90% of cancer deaths are attributed to metastasis. What exactly is metastasis ? In simple words it is the spread of cancer cells from the primary tumour sides to different tissues & distant organs. The process involves local invasion, detach from primary site, enter( intravasate) into circulation/blood stream, evade immune attack, enter other tissues /organs & proliferate/form secondary tumour at distant site. While the world is too much focussed on genetic mutations, the process of metastasis is so complex that it is too much to ask for genetic mutations that occur in random fashion. Most of the cancer cells have limited capacity to spread their wings to other sites inside the body. This is where the role of macrophages- the immune cells comes into picture. Macrophages are genetically programmed to go to the site of injury, heal the wound &/or kill that virus or harmful bacteria. These specialised immune cells cannot recognise the tumour cells & start throwing growth factors & cytokines which are stimulatory towards these cancer cells. Macrophages are fusogenic & they fuse with these tumour cells, making them transit from a respiratory energy metabolism state to fermentation stage. Ultimately these macrophages become rogue & start spreading to different parts of the body as they have free passage to different parts of the body due to their inherent nature & task of repair work. In the episode 3 of “ Prevent Cancer Podcast”, we discuss in detail -What causes metastasis? -Why do cancer cells spread to non-random locations? -Why in spite of having similar biochemical phenotype, stem cells may not express systemic metastasis ? Worth listening. Citation : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597235/ Watch our previous episodes: Episode 1- https://youtu.be/OOReAl0b7QQ Listen on Spotify- https://spotifyanchor-web.app.link/e/6WDSc0UxJNb Episode 2- https://youtu.be/_LEhJXladKM Listen on Spotify- https://spotifyanchor-web.app.link/e/cv0EWXUxJNb Check out what Genefitletics is doing in Cancer: www.genefitletics.com/oraonco #cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #cancercell #cancerprogression #tumour