Recorded to raise awareness on World COPD Day 2024, this episode of OnAir is dedicated to chronic obstructive pulmonary disease – the third-leading cause of deaths worldwide. But as well as discussing the prevalence, underlying causes and trajectories of the condition, expert guests Professor Jean-Louis Pépin and research scientist Elroy Boers share new perspectives provided by their recent findings on the subject, including: How real-world evidence can better reflect the complexity and heterogeneity of COPD Why analysing data on gender and socioeconomic differences can lead to greater understanding of the disease landscape What real-word evidence tells us about treating COPD patients with NIV Looking to the future, our guests finish on a positive note by discussing the potential beneficial impacts new COPD management strategies could have on patient outcomes and economic and healthcare burdens. Guests: Prof. Jean-Louis Pépin, PU-PH in Clinical Physiology, head of the HP2 research laboratory, Grenoble, France Dr Elroy Boers, Lead Health Research Scientist, ResMed Hosts: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  References and useful links: Boers, M. Barrett, J.G. Su, et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050. JAMA Netw Open. 2023;6(12):e2346598. doi:10.1001/jamanetworkopen.2023.46598 Boers, A. Allen, A. Benjafield, L.E. Crotty Alexander, A. Malhotra and M. Barrett. A scenario-based modeling study to project the future burden of COPD in Western Europe accounting for air pollution, tobacco smoking, and e-cigarette vaping. (abstract). ERS 2024. -L Pépin, P. Lemeille, H. Denis, A. Josseran, F. Lavergne, A. Panes, S. Bailly, A. Palot, A. Prigent, Health trajectories before initiation of non-invasive ventilation for chronic obstructive pulmonary disease: a French nationwide database analysis, The Lancet Regional Health - Europe, 2023, 100717, ISSN 2666-7762, doi: 10.1016/j.lanepe.2023.100717. 2 J.-L. Pépin, E. Herquelot, H. Denis, A. Josseran, F. Lavergne, A. Schmidt, S. Bailly, A. Palot, A. Prigent, and on behalf of the MedXcloud group. Impact of Long-term Domiciliary Non Invasive Ventilation (NIV) on Severe Exacerbations and Survival in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Nationwide Cohort Study Using Multistate Models (abstract). Am J Respir Crit Care Med 2024;209:A4978. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

With 4,300 unique presentations from an estimated 30,000 authors at this year’s ERS, there was a lot of information to absorb… so we invited Dr Meredith Barrett, Vice President of Patient Health Insights at ResMed, who attended the event in Vienna, Austria, to share her highlights. ERS’s theme was ‘Humans and Machines: Getting the Balance Right’ setting the scene for enthusiastic debate about artificial intelligence (AI) and what it means for the future of sleep and breathing health. Meredith distills the main talking points down into two key areas of insight: Potential benefits of AI: Increasing the accuracy of sleep-disordered breathing diagnostics Analysing predictive factors for chronic conditions such as COPD and asthma Detecting patterns in patient data to help personalise care Improving efficiency and reducing workload for healthcare professionals Questions and concerns about AI: Whether it could undermine the patient-clinician relationship The need for research on safety and effectiveness in real-world settings Ethical questions, such as whether AI could cause biased outcomes How patient data is handled and accessed As well as exploring these topics with host Daniela Gautschi, Meredith tells us about other aspects of the agenda that caught her attention – with a focus on digital health, novel diagnostics in sleep, understanding the future burden of respiratory disease, and how to promote treatment adherence by understanding a user’s social context. Guest: Dr Meredith Barrett, Vice President, Patient Health Insights, ResMed Host: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. References and useful links: Kaye, H.C. Lyson, E. Boers, A. Allen, V.T. Vuong, V. Bala, and M. Barrett. A Mixed-methods Exploration of Patient Perspectives on Pap Therapy Initiation: Implications for Improved Outreach and Education. D102. HOT TOPICS IN BEHAVIORAL SCIENCE AND HEALTH SERVICES RESEARCH. May 1, 2024, A7300-A7300 Boers, A. Allen, A. Benjafield, L.E. Crotty Alexander, A. Malhotra and M. Barrett. A scenario-based modeling study to project the future burden of COPD in Western Europe accounting for air pollution, tobacco smoking, and e-cigarette vaping. (abstract). ERS 2024. Kaye, L., Vuong, V., Benjafield, A., Gupta, P., & Barrett, M. (2024). Role of Partnership in Positive Airway Pressure (PAP) Therapy Adoption in Obstructive Sleep Apnea. Eur Respiratory Soc 2024 (abstract) Kaye, L., Vuong, V., Benjafield, A., Gupta, P., & Barrett, M. (2024). The association between behavioral clusters and short-term PAP usage in OSA. Eur Respiratory Soc 2024 (abstract) Zack, Travis et al. (2024) Assessing the potential of GPT-4 to perpetuate racial and gender biases in health care: a model evaluation study. The Lancet Digital Health, Volume 6, Issue 1, e12 – e22. doi: 10.1016/S2589-7500(23)00225-X The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

While research has shown that women who are diagnosed and treated for OSA may experience greater improvements in quality of life scores and higher CPAP usage than men1, actually getting a diagnosis in the first place can be an uphill struggle. So in this episode of OnAir we invite two leading experts on the topic, Prof. Sophia Schiza and Dr Alison Wimms, to explain why this is – and what can be done so more women with OSA can enjoy the benefits of therapy sooner and for longer... They have a lot to say on the subject, so we’ve divided up the recording by questions, so you can focus on the areas that interest you the most, or listen to it as a whole – the choice is yours!: Introduction 00:51 Schiza: Why is this an important topic? 03:09 Dr Wimms: What has kept you interested in this topic? Differences between OSA presentation in men and women 05:02 What are the main symptoms of OSA for male and female patients? 09:06 How can we see differences in patients’ diagnostic traces? 11:51 Why do these differences exist? 11:06 Are there also difference between the sexes when it comes to treatment acceptance and response? 21:25 Are there any other differences to highlight? Deep dive into female OSA research 27:25 Tell us more about the UK MERGE-data for mild OSA1... 33:54 ...and the ESADA-publication2 about OSA phenotypes where gender is one of the parameters of weight in the spider charts displaying patient characteristics? Conclusion 43:31 What is the most important practical advice for clinicians who see women every day and want to help those with sleep apnoea? Guests: Prof. Sophia Schiza, Head of the ERS Assembly 4 Sleep Disordered Breathing and head of Sleep Disorders Center, Department of Respiratory Medicine at the School of Medicine, University of Crete, Greece Dr Alison Wimms, Director of Medical Affairs in Clinical Research, ResMed Hosts: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. References and useful links: Wimms AJ, Kelly JL, Turnbull CD, McMillan A, Craig SE, O'Reilly JF, Nickol AH, Decker MD, Willes LA, Calverley PMA, Benjafield AV, Stradling JR, Morrell MJ; MERGE Trial Investigators. Mild obstructive sleep apnoea in females: post hoc analysis of the MERGE randomised controlled trial. ERJ Open Res. 2024 Feb 5;10(1):00574-2023. doi: https://doi.org/10.1183/23120541.00574-2023 PMID: 38333643; PMCID: PMC10851951. Yassen A, Coboeken K, Bailly S, Burghaus R, Buskova J, Dogas Z, Drummond M, Gouveris H, Joppa P, Lippert J, Lombardi C, Mihaicuta S, Pépin JL, Zou D, Hedner J, Grote L. Baseline clusters and the response to positive airway pressure treatment in obstructive sleep apnoea patients: longitudinal data from the European Sleep Apnea Database cohort. ERJ Open Res. 2022 Oct 31;8(4):00132-2022. doi: https://doi.org/10.1183/23120541.00132-2022 PMID: 36329798; PMCID: PMC9619251. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights

In this episode of OnAir Professor Ulla Møller Weinreich, Head of the Danish Lung Society, explains the why, who and how of the national guidelines for home HFT her team created in 20191, including: Why they started using home HFT and the clinical benefits they discovered, including reduced dyspnoea, easier work of breathing and improved mucus clearance, 2 and cost-effectiveness of the treatment.3 Which patients benefit the most from the treatment – and how it can ease some of the physiological strains experienced by those with COPD or bronchiectasis. How clinicians can initiate HFT with patients, starting by defining clear indications and treatment goals, before moving on to practical considerations such as setting the right flow and choosing the right cannula. Guest: Professor Ulla Møller Weinreich - Head of the Respiratory Research Unit, Aalborg University Hospital, Denmark, and Head of the Danish Lung Society Host: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  References and useful links: Storgaard LH, Hockey H, Laursen BS, Weinreich UM. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis. 2018;13:1195-1205. https://doi.org/10.2147/COPD.S159666 Weinreich, U. M., Juhl, K. S., Søby Christophersen, M., Gundestrup, S., Hanifa, M. A., Jensen, K., … Storgaard, L. H. (2023). The Danish respiratory society guideline for long-term high flow nasal cannula treatment, with or without supplementary oxygen. European Clinical Respiratory Journal, 10(1). https://doi.org/10.1080/20018525.2023.2178600 Sørensen SS, Storgaard LH, Weinreich UM. Cost-Effectiveness of Domiciliary High Flow Nasal Cannula Treatment in COPD Patients with Chronic Respiratory Failure. Clinicoecon Outcomes Res. 2021;13:553-564 https://doi.org/10.2147/CEOR.S312523 The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

In this episode of OnAir, host Daniela Gautschi is joined by two experts in ASV therapy* and real-world evidence: Prof. Michael Arzt (READ-ASV registry1, 2) and Prof. Renaud Tamisier (FACE-cohort3, 4 and FACIL-VAA5 registries). Experience shows that ASV can improve symptoms and quality of life for some patients with central sleep apnoea. But which patients are most likely to benefit and why? By performing large-scale database analyses, Prof. Arzt and Prof. Tamisier have been able to identify clinically meaningful clusters of CSA patients, explore phenotypes that have yet to be studied by RCTs, and shed light on the critical role played by sleep, respiratory and cardiovascular comorbidities. Listen now to understand how this research could transform the diagnosis, treatment and prognosis of patients with persistent CSA and Treatment-Emergent CSA. Guests: Prof. Michael Arzt - Professor of Internal Medicine, University Hospital Regensburg, Germany Prof. Renaud Tamisier - Professor of Clinical Physiology, Grenoble Alpes University and Director of the Sleep Exploration Centre, Grenoble Alpes University Hospital, France Host: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. References and useful links: Arzt M, Munt O, Pépin J-L, et al. Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation (READ-ASV): protocol and cohort profile. ERJ Open Res 2023; 9: 00618-2022 [DOI: https://doi.org/10.1183/23120541.00618-2022] Arzt M, Munt O, Pépin JL, Heinzer R, Kübeck R, von Hehn U, Ehrsam-Tosi D, Benjafield AV, Woehrle H. Effects of Adaptive Servo-Ventilation on Quality of Life: The READ-ASV Registry. Ann Am Thorac Soc. 2024 Jan 19. doi: https://doi.org/10.1513/AnnalsATS.202310-908OC Tamisier R, Damy T, Bailly S FACE study investigators, et al; Adaptive servo ventilation for sleep apnoea in heart failure: the FACE study 3-month data. Thorax 2022;77:178-185. https://thorax.bmj.com/content/77/2/178 Tamisier R, Damy T, Bailly S, Goutorbe F, Davy JM, Lavergne F, Palot A, Verbraecken JA, d'Ortho MP, Pépin JL; FACE investigators; Steering committee members; d'Ortho MP, Pépin JL, Davy JM, Damy T, Tamisier R; FACE study investigators. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort. Sleep Med. 2024 Jan;113:412-421. doi: https://doi.org/10.1016/j.sleep.2023.07.014 Observational Multicenter Cohort Study of French Patients With a Central or Combined Syndrome of Sleep Apnea With a Predominant Central SAS Treated by Adaptive Servo-Ventilation (FACIL-VAA) https://clinicaltrials.gov/study/NCT02835638 ERS workshop replay: The indication of use of ASV therapy, from evidence to clinical practice *ASV therapy is contraindicated in patients with chronic, symptomatic heart failure (NYHA 2-4) with reduced left ventricular ejection fraction (LVEF ≤ 45%) and moderate to severe predominant central sleep apnoea. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

The ATS (American Thoracic Society) International Conference is a key event in the global sleep and breathing health calendar. So in this episode of OnAir, we asked Kimberly Sterling and Luciana Rabello – who were there as part of ResMed’s Medical Affairs Team – to share the exciting developments and research findings that caught their attention. Topics discussed include: Endotypes: what they are and how they differ to phenotypes – with a look at the role endotyping can play in the management of heterogenous conditions like OSA, and why a collaborative approach to its application may be key. AI in medicine: how large-language models ‘think’ about complex care cases compared to the reasoning of seasoned clinicians, and the possibility of developing speech-based screening for sleep apnoea. GLP-1s: could the use of these anti-obesity medications be associated with increased PAP adherence? Kimberly and Luciana also tell us about connecting with peers to share scientific findings from the 26 abstracts ResMed supported at the event – including evidence that suggests PAP therapy reduces the risks of death and hospitalisation for patients with OSA.* Guests: Dr Kimberly Sterling - Vice President, Global Value & Access, Medical Affairs, ResMed Dr Luciana Rabello - Director of Clinical Advocacy, Medical Affairs, ResMed Host: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  References and useful links: ATS President’s Message *A. Malhotra, J.-L. Pépin, P.A. Cistulli, A. Wimms, F. Lavergne, F.H. Sert Kuniyoshi, S.H. Munson, B. Schuler, S.R. Badikol, C. Wilson, L. Willes, C. Kelly, T. Kendzerska, D.A. Johnson, R. Heinzer, C.-H. Lee, A.V. Benjafield, and on behalf of the medXcloud group. All-cause Mortality in Obstructive Sleep Apnea: Systematic Literature Review Including Randomised Trials and Confounding Adjusted Non-randomised Controlled Studies and Meta-analysis of Positive Airway Pressure Treatment (abstract). Am J Respir Crit Care Med 2024;209:A4735. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

Funded by a 15 million-euro grant from the EU’s Horizon 2020 programme for health demographic change and wellbeing, the Sleep Revolution project is an ambitious one that aims to shake up current diagnostic methods for sleep-disordered breathing (SBD). In this episode of OnAir, we talk to the head of the project, Professor Erna Sif Arnardóttir. She tells us how she believes strong collaboration between the project’s partners convinced the EU that the Sleep Revolution project could make real change, including: Bringing advanced sleep diagnostics from the hospital into patient’s homes Encouraging patients to participate in their own care with the help of technical solutions Developing different personalised treatment options for patients with SDB Creating a new European Sleep Questionnaire to help capture the whole sleep profile of a person for clinical and research purposes Prof. Arnardóttir also shares her thoughts on topics such as the importance of multi-night diagnostics, whether AHI is sufficient as parameter to classify the severity of OSA, and how digital tools – such as apps and wearables – and cooperation between different entities could transform the future of sleep medicine. Guest: Prof. Erna Sif Arnardóttir - Director of the Reykjavik University Sleep Institute; Associate Professor at the Department of Engineering and Department of Computer Science at Reykjavik University, Iceland Host: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  References and useful links: https://sleeprevolution.eu/en The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

In this episode of OnAir, sleep clinician Prof. Dr Manuel Sánchez-de-la-Torre and host Daniela Ehrsam-Tosi discuss the potential benefits of patient phenotyping for obstructive sleep apnoea. Prof. Dr Sánchez-de-la-Torre explores why patient phenotyping can be relevant during diagnosis, for making effective treatment decisions, and during the follow-up stage. He highlights the role of patient phenotype in predicting responses and understanding neutral effects, with a particular focus on blood pressure and hypoxic burden. He also emphasises the value of telemedicine in promoting engagement and treatment adherence. Listen to learn why progress in patient phenotyping could affect the way you treat and understand your OSA patients. Guest: Prof. Manuel Sánchez-de-la-Torre - University of Lleida, principal Investigator of the ‘Precision Medicine in Chronic Disease Group’ at the Biomedical Research Institute of Lleida, Spain. Host: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. Reference: Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. JAMA. 2023;330(13):1255–1265. https://doi.org/10.1001/jama.2023.17465 The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

In this episode of OnAir, clinical expert Professor Christoph Schöbel and host Daniela Ehrsam-Tosi discuss sleep quality and sleep disorders. There’s a growing awareness of the importance of sleep for our cardiovascular system and our general health and wellbeing. At the same time, our ability to get good sleep is increasingly challenged by everything from late-night scrolling to irregular work schedules, stress and anxiety. It’s thought that 10-30% of people worldwide suffer from insomnia1, not to mention other sleep disorders like OSA and restless leg syndrome. In this context, which diagnostic and treatment pathways should we be prioritising? Should primary care screening programmes focus on sleep as well as diet and exercise? What benefits might digital technology have to offer? Professor Schöbel shares his thoughts on these points, as well as discussing the new European Insomnia Guideline2 and the challenges of treating COMISA (co-morbid insomnia and sleep apnoea). Guest: Prof. Christoph Schöbel - Professor of Sleep Medicine with a focus on Telemedicine, University Medicine of Essen, Germany Host: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. References and useful links: 1. Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016 Oct-Dec;5(4):780-784. https://10.4103/2249-4863.201153. PMID: 28348990; PMCID: PMC5353813. 2. Riemann, D., Espie, C. A., Altena, E., Arnardottir, E. S., Baglioni, C., Bassetti, C. L. A., Bastien, C., Berzina, N., Bjorvatn, B., Dikeos, D., Dolenc Groselj, L., Ellis, J. G., Garcia-Borreguero, D., Geoffroy, P. A., Gjerstad, M., Gonçalves, M., Hertenstein, E., Hoedlmoser, K., Hion, T., … Spiegelhalder, K. (2023). The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. Journal of Sleep Research, 32(6), e14035. https://doi.org/10.1111/jsr.14035 The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

In this episode of OnAir, we ask whether treatment-adherent OSA patients could be lowering their cardiovascular risk while they sleep. Professor Frédéric Gagnadoux and host Nina Wiklund explore the design, results and implications of his recent 5,000-patient cohort study, which indicates that CPAP can deliver a significant reduction in major adverse cardiovascular events. They ask which patients are likely to benefit, discuss the importance of hours of usage, and consider the tools that clinicians can use to support therapy adherence. Listen to learn about the potential impact of CPAP therapy on the cardiovascular health of your OSA patients. Guest: Prof. Frédéric Gagnadoux - Head of the department of respiratory and sleep medicine, University Hospital of Angers, France. Host: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  References and useful links: Gerves-Pinquie C, Bailly S, Goupil F, Pigeanne T, Launois S, Leclair-Visonneau L, et al.; Pays de la Loire Sleep Cohort Study Group. (2022). Positive airway pressure adherence, mortality and cardiovascular events in sleep apnea patients. Am J Respir Crit Care Med, 206, pp. 1393–1404. DOI: 1164/rccm.202202-0366OC Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. 2023;330(13):1255–1265. doi:10.1001/jama.2023.17465 ERS 2023 Workshop: CPAP therapy and cardiovascular outcomes – what have we learned from real-life cohorts? The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

The world has changed profoundly in the 25 years since the internet became mainstream. Is it finally healthcare’s turn to experience a dramatic data-driven transformation? Daniela Ehrsam-Tosi and ResMed’s Chief Medical Officer Carlos Nunez explore the risks, realities and research potential of real-world data and deep machine learning. Their discussion starts with the perennial challenges of rising healthcare costs and ageing populations and invites us to look to a future where our data isn’t just used to serve us relevant advertising, but can also provide us with personalised healthcare in almost real time. Guest: Dr Carlos Nunez - Chief Medical Officer, Medical Affairs, ResMed. Host: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

Which factors make a real difference when it comes to keeping NIV patients comfortable, motivated and well cared for at home? In this episode of the OnAir podcast, respiratory expert Dr Jean-Michel Arnal and host Nina Wiklund discuss key issues in the delivery of home NIV, with a particular focus on troubleshooting, telemonitoring and patient engagement. As an ICU physician and the author of both a popular book1 and a recent article on home ventilation monitoring2, Dr Arnal has a deep interest and extensive experience in this field. He shares insights on using ventilator waveforms to identify common asynchronies, explains why the cycle feature is so important for patient comfort, and argues that our focus on finding data-driven predictors of exacerbation might be causing us to overlook an important low-tech solution. Listen now for an engaging tour of key topics in home NIV that provides useful insights for NIV experts while remaining accessible to anyone looking to learn more about the subject. Guest: Dr Jean-Michel Arnal - Resuscitation service and ventilation unit, Hôpital Sainte-Musse, Toulon. Host: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  References: Monitoring Mechanical Ventilation using Ventilator Waveforms, Springer: https://link.springer.com/book/10.1007/978-3-319-58655-7 Arnal J-M, Oranger M, Gonzalez-Bermejo J. Monitoring Systems in Home Ventilation. Journal of Clinical Medicine. 2023; 12(6):2163. https://doi.org/10.3390/jcm12062163 The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

Whether you attended ERS 2023 in person or are planning to catch up with the presentations and posters online, you won’t want to miss this episode of the OnAir podcast. As well as giving a flavour of the wide variety of topics covered, guests Adam Benjafield and Leanne Kaye share their conference highlights and key takeaways. The discussion ranges from the potential of behavioural science to drive PAP therapy adherence to the importance of personalised therapy, digital health and person-centred care, alongside new perspectives on OSA diagnosis and phenotyping. There’s also time to touch on the rise of HFT, digital health, a couple of eye-catching new studies based on real-world data, and the important relationship between climate and health. What might these developments mean for the future of sleep and respiratory research and therapy? Listen in to find out. Guests: Dr Leanne Kaye - Director, Behavioural Research & Digital Insights, ResMed. Dr Adam Benjafield - Vice President, Medical Affairs at ResMed. Hosts: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

In this episode of OnAir, we explore how Sweden is shaking up its approach to the diagnosis and treatment of obstructive sleep apnoea. Professor Ludger Grote explains the background and benefits of the Swedish National Sleep Guidelines, which are part of a concerted effort to improve diagnosis, waiting times, treatment and outcomes for patients across the country. The new, comprehensive approach is based on a diagnostic framework and treatment matrix that has been developed using registry data and input from both patients and professionals. Listen now to learn how and why Sweden is taking a broader view of OSA and what Prof. Grote thinks about the role of AHI and hypoxic burden in diagnosis.  Keen to learn more? Watch the webinar of Prof. Grote’s ESRS presentation or read the original study. Guest: Prof. Ludger Grote - Medical director of the Sleep Disorders Center at the Sahlgrenska University Hospital in Gothenburg, Sweden. Host: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

Following our previous podcast, which delved into the evolution of home high-flow therapy (HFT) and its implications for patient care, Dr Maxime Patout returns to offer more insights into the topic. This time round he describes the objectives of the large HiFAE trial he’s leading to assess the benefit of HFT when initiated after a severe exacerbation of COPD. Focused on French patients with severe forms of the condition, the study – which saw its first patient enrolled in late 2022 – aims to show that using HFT in a home setting can indeed decrease both the rate of exacerbations and mortality, as well as improve quality of life and respiratory function. Listen now to find out more! Guest: Dr Maxime Patout - Hospital Pitié Salpêtrière, Faculty of Medicine, Sorbonne University, France. Host: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

In this episode we’re joined by Dr Maxime Patout, who’s at the forefront of new research into home high-flow therapy (HFT). Listen now to find out why he thinks the evolving role of home HFT – especially in out-of-hospital care – means we’re on the verge of important change in respiratory medicine, with benefits for patients, healthcare professionals and healthcare systems. If you’d like to hear more from Dr Patout on this topic, tune in next time, when he’ll be offering insights into the French clinical trial HiFAE, and why it is important for increasing evidence in this field.  Guest: Dr Maxime Patout - Hospital Pitié Salpêtrière, Faculty of Medicine, Sorbonne University, France. Host: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed

In this episode, the focus is on the relationship between clinical outcomes, financial costs and societal impact. Dr Patrick Murphy explains the importance of collecting robust health economic data, using the example of the HOT-HMV trial that explored home NIV for COPD. If you’re interested in health economics, value-based healthcare, clinical commissioning or simply appreciate clear and informed discussion of a critical aspect of modern clinical research, you’ll want to tune in. Guests: Dr Patrick Murphy - Lane Fox Respiratory Unit, Guy’s and St Thomas’ Hospital, London. Melike Deger-Wehr - Health Economics and Outcomes Research Director, ResMed. Host: Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed