Recorded onsite at SLAS2023 in San Diego, California, podcast Editor Rob Howes speaks with Davide Gianni, Ph.D. (AstraZeneca) to learn more about Gianni's protocol paper, "A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets," published in Volume 28, Issue 2 of SLAS Discovery. Here Davide describes the development of a 384-well plate-based multi-parametric imaging assay designed to capture ex vivo primary islet proliferation, a known ...

Welcome to the SLAS Discovery Author Insights podcast! Today we are joined by Antonia Turberville and Geoffrey A. Holdgate to discuss their recent perspective article titled "A perspective on the discovery of enzyme activators". This article sheds light on the largely under-explored area of enzyme activation in drug discovery.Despite the successful application of enzyme activators in various therapeutic interventions, the field remains under-represented and poorly exploited. Antonia and Geoff...

Traditionally, SLAS Discovery has focused on publishing original research papers and reviews. With the introduction of this latest special issue, the journal is expanding its scope to include protocol articles. These articles are designed to provide a detailed, step-by-step guide to a particular experimental technique or methodology, enabling other researchers to replicate the work and build upon it.In this episode, we spoke with one of the special issue Guest Editors, Adam Zweifach, Ph.D. (U...

Tune in to this special episode of SLAS Discovery Author Insights, recorded onsite at SLAS Europe in Dublin, Ireland. Join podcast Editor Rob Howes as he chats with Jonathan Wingfield, Ph.D. (AstraZeneca UK) about the return to in-person meetings, his experience working as a global researcher, and his latest research projects and collaborations. Learn about his journey from a start in microbiology and academia, and his path leading to a role as Principal Scientist at AstraZeneca with a f...

Tune in to this special episode of SLAS Discovery Author Insights, which was recorded onsite at SLAS Europe in Dublin, Ireland. Join podcast Editor Rob Howes as he chats with Timothy Spicer, Ph.D. (Scripps Florida) about his myriad roles within SLAS as President, Associate Editor, volunteer, and even author. Hear more about his journey to becoming SLAS President, his significant contributions to SLAS Discovery, as well as his latest research and collaborations. For more information about...

Volume 27 Issue 3, April 2022Behind April's Special Issue: Join podcast host Rob Howes (Rosalind Franklin Laboratory) as he invites Guest Editor Glauco Souza (Greiner Bio-One) to discuss the special issue covering 3D Cell Culture. They cover the timeliness of this issue as the world recovers from a global pandemic that revealed the need for more realistic and predictive in vitro models for biology, as well as the demand for more efficient technologies as researchers catch up on their benchwor...

SLAS Discovery Editor-in-Chief Bob Campbell (Twentyeight-seven Therapeutics) welcomes Sarine Markossian, Ph.D. (National Center for Advancing Translational Sciences (NCATS)) and G. Sitta Sittampalam, Ph.D. (National Center for Advancing Translational Sciences (NCATS)) to discuss the research featured in the latest Special Issue of SLAS Discovery. Titled “Assay Guidance Manual for Drug Discovery: Robust or Go Bust”, this issue showcases the incorporation of best practices in early research sta...

Join Jill Hronek, SLAS Director of Marketing and Communications, and Ally Jump, SLAS Publishing Manager, as they speak with SLAS Discovery and SLAS Technology’s respective Editors-in-Chief, Robert M. Campbell, Ph.D., (Twentyeight-Seven Therapeutics, Boston, MA USA) and Edward Kai-Hua Chow, Ph.D., (National University of Singapore, Singapore) about SLAS’s new Open Access model for the Society’s two peer-reviewed journals. Beginning January 1, 2022 both SLAS Discovery and SLAS Techno...

Podcast Editor Rob Howes chats with Geoffrey A. Holdgate, Ph.D. (AstraZeneca) and Christian Bergsdorf, Ph.D. (Novartis), Guest Editors of the Special Collection: Applications of Biophysics in Early Drug Discovery. This special collection explores the use of biophysical methods in the identification and characterization of molecules in early drug discovery. The biophysical methods toolbox be applied to complement traditional biochemical approaches in research including early assay development ...

Volume 26 Issue 7, August 2021Podcast Editor Rob Howes chats with Jayme L. Dahlin, MD, Ph.D. (National Center for Advancing Translational Sciences (NCATS)), Guest Editor of the Special Collection: Approaches for Prioritizing High-Quality Chemical Matter in Chemical Probe and Drug Discovery.This Special Issue of SLAS Discovery discusses the art and science of identifying high-quality chemical matter in screening, to avoid diverting lab resources and flawed findings. For a more in-depth l...

Volume 26 Issue 4, April 2021Podcast Editor Rob Howes discusses the SLAS Discovery Special Issue on Advances in Protein Degradation with guest editors Paola Castaldi and Stewart Fisher. Targeted protein degradation has generated interest within the drug discovery arena due to the inhibition of one particular function of a protein not often delivering the successful results that comes from whole-protein depletion. This Special Issue of SLAS Discovery provides a useful overview of rapidly devel...

Volume 25 Issue 2, February 2021Podcast Editor Rob Howes chats with Marie-Claire Peakman, Ph.D. (Executive Director, Discovery Sciences, Pfizer), author of the featured paper "Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries" in the SLAS Discovery 2021 February Special Issue Hit Discovery Methodology with Guest Editors Mark Wigglesworth and Peter Hodder.This Special Issue of SLAS Dis...

SLAS Discovery 25.10 December 2020Rob Howes discusses the paper "High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2" with authors Meredith Gardner (Scripps Research) and Michael Farzan (Scripps Research). This research is part of the December Special Issue, Drug Discovery Targeting COVID-19 with Associate Editor Tim Spicer.

Volume 25 Issue 7, August 2020Podcast Editor Rob Howes talks with author Seungil Kim about his Open Access original research, "Comparison of Cell and Organoid-Level Analysis of Patient-Derived 3D Organoids to Evaluate Tumor Cell Growth Dynamics and Drug Response," a paper within the August 2020 SLAS Discovery Joint Special Issue with the Society for Biomolecular Imaging and Informatics: High-Content Imaging and Informatics.

Volume 25 Issue 6, July 2020Podcast Editor Rob Howes discusses the SLAS Discovery 2020 July Special Issue with Guest Editors Davide Gianni and Stuart Farrow.This Special Issue of SLAS Discovery presents the topic “Functional Genomics for Target Identification” and is focused on three strategic pillars that form the foundation of the functional genomics discipline. Articles span a variety of relevant topics, from the development of more translatable models of diseases to the creation of valida...

Volume 25 Issue 5, June 2020Podcast Editor Rob Howes discusses the SLAS Discovery 2020 June Special Collection with SLAS Discovery Editorial Board Member Joseph G. McGivern. To read the editorial by Joseph G. McGivern and Mei Ding, click here.This Special Collection of SLAS Discovery presents a special collection reflecting recent advances and continuing challenges in the development and application of assay technologies that are applicable to drug discovery for ion channel targets.

Volume 25 Issue 2, February 2020Podcast Editor Rob Howes discusses the SLAS Discovery 2020 February Special Issue with Martin Main and Andrew Zhang. To read their editorial, click here. In this Special Issue of SLAS Discovery, the authors explore multiple aspects of cellular target engagement; from direct measurement of compound-target interaction using BRET technologies, through measurement of compound induced changes in protein stability and localisation, to in vivo drug distribution and ta...

Robert M. Campbell, Ph.D., is Senior Research Advisor at Eli Lilly and Company in Indianapolis, IN, where he heads the Cancer Cell Growth and Epigenetics Group. Dr. Campbell has served as Editor-in-Chief of SLAS Discoveryfor the past 12 years, where he has been a vital leader to grow the journal and share its important content. In this podcast, Dr. Campbell talks with our SLAS Discovery Podcast Editor Rob Howes, Ph.D. (AstraZeneca Gothenburg, Sweden) to discuss his work with the journal, as w...