Chronic Kidney Disease is a global health problem. The biggest issue lies in its late diagnosis during the progression of disease. The clinical manifestation & plasma level indications such as eGFR that can indicate kidney health are reduced only at advanced stages of disease development. However the fact is the changes in biology & chemistry at molecular level takes place years before the nitrogenous substances such as urea & creatinine accumulates in the blood. Unfortunately, up till now, we had no models in place to detect the early signs of chronic kidney disease. Even some of the companies are tracking certain vital parameters such as weight monitoring, sleep, water tracking, nutrition & more but these practices are just focussed on managing kidney disease. It is no brainer that increased risk of type 2 diabetes or high blood glucose level could damage blood vessels of kidneys & increase risk /trigger chronic kidney disease. However, research & empirical evidence has now found that functions of oral & gut microbiome have a role to play in early onset of chronic kidney diseases & could be used as early indication & offer preventative solutions -Halitosis(bad breath) via oral microbial metabolites such as oral H2S, ammonia, polyamines & urease pathways is an early sign. -Secretion of gut microbial derived metabolites & uremic toxins such as p-cresol, Indoxyl Sulphate, TMAO & LPS could impact kidney function.High circulatory level of these toxins could lead to oxidative stress. Here comes a very important aspect which is missed by the current healthcare system. Oxidative stress leads to oxidation of certain metals on protein & enzymes, thereby making cells dysfunctional & disrupting nitric oxide. This establishes a clear correlation that chronic kidney disease could increase risk of type 2 diabetes & cardiovascular diseases as well. Our today’s podcast episode discusses this in detail