The Alzheimer’s Solution Revolution Podcast

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The Alzheimer’s Solution Revolution Podcast

Ralph Sanchez

23 episodes

8 months ago

Episode #22—Where We Left Off I’ll begin this episode by sharing an excerpt of the primary outcome from study #1 that I reviewed in part #1—#22—of this two part episode series. In that study, the authors found “a positive association between OC [plasma osteocalcin levels] and working memory capacity, executive functioning and global cognition scores.” Study #2—Excerpt The authors of study #2 remarked “we observed that in both older adults with osteopenia and older adults with AD [Alzhei...

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Health & Fitness

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Episode #22—Where We Left Off I’ll begin this episode by sharing an excerpt of the primary outcome from study #1 that I reviewed in part #1—#22—of this two part episode series. In that study, the authors found “a positive association between OC [plasma osteocalcin levels] and working memory capacity, executive functioning and global cognition scores.” Study #2—Excerpt The authors of study #2 remarked “we observed that in both older adults with osteopenia and older adults with AD [Alzhei...

Show more...

Health & Fitness

Episodes (20/23)

The Alzheimer’s Solution Revolution Podcast

The Bone-Heart-Brain Axis in the Risk for Alzheimer’s Disease and Dementia – Part 2

Episode #22—Where We Left Off I’ll begin this episode by sharing an excerpt of the primary outcome from study #1 that I reviewed in part #1—#22—of this two part episode series. In that study, the authors found “a positive association between OC [plasma osteocalcin levels] and working memory capacity, executive functioning and global cognition scores.” Study #2—Excerpt The authors of study #2 remarked “we observed that in both older adults with osteopenia and older adults with AD [Alzhei...

1 year ago

1 hour 5 minutes

The Alzheimer’s Solution Revolution Podcast

The Bone-Heart-Brain Axis in the Risk for Alzheimer’s Disease and Dementia—Part 1

Hello once again! This is your host Ralph Sanchez, and welcome to episode #22 and indeed, it has been much too long between this episode and the last one. I have been busy with new book projects on the key underlying risk factors for late-onset Alzheimer’s disease that are unique to women. I’ll have an announcement on when those books will be available here soon, and frankly, I'm looking forward to doing so. And on that note, I have in store for you another special episode today in which ...

1 year ago

1 hour 11 minutes

The Alzheimer’s Solution Revolution Podcast

Estrogen(s) in the Risk for Alzheimer’s—The Kind You Make, The Kind You Take, and The Kind You Eat.

Welcome! This is your host Ralph Sanchez, and this is episode #21, I am expanding on the last episode, #20, titled: “Estrogen Deficiency and Cardiometabolic Disease Underlies a Woman's Greater Risk for Alzheimer's Disease”. This episode—part two of this two-part episode series—on the linkages between perimenopausal and postmenopausal estrogen declines in women and the risk for age-related disorders— will focus primarily on three types of estrogen: Endogenous estrogen (the kind y...

3 years ago

1 hour 57 minutes

The Alzheimer’s Solution Revolution Podcast

Estrogen Deficiency and Cardiometabolic Disease at Midlife Underlies a Woman’s Greater Risk for Alzheimer’s Disease

Welcome! This is your host Ralph Sanchez, and this is episode #20 here at The Alzheimer's Solution Revolution podcast channel. Today we are expanding on and diving a little deeper into two primary risk factors associated with an increased risk for dementia and late-onset Alzheimer's disease (LOAD) in women—cardiometabolic disease and postmenopausal estrogen deficiency in women. In my book, and in episode #10 here on this channel, I covered the critical role that estrogen plays i...

3 years ago

55 minutes

The Alzheimer’s Solution Revolution Podcast

Viagra and Cialis in the Risk Reduction for Alzheimer’s—An Unfinished Story

Summary Hello and welcome to episode #19! This is Ralph Sanchez and today I’ll be talking the outcomes of two recent studies that investigated the potential use of Viagra and Cialis in the risk reduction for late-onset Alzheimer’s disease (LOAD). I was in part inspired to provide an overview on these two recent studies as they are cautionary tales on how many studies do not include the interrelated factors that are essential in arriving to an integrated assessment and ana...

3 years ago

1 hour 7 minutes

The Alzheimer’s Solution Revolution Podcast

Brain Detoxification—Part 3—Autophagy and the Synergistic Proteasomal Degradation System in Brain Detoxification

Summary Welcome! This is Ralph Sanchez and today I’ll be expanding on the last two episodes—#16 & #17—in this special brain detoxification series. This is the third or part three in that series. In our last two brain detoxification episodes I described the pathways of beta-amyloid and tau protein transport and clearance from the brain, and in their degradation in the liver in what I describe as the liver-brain axis in Alzheimer’s disease. Today I’ll provide an ...

3 years ago

53 minutes

The Alzheimer’s Solution Revolution Podcast

Brain Detoxification—Part 2—The Gut-liver-Brain Axis

Summary Hello and welcome to episode #17! This is Ralph Sanchez and today I’ll be expanding on the first episode’s overview with regard to beta-amyloid and tau protein clearance and detoxification. If you did not catch that episode (#16), I provided an in-depth overview on the role of the blood brain barrier (BBB) and the glymphatic system in clearing and transporting toxic beta-amyloid and tau protein from the brain. In today’s episode, I’ll review the emerging science and research wi...

3 years ago

57 minutes

The Alzheimer’s Solution Revolution Podcast

Brain Detoxification—Part 1—The Role of the Blood Brain Barrier and The Glymphatic System

Summary Hello and welcome to episode #16! Today I’ll be describing an elemental aspect in maintaining a healthy brain as you age and preventing the cognitive decline that is associated with unhealthy aging and the risk for Alzheimer’s disease as you age—brain detoxification. Because brain detoxification mechanisms are a very complex review, I will provide it in three parts–this episode and the next two. Now, most people that are oriented toward health and wellness ...

3 years ago

45 minutes

The Alzheimer’s Solution Revolution Podcast

Medical Foods and Nutraceuticals That Optimize Cognitive Function and Reduce the Risk for Late-Onset Alzheimer’s disease.

Summary Today, I'll review the formulations and research that illustrates the role of medical foods which are a unique classification of formulations that are approved by the FDA. Additionally, I will speak to the potential value of nutraceuticals and supplemental food-derived products in supporting cognitive health in aging individuals at risk for late-onset Alzheimer's disease (LOAD). And what are medical foods? Medical foods are defined products and nutrient for...

3 years ago

46 minutes

The Alzheimer’s Solution Revolution Podcast

The Vital Role of Diet-Derived Phytochemicals in the Protection Against Dementia and Alzheimer’s in Aging

Summary In today’s episode (#14), I’ll be providing an in depth overview one of the most powerful factors that underlies healthy body and brain aging—DIET! Indeed, healthy foods provide key nutrients and phytochemicals work to optimize cognitive function, and protect against dementia and Alzheimer’s in aging. However, since dietary therapies and specific foods in those diets that are linked to healthy aging is such a huge field of research, I’ll be focusing on a particular diet that has becom...

3 years ago

39 minutes

The Alzheimer’s Solution Revolution Podcast

Glucose Hypometabolism, Impairments in Mitochondrial Function, and Oxidative Stress as Major Risk Factors for Alzheimer’s Disease.

Summary Today I am very much looking forward to pod-talking about one of the most important components associated with accelerated aging processes, and in the risk for Alzheimer’s disease— the decline and inhibition of critical energy metabolism systems of the body and brain. Many studies have shown that alterations in mitochondrial energy metabolism, or bioenergetics, have been linked to numerous disorders that disrupt normal metabolism, and it is a factor in brain aging and a number ...

3 years ago

29 minutes

The Alzheimer’s Solution Revolution Podcast

DHEA, Pregnenolone and the DHEA to Cortisol Ratio in Longevity Wellness and the Protection and Optimization of Cognitive Function

Summary This episode (#12) continues the overview of neurosteroids and their critical function in the protection and enhancement of cognitive function. In episode #11, I reviewed the role of “Testosterone, Progesterone and Allopregnanolone—Critical and Timely Neurosteroid Interventions in the Risk Reduction of Alzheimer's Disease.”, and this podcast will add DHEA and pregnenolone to that overview. The focus today will center around the pressing fact that the declines of steroid hormones such ...

3 years ago

25 minutes

The Alzheimer’s Solution Revolution Podcast

Testosterone, Progesterone and Allopregnanolone—Critical and Timely Neurosteroid Interventions in the Risk Reduction of Alzheimer’s Disease.

In women, how important of a role does progesterone play in cognitive function? While a number of studies have shown that estrogen replacement therapy in women is protective against the risk for late-onset Alzheimer's disease (LOAD), only a few studies have demonstrated that progesterone also benefits cognitive function. Indeed, progesterone could be important in preserving cognitive function in women as they age—particularly in the menopausal transition when there is a precipitous drop in pr...

3 years ago

26 minutes

The Alzheimer’s Solution Revolution Podcast

Why Low Estrogen Levels in Women is Linked to an Increased Risk for Alzheimer’s Disease

In the U.S., two-thirds of diagnosed cases of dementia and Alzheimer's disease are women. A number of studies have shown that lower estrogen levels "before, during, and after menopause" is a risk for late-onset Alzheimer's disease. However, the risk factors associated with declining estrogen levels and late-onset Alzheimer's disease in women as they age is not widely known. Estrogen is a regulator of glucose metabolism in women and brain estrogen deficiency sets in motion a brain energy metab...

3 years ago

31 minutes

The Alzheimer’s Solution Revolution Podcast

Modifiers of the Gut-Brain Axis in the Risk for Dementia and Alzheimer’s Disease

The Gut-Brain Axis—what does that connection represent? Well, the gut-brain connection is often described as a bidirectional highway that is linked to many cause and effect health consequences, and many studies have explored the impact of the gut environment and microbiome on brain health in that gut-brain dynamic. Indeed, the role of the gut-brain axis is a significant factor in the risk for numerous health disorders throughout life, and it can have substantial implications on your body-...

3 years ago

29 minutes

The Alzheimer’s Solution Revolution Podcast

The Role of Cardiometabolic Disease and Insulin Resistance in Vascular Dementia, Type 3 Diabetes and Alzheimer’s disease

Today in episode # 8 I'll be reviewing the role of hypertension, obesity, type 2 diabetes and heart disease (cardiometabolic disease), and insulin resistance in your risk for late onset Alzheimer's disease. The metabolic and biochemical pathways by which cardiometabolic disease increases the risk for dementia and Alzheimer's later life is the central theme in my book: The Diabetic Brain in Alzheimer's Disease. The book thoroughly describes how and why the most prevalent age-related disorder...

3 years ago

26 minutes

The Alzheimer’s Solution Revolution Podcast

Genetic Variants in the Risk for Late-onset Alzheimer’s Disease—ApoE4 and Beyond

How does you unique genome increase the risk for Alzheimer's disease as you age? In todays episode—#7, I’ll be giving a comprehensive overview on the APOE gene, the ApoE4 genetic variant, and other genes and their genetic variants linked to the risk for late-onset Alzheimer's Disease (LOAD), and how, when, and why Alzheimer's takes root in certain individuals that are carriers of these genes and the variants associated with them. While the ApoE4 genetic risk variant is widely recognized as...

3 years ago

36 minutes

The Alzheimer’s Solution Revolution Podcast

How Early in Life Can You Begin to Assess AND Track Your Risk for Late-Onset Alzheimer’s Disease?

How early in your lifespan you can start to assess and track for specific biomarkers that are linked to the risk and earliest stages of late-onset Alzheimer's disease (LOAD), and have you given that much thought? In fact, there has been a significant shift in the progressive medical and research community over the last ten years in the understanding that you really have to start looking at your risk factors for LOAD earlier in life—at least by midlife, By midlife the brain damage assoc...

3 years ago

27 minutes

The Alzheimer’s Solution Revolution Podcast

The Role of Tau Protein and Tau Tangles in the Progression and Development of Alzheimer’s Disease

In the fifth episode of The Alzheimer’s Solutions Revolution podcast with Ralph Sanchez, I talk with my co-host Susan Brender, as we continue with our special podcast series called Think Ahead. In this week’s episode, I'll provide an overview on the role of tau protein and neurofibrillary tangles (tau tangles) in the progression and development of late-onset Alzheimer's disease (LOAD). The toxic accumulation of tau tangles in brain cells (neurons) are one of the two hallmark lesions associ...

3 years ago

19 minutes

The Alzheimer’s Solution Revolution Podcast

The Role of Beta-Amyloid Protein in the Progression and Development of Alzheimer’s Disease that Spans Decades

In this Alzheimer's Solution Revolution episode #4, I’ll give an overview of episode #3, and I’ll provide several key insights about a protein that is associated with the pathology of Alzheimer’s disease—beta-amyloid protein, which forms the proverbial amyloid plaque that is often cited as a principal lesion of the disease process. Additionally, in this Think Ahead podcast, I pick up where we left off on the last episode (#3) with regard to the genesis of Alzheimer’s, disease in the brain, ...

3 years ago

24 minutes