Do you know which is the most complex machinery ever made on this planet earth?
Yes , it's the human body!
Our body is a sack of chemicals & biochemical reactions that need to work in synchrony to keep our body in homeostasis. It needs flow of electrons, voltage & current to keep all biological functions moving. Literally everything is connected- what happens in the mouth, spreads everywhere , what happens in mouth influences the functions your gut microbiome performs, what happens in the gut impacts your brain, heart, hormones & more.
What we eat feeds our microbiome which in turn extracts chemical energy for their survival & as a byproduct releases molecules, chemicals & metabolites that impact our overall health.Still when it comes to metabolic health, we are too obsessed with solving /suppressing our blood sugar response without understanding the biochemistry behind. How many CGM companies actually solve for heart health, kidney health or sexual health?
Actually no one! Oh I forgot , a number of these companies track cholesterol levels assuming cholesterol is root cause of heart disease.
Probably, they have forgotten the basics or do not understand how human biology works.
Hard truth for everyone, there is no life without cholesterol- it is synthesized by every cell inside the body & is required for various biochemical processes including producing bile acid, regulating sex hormones, and producing vitamin D.
Since some cells synthesize less than they require while others synthesize in excess, some cells are net exporters while others are net exporters. Therefore cholesterol is transported from one cell to another which needs to be packaged with protein( since cholesterol is not soluble in water) which is referred to as lipoprotein. Cholesterol is packaged with VLDL & LDL & transported to other cells in need. Once the cell utilizes cholesterol, it is transported back via reverse cholesterol transport process.During his process, the liver synthesizes APOA-1 which is released in the bloodstream. The cholesterol moves into APOA-1( made us of 70% HDL) which is transported in liver to perform other cellular processes.
Although some may say we track APOA-1 & APOB-100, the truth is expression of apolipoprotein is regulated /impacted by metabolites secreted by your gut & oral microbiome. Certain metabolites that can impact your LDL production & expression of APOA-1 includes Butyrate, TMAO, Indole Propionic Acid, LPS production, nitric oxide, p-cresol, PAG & more.
Therefore rather than measuring your cholesterol or APOA-1/APOB-100, you should focus on measuring your microbial biochemistry & metabolites secreted by your gut & oral microbiome.
Our video discusses this in detail
Know more at www.genefitletics.com/orahyg
Citations
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1271001/full#B35https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962737/
https://www.sciencedirect.com/science/article/abs/pii/S156757692300869X
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290464/
https://pubmed.ncbi.nlm.nih.gov/35893593/
https://pubmed.ncbi.nlm.nih.gov/33914709/
#heartdisease #heartattack #heartdiseaseawareness #hearthealth #metabolichealth #type2diabetes #coronaryarterydisease #cardiology #cardiologist #highbloodpressure #lowbloodpressure #hypertension