are the only company in India that analyses oral microbiome functions to translate early pre-disease signals into unique molecular insights & carve our precision nutrition interventions to bring back your body back into homeostasis. More details here :https://genefitletics.com/orahyg/
We have become a protein obsessed nation! Have you ever wondered why? We are told we are deficient in protein! But does this apply to everyone? Is the entire adult population protein deficient? What is the basis of the claim ? How do we calculate deficiency? If you are recommended some X grams / kg of body weight to meet your protein requirement, you are misguided. These recommendations are based on population studies which considers you as an average healthy individual & metabolising food/protein in the same way others metabolise? These are wrong claims as our biology is as unique as our fingerprint. We need protein for various cellular processes, brain functioning, energy & more but how much each individual needs & which ones is & should be driven by his/her unique biochemical profile. There are multiple factors at play when it comes to protein consumption & absorption which includes digestive enzymes. Your microbes could tell you if you are digesting protein efficiently via activating certain pathways such as Protein Fermentation & digestive efficiency. If you are not digestive protein efficiently or eating excess protein, it may land up in your large intestine where certain microbes- Proteobacteria interact with amino acid & produce harmful metabolites such as Ammonia, methane, H2S,p-Cresol, Putrescine, PAG, TMAO & more which could range of chronic health conditions including autoimmune disorders, cardiovascular diseases & more. Research has found that excess production of p-cresol could suppress GLP-1 production which is said to cause obesity even typ3 2 diabetes. Even when it comes to type 2 diabetes, do not fall for a high protein diet as a solution for type 2 diabetes.Understand your unique biology- Certain polyphenols such as walnuts, Pomegranate, Strawberry & more when converted by your microbiome into Urolithin A improve your hypoglycemic response & pancreatic B Cell function. Do not fall for these generic recommendations, your biology is unique, you deserve nutrition choices aligned with your biochemical individuality. Our today’s talk deep dives into role of protein in detail
Metabolic disease is taking a giant leap forward with the number of people developing obesity, type 2 diabetes & more is increasing. Although we have all resources & tech in place, still we do not have any preventative solutions to stop these diseases from developing in the first place. There is need to understand -Food processing, farming practices & industrial practices to improve the shelf life: Although labels will show the same value, processed foods such as rolled oats or commercially grinded nuts would be processed differently. Besides, it is also important to decode the functions of your microbiome as 99% of biological functions are performed by them. The interaction between food & microbiome also determine how each food is processed, how much calories are extracted what byproducts is produced as a result - Glycemic response to various foods: Over the last 2 years, we have seen a number of companies coming up with continuous glucose monitoring machines but there are multiple structure & functional issues associated with CGM. CGM are not more that a guess work -CGM measures your glycemic response to various foods post its consumption, does not predict glucose spike -CGM measures response to a meal, not food, not specific molecules in food. We really need to understand how each of molecule contribute to our blood sugar response -You may fix CGM for 2-3 weeks to make a list of food that is going to spike more than others & may consider it static for you. However, as you feed your microbiome, functional pathways & composition changes, glycemic response to food changes & therefore you need to track glycemic response every month, making you endlessly spend on CGM every month. -CGM does not tell you why you have a glycemic response to specific foods as it does not decode the interaction between food you eat & your gut/oral microbiome. - Rather than just tracking glycemic response using CGM, the focus is on understanding the level of production of nitric oxide(which is a signal that tells GLUT 4 to clear the glucose from the circulation, LPS Production, TMAO, P-cresol & more. Our today’s talk discusses in detail We at Genefitletics, based on functional pathways of gut & oral microbiome measure & quantify 17 pls microbial pathways to predict onset & progression of type 2 diabetes & even predict insulin response to 317 foods. More details here: www.genefitletics.com
Digitise your body before you put a fork inside your mouth! If someone would have told you this 5 to 7 years ago, you would have told them you must be joking! Technology has taken leap & bounds over last few years still when it comes to nutrition as medicine, we get inclined towards that lucrative quick fix without understanding our unique biology & chemistry “ Oh, have 25 grams of veggies daily! Which one is Broccoli? Tomatoes? Bell Pepper? Carrot? Broccoli - really? What if my microbes producing hydrogen Sulphide are active? What if it could cause bad breath YOur body needs a lot of antioxidants, take pomegranate! What if you do not right set of gut microbes to convert ellagic acid in Pomegranate into Urolithin A We need to think good beyond calories. Food is an ecosystem of 25,000 plus molecules. When you put a fork inside your mouth, around 1,000 molecules are hitting your top & bottom of the digestive tube. Food ingredients & molecules are first available to your microbes who convert them into metabolites /by products which are made available to your body. How your microbe interacts with each of these food substrates is what matters. One important case in point is PROTEIN. “ Oh you need to lose 10 Kgs, please stop eating wheat, reduce your carbohydrates, eat lot of protein” But did you know the excess protein you are ingesting lands up in your gut when a group of microbes called proteobacteria can synthesise some specific amino acids into harmful metabolites which are connected with onset & progression of type 2 diabetes, cardiovascular diseases, chronic kidney disease & more. Some of these metabolites include P-cresol: byproduct of tyrosine implicated in pathogenesis of Chronic Kidney Disease, Cardiovascular disease, Obesity & type 2 diabetes( by suppressing GLP-1). -Phenylacetylglutamine(PAG): byproduct of phenylalanine which is connected with increasing LDL production & heart failure -TMAO-byproduct of lecithin, choline & L-carnitine which is said to cause plaque in arteries -Indoxyl Sulphate-byproduct of Tryptophan which is said to cause chronic kidney disease & cardiovascular issues & the list goes on Think before you replace your carbohydrates with protein. When it comes to carbs, processed foods are complete no but it does not mean wheat or rice is bad. Our today’s talk deep dive into interaction between amino acids & gut microbiome in detail
Last few years have seen advancement in technology which has opened up flood gates to revisit how we measure our health. This has transformed the methods of collecting healthcare delivery data & point of care diagnostics with usage of Wearables- Smart rings, smart watches & CGM However are the healthcare delivery data & plasma level indications really solving healthcare problems? Some facts 1)Globally,41 million people die of chronic diseases every year 2)55 million+ people suffer from dementia worldwide 3)Global incidence of Non- Alcoholic Fatty Liver Disease(NAFLD) is 47 for every 1000 people 4)100 million plus Indians are either prediabetic or suffering from type 2 diabetes 5)13% of Indian population have high risk of cancer 6)10% of Indian population suffers from chronic kidney disease; Renal failure is detected at a late stage & most of the patients end up in dialysis with no curative solution 7)Diseases such as NAFLD, Oral & Throat Cancer & Dementia are hard to detect & the list goes on Still these new age technologies in the name of AI & ML are just helping us manage the symptoms of chronic diseases not finding or identifying asymptomatic signatures predictive of chronic diseases & biggest thing these models have missed out tracking 99% of biology AI/ML is a system & we need to feed the right set of data sets to draw meaningful outcomes that could help us understand the pathogenic process involved in onset & progression of chronic diseases. We need to focus not on plasma level biomarkers & DNA but on downstream functions via RNA & Metabolites We need to collect a lot of molecular & biological data sets & apply AI/ML tools to deep dive on what is happening at molecular level & changes in chemistry before & during disease onset. This could help us identify molecular indications which are invisible & cannot be identified by POC diagnostics/Wearables & compute interventions to kill these molecules so that disease does not even develop in the first place. Today we unveiled what data sets should be collected & analysed to eradicate epidemic of chronic diseases.
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Sexual health issues among male population, specifically, Erectile Dysfunction(ED), has become one of the major chronic health conditions with over 50% of male population in the age band of 40-70 years facing ED.
Research has found that men having obesity or suffering from type 2 diabetes &/or high blood pressure are at high risk of Erectile dysfunction. Besides, chronic stress can also lead to ED.
All these are interconnections with a common underlying cause- Nitric Oxide(NO) Deficiency.
NO is the most important gas produced inside our body which plays a key role in cellular communication, acts as vasodilator, regulates blood flow, oxygen uptake & delivery & facilitates insulin signalling.
Infact Erectile Dysfunction is caused by lack of vasodilation & blood flow attributed to NO deficiency
NO is produced through two pathways
-Endothelial Cell : ENOS, enzyme when coupled with Endothelial cell produces NO by metabolising L-arginine in presence of oxygen. L-arginine is a semi essential amino acid produced inside our body through the Urea Cycle. We do not need to consume excess L-arginine as it could activate Arginase Enzyme & NOS could produce Superoxide, causing oxidative stress. Oxidative stress, inflammation, high glycemic diet as well as oxidation of Tetrahydrobiopterin(BH4 to BH2) which uncouples ENOS, thereby shutting down NO production. As we age ENOS’s ability to produce NO reduces by 10% every year & therefore by the time we reaches age of 50, ENOS ability to produce reduces by 50% & therefore second pathway becomes more important
Oral microbiome triggers Nitrate-Nitrite-NO pathway: Microbes in our mouth can metabolise nitrate in green leafy vegetables into nitrite which when mixed with stomach acid produces NO. If your oral microbiome is imbalanced, it could reduce its ability to produce NO.
Certain lifestyle choices can disrupt NO production including use of mouthwash, Fluoride in toothpaste, processed foods & deficient sleep
If you think Supplements /Drugs such as Viagra, Ashwagandha & Shilajit could help in curing erectile dysfunction, you are in for the biggest shock.
Drugs such as Viagra is not a NO donor but is NO dependent. NO when produced activates a messenger cyclic GMP which is a vasodilator. Viagra makes sure that cGMP does not break down. However if your body is not producing NO, Viagra will never work as the substrate on the basis of which it functions is not activated. DO not fall for these supplements as they will never work if your body is not production NO.
Our today’s talk deep dive into role of NO & oral microbiome in Erectile Dysfunction.
Obesity is a global epidemic with more than a quarter of the population dealing with this metabolic syndromeWhile there are tens of thousands of solutions to suppress your weight/make you lose weight, 99% of them are band-aid solutions & do not focus on what makes you obese. Those companies &/or coaches, it is a financial model! You need to maintain your weight, you need to pay them every month to subscribe to their fad diet solutions & working schedules/plans. What causes Obesity? It is low grade chronic inflammation! So you must be wondering how inflammation in your intestines can make you gain weight? There is whole science behind & most of the biological decisions inside our body are driven by our microbiome. You may blame energy metabolism & try to create that energy deficit by eating less & burning more but energy metabolism is not about this mathematical equation. There is a web of molecular features & pathways driven by interaction between your microbiome & external environment & nutrition choices. These microbes impact/produce certain protein /hormones such as GLP-1, PYY Ghrelin & Leptin that impacts your satiety & hunger responses. While these are not the only pathways! There are multiple other interactions such as production of nitric oxide & expression of Nitric Oxide synthase that can impact your weight management & make you develop obesity However, new age medical weight loss companies have made you believe that anti-obesity drugs such as GLP-1 receptor agonists can make you lose weight. This is far away from reality -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. Today we discussed what could render GLP-1 drug ineffective. We at Genefitletics measures each of these gut & oral microbiome pathways to understand the changes in biology & chemistry before & during disease onset & provide interventions to bring your body back into homeostasis position.