Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Elias Klemperer from the University of Vermont, USA. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Elias Klemperer behavioural scientist and licenced clinical psychologist, Department of Psychiatry, University of Vermont, USA. Elias works in the field of tobacco regulatory science and tobacco control. He has a special interest in long-term users of both cigarettes and e-cigarettes, dual users, a group who take in nicotine via two methods. In the July podcast Elias Klemperer discusses his recent 2 × 2 factorial trial randomized trial of nicotine replacement therapy (patches and lozenges) in 396 young adult dual users aged 18–29 (DOI: 10.1093/ntr/ntaf119). In a randomized factorial trial participants are randomly placed into different groups to test more than one treatment at the same time. The study was funded by the National Institute of General Medical Sciences, the Food and Drug Administration, the National Institute on Drug Abuse, and the National Cancer Institute, USA. Elias Klemperer and his team carried out this study as little is known regarding nicotine replacement therapy for young adult dual users, or whether to recommend quitting versus continuing e-cigarettes during smoking cessation treatment. The participants received 12 weeks of combination NRT compared to no NRT for stopping smoking, plus text-based treatment recommendations to quit or to continue using e-cigarettes. This advice was delivered via written material, an animated video they developed in-house, and text message support during the 12-week treatment period. The study looked at abstinence from cigarettes at 12 and 24 weeks. Their study found that NRT was effective in promoting early smoking cessation among young adult dual users. Their secondary findings indicated that pairing NRT with support to quit both products could enhance the effects on prolonged cigarette abstinence. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st July 2025 found six papers linked studies included in the review (10.1101/2025.05.06.25327053; 10.1016/j.jacadv.2025.101833; 10.1016/j.drugalcdep.2025.112740; 10.1186/s13722-025-00575-w; 10.1038/s41598-025-03904-w; 10.1136/bmjopen-2024-098005). Our search for our interventions for quitting vaping review up to 1st July 2025 found one new study by Klemperer et al discussed in this podcast (10.1093/ntr/ntaf119), one new ongoing study (10.1136/bmjopen-2024-096963), and two linked papers (10.1093/heapro/daaf085; 10.1016/j.jadohealth.2025.04.012). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.