Roberto Medri, VP of Data Science at Instagram, explains why most experiments fail, how misaligned incentives warp product development, and what it takes to drive real impact with data science. He shares what teams get wrong about launches, why ego gets in the way of learning, and how Instagram turned Reels from a struggling product into a global success. A candid look at product, data, and decision-making inside one of the world’s most influential platforms.
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Fei-Fei Li—co-director of Stanford’s Human-Centered AI Institute and one of the most respected voices in the field—reflects on AI’s evolution from the early days of ImageNet to the rise of foundation models. She explains why spatial intelligence may be the next major shift, how human-centered design applies in practice, and why AI should be understood as a civilizational technology—one that shapes individuals, communities, and society at large.
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Eoin O'Mahony—data science partner at Lightspeed, former Uber science lead, and co-designer of the system that kept NYC’s Citi Bikes available across the city—argues that positive metrics are meaningless if you don’t understand the mechanism behind them. At Uber, he often blocked launches that looked good on paper but didn’t make sense in practice. Now in venture, he’s applying that same rigor to unstructured data—using GenAI to scale a kind of work that’s long resisted systematization.
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Barr Moses—co-founder and CEO of Monte Carlo—thinks we’re headed for an AI reckoning. Companies are building fast, but most are still managing data like it’s 2015. In this episode, she shares high-stakes failure stories (like a $100M schema change), explains why full-stack observability is becoming essential, and breaks down how LLM agents are already transforming data debugging. From culture to tooling, this is a sharp look at what real AI readiness requires—and why so few teams have it.
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Tim O’Reilly—founder of O’Reilly Media and one of the most influential voices in tech—argues we’re not witnessing the end of programming, but the beginning of something far bigger. He draws on past computing revolutions to explore how AI is reshaping what it means to build software, why real breakthroughs come from the edge—not incumbents—and what it takes to learn, teach, and build responsibly in the age of AI.
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Stefan Wager—Professor at Stanford and expert on causal machine learning—has worked with leading tech companies including Dropbox, Facebook, Google, and Uber. He challenges the widespread assumption that better predictions mean better decisions. Traditional machine learning excels at prediction, but is prediction really what your business needs? Stefan explores why predictive models alone often fail to answer critical “what-if” questions, how causal machine learning bridges this gap, and provides practical advice for how you can start applying causal ML at work.
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Peter Wang—Chief AI Officer at Anaconda and a driving force behind PyData—challenges conventional thinking about AI’s role in software development. As AI reshapes engineering, are we moving beyond writing code to orchestrating intelligence? Peter explores why companies are fixated on models instead of integration, how AI is breaking traditional software workflows, and what this shift means for open source. He also shares insights on the evolving role of engineers, the commoditization of AI models, and the deeper questions we should be asking about the future of software.
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Ari Kaplan—Global Head of Evangelism at Databricks and a pioneer in sports analytics—explains why businesses fixated on AI often overlook the real advantage: making better decisions with their own data. He shares lessons from his work building analytics teams for Major League Baseball, advising McLaren’s F1 strategy, and helping companies apply AI where it actually works—without falling into hype-driven traps.
SHOW NOTES
In this episode of High Signal, Eric Colson—former Chief Algorithms Officer at Stitch Fix and VP of Data Science and Machine Learning at Netflix—breaks down why most companies fail to unlock the full potential of their data science teams. Drawing from years of experience leading data functions at top tech companies, Eric shares how organizations can shift from treating data scientists as a service function to empowering them as strategic drivers of business impact.
Key topics from the conversation include:
💡 Tune in to learn how leading companies structure their data teams for impact, why experimentation beats rigid planning, and how treating data science as a strategic function can unlock new business opportunities.
You can find more on our website: https://high-signal.delphina.ai/
SHOW NOTES
In this episode of High Signal, Elena Grewal—former Head of Data Science at Airbnb, political consultant, professor at Yale, and ice cream shop owner—shares her journey of building data teams that scale across vastly different contexts. Drawing on her experiences in tech, consulting, and brick-and-mortar, Elena offers practical lessons on leadership, trust, and experimentation.
Key topics from the conversation include:
💡 Tune in to explore how data science principles can scale across industries, the leadership skills required to build impactful teams, and why experimentation is as relevant to ice cream as it is to AI systems.
You can find more on our website: https://high-signal.delphina.ai/
SHOW NOTES
In this episode of High Signal, Chris Wiggins—Chief Data Scientist at The New York Times, Professor at Columbia University, and co-author of How Data Happened—shares how organizations can move beyond prediction to actionable decision systems. Drawing on his work at The New York Times and in academia, Chris explains how to scale data teams, optimize systems, and align data science with organizational impact.
Key topics from the conversation include:
• From Prediction to Prescription: Why organizations need to focus on interventions that drive outcomes, illustrated with insights like, “Imagine a hospital prescribing treatments instead of just diagnosing conditions.”
• The AI Hierarchy of Needs: Foundational practices, such as data logging and engineering, that enable advanced machine learning and AI.
• Personalization and Optimization: How reinforcement learning and exploration-exploitation methods help optimize KPIs and adapt to user context.
• Scaling Data Teams: Strategies for attracting and retaining talent by emphasizing autonomy, mastery, and purpose.
• Empathy as a Data Science Skill: The importance of collaborating with other teams and understanding their goals to drive adoption and success.
🎧 Tune in to learn how to build decision systems, integrate causality into workflows, and develop scalable data science teams for real-world impact.
You can find more on our website: https://high-signal.delphina.ai/
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In this episode of High Signal, Hilary Mason—renowned data scientist, entrepreneur, and co-founder of Hidden Door—shares her unique insights into the evolving world of data science and generative AI. Drawing from her pioneering work at Fast Forward Labs, Bitly, and Hidden Door, Hilary explores how creativity, judgment, and empathy are reshaping the data landscape.
Highlights from the discussion include:
The conversation concludes with Hilary’s optimistic take on how the data science community can continue to thrive by embracing creativity, empathy, and interdisciplinary collaboration.
🎧 Tune in to gain practical insights into building robust AI systems, navigating career shifts, and leveraging generative AI for meaningful innovation.
You can find more on our website: https://high-signal.delphina.ai/
LINKS
In this episode of High Signal, Gabriel Weintraub (the Amman Professor of Operations, Information, and Technology at Stanford Graduate School of Business), brings his expertise in market design, data science, and operations, enriched by his experience with global platforms like Uber and Mercado Libre, to a conversation that spans practical strategies, cultural insights, and global perspectives on data and AI.
Highlights from the discussion include:
The conversation concludes with a forward-looking exploration of opportunities in government, education, and healthcare, and Gabriel’s optimism about building ecosystems where startups and local talent thrive.
🎧 Tune in to learn from Gabriel’s thoughtful perspectives on navigating the complexities of building data-driven cultures, the global AI landscape, and how to leverage data for impactful change.
You can find more on our website: https://high-signal.delphina.ai/
Ramesh Johari (Stanford, Uber, Airbnb, and more) explores the art and science of online experimentation, especially in the context of marketplaces and tech companies.
Ramesh shares insights on how organizations evolve from basic experimentation practices to becoming fast, adaptive, and self learning organizations. We dive into challenges like the risk aversion trap, the importance of learning from negative results, and how generative AI is reshaping the experimentation landscape.
We also talk about common failure modes and the types of things you're probably doing wrong, along with strategies to avoid these pitfalls. Plus, we discussed the role of incentives, the necessity of data driven decision making, and what it means to experiment in high stakes environments.
Chiara Farronato (Harvard Business School) discusses how digital platforms like Airbnb and Uber have transformed industries. She explores the challenges of fostering collaboration between managers and data scientists, bridging communication gaps, and building data-driven cultures. Chiara also delves into the complexities of managing peer-to-peer marketplaces and the evolving role of data in decision-making. This episode offers key insights for business leaders working with technical teams and navigating platform-based innovation.
Hugo Bowne-Anderson welcomes Andrew Gelman, professor at Columbia University, to discuss the practical side of statistics and data science. They explore the importance of high-quality data, computational skills, and using simulation to avoid misleading results. Andrew dives into real-world applications like election predictions and highlights causal inference’s critical role in decision-making. This episode offers insights into balancing statistical theory with applied data analysis, making it a must-listen for both data practitioners and those interested in how statistics shapes our world.
Michael Jordan (UC Berkeley) on the future of machine learning as it extends to a planetary scale in "The Next Evolution of AI: Markets, Uncertainty, and Engineering Intelligence at Scale." In this episode, Mike speaks with Hugo about the evolution of AI, the importance of integrating machine learning, computer science, and economics, and how AI can scale to address planetary-level challenges.
