Episode 191: acetaminophen, leucovorin, MMR and autism; the value of primary care

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Primary Care Update

Mark Ebell

193 episodes

6 days ago

Four healthily skeptical primary care physicians discuss the latest in primary care medicine. Join Essential Evidence Editor Mark Ebell MD, Rush University's Kate Rowland MD, MSU Professor of Medicine Gary Ferenchick MD, and POEMs co-founder Henry Barry MD, MS for this fast-paced weekly update on evidence-based primary care.

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Episode 191: acetaminophen, leucovorin, MMR and autism; the value of primary care

Primary Care Update

30 minutes 44 seconds

4 weeks ago

Episode 191: acetaminophen, leucovorin, MMR and autism; the value of primary care

This week, primary care physicians Kate Rowland, Mark Ebell, and Henry Barry want to arm our primary care colleagues with the best evidence on whether acetaminophen causes autism, whether MMR causes autism, and whether leucovorin can treat autism. Gary then turns to a study of the value of continuity in primary care, and its association with better health outcomes.

Links:

Henry's essay on Ignaz Semelweis, handwashing, and postage stamps: https://thestampforum.boards.net/thread/13044/current-issue-volume-jul-2025

Essential Evidence Plus and POEMs: www.essentialevidenceplus.com

Acetaminophen in pregnancy and autism: https://www.ncbi.nlm.nih.gov/pubmed/38592388

Leucovorin to treat autism: https://www.ncbi.nlm.nih.gov/pubmed/15781839, https://www.ncbi.nlm.nih.gov/pubmed/34834493

MMR and autism, Wakefield investigation: https://www.bmj.com/content/342/bmj.c5347

MMR and autism, Madsen's Danish study: https://pubmed.ncbi.nlm.nih.gov/12421889/

Value of primary care continuity: https://www.ncbi.nlm.nih.gov/pubmed/40355250

And do NOT eat roadkill. Definitely.