I sat down with Joseph Krause, Co-Founder and CEO of Radical AI, for a deep dive into how artificial intelligence is reshaping the future of scientific discovery. Radical AI is building autonomous, AI-driven research systems, what Joseph calls “self-driving labs,” that accelerate the discovery of new materials and breakthroughs across industries. Backed by over $55 million in funding by Nvidia and more, his team is merging deep tech, data, and science to fundamentally change how innovation happens.

In this episode, we explored how Radical AI approaches experimentation and learning, what it takes to build infrastructure at the intersection of AI and materials science, and how Joseph thinks about long-term impact and risk in a field evolving faster than ever. We also talked about the broader implications of AI for research, creativity, and progress itself.

If you’re interested in where deep tech meets real-world innovation, and how AI can accelerate the pace of discovery, this one’s for you.

I sat down with Michele Griffin, former Partner at Andreessen Horowitz (a16z) and now the Founder & CEO of Premier GTM, where she’s helping startups master the art of go-to-market. Michele has spent years advising early-stage founders on how to turn great products into scalable businesses, from refining messaging to building repeatable sales motion, and her track record speaks for itself.In this episode, we dive deep into what makes a go-to-market truly work and why so many startups get it wrong. We also discuss how GTM strategy is evolving in the age of AI and what founders can do differently today to stand out.If you’ve ever wondered how the best operators think about taking products from zero to one and then from one to many, this episode is for you.

I sat down with Charles Hudson, Founder and Managing Partner of Precursor Ventures, one of the most respected early-stage funds in venture capital. Charles has built Precursor on a set of unorthodox ideas, from how he sources founders to how he supports them, and it’s worked.

In this episode, we explored why going against the grain has been central to his success, the philosophy behind Precursor’s early bets, and how he evaluates founders at the earliest stages. We also got into what’s changing and what’s not in today’s VC landscape.

If you’ve ever wondered what it really takes to back founders before the rest of the world sees it, this one’s for you.

Thank you to Puddle for sponsoring this episode! Puddle is helping talented people find the best jobs: one interview, pass and get matched!

I sat down with Max Marchione, Co-Founder of Superpower, the AI health company helping humans live longer. Backed by Giannis Antetokounmpo, Vanessa Hudgens, and other leading investors, Superpower has raised over $30M and is scaling fast.

We talked about the culture and principles that drive Superpower’s growth, how Max builds teams around clarity and ambition, and the lessons he’s learned from years of company-building. Max also shared what’s next for Superpower as they push the boundaries of AI-driven longevity and personal health.

If you’re interested in the intersection of health, AI, and company-building, or want to hear how culture compounds in startups, this one’s a must-listen.

Thank you to Puddle for sponsoring this episode! Puddle is helping talented people find the best jobs: one interview, pass and get matched!

I sat down with Vanessa, former Partner at NEA where she invested in both B2B and B2C companies and an operator who held leadership roles at Twilio and Box, for a wide-ranging conversation on the state of consumer tech.

In this episode, we explored how AI is reshaping the consumer landscape, what defensibility looks like in a world of fast-moving competitors, and the behavioral shifts founders should be paying attention to. Vanessa also shared her perspective on the evolution of the job market, how consumer startups can adapt to changing dynamics, and which trends she believes are more hype than substance.

If you’re building or investing in the next wave of consumer products, this one is full of insights from someone who’s seen both sides of the table.

Thanks Zephyr Technologies for sponsoring!

I sat down with Jimmy Yun, Principal at 8VC, for a conversation on how he approaches partnering with founders in enterprise software and frontier technology. At 8VC, Jimmy also plays a key role in the firm’s Build, a model focused not just on investing in great companies, but helping to create them from the ground up.

In this episode, we explored how Jimmy evaluates opportunities at the edge of enterprise and frontier markets, the principles that guide his own approach to investing, and how 8VC’s Build strategy shapes the companies they back. We also dug into the unique challenges and opportunities founders face in these spaces, and where Jimmy sees the most exciting opportunities to build today.

If you want a look into how top-tier investors think about both backing and building companies from day one, this episode is a must-listen.

I sat down with Wesley Tian, founder of Aragon AI, for a conversation on what it takes to scale a breakout AI company at record speed. Aragon develops AI-generated headshots and has grown to over $10M in annualized revenue within just two years, a rare trajectory in the consumer AI space.

In this episode, Wesley shared how Aragon found product–market fit, the strategies that fueled its rapid growth, and what he’s learning as one of the few founders operating at this scale in AI today. We also dug into the challenges of building in a fast-moving market, and how Aragon plans to stay ahead as AI adoption accelerates.

If you’re curious about what hypergrowth in consumer AI really looks like, this is an inside look you won’t want to miss.

Special thanks to Yasin Ehsan and Headstarter for sponsoring this episode!

I sat down with Adam Draper, Founder and Managing Director of Boost VC, for a conversation on what it means to invest at the very edge of technology. Since starting Boost, Adam has backed frontier founders in crypto, deep tech, and beyond, often years before these spaces went mainstream.

In this episode, we explored the unique lens through which Boost operates, how Adam first discovered crypto and leaned into one of the most disruptive shifts of our time, and why some of his riskiest early investments ended up defining categories. We also got into how he built Boost to stay at the forefront of venture, and what he’s seeing now in the next wave of breakthrough companies.

If you’re curious about how bold bets get made and what it takes to stay ahead of the curve in deep tech, this one is a must-listen.

I sat down with Kyle Stanford, Director of U.S. Venture Capital Research at PitchBook, for a conversation on what the data really says about today’s venture landscape. Kyle has a front-row seat to the numbers that shape how investors, founders, and markets think... from unexpected shifts in U.S. venture activity to the statistics driving AI’s explosive growth.

In this episode, we unpack the surprising trends behind the headlines, where the data tells a different story than conventional wisdom, and how Kyle sees the venture and AI markets evolving from here.

I had the opportunity to chat with Tamar Yehoshua, former Chief Product Officer at Slack and ex-President of Glean, for a conversation on what it takes to help build generational companies. Tamar has held leadership roles early at Amazon, Google, Slack, and Glean, giving her a rare perspective on how the world’s most iconic organizations define their goals and sustain momentum. In this episode, we explored the common threads she’s seen across these giants, the distinct choices that set them apart, and how the idea of a growth mindset has evolved over time. For anyone interested in how great companies are built and how to apply those lessons to today’s startups, this episode is a must-listen.

Thank you Cliqk for sponsoring!

I sat down with Samir Kaul, Founding Partner and Managing Director at Khosla Ventures, for a wide-ranging conversation on what it means to invest at the edge of what's possible. Samir has long been at the forefront of transformative innovation, spanning AI, sustainability, health, and the future of food. In this episode, we explored how he thinks about betting early on breakthrough technologies and visionary founders. We got into the psychology of high-agency entrepreneurs, how to navigate uncertainty in deep tech, and where he sees the next major shifts coming. If you're building or backing bold ideas with long-term impact, this one is a must-listen.

I had an insightful conversation with Jason Shuman, General Partner at Primary Venture Partners and Forbes 30U30, where we dove deep into how he’s helping reshape the venture capital landscape, especially through a uniquely hands-on approach to supporting early-stage founders. We explored the evolution of DTC businesses (where Jason has deep roots as a founder himself), the operational challenges most commonly facing startups today, and why Primary’s model, where the operations team outnumbers the investment team, is a game-changer. If you're building in DTC, raising capital, or rethinking what modern VC partnerships should look like, you won’t want to miss this one.

I caught up with Bradley Tusk, founder of Tusk Ventures, to talk about how regulation is reshaping the VC landscape, and how he's actively working to bring mobile voting to the mainstream. We also got into his perspective on the coming wave of AI regulation, and why it matters now in the AI race. Finally, Bradley shared stories from putting together Bloomberg’s mayoral campaign and launching Ivory Gaming Acquisition Corp on the NASDAQ. If you're curious about the intersection of tech, policy, and early-stage investing, this one's for you.

I had a great conversation with Lily Lyman, partner at Underscore VC, where we dug into the current state of the startup and venture scene in Boston... what makes it unique, what’s changing, and what founders should know. We also talked about how she evaluates early-stage companies, the GTM challenges she sees most often, and how founders can navigate them in today’s market. Finally, Lily shared reflections from her time scaling new products at Facebook to 100M new users in 4 years and how that experience shaped her perspective on product, growth, and leadership. If you're curious about venture capital, early-stage company building, or how global trends are shaping the next wave of innovation, this one’s for you.

I had the change to speak with Zach Lloyd, founder of Warp, to unpack how he’s rethinking one of the most foundational tools in software... the TERMINAL. We talk about how Warp is different from the traditional command line, why it matters for modern developers, and what it takes to build a tool that engineers actually love using.

We also dive into how Zach has approached go-to-market for Warp... from building in public to creating a product-led motion around a category that hasn't changed in decades. And we revisit his time at Google, where he led engineering for Docs and Sheets, and how that experience shaped his approach to product, scale, and engineering culture.

If you’re interested in dev tools, GTM strategy, or what it looks like to build truly novel software, you will enjoy this!

In this episode, I sit down with Landon Campbell, General Manager of Drive Capital’s Chicago office, to unpack why the Midwest is having a tech moment. We explore how the startup scene in cities like Chicago is shifting rapidly, what’s pulling Big Tech inland, and why the next wave of innovation in quantum, healthcare, AI, and more might come from the middle of the map. If you're curious about what’s happening beyond the coasts, this conversation is a must-listen.

In this episode, I sit down with Ann Miura-Ko, co-founder of Floodgate and one of the most respected early-stage investors in Silicon Valley. We explore what authenticity really looks like in a founder, how technical builders can develop the softer skills that drive long-term success, and Floodgate’s powerful thesis around “Prime Movers”. Ann shares wisdom on storytelling, team-building, and what she looks for before writing a first check. If you’re a founder or aspiring investor, don’t miss this one.

In this episode, I chat with Teddy Solomon, co-founder and CEO of Fizz — the viral, anonymous social app taking over college campuses! With $42M raised and presence on 350+ campuses, Fizz is redefining Gen-Z social with raw, unfiltered community. We dive into how they’ve scaled so fast, why anonymity is their superpower, and what’s next as they roll out new features and expand beyond college. If you care about social, growth, or building for Gen-Z… this one’s a must-listen!

In this episode, I sit down with Jake O’Shea, Principal at Antler and one of the sharpest thinkers on early-stage venture strategy. We dive into how founders can build real moats in a world where speed is everything, why GTM is the new product, and how momentum can become its own form of defensibility. Jake shares candid insights from working with dozens of startups globally—and what he’s seeing in the founders who are breaking through right now.

In this episode, I sit down with Brad Feld, cofounder of Techstars and Foundry Group, and one of the most respected voices in early-stage venture. We talk about what’s changed—and what hasn’t—over his 25+ years in tech, the real ingredients behind lasting entrepreneurship networks, and why timing and emotional resilience matter more than most founders think. Brad shares hard-won lessons about Giving First and reflects on how to build companies (and careers) that stand the test of time.