Paras Doshi (Head of Data, Opendoor; former data leader at Amazon) joins High Signal to unpack the playbook for building an indispensable data function. He shares his experience tackling the classic scaling challenge of fragmented data at Opendoor, where rapid growth led to inconsistent metrics across the business, and turning the data function into a centralized strategic asset.
We dive deep into how to earn a true seat at the table, why he believes AI is creating the "100x individual contributor," and how the principles of agency, autonomy, and adaptability are the new essentials for data careers. The conversation also explores the pragmatic divide between batch and real-time ML, how to identify a truly data-led company, and why leaders must shield their top talent to unlock disproportionate impact.
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Vishnu Ram Venkataraman (Generative AI Executive & Entrepreneur; former AI Leader at Credit Karma and Intuit) joins High Signal to unpack the true cost of generative AI. Having scaled AI solutions impacting over 140 million users, Vishnu reveals why the ease of shipping Gen AI prototypes often masks significant operational and engineering debts, challenging the conventional wisdom of rapid deployment.
We dive deep into the strategic shift from traditional ML to Gen AI, discussing why the shelf value of code is dramatically falling, how to design new organizational triads for continuous iteration, and the critical differences in testing probabilistic AI systems. The conversation also explores how to manage risk with sensitive data, the power of synthetic data in early development, and which mature ML practices remain indispensable in the new AI era.
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Sergey Fogelson (VP of Data Science, Televisa Univision) joins High Signal to reveal how the world’s largest Spanish-language media company built a sophisticated data engine from the ground up. This transformation fueled a tenfold expansion of its digital streaming business by redefining how the company connects with 300 million viewers worldwide. At the heart of this success is a proprietary household graph that creates a single, privacy-first view of a massive and culturally diverse audience.
We dig into the journey from basic data unification to building production-ready recommendation engines, how his team uses embeddings on user behavior to uncover surprising connections in content consumption, and the trade-offs between investing in internal data tools versus direct revenue-driving products. The conversation also explores a pragmatic framework for AI adoption, showing how foundational machine learning often outperforms chasing the latest trends and where LLMs can deliver real, measurable value.
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Andrés Bucchi (Chief Data Officer, LATAM Airlines) joins High Signal to unpack how a century-old airline reinvented itself with data and AI—and how that transformation is unlocking value from fuel efficiency to fraud detection. LATAM has built a massive data operation, experimenting across everything from pricing to operations, while customers benefit from a more reliable and secure travel experience.
We dig into how LATAM fostered an experimentation culture, why existing data infrastructure is a critical asset, and how the biggest bottleneck in AI adoption isn't the technology itself, but human decision-making. The conversation also looks ahead to the future of generative AI as a software engineering problem, and the organizational changes needed to unlock its full potential.
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Anu Bharadwaj (President, Atlassian) joins High Signal to unpack how humans and AI agents will work together across the enterprise, and how that shift could change the very nature of teamwork. Atlassian employees have already built thousands of agents across product, marketing, engineering, and HR teams, while customers like HarperCollins are cutting manual work by 4x as industries from publishing to finance rethink their workflows.
We dig into how Atlassian’s culture enables bottom-up experimentation, why grounding and reliability are critical for adoption, and how non-technical teams are often the ones creating the most useful agents. The conversation also looks ahead to the frontiers of multiplayer agent collaboration, proactive and ambient workflows, and the governance and compliance challenges enterprises will face as agents move from tools to teammates.
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Tomasz Tunguz (Theory Ventures) joins High Signal to unpack why a trillion dollars of market cap is up for grabs as AI reshapes enterprise software. He explains why workflows are now changing faster than packaged software can keep up, how “liquid software” is redefining CRM and marketing automation, and why background agents will require a new kind of “agent inbox.” We discuss the compounding errors that arise when tools are chained too finely, the hidden AI technical debt accumulating in today’s systems, and why modular stacks—mixing local and cloud models—will beat monolithic apps. The conversation also surfaces early memory architectures, what breaks when one IC manages 100 agents, and how these shifts change the real bottlenecks in scaling AI.
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Amy Edmondson (Harvard Business School) and Mike Luca (Johns Hopkins) join High Signal to unpack what actually drives good decisions in data‑rich organizations. Using contrasts like the Bay of Pigs vs. the Cuban Missile Crisis and product cases such as Airbnb’s work on measuring discrimination, they show how decision quality tracks conversation quality—framing options, surfacing uncertainty, and challenging assumptions. We cover common failure modes (correlation vs. causation, anchoring, hierarchy, false precision), practical meeting designs that raise the signal, and where algorithms and LLMs help or hinder human judgment.
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Daragh Sibley, Chief Algorithms Officer at Literati and former Director of Data Science at Stitch Fix, joins High Signal to unpack how machine-learning moves from slide-deck promise to bottom-line impact. He walks through his shift from academic research on how kids learn to read to owning inventory and personalization algorithms that decide which five books land in every child’s box. We dig into the moment a data leader stops advising and starts owning P&L-critical calls, why some problems deserve simple analytics while others need high-dimensional models, and how to design workflows where human judgment and algorithmic predictions share accountability. Along the way we talk incentive design, balancing exploration and exploitation in inventory, and measuring success in dollars—not dashboards.
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Lis Costa, Chief of Innovation and Partnerships at the Behavioural Insights Team, joins High Signal to explore how behavioral science is reshaping public policy, digital platforms, and machine learning.
She explains how defaults influence behavior at scale, why personalization and chatbots are unlocking new kinds of interventions, and what happens when AI systems meet real-world complexity. We also discuss the limits of nudging, the promise of boosting, and why building for human decision-making requires more than just good models.
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Sudarshan Seshadri—VP of AI, Data Science, and Foundations Engineering at Alto Pharmacy—joins us to explore what it takes to build high-stakes AI systems that people can actually trust. He shares lessons from deploying machine learning and LLMs in healthcare, where speed, safety, and uncertainty must be carefully balanced. We talk about designing AI to support pharmacist judgment, the shift from bottlenecks to decision backbones, and why great data leaders are really architects of how irreversible decisions get made.
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Roberto Medri, VP of Data Science at Instagram, explains why most experiments fail, how misaligned incentives warp product development, and what it takes to drive real impact with data science. He shares what teams get wrong about launches, why ego gets in the way of learning, and how Instagram turned Reels from a struggling product into a global success. A candid look at product, data, and decision-making inside one of the world’s most influential platforms.
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Fei-Fei Li—co-director of Stanford’s Human-Centered AI Institute and one of the most respected voices in the field—reflects on AI’s evolution from the early days of ImageNet to the rise of foundation models. She explains why spatial intelligence may be the next major shift, how human-centered design applies in practice, and why AI should be understood as a civilizational technology—one that shapes individuals, communities, and society at large.
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Eoin O'Mahony—data science partner at Lightspeed, former Uber science lead, and co-designer of the system that kept NYC’s Citi Bikes available across the city—argues that positive metrics are meaningless if you don’t understand the mechanism behind them. At Uber, he often blocked launches that looked good on paper but didn’t make sense in practice. Now in venture, he’s applying that same rigor to unstructured data—using GenAI to scale a kind of work that’s long resisted systematization.
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Barr Moses—co-founder and CEO of Monte Carlo—thinks we’re headed for an AI reckoning. Companies are building fast, but most are still managing data like it’s 2015. In this episode, she shares high-stakes failure stories (like a $100M schema change), explains why full-stack observability is becoming essential, and breaks down how LLM agents are already transforming data debugging. From culture to tooling, this is a sharp look at what real AI readiness requires—and why so few teams have it.
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Tim O’Reilly—founder of O’Reilly Media and one of the most influential voices in tech—argues we’re not witnessing the end of programming, but the beginning of something far bigger. He draws on past computing revolutions to explore how AI is reshaping what it means to build software, why real breakthroughs come from the edge—not incumbents—and what it takes to learn, teach, and build responsibly in the age of AI.
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Stefan Wager—Professor at Stanford and expert on causal machine learning—has worked with leading tech companies including Dropbox, Facebook, Google, and Uber. He challenges the widespread assumption that better predictions mean better decisions. Traditional machine learning excels at prediction, but is prediction really what your business needs? Stefan explores why predictive models alone often fail to answer critical “what-if” questions, how causal machine learning bridges this gap, and provides practical advice for how you can start applying causal ML at work.
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Peter Wang—Chief AI Officer at Anaconda and a driving force behind PyData—challenges conventional thinking about AI’s role in software development. As AI reshapes engineering, are we moving beyond writing code to orchestrating intelligence? Peter explores why companies are fixated on models instead of integration, how AI is breaking traditional software workflows, and what this shift means for open source. He also shares insights on the evolving role of engineers, the commoditization of AI models, and the deeper questions we should be asking about the future of software.
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Ari Kaplan—Global Head of Evangelism at Databricks and a pioneer in sports analytics—explains why businesses fixated on AI often overlook the real advantage: making better decisions with their own data. He shares lessons from his work building analytics teams for Major League Baseball, advising McLaren’s F1 strategy, and helping companies apply AI where it actually works—without falling into hype-driven traps.
SHOW NOTES
In this episode of High Signal, Eric Colson—former Chief Algorithms Officer at Stitch Fix and VP of Data Science and Machine Learning at Netflix—breaks down why most companies fail to unlock the full potential of their data science teams. Drawing from years of experience leading data functions at top tech companies, Eric shares how organizations can shift from treating data scientists as a service function to empowering them as strategic drivers of business impact.
Key topics from the conversation include:
💡 Tune in to learn how leading companies structure their data teams for impact, why experimentation beats rigid planning, and how treating data science as a strategic function can unlock new business opportunities.
You can find more on our website: https://high-signal.delphina.ai/
SHOW NOTES
In this episode of High Signal, Elena Grewal—former Head of Data Science at Airbnb, political consultant, professor at Yale, and ice cream shop owner—shares her journey of building data teams that scale across vastly different contexts. Drawing on her experiences in tech, consulting, and brick-and-mortar, Elena offers practical lessons on leadership, trust, and experimentation.
Key topics from the conversation include:
💡 Tune in to explore how data science principles can scale across industries, the leadership skills required to build impactful teams, and why experimentation is as relevant to ice cream as it is to AI systems.
You can find more on our website: https://high-signal.delphina.ai/
SHOW NOTES
