Recorded to raise awareness on World COPD Day 2024, this episode of OnAir is dedicated to chronic obstructive pulmonary disease – the third-leading cause of deaths worldwide. But as well as discussing the prevalence, underlying causes and trajectories of the condition, expert guests Professor Jean-Louis Pépin and research scientist Elroy Boers share new perspectives provided by their recent findings on the subject, including: How real-world evidence can better reflect the complexity and heterogeneity of COPD Why analysing data on gender and socioeconomic differences can lead to greater understanding of the disease landscape What real-word evidence tells us about treating COPD patients with NIV Looking to the future, our guests finish on a positive note by discussing the potential beneficial impacts new COPD management strategies could have on patient outcomes and economic and healthcare burdens. Guests: Prof. Jean-Louis Pépin, PU-PH in Clinical Physiology, head of the HP2 research laboratory, Grenoble, France Dr Elroy Boers, Lead Health Research Scientist, ResMed Hosts: Daniela Gautschi is ResMed’s Director Clinical Advocacy Europe, and has a passion for exploring the latest developments in the world of sleep and breathing health. Her key focus is advocating for digital health innovations to help ensure access to good quality care. Nina Wiklund is ResMed’s Global Medical Marketing Content Lead, and has a burning enthusiasm for clinical research. She is especially interested in the additional insights and possibilities real-world evidence can add to existing RCTs.  References and useful links: Boers, M. Barrett, J.G. Su, et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050. JAMA Netw Open. 2023;6(12):e2346598. doi:10.1001/jamanetworkopen.2023.46598 Boers, A. Allen, A. Benjafield, L.E. Crotty Alexander, A. Malhotra and M. Barrett. A scenario-based modeling study to project the future burden of COPD in Western Europe accounting for air pollution, tobacco smoking, and e-cigarette vaping. (abstract). ERS 2024. -L Pépin, P. Lemeille, H. Denis, A. Josseran, F. Lavergne, A. Panes, S. Bailly, A. Palot, A. Prigent, Health trajectories before initiation of non-invasive ventilation for chronic obstructive pulmonary disease: a French nationwide database analysis, The Lancet Regional Health - Europe, 2023, 100717, ISSN 2666-7762, doi: 10.1016/j.lanepe.2023.100717. 2 J.-L. Pépin, E. Herquelot, H. Denis, A. Josseran, F. Lavergne, A. Schmidt, S. Bailly, A. Palot, A. Prigent, and on behalf of the MedXcloud group. Impact of Long-term Domiciliary Non Invasive Ventilation (NIV) on Severe Exacerbations and Survival in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Nationwide Cohort Study Using Multistate Models (abstract). Am J Respir Crit Care Med 2024;209:A4978. The podcast OnAir, with Clinical Respiratory News (CRN) is a medical education non-promotional for healthcare professionals organised by ResMed. Learn more at https://webinars.resmed.eu/podcasts-list/. This podcast is intended for healthcare professionals only. Disclaimer: This programme is non promotional and is sponsored by ResMed. The speakers are being compensated and/or receiving an honorarium from ResMed in connection with this programme. The content contained in this programme was jointly developed by the speakers and ResMed, and is not eligible for continuing medical education (CME) credits. Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in sleep and breathing health. © ResMed