In this podcast, we explore groundbreaking research on inhibiting IL-11 signaling to extend health span and lifespan. IL-11, a key player in inflammation, may hold the key to anti-aging therapies. By studying mice, researchers found that blocking IL-11 activity led to significant lifespan extension, up to 20%. IL-11 acts as a spark, triggering molecules like ERK, AMPK, and MTORC1, impacting cell repair, energy use, and nutrient processing. This discovery offers promising insights into the mechanisms of aging and potential interventions for extending human lifespan significantly. Study: https://www.nature.com/articles/s41586-024-07701-9 While we don't see anything no where near as potent as the anti-bodies described in the study, there are some interesting natural things that might move the needle in the right direction: Curcumin: Studies have found that curcumin can reduce fibrosis, and indirectly may also impact IL-11 since IL-11 is involved in fibrotic signaling. But you may need MetaCurcumin as normal curcumin has a problem with natural bioavailability. Resveratrol: Resveratrol is known to inhibit fibrogenesis, particularly in the liver and heart, which suggests a potential indirect effect on pathways involving IL-11. A better one would be M98 Resevratrol (Polydatin) as the bioavailability is much stronger than Resveratrol. EGCG: EGCG has been shown to reduce fibrosis in several organs, suggesting that it could help in the regulation of IL-11 indirectly. Quercetin: It downregulates cytokine production and has demonstrated anti-fibrotic properties, suggesting potential impacts on IL-11-driven fibrosis. N-Acetylcysteine (NAC): NAC has been shown to have protective effects against fibrosis in various organs, possibly affecting IL-11 indirectly. Vitamin D: Vitamin D deficiency is linked to increased fibrosis, and supplementation has shown a reduction in fibrotic signaling, which could indirectly influence IL-11 activity. Silibinin (Milk Thistle): Silibinin has been shown to protect against liver fibrosis, indicating a possible reduction in IL-11-mediated effects. Omega 3: Studies indicate that omega-3 fatty acids reduce fibrosis in organs like the liver and kidney, potentially modulating IL-11 indirectly through decreased inflammation. Boswelia Serrata (Boswellic Acid): Animal studies have demonstrated that boswellic acid reduces organ fibrosis and inflammatory cytokine production, suggesting a potential indirect inhibition of IL-11. We do have the first 3, if that's something you would like to try: https://www.revgenetics.com/collections/longevity-supplements