The legalization of cannabis has created a billion-dollar problem that technology is only now catching up to solve: how can we accurately measure impairment, not just use? In this episode of the Orange Pill Podcast, we dive into groundbreaking research featuring the Cognalyzer®- a novel EEG-based device that measures brainwave alterations to detect cannabis impairment directly. Unlike traditional methods such as saliva or blood tests, which can penalize sober individuals long after consumption, this technology focuses on what truly matters: the brain’s current state. This episode challenges assumptions, highlights the science, and explores how objective data can pave the way for smarter regulation and safer consumption.

Aggression, from playground fights to serious violence,  has long challenged families and communities alike. But what if one of the simplest, safest, and most effective tools for reducing aggression has been sitting on our dinner plates all along? In this episode, we explore a groundbreaking new meta-analysis spanning nearly 30 years of research that reveals how omega-3 supplementation, the same fatty acids found in fish oil, can reduce aggression by up to 30%. Join us as we unpack: The evidence behind 29 randomized controlled trials How omega-3 helps regulate both “hot” and “cold” aggression Why experts are calling for its immediate implementation And how this simple nutritional step could transform mental health strategies Tune in to discover how a small dietary change could make a big difference in behavior, brain health, and community well-being.

We all try to eat better,  loading up on antioxidant-rich berries, turmeric, and green veggies,  but here’s the surprising truth: many of those “super-nutrients” never make it past your digestive system. In this episode of the Orange Pill Podcast, we explore how nanotechnology is rewriting the rules of nutrition. From nanoencapsulation that protects fragile compounds like curcumin and quercetin, to upcycling food waste into potent new supplements, science is finally addressing the “bioavailability bottleneck.” But with every breakthrough comes new questions, about safety, regulation, and the fine line between innovation and over-engineering our food. Are we entering an era of “programmed nutrition,” and what will it mean for the future of health and wellness?

Fermented foods like cheese, wine, and cured meats are celebrated for their complex flavors, but they may harbor hidden risks. In this episode of The Orange Pill Podcast, we explore the world of biogenic amines (BAs), naturally occurring compounds that can pose health hazards despite their delicious origins. From the “cheese effect” of tyramine to toxic synergy among multiple amines, we discuss why regulating histamine alone isn’t enough. Learn why food safety experts are calling for clear specifications for biogenic amines in foods and dietary supplements, and how manufacturers can proactively protect consumers.

In Episode 64, we continue to unpack the regulatory evolution of cannabis and cannabidiol (CBD) in Canada (continuation of Episode 44) and what’s next for the industry. From the Cannabis Act to proposed pathways that could finally allow CBD Natural Health Products (NHPs) to be sold without prescriptions, this episode dives deep into how Health Canada’s changing stance could reshape accessibility, innovation, and economic opportunity. 

For most Americans, a government shutdown means furloughs, temporary disruptions that end when funding returns. But October 2025 marks a turning point. The Trump administration’s move to issue Reductions in Force (RIFs) across key agencies like HHS, FDA, and the CDC has transformed a short-term budget standoff into a permanent restructuring of the federal workforce. In this episode, we break down: The difference between a furlough and a RIF, and why it matters now more than ever. The scale of workforce reductions and their ripple effects on public health and food safety. The political and economic motivations behind using the shutdown as a tool to shrink government size. Historical parallels to past administrations and what they reveal about the long-term agenda. Tune in to explore how this unprecedented move could reshape America’s public health infrastructure, and redefine the meaning of “non-essential.”

After nearly three years of uncertainty, the FDA has officially reversed its stance on Nicotinamide Mononucleotide (NMN), the popular anti-aging compound once banned from supplement shelves. In this episode, we unpack the twists and turns that led to the agency’s dramatic U-turn, the key legal reinterpretation that changed everything, and how relentless industry advocacy forced the FDA’s hand. From Citizen Petitions to regulatory chaos, discover what really happened behind the scenes, and why this win for NMN could foreshadow the next big battle in dietary supplement regulation. Tune in to understand the future of NMN, the gaps still left unaddressed, and what this means for innovation in the supplement industry.

Most diets promise weight loss but leave you battling hunger, losing precious muscle, and facing rebound weight gain. But what if there’s another way? In this episode of the Orange Pill Podcast, we break down a recent clinical trial published in Clinical Nutrition Open Science that tested the Bone Broth Diet (BBD), a mix of intermittent fasting, high-protein/low-carb meals, and collagen-rich bone broth.   The results? Surprisingly powerful: ✅ Fat loss with muscle preservation ✅ Reduced hunger and cravings without sacrificing satisfaction ✅ Improved blood sugar, triglycerides, and waist circumference ✅ Built-in flexibility for long-term success   This isn’t just another diet trend — it’s a new perspective on sustainable weight management.

From sourdough bread to kombucha, fermentation has long been a cornerstone of human diets. But what was once a preservation method is now driving some of the boldest innovations in food science. In this episode, we explore five surprising ways fermentation is transforming the future of food—from unlocking hidden nutrition and reintroducing microbial diversity, to turning food waste into gourmet ingredients, breeding microbes for flavor, and even creating animal products without the animal. Fermentation has evolved from an ancient art into a modern marvel, one that promises healthier, more sustainable, and more exciting food for the future.

From farm to fork, our food supply chain is one of the most complex in the modern world. But while we often imagine technology’s role as simply faster machines or warehouse robots, the true disruption is happening in ways we don’t see. In Episode 59 of the Orange Pill Podcast, we uncover four surprising ways AI and IoT are secretly reshaping the food industry—from collapsing product development timelines and predicting real consumer trends, to making food safety proactive and even delivering unexpected green dividends in logistics. You’ll hear how these “invisible” systems are bringing clarity, foresight, and accountability to the food we eat, and why the biggest changes are still just over the horizon.

Caffeine is the world’s most widely consumed psychoactive substance, naturally found in coffee, tea, and chocolate, but now added to everything from energy drinks and supplements to waffles and chewing gum. With this rapid expansion, regulators and health experts are re-examining the science and safety of caffeine consumption. In this episode, we break down: Safe daily intake levels for healthy adults and vulnerable groups. The unique risks for children, adolescents, and pregnant women. How genetics can influence caffeine sensitivity and cardiovascular risk. Emerging concerns with energy drinks, substance interactions, and long-term effects. Where the science is strong—and where the biggest data gaps remain.

Coffee and caffeine are cultural cornerstones in the United States, but consumption trends have shifted dramatically over the past century. From the wartime rise of instant coffee to today’s specialty café culture and booming energy drink market, Americans’ relationship with caffeine keeps evolving. In this episode of the Orange Pill Podcast, we unpack key findings from recent research on coffee and caffeine consumption patterns in the U.S. Tune in as we break down the data, the history, and the health implications of America’s caffeine habits.  

In this episode of the Orange Pill Podcast, we explore the promise of D-mannose, a functional sugar gaining recognition as a non-antibiotic solution for urinary tract infections (UTIs). We break down findings from a randomized, triple-blind, placebo-controlled study (Current Urology, 2025) where the product UClear, developed by KEB Nutraceuticals and clinically tested by KGK Science, demonstrated significant improvements in UTI symptoms after just 3 days of supplementation. Join us as we unpack the science, the clinical trial data, and the broader implications for women’s health and nutraceutical innovation.

In Episode 55 of the Orange Pill Podcast, we dive into the newly released “Make Our Children Healthy Again Strategy” from the Make America Healthy Again (MAHA) Commission, chaired by U.S. Health and Human Services Secretary Robert F. Kennedy Jr. This landmark strategy, unveiled on September 9, 2025, lays out more than 120 initiatives to combat the epidemic of chronic disease among America’s children. From restoring gold-standard science and reforming dietary guidelines to improving food labeling and expanding access to healthier options, the plan is designed to realign food and health systems for the next generation. We’ll explore the strategy’s five core pillars: Restoring rigorous science and research. Executive actions to reform nutrition policies and labeling. Streamlined access to healthier foods. Education and public awareness initiatives. Collaboration with the private sector to tackle root causes of disease. Join us as we unpack how this sweeping vision could reshape the health landscape for families across the U.S. and what it means for the future of nutrition, wellness, and food policy.

Gen Z is reshaping the future of food. From sustainability and ethics to bold flavors, functional foods, and the powerful role of social media, their choices reflect values as much as taste and price. In this episode, we explore what drives Gen Z’s food preferences, the trends that matter most, and what brands need to know to stay relevant in a market increasingly defined by this generation. Whether you’re in product development, marketing, or food innovation, this episode is packed with insights into the consumers of tomorrow.

Statistics can make or break the credibility of a clinical trial, but too often they’re misunderstood. In this episode, we dive into the statistical backbone of clinical research — P-values, null hypothesis, sample size, effect size, and safety data — and uncover the common misconceptions that can distort how results are interpreted. From the chronic confusion around what a P-value really means, to why sample size isn’t everything, to the difference between statistical significance and clinical relevance, we break it down in plain language for anyone working in dietary supplement and nutraceutical research. Whether you’re a sponsor, regulator, or just passionate about evidence-based wellness, this episode will give you a clearer perspective on how to read between the numbers.

The women’s health supplement market is booming, projected to hit nearly $91 billion by 2033. But is this growth empowering women, or exploiting them? In this episode, we unpack the drivers behind the surge, from the self-care movement and influencer marketing to life-stage–specific formulas targeting PMS, fertility, and menopause. We also dive into the risks of a largely unregulated market, the red flags consumers should watch for, and the critical role of third-party testing and professional guidance. With insights from health experts, we separate fact from fiction to help women make informed, evidence-based choices. From gummies to personalized packs, discover how innovation, marketing, and regulation are shaping the future of women’s wellness, and what it means for you.

The protein wars are heating up, and one bar is leading the charge. In this episode, we unpack the “protein bar arms race” and the meteoric rise of the David Bar—a hyper-optimized, influencer-backed product redefining the category. From its extreme protein-to-calorie ratio and luxury branding to its aggressive supply chain play with Epogee, David is more than just a snack; it’s a symbol of the cultural obsession with protein and optimization. We explore: Why protein is now the undisputed king macronutrient. How the David Bar’s marketing blitz turned influencers into pitchmen. The role of fat substitute E.P.G. in reshaping product innovation. The booming GLP-1 user demographic fueling protein demand. Whether the protein craze is here to stay—or just another hype cycle. Tune in as we dissect the science, strategy, and spectacle behind the “Scud missile of protein bars” and what it tells us about the future of food and wellness.

The FDA’s “Generally Recognized as Safe” (GRAS) rule was meant to keep food safe. But for decades, the self-GRAS loophole has allowed companies to introduce new additives without FDA review or public disclosure. In this episode of the Orange Pill Podcast, we break down the unprecedented wave of reform efforts in 2025: Executive action from HHS Secretary RFK Jr. and FDA Commissioner Marty Makary. Congressional bills aiming to permanently close the loophole. State-level legislation in New Jersey, Pennsylvania, and New York pushing transparency and bans. The message is clear: the era of self-approved food additives is ending. Tune in as we unpack what this shift means for consumers, industry, and the future of food safety.

In this episode, we dive deep into the Make America Healthy Again (MAHA) Commission’s leaked strategy report, submitted to President Trump earlier this month and quietly leaked before its official release. The “Make Our Children Healthy Again Strategy” lays out sweeping changes to how the federal government addresses childhood chronic disease, from overhauling nutrition guidelines and banning food dyes, to tackling overmedicalization and rethinking the role of ultra-processed foods. But the report isn’t without controversy. Critics point to missing depth on root causes like poverty and food insecurity, questionable transparency in its citations, and concerns about agricultural and pharma industry influence. Join us as we break down: The four drivers of childhood chronic disease identified by the Commission. The most significant, and contentious, policy recommendations. Why the report’s leak, delays, and past credibility issues are fueling political and public backlash. The broader implications for public health, industry, and the future of U.S. nutrition policy. This is more than a health policy debate, it’s about the future of America’s children and whether government intervention can truly move the needle.