In this episode of The Deep Dive, supported by RevGenetics, we explore how the world’s oldest people may hold the key to treating one of the rarest aging diseases, Hutchinson-Gilford Progeria Syndrome (HGPS).

HGPS is caused by a mutation in the LMNA gene, which produces a toxic protein called progerin that causes rapid aging. However, super centenarians, people who live beyond 110 years, have a special LMNA gene variant that helps protect their cells from progerin damage.

Researchers now believe this longevity variant could help protect children with HGPS from early heart problems, especially diastolic dysfunction, an early sign of heart failure. This study offers new hope for immediate heart protection and a better understanding of how some humans naturally resist aging.

Join us as we explore the connection between genetic longevity and progeria research, and what it could mean for longer, healthier lives.

Supported by RevGenetics – Science-Based Supplements For Healthy Aging
Explore Longevity Products

Referenced Study:
Supercentenarian LMNA Variant and HGPS – Nature Cell Discovery

Hashtags:
#Progeria #HGPS #LongevityResearch #SuperCentenarians #LMNAGene #RevGenetics #HealthyAging #AntiAgingScience #HeartHealth #Progerin #GeneticLongevity #CellularResilience #LongevityPodcast #AgeReversal #ScienceBreakthroughs #CardiovascularResearch #LongevityPotential #DeepDivePodcast #RevGeneticsSupport

In this episode of The Deep Dive, supported by RevGenetics, we explore a surprising breakthrough in longevity research: psilocybin, the active compound in magic mushrooms, may do more than just improve mental health.A recent study published by the Japanese Society of Anti-Aging Medicine introduces the psilocybin telomere hypothesis, suggesting that psilocybin’s mood-enhancing effects could be linked to telomere length, a key marker of cellular aging. In lab tests, psilocin, a metabolite of psilocybin, showed the ability to improve cell survival and extend lifespan in aging human cells.Even more compelling, older mice treated with psilocybin showed signs of enhanced survival and vitality, opening the door to a bold new direction in anti-aging science. Could psilocybin influence biological aging itself?Join us as we unpack the implications of this study and what it might mean for the future of longevity, mental wellness, and telomere science.Supported by RevGenetics – Science-Based Supplements For Healthy Aging 👉 [Explore Longevity Products](https://www.revgenetics.com)Referenced Study:🔗 [Psilocybin and Telomeres Study – Nature](https://www.nature.com/articles/s41514-025-00244-x)Hashtags:#Psilocybin #LongevityResearch #TelomereScience #HealthyAging #PsilocybinPodcast #AntiAgingMedicine #RevGenetics #PsilocinStudy #DeepDivePodcast #MentalHealthAndAging #ScienceBreakthroughs #CellularLifespan #TelomereLength #PsilocybinLongevity #MushroomMedicine #Neurobiology #LongevityPotential #AntiAgingBreakthrough #PsychedelicScience #RevGeneticsSupport

Can aging be reversed? A landmark 2025 Cell study says… maybe. Scientists engineered human senescence-resistant mesenchymal progenitor cells (SRCs) and infused them into aged primates,with mind-blowing results.

These SRCs didn’t just slow aging, they reversed biological age in key organs like the brain, bones, and reproductive system. Cognitive performance improved. Brain volume and connectivity bounced back. Even fertility markers surged in both male and female subjects.

The secret? SRCs released exosomes, tiny vesicles packed with rejuvenating signals, that triggered wide-scale cellular repair and anti-inflammatory effects across the body. From improved memory and myelination to restored spermatogenesis and oocyte health, this research opens new doors for regenerative therapies targeting aging at the root.

While human trials are still on the horizon, this could mark a turning point in the science of longevity and systemic rejuvenation.

Join us as we explore the science behind this game-changing breakthrough.

👉 Subscribe for More Longevity Updates: https://www.youtube.com/revgenetics
👉 Get Longevity Support From RevGenetics: https://www.revgenetics.com/collections/longevity-supplements

Referenced Study:
🔗 Cell (2025): Senescence-Resistant Cells Reverse Aging in Primates
https://doi.org/10.1016/j.cell.2025.05.021

Hashtags:
#LongevityBreakthrough #AntiAgingResearch #SenescenceResistance #StemCellTherapy #BrainHealth #ReproductiveHealth #CognitiveSupport #RegenerativeMedicine #HealthyAging #ExosomeTherapy #BiologicalAgeReversal #FOXO3 #FutureOfMedicine #RevGenetics #LongevityScience #PrimatesToPeople #StemCellNews #AgingReversal #RegenTech #SRCs

In this RevGenetics podcast, Les and Amy introduce the new advanced NAD supplement with a special delivery system in BioVXR capsules. The formula addresses challenges with NAD breakdown by NNMT enzyme, using NAD shield with an NNMT inhibitor and low-dose NAD precursor strategy. Ingredients include NAD precursor, trans resveratrol for antioxidant properties, and NNMT inhibitor from vanilla beans. Probiotics Bifidobacterium infantis and Lactobacillus salivarius support gut health for better nutrient absorption. This targeted approach offers a promising solution for boosting NAD levels and promoting healthy aging. Study: https://cdn.shopify.com/s/files/1/2088/8715/files/Eurofins_-_Capsule_Tests.png?v=1733770624 https://cdn.shopify.com/s/files/1/2088/8715/files/MUV1cm9maW5zX0Rpc2ludGVncmF0aW9uIFJlcG9ydC5wZGY_1.pdf?v=1733769841 Get Advanced NAD + NADshield Here: https://www.revgenetics.com/products/advanced-nad-and-nadshield-nnmt-inhibitor-stop-nad-deficiency

In this podcast by RebGenetics, we explore peripheral nerve regeneration. When nerves are damaged, they can regrow, but the process is slow and doesn't always lead to full recovery. Wallarian Degeneration breaks down the injured nerve, paving the way for regrowth. Schwann cells act as cleanup crew and guide axon regrowth. Time and distance affect recovery, making it a race against time. Electrical stimulation, like post-operative and conditioning stimulation, can aid in nerve regeneration by providing guidance and support. Overall, understanding the complexities of nerve regeneration can help improve recovery outcomes.

In this podcast, we explore the groundbreaking potential of **NMN (Nicotinamide Mononucleotide)**, a crucial molecule for **NAD+ production** in the body. As NAD+ levels naturally decline with age, NMN emerges as a promising solution to combat age-related health issues. Recent studies, including a groundbreaking **Nature study**, highlight NMN's ability to protect neurons and synapses critical for memory and cognition, offering hope in the fight against **Alzheimer's disease**. By activating the **ATF4 pathway**, NMN helps clear harmful proteins linked to Alzheimer's, showcasing its neuroprotective benefits. NMN is also gaining attention for its role in **fertility**. Research suggests NMN supports mitochondrial health, improves oocyte quality, and may help address age-related fertility challenges. These findings underscore NMN's dual potential to improve both cognitive function and reproductive health. While research is still in preclinical stages, the possibilities for **longevity** and **healthspan enhancement** are compelling. Join us for a deep dive into the transformative potential of NMN! **Referenced Studies:** 🔗 [Study 1](https://www.nature.com/articles/s41419-024-07062-1) 🔗 [Study 2](https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2024.1480617/full) 🔗 [Study 3](https://www.sciengine.com/ABBS/doi/10.3724/abbs.2024167;JSESSIONID=009a062c-0115-4c3c-b85e-ef7e777a97e2) 🔗 [Study 4](https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01903-4) **Get RevGenetics Advanced NMN 1000 (60 Caps - 500 mg each):** 👉 [RevGenetics Advanced NMN](https://www.revgenetics.com/collections/advanced-nmn-products/products/advanced-nmn-1000-nicotinamide-mononucleotide-limited-production) #NMNAlzheimers #NMNFertility #NMNResearch #NADBoosters #AlzheimersResearch #FertilitySupport #LongevityScience #HealthyAging #MitochondriaHealth #ATF4Pathway #BrainHealth #CognitiveSupport #AgeRelatedFertility #Podcast #ScienceBreakthroughs #RevGenetics

Discover the incredible potential of spermidine for longevity and reproductive health in this podcast! Spermidine, a natural polyamine found in all living organisms, plays a vital role in cellular health. Cutting-edge research reveals that spermidine supplementation can help combat cellular deterioration, enhance **oocyte quality** in aging females, and even slow down the aging process.

Exciting studies also suggest that spermidine may improve fertility by boosting sperm binding and increasing fertilization rates in aged oocytes, offering hope for couples dealing with age-related fertility challenges. Dive in as we explore how spermidine is transforming the fields of anti-aging and reproductive science, showcasing its immense potential for improving quality of life.

**Referenced Studies:**

🔗 [Research Study 1](https://assets-eu.researchsquare.com/files/rs-4966373/v1/d2083cc8-b013-46e9-bd24-08c6d60bc720.pdf?c=1729174608)

🔗 [Research Study 2](https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01881-7)

🔗 [Research Study 3](https://www.semanticscholar.org/paper/Harnessing-Mitophagy-for-Therapeutic-Advances-in-Ghosh-Kumar/a9be508d021f6cbdf453e437ec7baaa5de9d0c2e)

🔗 [Research Study 4](https://link.springer.com/article/10.1007/s10571-024-01493-2)

🔗 [Research Study 5](https://academic.oup.com/ismecommun/article/4/1/ycae123/7826681?login=false)

**Get Spermidine Supplements Here:**

👉 [RevGenetics Spermidine Supplements](https://www.revgenetics.com/collections/longevity-supplements/products/rapymine-with-spermidine-rx)

#Spermidine #Longevity #ReproductiveHealth #FertilitySupport #AntiAging #CellularHealth #OocyteQuality #FertilityScience #AgeRelatedFertility #HealthyAging #Podcast #BreakthroughResearch #NaturalSupplements

In today's podcast, we explore the exciting potential of resveratrol in addressing COVID-19 and Parkinson's disease. Researchers have discovered that resveratrol targets critical processes in lung damage, offering hope for reducing infection and scarring. Using advanced virtual models, they’ve observed how resveratrol interacts at a molecular level, suggesting promising therapeutic effects. For Parkinson's disease, cutting-edge science is investigating nanoparticle delivery systems to optimize resveratrol's benefits, paving the way for groundbreaking treatments. Dive into the latest research and learn how this natural compound is shaping the future of medicine. **Referenced Studies:** 🔗 [De Gruyter Study](https://www.degruyter.com/document/doi/10.1515/chem-2024-0012/html) 🔗 [PubMed Study 1](https://pubmed.ncbi.nlm.nih.gov/39400013/) 🔗 [PubMed Study 2](https://pubmed.ncbi.nlm.nih.gov/39395579/) 🔗 [PubMed Study 3](https://pubmed.ncbi.nlm.nih.gov/39426178/) 🔗 [Preprint Study](https://www.preprints.org/manuscript/202410.0596/v1) **Get Resveratrol or Polydatin Here:** 👉 [RevGenetics Resveratrol Supplements](https://www.revgenetics.com/collections/resveratrol-supplements) **Hashtags:** #Resveratrol #COVID19Research #ParkinsonsDisease #LungHealth #Nanotechnology #CuttingEdgeScience #RevGenetics #NaturalMedicine #HealthInnovation #ScientificBreakthroughs

Can eating make us age faster? 🧐 In this video, we take a fascinating deep dive into the science of aging and digestion. Research suggests that as we age, digestive enzymes like trypsin and elastase may leak out of the gut, wreaking havoc on our organs and collagen. These enzymes, designed to break down food, can mistakenly start breaking down other parts of our bodies, potentially contributing to wrinkles, sagging skin, and other aging effects.

A recent study found that older rats had higher levels of these enzymes, leading to significant collagen damage in various organs. The connection between leaky gut, rogue enzymes, and collagen breakdown sheds new light on how our bodies change with age.

We also discuss natural trypsin inhibitors found in foods like egg whites, soybeans, sweet potatoes, and more, and how they could play a role in managing this process.

Stay tuned for more on the link between digestion and aging—this is one video you don’t want to miss!

Trypsin Inhibitor-Rich Foods:

🥚 Egg Whites

🌱 Soybeans

🍠 Potatoes & Sweet Potatoes

🌾 Amaranth Seeds

🍲 Beans, Lentils, & Peas

Hashtags:

#AgingScience #LeakyGut #CollagenHealth #Wrinkles #SkinCareTips #AntiAging #DigestiveHealth #NaturalRemedies #HealthyAging #GutHealth #ScienceOfAging #TrypsinInhibitors Study: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312149 Get 120 Capsules of Spermidine (25 mg each) Here: https://www.revgenetics.com/collections/longevity-supplements/products/rapymine-with-spermidine-rx

In this podcast, researchers explore the link between gut health and fighting off MRSA infections. They found that antibiotics disrupting gut bacteria made mice more susceptible to severe MRSA infections. However, fecal transplants from healthy mice improved infections drastically. The key molecule identified was spermidine, produced by gut bacteria. Mice with higher spermidine levels showed improved survival rates and reduced infection severity when infected with MRSA. Spermidine seemed to boost the immune system's response to the infection. This research highlights the importance of gut health in combating antibiotic-resistant superbugs like MRSA. Study: https://pubs.acs.org/doi/epdf/10.1021/acsinfecdis.3c00669?ref=article_openPDF Get 120 Capsules of Spermidine (25 mg each) Here: https://www.revgenetics.com/collections/longevity-supplements/products/rapymine-with-spermidine-rx

In this Podcast, we explore cutting-edge cancer research on the mitochondrial stem cell connection (MSCC). Published in September 2024, this study challenges traditional views by focusing on cellular energy crises. The MSCC theory suggests that malfunctioning mitochondria in stem cells can trigger tumor formation, leading to aggressive cancer growth. Cancer cells, desperate for energy, become "sugar addicts," relying on glucose and glutamine for fuel. This research highlights seven key points, emphasizing the importance of understanding how cellular energy processes impact cancer development. Stay tuned for more insights into this fascinating and groundbreaking study that provides dose and information on Intravenous Vitamin C, Oral Vitamin D, Zinc, Ivermectin, Benzimidazoles (Mebendazole), DON, Dietary Interventions and Additional Therapeutics. Study: https://isom.ca/article/targeting-the-mitochondrial-stem-cell-connection-in-cancer-treatment-a-hybrid-orthomolecular-protocol/ Support RevGenetics by purchasing a world class NMN, M98 Resveratrol (Polydatin), Spermidine, Or Fisetin Supplement: https://www.revgenetics.com/collections/longevity-supplements

Scientists are exploring how aging impacts COVID severity, focusing on lung aging and cellular senescence. As we age, our lungs lose efficiency in repair mechanisms, like basal cells and cilia, making us more vulnerable to infections. Cellular senescence leads to zombie cells releasing inflammatory molecules, creating an inflammatory soup that affects healthy cells. This process, known as SASAP, worsens with SARS-CoV-2 infection, potentially explaining why COVID hits some harder than others. By understanding these aging-related factors, researchers hope to develop new strategies like Senolytics to combat COVID and improve outcomes. Study: https://link.springer.com/article/10.1186/s13619-024-00201-1 Try RevGenetics Senoyltics Supplement available here, for your next study: https://www.revgenetics.com/collections/longevity-supplements/products/senolytics-500-fisetin-500mg

In this podcast, we explore a study on whether chocolate high in flavanols can protect skin from the sun. Flavanols are antioxidants found in cocoa beans, fruits, and vegetables. The study involved women aged 20-65 consuming chocolate daily for 12 weeks. Researchers measured skin protection using the minimal erythema dose (MED), which indicates sun sensitivity. By tracking MED changes, they assessed the impact of chocolate consumption on skin reaction to UV radiation. The study aimed to determine if flavanols in chocolate could provide additional antioxidant protection for the skin. Stay tuned to learn more about the fascinating findings! Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082621/ Longevity Supplements: https://www.revgenetics.com/collections/longevity-supplements

In this podcast, we explore groundbreaking research on inhibiting IL-11 signaling to extend health span and lifespan. IL-11, a key player in inflammation, may hold the key to anti-aging therapies. By studying mice, researchers found that blocking IL-11 activity led to significant lifespan extension, up to 20%. IL-11 acts as a spark, triggering molecules like ERK, AMPK, and MTORC1, impacting cell repair, energy use, and nutrient processing. This discovery offers promising insights into the mechanisms of aging and potential interventions for extending human lifespan significantly. Study: https://www.nature.com/articles/s41586-024-07701-9 While we don't see anything no where near as potent as the anti-bodies described in the study, there are some interesting natural things that might move the needle in the right direction: Curcumin: Studies have found that curcumin can reduce fibrosis, and indirectly may also impact IL-11 since IL-11 is involved in fibrotic signaling. But you may need MetaCurcumin as normal curcumin has a problem with natural bioavailability. Resveratrol: Resveratrol is known to inhibit fibrogenesis, particularly in the liver and heart, which suggests a potential indirect effect on pathways involving IL-11. A better one would be M98 Resevratrol (Polydatin) as the bioavailability is much stronger than Resveratrol. EGCG: EGCG has been shown to reduce fibrosis in several organs, suggesting that it could help in the regulation of IL-11 indirectly. Quercetin: It downregulates cytokine production and has demonstrated anti-fibrotic properties, suggesting potential impacts on IL-11-driven fibrosis. N-Acetylcysteine (NAC): NAC has been shown to have protective effects against fibrosis in various organs, possibly affecting IL-11 indirectly. Vitamin D: Vitamin D deficiency is linked to increased fibrosis, and supplementation has shown a reduction in fibrotic signaling, which could indirectly influence IL-11 activity. Silibinin (Milk Thistle): Silibinin has been shown to protect against liver fibrosis, indicating a possible reduction in IL-11-mediated effects. Omega 3: Studies indicate that omega-3 fatty acids reduce fibrosis in organs like the liver and kidney, potentially modulating IL-11 indirectly through decreased inflammation. Boswelia Serrata (Boswellic Acid): Animal studies have demonstrated that boswellic acid reduces organ fibrosis and inflammatory cytokine production, suggesting a potential indirect inhibition of IL-11. We do have the first 3, if that's something you would like to try: https://www.revgenetics.com/collections/longevity-supplements

In the video, researchers delve into the science of aging and skincare, focusing on a plant extract from Goldenrod that shows promising anti-aging properties. The extract, derived from Solidago vergaria subspecies alpestris, was found to slow down the aging process in skin cells called fibroblasts. It helps preserve youthful fibroblasts by delaying a transition that occurs with age. Additionally, the extract reduces the senescence-associated secretory phenotype, a process that occurs when cells age. This research offers a deeper understanding of how skin cells age and the potential benefits of using Goldenrod extract for maintaining youthful skin. Study: https://www.nature.com/articles/s41514-018-0023-5 Stem Cell Pro features Goldenrod as one of the many ingredients provided for youthful glow and Stem Cell health: https://www.revgenetics.com/collections/resveratrol-supplements/products/new-formula-stem-cell-pro-iv-proxystem-core-formula

Polydatin vs Downs Syndrome? In today's deep dive, we explore groundbreaking research on improving brain development in individuals with Down syndrome. The study focuses on neurogenesis and dendritogenesis, crucial processes for cognitive function. Disruptions in these processes can impact learning and memory. The potential hero is polydatin (aka M98 Resveratrol), a polyphenol found in grapes. Polyphenols act as brain guardians, protecting cells and stimulating neurogenesis. They also enhance synaptic plasticity, the brain's ability to rewire itself. This research offers hope for enhancing brain function in individuals with Down syndrome using a natural compound. Stay tuned for more exciting updates on brain health. Polydatin goes by many names in science, from (Piceid, Trans-resveratrol-O-3-glucoside, and M98 Resveratrol). These all refer to the same molecule. Study: https://www.sciencedirect.com/science/article/abs/pii/S0028390824003393?via%3Dihub RevGenetics M98 Resveratrol Powder (Polydatin) and Nitro500: https://www.revgenetics.com/collections/resveratrol-supplements

In this video, we explore the potential of green tea, specifically EGCG, to combat the harmful effects of organophosphate pesticides (OPs). OPs disrupt the crucial enzyme ACE, leading to neurological issues and long-term risks like Alzheimer's. Researchers conducted a study using zebrafish, finding that EGCG reversed the enzyme inhibition caused by OPs, increasing enzyme activity by over 50%. EGCG competes with OPs for binding sites on the ACE enzyme, acting as a protective shield. This research highlights the promising protective effects of EGCG from green tea against pesticide exposure, offering a potential solution to mitigate health risks. Studies: https://journalofethnicfoods.biomedcentral.com/articles/10.1186/s42779-024-00248-0 https://ojs.bbwpublisher.com/index.php/PAR/article/view/8323/7218 https://www.nature.com/articles/s41598-024-72637-z https://www.mdpi.com/1661-3821/4/4/27 RevGenetics EGCG 800mg (98% Pure & No Caffeine). You would need to drink approximately 8 liters of green tea to consume 800 mg of EGCG: https://www.revgenetics.com/collections/longevity-supplements/products/revgenetics-egcg-800-800-mg-98-pure-no-caffeine

Pregnancy Health with Aminos and Polyamines. In this video, we explore groundbreaking research from Russia on pregnancy health, focusing on fetal growth restriction (FGR) and preeclampsia. By delving into metabolomics, researchers are deciphering molecular clues in pregnant women's blood to detect issues early. They are honing in on amino acids and polyamines, essential for cellular function. Findings show that women with FGR and preeclampsia had distinct amino acid and polyamine profiles compared to those with healthy pregnancies. Maintaining the right balance of amino acids is crucial, with arginine and lysine playing key roles in FGR. This innovative approach offers promising insights for early detection and management of pregnancy complications. Study: https://vestnik.rsmu.press/archive/2024/4/4/abstract?lang=en https://www.preprints.org/manuscript/202409.2096/v1 Try World Class Supplements From RevGenetics: https://www.revgenetics.com/collections/longevity-supplements

In a recent study from Spain, researchers explored the concept of epigenetic noise and its impact on lifespan in mammals. Epigenetics is like software updates for your DNA, influenced by your environment and experiences. The study found that mammals with longer lifespans accumulate epigenetic noise at a slower rate than those with shorter lifespans. This noise can be likened to chaotic scribbles on an instruction manual, making it harder for cells to read genetic instructions accurately. By understanding and managing epigenetic noise, we may uncover insights into aging and potentially extend lifespan. Study: https://www.biorxiv.org/content/10.1101/2024.09.06.611669v1 World Class RevGenetics Supplements: https://www.revgenetics.com/collections/longevity-supplements