In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the September 2025 Emergency Medicine Practice article, Emergency Department Management of Patients With Status Epilepticus Topic Introduction* Focus: Status Epilepticus in Adults* Reference to recent pediatric episode* Article authors: Dr. Marquez, Dr. Kaur, Dr. LayWhy Status Epilepticus Matters* Teaching value and clinical challenge* Team-based care and multidisciplinary involvementGuidelines and Evidence* Review of major guidelines (International League Against Epilepsy, Neurocritical Care Society, American Epilepsy Society)* Key trials: EcLiPSE, ConSEPT, ESETT* Updated definition of status epilepticusClassification and Diagnosis* Convulsive vs. non-convulsive status* Importance of repeated neurologic exams* Diagnostic challenges and mimics (e.g., syncope, psychogenic seizures)Etiology and Workup* Acute vs. non-acute causes* Common triggers: medication noncompliance, metabolic issues, infections, trauma* Importance of sleep patterns and ammonia levels* The NORSE acronym (new onset refractory status epilepticus)Prehospital and ED Management* Airway, breathing, circulation priorities* Early pharmacologic intervention (IM midazolam preferred in prehospital)* Gathering history and medication information* Positioning and airway protectionDiagnostics* Laboratory workup: glucose, CBC, metabolic panel, drug levels, pregnancy test* Imaging: non-contrast CT, MRI, ultrasound, lumbar puncture* EEG: spot vs. continuous monitoringTreatment Approach* First-line: Benzodiazepines (lorazepam, midazolam)* Second-line: Levetiracetam, valproate, fosphenytoin, phenobarbital, lacosamide* Third-line: Continuous infusions (midazolam, propofol, pentobarbital, thiopental, ketamine)* Dosing pearls and importance of rapid escalationSpecial Populations* Pregnancy (eclampsia: magnesium as first-line)* Substance-induced status epilepticus (e.g., isoniazid toxicity and pyridoxine)* Brief mention of pediatric management and the PD stat appRisk Management Pitfalls* Non-convulsive status is common and easily missed* Importance of weight-based dosing* Need for formal EEG in ambiguous cases* Don’t assume non-adherence is the only cause in known epileptics* Always consider higher level of care for status patientsClinical Pathway* Stepwise approach to medication and escalation* Emphasis on having a pathway/checklist for these high-stress casesConclusion* Recap of key points* Thanks to authors and listeners* Reminder to visit ebmedicine.net for CME and resourcesEmergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net
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