Researchers have found inexpensive, food-grade alternatives to expensive serum albumins in cell culture media, potentially cutting costs for cultivated meat production and biopharmaceuticals by up to 73%. This breakthrough addresses a major bottleneck, making sustainable protein and affordable medicines more accessible.

A meta-analysis reveals the core genetic blueprint and dynamic gene regulation of CHO cell factories.

This podcast details the engineering of transmembrane alkane monooxygenases (AlkB) to improve Tulipalin A synthesis. The research focuses on enhancing the hydroxylation of isoprenyl acetate, a crucial step for this polymer precursor. Through rational design and site-directed mutagenesis, AlkB variants with significantly improved activity were developed, while maintaining selectivity. The engineered enzyme is part of a novel biocatalytic cascade, representing a significant step towards sustainable production of Tulipalin A and expanding bio-based chemicals.

Dive deep into the complex world of Adeno-Associated Virus (AAV) purification for gene therapy. Our expert guest explains the challenges of separating perfect therapeutic AAVs from a myriad of impurities and discusses the cutting-edge downstream processing techniques—from ultracentrifugation to advanced chromatography—that are making these revolutionary treatments safer, more effective, and accessible.

 Discover how scientists harnessed a unique bacterial lipase, SpL, featuring a novel catalytic tetrad and dual access tunnels, to achieve highly efficient synthesis of pharmaceutical-relevant amides directly in water. This breakthrough bypasses traditional wasteful methods, offering a greener, faster route for chemical manufacturing.

This interview explores the systematic immobilization of L-lactate oxidase on various porous carriers, revealing that hydrophilic agarose supports with amine groups yield the highest activity. Key discussion points include the unexpected efficiency and stability achieved through simple adsorption versus covalent binding, and the crucial role of ionic interactions governing the enzyme's attachment to different functionalized surfaces.

Explore the innovative research from acib GmbH on using NADH-driven enzymes for the sustainable reduction of carboxylic acids into valuable aldehydes and alcohols. Learn about the potential of this biocatalytic approach and its significance to industrial biotechnology.

Explore a breakthrough in biocatalysis: a highly efficient, one-pot enzyme cascade synthesizes pseudouridine-5'-phosphate and related C-nucleosides from simple sugars and nucleobases. Discover how process intensification and smart enzyme combination pave the way for more sustainable production of vital components for mRNA therapeutics.