Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Justin Strickland, Johns Hopkins University School of Medicine. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Justin Strickland, Associate Professor of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine. In the October 2025 podcast Justin Strickland talks about his work on e-cigarette withdrawal syndrome presented at the 13th Annual Vermont Center on Behavior and Health Conference, held in Vermont, USA. Justin is a behavioural pharmacologist working with substance use and substance use disorder. His research applies behavioural economic methods to evaluate choice and decision-making mechanisms that may underlie substance use and identify targets for their reduction. Justin begins by describing behavioral economics and how our environment and context shape the decisions we make, for example, how the cost of goods can influence patterns of consumption. As a relatively new class of products less is known about e-cigarette withdrawal than tobacco withdrawal syndrome. Justin describes his ongoing study of e-cigarette withdrawal syndrome among people who have exclusively used e-cigarettes. Participants stay in a residential unit for one week, where their behaviour, physiology and other measures, including their nicotine clearance, are measured. Preliminary findings indicate that participants do experience withdrawal to e-cigarettes, for example cravings that reduce over time. Looking to the future he calls for longer-term trials to observe behaviour and to explore predictors of complete cessation. Such research could inform the development of more effective behavioral interventions or pharmacological treatments to support individuals experiencing e-cigarette withdrawal. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our searches for the EC for smoking cessation review carried out on 1st October 2025 found: 1 new study (10.18332/852498tivblr); 2 ongoing new studies (ISRCTN12504090, 10.1177/29768357251337050); and 4 linked reports (10.1016/j.ypmed.2025.108414, 10.1037/pha0000803, 10.1093/ntr/ntaf200, 10.1101/2024.06.21.24309282). Our search for our interventions for quitting vaping review carried out 1st October 2025 found: 1 new ongoing study (10.3389/fpubh.2025.1618341). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Ryan Courtney from the University of New South Wales, Australia. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Associate Professor Ryan Courtney from the National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia In the September podcast Ryan Courtney talks about his recent randomised controlled trial looking at vaporised nicotine products (VNP, e-cigarettes) compared to nicotine replacement therapy (gum/ lozenges) for smoking cessation among people experiencing social disadvantage. This study was funded by Australian National Health and Medical Research Council and included 1045 people at the start of the study with 866 people completing follow up. The verified 6-month continuous abstinence rate was 28.4% (148 of 522) in the e-cigarette group and 9.6% (50 of 523) in the NRT group. Their findings indicate that e-cigarettes are more effective than NRT for smoking cessation in this population. Given the challenges for cessation among these socially disadvantaged populations, the authors of the study consider that e-cigarettes present a promising treatment option for this priority group. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our searches for the EC for smoking cessation review carried out on 1st August and 1st September 2025 found four new studies (10.7326/ANNALS-24-03531 by Courtney et al discussed in this podcast; 10.1016/S2468-2667(25)00101-X; 10.1186/s12916-025-04167-y; 10.1016/j.ypmed.2025.108389). The searches found six papers linked studies included in the review (10.57187/s.4571; 10.1186/s13063-025-08954-z; 10.1111/add.70115; 10.1016/j.ypmed.2025.108353; 10.1016/j.drugalcdep.2025.112821; 10.3310/JHFR0841). Our search for our interventions for quitting vaping review carried out 1st August and 1st September 2025 found two new ongoing studies (NCT07040566; ISRCTN11383698), and one linked paper (10.1016/S2468-2667(25)00145-8). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Elias Klemperer from the University of Vermont, USA. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Elias Klemperer behavioural scientist and licenced clinical psychologist, Department of Psychiatry, University of Vermont, USA. Elias works in the field of tobacco regulatory science and tobacco control. He has a special interest in long-term users of both cigarettes and e-cigarettes, dual users, a group who take in nicotine via two methods. In the July podcast Elias Klemperer discusses his recent 2 × 2 factorial trial randomized trial of nicotine replacement therapy (patches and lozenges) in 396 young adult dual users aged 18–29 (DOI: 10.1093/ntr/ntaf119). In a randomized factorial trial participants are randomly placed into different groups to test more than one treatment at the same time. The study was funded by the National Institute of General Medical Sciences, the Food and Drug Administration, the National Institute on Drug Abuse, and the National Cancer Institute, USA. Elias Klemperer and his team carried out this study as little is known regarding nicotine replacement therapy for young adult dual users, or whether to recommend quitting versus continuing e-cigarettes during smoking cessation treatment. The participants received 12 weeks of combination NRT compared to no NRT for stopping smoking, plus text-based treatment recommendations to quit or to continue using e-cigarettes. This advice was delivered via written material, an animated video they developed in-house, and text message support during the 12-week treatment period. The study looked at abstinence from cigarettes at 12 and 24 weeks. Their study found that NRT was effective in promoting early smoking cessation among young adult dual users. Their secondary findings indicated that pairing NRT with support to quit both products could enhance the effects on prolonged cigarette abstinence. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st July 2025 found six papers linked studies included in the review (10.1101/2025.05.06.25327053; 10.1016/j.jacadv.2025.101833; 10.1016/j.drugalcdep.2025.112740; 10.1186/s13722-025-00575-w; 10.1038/s41598-025-03904-w; 10.1136/bmjopen-2024-098005). Our search for our interventions for quitting vaping review up to 1st July 2025 found one new study by Klemperer et al discussed in this podcast (10.1093/ntr/ntaf119), one new ongoing study (10.1136/bmjopen-2024-096963), and two linked papers (10.1093/heapro/daaf085; 10.1016/j.jadohealth.2025.04.012). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson interview Lauren McMillan, University of Stirling about her project evaluating the effectiveness of an e-cigarette intervention for smoking cessation at centres for people experiencing or at risk of homelessness. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Lauren McMillan from the Institute for Social Marketing and Health (ISMH) at the University of Stirling. In the June podcast Lauren discusses Project SCeTCH - a cluster RCT that evaluates the effectiveness of an e-cigarette intervention vs usual care at centres for people experiencing or at risk of homelessness. The study measures smoking abstinence over a 6 month follow-up period and includes embedded process and economic evaluations. If effective, the results will be used to inform the larger-scale implementation of offering e-cigarettes throughout centres for people experiencing or at risk of homelessness to aid smoking cessation. Lauren is part of the research team, led by Dr Allison Ford at the University of Stirling, that conducted the process evaluation of the SCeTCH trial . The main SCeTCH trial was led by Professor Lynne Dawkins (London Southbank University) and Dr Sharon Cox (University College London). This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st June 2025 found 1 ongoing study: https://clinicaltrials.gov/study/NCT06948058 Our search for our interventions for quitting vaping review up to 1st June 2025 found 2 new (DOI 10.1093/ntr/ntaf112; 10.1016/j.amepre.2025.107664) and 2 linked papers (DOI: 10.2196/72002; 10.1016/j.cct.2025.107958) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Steve Cook from the University of Michigan USA about the importance of correctly interpreting and assessing the available data. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Steven Cook from the Department of Epidemiology, School of Public Health University of Michigan and the Centre for Assessment of Tobacco Regulations, University of Michigan. In the May podcast Steve Cook discusses the methodological problems of cross-sectional data on the health effects of e-cigarette use a topic he addressed at the May 2025 EC Summit, Washington DC. Steve Cook underlines why all cross-sectional health effects studies should be interpreted with extreme caution unless they examine dose-response relationships and account for temporality and cigarette smoking confounding. Dr Cook emphasises the importance of other information such as smoking histories and health histories and the importance of developing a best practice to ensure that we minimize the risks associated with spurious association and maximise predictive accuracy. Steven Cook receives National Institute for Health (NIH) and Food and Drug Administration’s (FDA) Center for Tobacco Products (CTP) funding. This is not deemed a conflict of interest. EC Summit, Washington DC: https://www.e-cigarette-summit.com/program-2025/ Recent paper: 10.1016/j.isci.2025.111985 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st May 2025 found 1 ongoing (NCT06922617) and 1 linked study (DOI: 10.1101/2025.02.17.25322409). Our search for our interventions for quitting vaping review up to 1st May 2025 found 1 new (DOI 10.1001/jama.2025.3810) and 4 ongoing studies (DOI 10.2196/71961, KCT0010346, NCT06909500, NCT06929520). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson explore new e-cigarette research and speak with Eden Evins from Massachusetts General Hospital and Harvard Medical School, about her randomized clinical trial on varenicline for youth vaping cessation. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Eden Evins from Massachusetts General Hospital and Harvard Medical School, Boston. In the April podcast Eden Evins discusses the findings of their new randomised clinical trial to evaluate the efficacy of varenicline for nicotine vaping cessation in 261 treatment seeking youth (16-24 years) who do not smoke tobacco regularly. This study has just been published in JAMA, April 2025 (DOI:10.1001/jama.2025.3810 NCT05367492). Professor Evins describes her interest in the high use of vapes among young people and the speed at which this increase to a different flavoured form of nicotine has occurred. Professor Evins and her team thought that varenicline, a pill based drug that is used for quitting smoking, could work for vaping cessation. She talks about the huge demand to take part in the study and how the team had to pause recruitment to keep up. She describes how young people were indignant, they had not expected to become addicted. Professor Evins says that when young people found they couldn't sit through a study session without needing to vape they were surprised and felt taken advantage of by marketers and these flavored products that they had thought were for fun. Their study funded by the National Institutes of Health in the US shows that the continuous abstinence rates in the last month of treatment (51% vs 14%) and at 6-month follow-up (28% vs 7%) are higher in the varenicline group than in the placebo group. This was a 12-week trial with 6 month follow up. Treatment-emergent adverse events did not differ significantly between groups. In summary varenicline, when added to brief cessation counselling, is well tolerated and promotes nicotine vaping cessation compared with placebo in youth with addiction to vaped nicotine. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st April 2025 found 1 new ongoing study (NCT06789692) and 5 linked papers. Our search for our interventions for quitting vaping review up to 1st April 2025 found 3 new ongoing studies (NCT06862050; TCTR20250203006; NCT06885606), For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Monserrat Conde from the University of Oxford. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Monserrat Conde from the Nuffield Department of Primary Care Health Sciences, University of Oxford. In the March podcast Monserrat Conde discusses the findings of the recent systematic review of electronic cigarettes and subsequent smoking in young people and an evidence and gap map. The systematic review aims to assess the evidence for a relationship between the use of e-cigarettes /vapes and subsequent smoking in young people under 30, and whether this differs by demographic characteristics. There is very low certainty evidence suggesting that e-cigarette use and availability are inversely associated with smoking in young people (i.e. as e-cigarettes become more available and/or are used more widely, youth smoking rates go down or, conversely, as e-cigarettes are restricted, youth smoking rates go up). At an individual level, people who vape appear to be more likely to go on to smoke than people who do not vape; however, it is unclear if these behaviours are causally linked. Monserrat discusses the differences in the information coming from the population studies compared to the individual level studies and notes that most studies are from high income countries, in particular from the US. To see the full review: https://doi.org/10.1111/add.16773 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our literature searches for the EC for smoking cessation review carried out on 1st March 2025 found 1 new study (DOI: 10.1016/j.drugalcdep.2024.112271), one new ongoing study (ACTRN12625000179437) and two records linked to studies included in the review. Our literature searches for the interventions for quitting vaping review carried out on 1st March 2025 found 2 new ongoing studies (NCT06832098, ACTRN12625000143426) and four records linked to studies included in the review. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Olivier Drouin from the University of Montreal, Canada. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Olivier Drouin. Dr Olivier Drouin is a Clinical Assistant Professor in both the Department of Paediatrics and Department of Social and Preventive Medicine at Université de Montréal. In the February podcast Olivier Drouin discusses his ongoing pilot randomized trial of a brief digital screening and intervention tool for parental and adolescents to address tobacco and electronic cigarette use, CanCEASE. This study takes place in paediatric medical care settings in Canada and is funded by the Canadian Institutes of Health Research. Their pilot study aims to demonstrate the feasibility and evaluate the preliminary effectiveness of the CEASE program for parental smoking cessation and its adapted version for adolescent smoking cessation and adolescent and parental vaping cessation. There is a strong need for effective and cost-effective smoking and vaping cessation interventions for parents and adolescents. If successful, this study will help inform the preparation of a fully powered randomized controlled trial of CEASE in Canada in these populations. Olivier Drouin discusses the importance of behavioural science in understanding the drivers of behaviour and health behaviour change, including the use of scientific method to understand rational and irrational behaviours, habit formation and the role of peer pressure and social norms. The pilot study discussed in this podcast by Chadi at al 2023 is DOI: https://dx.doi.org/10.2196/47978; NCT05366790. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our literature searches for the EC for smoking cessation review carried out on 1st February 2025 found 2 new studies (Ikonomidis 2024 DOI: 10.1093/eurheartj/ehae666.3388; Kouroutzoglou 2024 DOI: 10.1093/eurheartj/ehae666.2955) and 6 papers linked to studies included in our review. Our catch-up search for our interventions for quitting vaping review up to 1st February 2025 found 7 new ongoing studies and 4 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and talk about the findings of their newly published Cochrane review of interventions for quitting vaping. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research. Jamie and Nicola share the findings of their new Cochrane review of interventions for quitting vaping published in January 2025 and funded by Cancer Research UK (https://doi.org/10.1002/14651858.CD016058.pub2). This new review included nine studies in just over 5,000 participants. Studies tested nicotine replacement therapy, cytisine, varenicline, nicotine/vaping reduction and text message-based interventions. The review found that text-message-based interventions may help young people to stop vaping and that varenicline may help people to stop vaping when compared to no or minimal support. There was some promising evidence from a shorter study of cytisine. More information is needed on other interventions, on potential harms and on the effect on use of tobacco cigarettes. Twenty ongoing studies looking at a range of interventions were identified in the review. The motivation for the review and the press coverage is also discussed. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our literature searches for the EC for smoking cessation review carried out on 1st December and 1st January found 3 new studies (Kale 2024 DOI 10.1101/2024.09.13.24313612; Pericot-Valverde 2024 DOI 10.1093/ntr/ntae260; Sifat 2024 DOI 10.1016/j.dadr.2024.100295) and 3 linked studies (DOIs 10.1016/j.heliyon.2024.e39695; 10.1111/add.16698; 10.1093/ntr/ntae223) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Marathi Vojjala from New York University, Global Institute of Public Health, USA. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Marathi Vojjala from the Global Institute of Public Health, New York University, USA. In the November podcast Marathi Vojjala discusses her pilot randomised controlled trial (RCT) that aims to investigate the effects of switching to electronic cigarettes from combustible cigarettes and the potential acceptability of e-cigarettes or as a harm reduction strategy among individuals with chronic diseases who smoke. This study examines examining the potential of behavioural counselling paired with e-cigarettes versus nicotine replacement therapy (e.g. nicotine patches or gum) for achieving harm reduction and decreased combustible cigarette use. The findings from this pilot RCT hold significant implications for chronic conditions such as COPD, asthma, CAD, and peripheral arterial disease who smoke combustible cigarettes. The observed reduction in CPD and improvement in respiratory symptoms suggest that switching to e-cigarettes appears feasible and acceptable among those with chronic diseases. These results suggest that e-cigarettes may offer an alternative for individuals struggling to quit combustible cigarette smoking through existing pharmacotherapies. This study supports further exploration of switching to e-cigarettes as a harm reduction strategy among combustible cigarette users who have been unsuccessful at quitting by other means. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st November found 1 new ongoing study (NCT06614504) & 2 linked papers (DOIs: 10.1111/dar.13953 & 10.1001/jamainternmed.2024.5196) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Stephen Higgins from the University of Vermont Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Stephen Higgins from the University of Vermont Tobacco Center of Regulatory Science, Burlington, USA. Professor Stephen Higgins uses the concepts and methods of behavioural economics and behavioural pharmacology to investigate tobacco, illicit drugs, and other health-related risk behaviours in vulnerable populations. In the October podcast Stephen Higgins describes his recent studies on reduced nicotine cigarettes and e-cigarettes in high-risk populations. Their three randomised clinical trials involved 326 participants. They found that decreases in cigarettes smoked daily, resulting from smoking cigarettes with reduced nicotine content, were significantly larger when adults from at-risk populations had access to e-cigarettes in their preferred flavours. Their study findings indicate that access to preferred flavoured e-cigarettes has the potential to enhance the effect of a nicotine-reduction policy on cigarette smoking in populations with psychiatric conditions or lower education level who are at greatest risk for smoking and associated harm. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st October found: 2 new studies. The study by Higgins et al described on this podcast (DOI: 10.1001/jamanetworkopen.2024.31731) and DOI: 10.1093/ntr/ntae212. We also found 3 linked papers (10.2196/58260, 10.1111/add.16633, 10.1038/s41415-024-7850-5) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping. Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours. In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping. Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours. In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jamie Brown, University College London Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jamie Brown. Jamie Brown is Professor of Behavioural Science and Director of the Tobacco and Alcohol Research Group at University College London. He co-leads a research programme that aims to provide insights into population-wide influences on smoking, smoking cessation and alcohol reduction via management and analysis of the major population surveys, the Smoking and Alcohol Toolkit Study. He is also involved in the development of digital behaviour change technologies. His particular focus is on real-world monitoring and evaluation of national tobacco control and alcohol policies, events and stop smoking treatments including e-cigarettes and nicotine replacement therapy. In this podcast Jamie describes how he became involved in this research field. Jamie talks about the national surveillance programme, the Smoking Toolkit Study in relation to e-cigarettes. The Smoking Toolkit Study aims to monitor trends and provide insights into population wide influences on smoking and smoking cessation and be representative of adults in Great Britain. Each month a new sample of about 2400 adults complete a detailed survey with a trained Ipsos Mori interviewer. The study was started by Professor Robert West, almost 20 years ago in 2006 and has accumulated data from almost 400,000 different adults. This is an open toolkit or resource and the data is intended to be used by other researchers, policy makers and practitioners. Jamie talks about the different kinds of information that can be gathered from surveys compared to randomized controlled trials and discusses the importance of gathering data from different sources, to enhance the credibility of research findings. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st July found: found 2 new studies (DOI:10.1001/jamainternmed.2024.1822; DOI: 10.1158/1538-7445.AM2024-LB086), 1 new ongoing study (NCT03862924) & 4 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jamie Brown, University College London Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jamie Brown. Jamie Brown is Professor of Behavioural Science and Director of the Tobacco and Alcohol Research Group at University College London. He co-leads a research programme that aims to provide insights into population-wide influences on smoking, smoking cessation and alcohol reduction via management and analysis of the major population surveys, the Smoking and Alcohol Toolkit Study. He is also involved in the development of digital behaviour change technologies. His particular focus is on real-world monitoring and evaluation of national tobacco control and alcohol policies, events and stop smoking treatments including e-cigarettes and nicotine replacement therapy. In this podcast Jamie describes how he became involved in this research field. Jamie talks about the national surveillance programme, the Smoking Toolkit Study in relation to e-cigarettes. The Smoking Toolkit Study aims to monitor trends and provide insights into population wide influences on smoking and smoking cessation and be representative of adults in Great Britain. Each month a new sample of about 2400 adults complete a detailed survey with a trained Ipsos Mori interviewer. The study was started by Professor Robert West, almost 20 years ago in 2006 and has accumulated data from almost 400,000 different adults. This is an open toolkit or resource and the data is intended to be used by other researchers, policy makers and practitioners. Jamie talks about the different kinds of information that can be gathered from surveys compared to randomized controlled trials and discusses the importance of gathering data from different sources, to enhance the credibility of research findings. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st July found: found 2 new studies (DOI:10.1001/jamainternmed.2024.1822; DOI: 10.1158/1538-7445.AM2024-LB086), 1 new ongoing study (NCT03862924) & 4 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Louise Ross from the National Centre for Smoking Cessation and Training (NCSCT). Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Louise Ross from the National Centre for Smoking Cessation and Training (NCSCT). Louise Ross has worked in smoking cessation for over 20 years and consults for the NCSCT, and is part of the senior team on the Smoke Free App, a digital service for helping people stop smoking. NCSCT is a social enterprise committed to supporting the delivery of effective evidence-based tobacco control programmes and smoking cessation interventions provided by local stop smoking services, and by colleagues in the NHS and the social care sector. For further information about NSCST: https://www.ncsct.co.uk/ Louise Ross talks about the swap to stop scheme that aimed to reach a million people who smoke to give them a chance to switch less harmful vapes. The swap to stop training is not only for qualified stop smoking practitioners but is also aimed at the frontline services working with for example debt management teams within social housing, homelessness, substance use, and other groups. The training models how to raise the subject of quitting smoking and swap to stop. A four week supply of e-liquid is provided and, if funds are available, a 12 week supply. People are advised how much they should use their vape and to use an e-liquid that is strong enough to manage their withdrawal symptoms, as they would be with nicotine replacement therapy. They are also advised not to stop using a vape too soon as they may go back to tobacco smoking. Jamie and Nicola discuss ongoing work on brief opportunistic advice in financial support settings. The scoping review mentioned is available here: https://onlinelibrary.wiley.com/doi/full/10.1111/add.16533 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st June found: One linked study: Leavens E.; Nollen N, Ahluwalia J, Mayo M, Rice M, Brett E, Pulvers K. Changes in dependence, withdrawal, and craving among adult smokers who switch to nicotine salt pod-based e-cigarettes, Journal of Clinical and Translational Science / 2021;5(Supplement 1):85-86, DOI: 10.1017/cts.2021.622 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Andrea Villanti. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Associate Professor Andrea Villanti, Department of Health Behavior, Society, and Policy, Rutgers School of Public Health. Andrea Villanti's research focuses on young adult tobacco use including predictors and patterns of use and interventions to reduce tobacco use in young adults. Dr Villanti describes their randomised controlled trial to test the effect of three exposures to eight nicotine corrective messages on beliefs about nicotine, nicotine replacement therapy, e-cigarettes and reduced nicotine content cigarettes at 3-month follow-up. Their study concluded that repeated exposure to NCM was necessary to reduce false beliefs about nicotine and tobacco products and is reported in Tobacco Control e-publication, doi:10.1136/ tc-2023-058252. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st May found: One new study by Rabenstein A et al, Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial. European Addiction Research / 2024;(c60, 9502920):1-9 Three new ongoing studies: NCT06372899; NCT06373679 and Polosa et al, Protocol for the "magnitude of cigarette substitution after initiation of e-cigarettes and its impact on biomarkers of exposure and potential harm in dual users" (MAGNIFICAT) study, Frontiers in Public Health / 2024;12(101616579):1348389, DOI 10.3389/fpubh.2024.1348389 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jaqueline Avila. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jaqueline Avila from the Department of Gerontology, University of Massachusetts Boston, USA. Professor Avila describes their pilot study to assesses the harm-reduction potential of e-cigarettes and oral nicotine pouches among people who smoke with low socioeconomic status. This pilot of 45 people provides novel evidence that e-cigarettes and nicotine pouches can be a harm-reduction tool for individuals with lower SES who smoke and are not willing to quit smoking, contributing to reducing tobacco-related disparities in this population. This study is funded by Brown University. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st April found: Avila JC, Maglalang DD, Nollen N, Lee SC, Suh R, Malone M, Binjrajka U, Ahluwalia JS, Using pod based e-cigarettes and nicotine pouches to reduce harm for adults with low socioeconomic status who smoke: a pilot randomized controlled trial Nicotine & tobacco research 2024. 10.1093/ntr/ntae047. Featured in our podcast. Four papers linked to studies included in the review: Belderson et al 2024, DOI 10.1136/bmjopen-2023-078677; Liu et al, 2024, DOI 10.1001/jamainternmed.2024.1125; Yingst et al 2024, DOI 10.1136/tc-2023-058282; Conte et al 2024, DOI 10.2196/53222. Two new ongoing studies: NCT06264154 and NCT06260683 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Ian Pope. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Ian Pope, an emergency medicine physician and honorary associate professor at Norwich Medical School, about his new trial, which he co leads with Professor Caitlin Notley from the University of East Anglia. The new trial is the COSTED trial, the Cessation of Smoking Trial in the Emergency Department and funded by the British National Institutes of Health Research. This is a multi-centre randomised controlled trial, based in 6 emergency departments around the UK. This study tested the real-world effectiveness of an emergency department based smoking cessation intervention that included provision of an e-cigarette starter kit compared to usual care. (ClinicalTrial.gov:NCT04854616). Adults who smoke tobacco and were attending one of six EDs across the UK were randomised to either control (in which case they were given written information about stop smoking services) or intervention (brief smoking cessation intervention, provision of an e-cigarette starter kit, and referral to stop smoking services). Both groups were followed up 1, 3 and 6 months after randomisation. Smoking abstinence was biochemically verified at 6 months. There were over a thousand participants and biochemically verified smoking cessation rate of 7.2% in the intervention group 4.1% in the control group. The study found that it was feasible to implement a smoking cessation intervention in EDs with dedicated staff time to deliver the intervention and that EDs may represent an excellent opportunity to engage hard to reach smokers. Pope I, Notley C, Boyle A, Results of the cessation of smoking trial in the emergency department (COSTED), Emergency Medicine Journal / 2023;40(12):873-874 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st March found the following 1 new study: Hoeppner BB, Eddie D, Schick M, Hoeppner SS, Kelly L, Kelly JF, Feasibility of and reactivity to ecological momentary assessment (EMA) during electronic cigarette use initiation in adults who smoke daily: MASKED FOR REVIEW, European Journal of Psychiatry / 2024;38(3):100247. 10.1016/j.ejpsy.2023.100247 3 papers linked to studies included in the review: Auer R, Schoeni A, Humair J-P, Jacot-Sadowski I, Berlin I, Stuber MJ, Haller ML, Tango RC, Frei A, Strassmann A, Bruggmann P, Baty F, Brutsche M, Tal K, Baggio S, Jakob J, Sambiagio N, Hopf NB, Feller M, Rodondi N, Berthet A, Electronic Nicotine-Delivery Systems for Smoking Cessation, The New England journal of medicine / 2024;390(7):601-610. 10.1056/NEJMoa2308815 Piper ME, Schlam TR, Donny EC, Kobinsky K, Matthews J, Piasecki TM, Jorenby DE, The Impact of Three Alternate Nicotine-Delivery Products on Combusted Cigarette Use: A Randomized Controlled Trial, Nicotine & Tobacco Research, 2024;, ntae014, 10.1093/ntr/ntae014 Correction to Yingst: Changes in Nicotine Dependence Among Smokers Using Electronic Cigarettes to Reduce Cigarette Smoking in a Randomized Controlled Trial, Nicotine & Tobacco Research, 2023;, ntad229, 10.1093/ntr/ntad229 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Reto Auer, Bern University, Switzerland. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes. Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation’. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone. DOI: 10.1056/NEJMoa2308815 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st February found the following 1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).) 3 new ongoing studies: NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa. ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness. Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9 3 papers linked to studies included in the review: Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113 Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024 Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes. Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation’. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone. DOI: 10.1056/NEJMoa2308815 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st February found the following 1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).) 3 new ongoing studies: NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa. ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness. Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9 3 papers linked to studies included in the review: Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113 Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024 Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK. This podcast is supported by Cancer Research UK. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/