Join Mark, Kate, Henry and Gary as they discuss 4 new POEMs: a new and very hard to pronounce antibiotic for uncomplicated UTI, the best drugs for relieving pain in adults with fibromyalgia, a clinical trial of a multicancer detection test in asymptomatic persons, and bedtime vs morning administration of antihypertensives.
Gepotidacin for uncomplicated UTI: https://pubmed.ncbi.nlm.nih.gov/38342126/
Drugs for fibromyalgia: https://www.ncbi.nlm.nih.gov/pubmed/39705187
Multicancer detection test trial: https://pubmed.ncbi.nlm.nih.gov/39948555/
TIming of antihypertensives: https://pubmed.ncbi.nlm.nih.gov/40354045/
This week, join Kate, Mark and Henry as they discuss all in one triple inhalers for COPD, the best medication for pain management in children and suzetrigine, a new medicine for acute pain in adults. Gary is off this week, working on his French lessons. And we add intro music! Yay!
Join Mark, Henry, and Gary (we are Kate-less unfortunately this week) for discussion of epidural steroid injections for adults with radicular back pain, post a fib ablation management, and oral semaglutide for high-risk patients with Type 2 DM
This week, Kate, Mark, Gary and Henry discuss 4 great new POEMs: foot care wipes for patients at risk of diabetic foot infection, resuming DOACS following intracerebral hemorrhage in adults with a fib, treating prediabetes with tirzepatide, and more on intermittent fasting.
Show links
BMJ Magic Evidence interactive review of diabetes medications. A great practice and teaching tool: https://matchit.magicevidence.org/230125dist-diabetes/#!/
https://www.ncbi.nlm.nih.gov/pubmed/31574019
https://pubmed.ncbi.nlm.nih.gov/39964684/
https://pubmed.ncbi.nlm.nih.gov/40023176/
This week, Kate, Gary, Mark and Henry chat about the health effects of dance for older adults, POCUS for diagnosing clavicular fractures, treating male partners of women with BV, and prehabilitation before elective surgery .
Links:
Dance for older adults: https://pubmed.ncbi.nlm.nih.gov/39480190/
POCUS for clavicle fractures: https://pubmed.ncbi.nlm.nih.gov/39626455/
Oral + topical treatment of male partners for BV: https://pubmed.ncbi.nlm.nih.gov/40043236/
Prehabilitation before elective surgery: https://pubmed.ncbi.nlm.nih.gov/39843215/
Case series of avian flu patients: https://www.nejm.org/doi/full/10.1056/NEJMoa2414610
This week join our intrepid primary care physicians Kate, Gary, Henry and Mark as they discuss 4 new studies: an experimental treatment for chronic migraines, safety of albuterol in wheezy kids under 2, oral gepotidacin for uncomplicated UTI, and vitamin K2 and Leg Cramps.
Here are the links:
Lukas' Fund supporting the Piedmont Athens and Grady Atlanta NICUs: https://www.lukasfund.org
Essential Evidence Plus: http://www.essentialevidenceplus.com
Vibrating intranasal balloons for migraine: https://pubmed.ncbi.nlm.nih.gov/39787477/ and Ozilia
Safety of albuterol in infants: https://www.ncbi.nlm.nih.gov/pubmed/39266286
Oral gepotidacin for uncomplicated UTI: https://www.ncbi.nlm.nih.gov/pubmed/38342126
Vitamin K2 for nocturnal leg cramps: https://pmc.ncbi.nlm.nih.gov/articles/PMC11581596/
This week Kate, Gary, Mark and Henry discuss discontinuation of benzodiazepines and treatment of insomnia, the value of baseline cognitive testing of college athletes, vonoprazan vs PPI for preventing and treating ulcers, and whether herpes zoster vaccine reduces dementia risk.
Show links:
Essential Evidence Plus: www.essentialevidenceplus.com
Tapering benzos: https://pubmed.ncbi.nlm.nih.gov/39374004/
Baseline neuro eval for athletes: pubmed.ncbi.nlm.nih.gov/39741470/
David Kaufman, “We Need You in the Locker Room” https://thesagergroup.net/books/in-the-locker-room
Vonoprazan vs PPIs for ulcers: https://pubmed.ncbi.nlm.nih.gov/39294424/
Zoster and dementia: https://pubmed.ncbi.nlm.nih.gov/40175543/
This week Gary, Mark, Kate and Henry discuss: adverse effects from inhaled steroids in asthma, Italian dementia guideline, fezolinetant for treatment of vasomotor symptoms, and updated USPSTF recommendations for osteoporosis screening.
Show notes and links:
Asthma and risk of CV events: https://pubmed.ncbi.nlm.nih.gov/39088770/
GINA 2024 guidelines: https://ginasthma.org/2024-report/
Italian dementia guidelines: https://www.ncbi.nlm.nih.gov/pubmed/39544104 with link to full report in Inglese: https://www.iss.it/documents/d/guest/the-full-guideline-english-version
Fezolinetant for vasomotor symptoms: https://pubmed.ncbi.nlm.nih.gov/39557487/
USPSTF osteoporosis screening guideline: https://pubmed.ncbi.nlm.nih.gov/39808425/
Dietary assessment tool: https://epi.grants.cancer.gov/asa24/
Article on interval for next BMD screening based on initial result: https://pubmed.ncbi.nlm.nih.gov/22256806/
Join Kate, Gary, Mark and Henry as they discuss 4 new POEMs relevant to primary care: bright light therapy for non-seasonal depression, fever control in children, abelacimab for atrial fibrillation, antibiotics vs surgery in children with nonperforated appendicitis. Get all of the POEMs (a new one every day) by going to Essential Evidence Plus and subscribing.
Links from today's podcast:
Bright lights for non-seasonal depression: https://pubmed.ncbi.nlm.nih.gov/39356500/
Controlling fever in children: https://pubmed.ncbi.nlm.nih.gov/39318339/
Abelacimab for anticoagulation in atrial fib: https://pubmed.ncbi.nlm.nih.gov/39842011/
Antibiotics vs surgery for appendicitis in kids: https://www.ncbi.nlm.nih.gov/pubmed/39826968
Independent predictors of suicidal ideation: https://pubmed.ncbi.nlm.nih.gov/7966924/
Here is the probability of suicidal ideation by # of risk factors:
0: 0.5%
1: 3.0%
2: 7.4%
3: 23%
4: 46%
This week, Gary, Kate, Henry and Mark discuss 4 new studies relevant to primary care practice: the effectiveness of RSV monoclonals in infants, acupuncture for sciatica associated with disk herniation, zoledronate every 5 years for low risk women, and the effect of arm position on blood pressure readings. Plus a quiz! Please see below for show notes and links:
Learn more about Essential Evidence Plus: www.essentialevidenceplus.com
Real world study of nirsevemab for average risk infants: https://pubmed.ncbi.nlm.nih.gov/39257372/
Acupuncture effective for sciatica: https://pubmed.ncbi.nlm.nih.gov/39401008/
Zoledronate every 5 years for average risk women: https://pubmed.ncbi.nlm.nih.gov/39813642/
Importance of correct arm position for BP: https://pubmed.ncbi.nlm.nih.gov/39373998/
A nice infographic for measuring BP correctly from the AMA and Johns Hopkins: https://targetbp.org/wp-content/uploads/2016/10/MAPHypertension_7StepsInOfficeInfographic_Landscape_English_NoCropsNoBleeds-12.pdf
Join Kate, Mark, Gary and Henry as they discuss 4 new POEMs on treatment of sexual dysfunction, the benefits and harms of GLP-1 agonists, active surveillance vs usual care for ductal carcinoma in situ, and medications to prevent episodic migraine headache.
This week, join Kate, Mark, Gary and Henry as they discuss 4 new studies: prenatal cannabis exposure, fluid resuscitation during acute sickle crises, edoxaban or edoxaban + ASA for afib with CAD, and the impact of aerobic exercise on weight loss in adults
Join Henry, Kate, Mark and Gary as they discuss 4 new POEMs: an RCT of mindfulness for chronic pain, use of methotrexate (huh?) for pain relief in adults with knee DJD, a new way to eradicate H., and oral resveratrol for adults with painful DJD of the knee (you know, the stuff from red wine). And a quiz: what actually are the benefits of lower BP targets?
Links
Mindfulness for chronic pain: https://pubmed.ncbi.nlm.nih.gov/39158851/
Methotrexate for OA: https://pubmed.ncbi.nlm.nih.gov/39074374/
Eradicating H. pylori: https://pubmed.ncbi.nlm.nih.gov/38906695/
Resveratrol for OA: https://www.ncbi.nlm.nih.gov/pubmed/39137167
Cochrane Review: Blood pressure targets in adults with hypertension.
This week join our intrepid team of skeptical primary care doctors as Kate, Mark, Henry and Gary discuss a web- and text-based intervention to prevent obesity in babies, the best timing of DOAC initiation after ischemic stroke in adults with atrial fibrillation, using semaglutide for knee osteoarthritis, and the differential diagnosis of thunderclap headaches. Plus the BEST quiz ever.
Links:
Preventing obesity in babies: https://pubmed.ncbi.nlm.nih.gov/39489149/
https://www.ncbi.nlm.nih.gov/pubmed/39491870
Semaglutide to reduce pain in knee OA: https://pubmed.ncbi.nlm.nih.gov/39476339/
Causes of thunderclap headaches: https://www.ncbi.nlm.nih.gov/pubmed/39303457
This month Kate, Mark, Gary and Henry discuss yoga for treating urinary incontinence in older women, benefits and harms of muscle relaxants for adults with chronic pain, maternal prenatal cannabis use and developmental delays, and bariatric surgery vs. glucagon-like peptide 1 receptor agonists in obese adults with T2DM.
Links:
Yoga for incontinence: https://pubmed.ncbi.nlm.nih.gov/39186785/
Muscle relaxants for painful conditions: https://pubmed.ncbi.nlm.nih.gov/39298168/
Maternal cannabis use and developmental delays: https://pubmed.ncbi.nlm.nih.gov/39422907/
Bariatric surgery vs. GLP-1s: https://www.ncbi.nlm.nih.gov/pubmed/39235379
This week Mark, Kate, Gary and Henry talk about the comparative effectiveness of migraine medications, strategies for adults with plantar fascia pain, whether to continue beta-blocker use after acute MI, and the outcomes of 5-alpha reductase inhibitor use prior to prostate cancer diagnosis.
Links
Migraine: https://www.bmj.com/content/386/bmj-2024-080107
Plantar fasciitis: https://pubmed.ncbi.nlm.nih.gov/38904119/ and https://pubmed.ncbi.nlm.nih.gov/16801514/
Beta-blockers post MI: https://pubmed.ncbi.nlm.nih.gov/39213187/
Prostate cancer: https://pubmed.ncbi.nlm.nih.gov/39190306/
This week listen in as Kate, Mark, Gary and Henry discuss antiviral treatment for infant RSV, colonoscopy competence by specialty, oral minoxidil for hair loss in men, and artificial intelligence performance on interpreting electrocardiograms .
RSV medication:
https://www.nejm.org/doi/full/10.1056/NEJMoa2313551#ap2 and https://pubmed.ncbi.nlm.nih.gov/39321361/
Colonoscopy by specialty
https://pubmed.ncbi.nlm.nih.gov/38588561/
https://aapce.wildapricot.org/
Minoxidil:
https://pubmed.ncbi.nlm.nih.gov/38598226/
AI for ECGs:
https://www.ncbi.nlm.nih.gov/pubmed/39096711
Join Kate, Gary, Henry and Mark as they discuss a new therapy for dry eye syndrome, antibiotics for suspected UTI in adults with delirium, a new ACG guideline for treating H pylori, and the prevalence of knee pathology in asymptomatic adults. See below for links to the articles and other stuff:
Dry eye treatment
BMJ: https://www.bmj.com/content/386/bmj-2024-080474
Patient instructions: https://www.bmj.com/content/bmj/suppl/2024/09/11/bmj-2024-080474.DC1/liji080474.ww2.pdf
Antibiotics for UTI in delirium: https://pubmed.ncbi.nlm.nih.gov/38895992/
ACG guideline for H. Pylori: https://pubmed.ncbi.nlm.nih.gov/28071659/ MRI of asymptomatic knees: https://pubmed.ncbi.nlm.nih.gov/32060622/
Elections and CVD: https://pmc.ncbi.nlm.nih.gov/articles/PMC9021908/
Join Gary, Kate, Mark and Henry as they discuss text messages for adolescent vaping cessation, stopping BP meds in nursing home residents with dementia, the benefits of SGLT-2 inhibitors, and mobile phone app–based artificial intelligence for diagnosing melanoma.
Click here for transcript, notes and links for this episode.
It's biscuit week, oops, I mean flu week here on the Great Primary Care Update. Join our bakers, I mean POETs, as they discuss preventing influenza, treating severe influenza, psychedelics for depression, and GLP-1 agonists to treat sleep apnea of all things.
