Decoding CHO Cell Survival: CRISPR Reveals Essential Genomic "Dark Matter"

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BiotecInsights

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23 episodes

5 days ago

Let's dive into the results of industrial biotechnology at acib. This short podcast episodes shortly summarize our scientific publications and give a quick hint about the main findings.

Life Sciences

Science

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Let's dive into the results of industrial biotechnology at acib. This short podcast episodes shortly summarize our scientific publications and give a quick hint about the main findings.

Life Sciences

Science

https://d3t3ozftmdmh3i.cloudfront.net/staging/podcast_uploaded_nologo/43483273/43483273-1745414184751-8fa7874b12ff2.jpg

Decoding CHO Cell Survival: CRISPR Reveals Essential Genomic "Dark Matter"

BiotecInsights

7 minutes 46 seconds

1 month ago

Decoding CHO Cell Survival: CRISPR Reveals Essential Genomic "Dark Matter"

We performed a genome-scale CRISPR screen in CHO cells using paired guide RNAs, identifying 427 essential genomic regions, including unannotated "dark matter." Deleting these regions impairs cell survival, revealing critical regulatory functions and enabling advanced bioprocess engineering.