#MEDICALINNOVATION #OLYMPICSWIMMING #championmindset

This is an inspirational keynote presentation on October 6, 2025, at the Opening Ceremony of the 2025 Medical lnnovation Olympics from Chris Cook, double Olympian swimmer, double Commonwealth Games Champion, World Championship Bronze Medalist, motivational speaker at companies such as Microsoft and some of the largest health systems across the globe, and consultant to the U.K.'s government's National Health Service.Chris shares three specific personal stories that span Olympic level training, building the next generation of Olympic champions, and transformation of teamwork across a Healthcare system with psychological safety.

0:00 Timeline - Highlights

2:12 - Intro: 3 Key Messages - Evidence-based Confidence, Clarity, and Psychological Safety

3:28 - Biggest lesson on Confidence during the Toughest Season (2006)

4:57 - Measure what Matters: Heart Rate, Stroke Rate, Time, Perceived Exertion

5:35 - Challenge: Beat the Average from Previous Week

5:51 - Turning Point: Started to be obsessed with Progress

7:10 - Leadership Phase after Retirement

7:27 - Ambition Programme - Team Great Britain - less than 8% of first time Olympians medal, intense build-up, media attention of the Olympics

8:35 Pilot Project of First-time Olympians Created environment for potential stars to feel like Olympians, media mock-interviews, etc.

9:41 Ambition Programme Alumni & Results307 athletes have finished this program40% represent Team GB 11% of the athletes in the program win a medal

10:12- When we get clear we level up certainty

Ask it, answer it, and action it - the last one drives certainty

10:50 - Collaboration with the National Health Service in the UK

New programs: 1) Creating Psychological Safety to share, contribute, and debate; 2) Radical Candor. In less than 18 months, the pilot transformed one department, then started to spread

12:34 - Teamwork thrives on Psychological Safety

12:56 - Keynote SummaryConfidence is built from evidenceWhen we are unclear, things become uncertain - Challenge to the audience!True teamwork starts when we are safe to take risks

On October 6, the Host of the 4th annual global, virtual Medical Innovation Olympics, recognized as one of the top 4 innovation challenges across the globe by Fierce Pharma in 2025, Tim Mikhelashvili, CEO and Co-Founder of Amedea Pharma, welcomed all the guests and competitors at this 16-day competition along with two industry executives on the Board and Expert Judges - Melissa Norcross, Vice President, Corporate Strategy, Hyland Software, and Eddie Power, CEO, emPower medical.

0:00 Welcome - Tim Mikhelashvili, CEO, Amedea Pharma, Host #MIO2025

1:38 Power of Gathering Leaders who do not usually Interact Together

1:58 Layer the Science - Horizontal Innovation to Master Consistency

2:21 Power of Creating Momentum - Lorne Whitehead's Domino Experiment

3:13 Leap with Defiance - Healthcare Ecosystem is hostile to Innovation

3:47 Advances in Neurocircuitry, Alzheimer's biomarkers, Wearable Devices

4:58 Why Humans are Resilient and Innovators by Design

5:36 Today We have to be More Responsible than ever, not only Resilient

6:14 Innovation in Medicine is like Building a Tall Jenga Block Tower6:54 Why MIO2025 requires Competitors to Present Multiple Times x 16 days

7:54 Goal = Feel Like Healthcare Champions Ready for Future Challenges

8:25 Melissa Norcross, PhD - Peer Group to Bring out Your Best

9:20 Eddie Power, CEO, emPower Medical - Power of Learning, Curiosity

On this episode of Alloutcoach, host Tim Mikhelashvili, CEO, Amedea Pharma convenes a panel you rarely hear in one room: a policy-minded biohacker and investor (John Hemming, CEO of Cirrostratus, Biohacking Team Leader), a strategy and operations leader who reshapes patient journeys (Bart Zoni, Senior Vice President, Marketing, Woven Health Collective), and an early-stage investor focused on medical technologies (Chris Piedmonte, Managing Director, Neoterra Capital) as well as a senior pharma thought leader in Medical Affairs and Health Economics, Janelle Hardisty. Their catalyst? Fresh takeaways from the 2025 Financial Times US Pharma summit — and an honest look at what’s truly accelerating innovation, what’s stalling it, and where capital and talent should go next.

00:00:00 Cold Open - Episode Highlights: AI accuracy and access
00:03:43 Host Intro and Why This Episode
00:04:41 Guest Intros
00:08:06 State of Innovation - Tailwinds and Headwinds
00:12:41 What’s Really Accelerating Innovation?
00:19:27 Drug Discovery - Reducing the 90% Failure Rate
00:22:01 Clinical Trials - Modernize or Stall
00:25:11 Access, PBMs, and Direct-to-Patient
00:27:03 Longevity and Prevention - Can We Measure It?
00:36:52 Data Culture Maturity and Pilot Fatigue
00:45:52 Training the Future Workforce
00:51:09 Investing - Where Should Capital Flow?
00:57:08 Regulatory Reality and Time-to-Access
00:59:27 Closing and Invite to Medical Innovation Olympics

Ellie Holbert, founder and principal of Empact Advisory Services, is a scientist, researcher and organizational change expert who has mastered unlocking full potential of organizations including transforming some of the largest health systems in the U.S. as well as large enterprises with over 250,000 employees. In this latest episode, she highlights the key factors to her system of discovering the human potential to perform in organizations with KPI structure, culture, and habits that drive results.

0:00 Episode Highlight 1 - Redefining Failure & Circle of Safety

0:42 Episode Highlight 2 - Case: Wrong KPIs harmed Customer Satisfaction in a Large U.S. Healthcare System

03:34 Personal Inspiration: Lessons from Motherhood & Reading
“Redefining strength, resilience, and inspiration.”

04:53 Academic Excellence & Early Career Discipline
“Why structure, early mastery, and emotional intelligence shaped her career.”

07:46 Metrics vs. Culture: Avoiding the Wrong Incentives
“How poorly designed KPIs can backfire—and what to measure instead.” Importance of balancing individual and team metrics. Measuring trust, approachability of leaders and emotional intelligence factors is linked to observable leadership that drives business outcomes.

10:30 Unintended Problems of Procurement KPIs in Largest US Health System. Created Customer Dissatisfaction despite opposite intentions.

11:40 When to Invest in Team Effectiveness Interventions
“Times of change, fear, and stagnation demand cultural investment.”

Employees are operating from self-protection which is slowing innovation, and performance.

16:42 Today's Need to Protect Top Performers & Measure ROI
“Why high performers deliver 8X output and how to retain them.”

19:49 Building Self-Driven Teams That Last Beyond Consulting
Ellie anchors specific techniques to “Psychological safety, retrospectives, and boldness as cultural cornerstones.”

20:30 Leadership Power of Describing Reality Accurately without BlameSelf-regulation is a norm in the most successful teams, centered on creating structure with clarity, safe environment and analysis of emotional intelligence.

24:48 Keys to Thrive in Uncertainty: Mindset, Delegation & Letting Go

27:57 Redefining the Modern Organization
Ellie reacts to Netflix custom to encourage executives to make $1 million dollar mistakes. Failure is a critical part of our success, as well as sharing lessons from failures because of the benefits of learning. “The four pillars: psychological safety, belonging, clarity, and purpose.”

33:03 Case Study: From Chaos to Clarity in 8 Weeks
Ellie tells how she created champions in a financial services organization with 5000 employees handling a major cybersecurity initiative, pressure and uncertainty. “How one healthcare team improved ROI by 45X and revenue by 11X.”

37:35 – Final Words & Team Health Assessment
“Start small: measure and improve team health."

Watch my first-ever conversation with a political leader on the Alloutcoach show who has also transcended business, entrepreneurship, community service, women's rights advocacy and sports science. This episode uncovers a personal story and manifestation of character and integrity of an inspiring, dynamic, and powerful leader, Hon. Leela Aheer, former Canadian Minister of Culture, Multiculturalism, and Women's rights, musician, and activist throughout her journey of transformation into becoming a business executive, entrepreneur and expert in optimizing athletic performance.In addition to lessons on sportsmanship-centered leadership in business, you will discover the difference precision medicine with multi-omics and slightest variance in our microbiome DNA can have on creating gold medalists in sports, and champions in health, training, rehabilitation and recovery. 🎧 Genomics, Grit & Team-First Leadership with Hon. Leela AheerElite sport precision meets everyday leadership: integrity, listening, and multi-omics that turn guesswork into wins.📍 Chapters00:00 🔥 Highlight 1 - Cold open — integrity & sport’s “magic”00:53 🔥 Highlight 2 - Sports magic and translation into business02:04 🔥 Highlight 3 - From Silver to 2X World Championship Gold03:36 🎙️ Intro — welcome to ALLOUTCOACH & Episode04:53 👋 Guest greeting05:03 🗳️ “Politics found me” — grassroots to public service11:20 💼 Business → politics: budgets, messaging, listening12:12 🧭 Integrity as a non-negotiable15:21 🎶 Music & mindset — choirs, Stampede, and learning19:49 🧑‍🏫 Mentors & lifelong learning (Gandhi insight)21:04 🚪 Career Pivot to sport & BioSport — How it Started23:59 🧬 BioAero → BioSport: DNA, microbiome, vagus nerve26:16 🧠 Personalization over averages — why your plan must be yours26:50 ⛸️ SPEED-SKATER GOLD MEDAL CASE STUDY — meet Hayden Mayeur 27:04 🧬 DNA → microbiome: the real unlock27:21 🍗 Carb-loading vs protein-first for Hayden 27:42 ⏱️ Why protein timing mattered; energy systems explained27:59 ⚡ Short-burst vs long-release energy — matching sport to physiology28:31 ♻️ Recovery & injury-risk flags — ending guesswork with data29:11 🧪 Multi-omics 101: proteomics, supplements, transcriptomics29:43 🏗️ Sequencing 100 athletes + capital raise → building the app34:59 🤝 Team culture — elevate the assist, build trust37:00 🧵 Closing — Discipline & Teamwork

Celebrate the start of your busy summer with an inspirational conversation that will drive you to see the bigger goals more clearly and celebrate your smaller wins more often. This episode is full of real-world stories and case studies with a gifted healthcare innovator, scientist and sports athlete turned Sales executive, Graham Long, Chief Commercial Officer, Tobin Scientific. Graham is a Commercial Leader specializing in sales, marketing, and business development within high-growth life science research, drug discovery, and diagnostic sectors who had previously worked for BioPharma (Glaxo Group Research ,Ciba-Geigy) and biotech (Biotal Ltd.) companies in various research roles. He is an expert in building winning teams and transforming life science companies such as SmartLabs with a proven track record in revenue generation, portfolio management, global product launches, and strategic partnerships.

0:00 Episode Highlight #1 - How Data Transparency Inspires Meaning and Performance

1:24 Episode Highlight #2 - Detailed Data Analysis Driving an Underdog to Win

3:19 Speaker Introduction

5:27 Key Lessons from the Career of a Scientist Athlete-turned Biotech Sales Executive

7:13 Early cancer research highlights in oncogene and pharma transition

9:53 Career Turning Point

Industry first technology from a Harvard spinout

12:13 How Graham continues to be an innovator regardless of the tough journey

Power of giving voice and psychological safety to unlock human creativity and superpower in teaming and using technology.

16:10 Critical value of curiosity, desire for learning, adaptability to address blind spots

17:14 Qualities of mentors that influenced Graham to

18:20 Identifying small windows of opportunity to scale companies like SmartLabs

Timing of the interaction between the client and vendor have happen at the

Identifying end-user journey

Why end-users can benefit from the product

Communication of benefits

Reaching end users

Processes to identify recurrent patterns in type of clients and needs

21:25 Metrics details necessary in manufacturing and high stakes regulatory scenarios

Regulatory environment does not leave any room for error and calls for right metrics

Log and track where errors occur

Constant process improvement mindset

SOP is fixed in manufacturing but root cause analysis

26:05 John McNeil - former Sales/Mktg President @Tesla: Innovation by Subtraction

26:50 How Performance Analytics transformed the Oxford vs. Cambridge Boat Race

29:13 From a Personal Sports Background to Scaling Companies: See the Bigger Goals, and Celebrate Small Wins along the Journey

31:08 Individual Recognitions in Teams are critical

33:07 Ultimate benefits of Data on Individual Motivation and Team Progress

34:47 Shifts in Mindset necessary to transform into a Winning Commercial Leader

36:22 Technical shifts to drive Commercial Success - validation, research, and insights

38:55 Game-changing steps of financial modeling, viability and economics

40:30 Bridge from R & D to Commercial through a Tech Transfer Scientist role

42:27 Final Thoughts - Maintain Excitement and Curiosity for Healthcare Advances

In late 2024 I spoke with an academically trained cardiologist expert in cardiometabolic risk prevention and obesity medicine, educator, Dr. Eldad Einav, from Beverly Hills, CA about the ongoing controversy about the shortage and patient access to the exciting new weight loss treatments such as GLP1 agonists. He shared many practical, clinical insights and research that are important to revisit today for patients, physicians, and payers who are seeking to provide the best solutions and learn from some recent shortcomings.

0:00 Highlight #1 - Distinguishing the quality of weight loss solutions

1:26 Highlight #2 - Providing reliable 503B Facility source for patients w/ no access to GLP1

3:18 - Speaker Introduction

6:14 - Why Dr. Einav decided to specialize in obesity / weight loss

9:38 - Why should cardiologists focus on weight management - preventive care?

11:58 - Not many cardiologists manage weight

12:34 - Patient preferences to treat weight vs hypertension or cholesterol

14:34 - Problem of maintaining long-term weight loss

15:00 Look AHEAD study - well-controlled lifestyle study of weight loss with

16:19 Drugs meeting newer targets of 15% or higher weight loss

16:57 - Select Trial: weight loss reduces risk of heart attack, stroke by 20%

19:07 - New drugs approaching efficacy of bariatric surgery

21:29 - 2024 Shortage and patient access to new GLP1 drugs

23:11 - Specialty pharmacy compounding GLP controversy

26:06 - What doctors should know about choosing compounded drug alternatives

27:54 - What patients should know about choosing their weight loss drugs

31:22 - Reality of types of compounded medications used by US hospitals

32:11 - Removing the double-standard of compounded medications to improve patient access

33:46 - Helpful resources to learn how to access the right weight-loss medication

37:47 - Final Advice to Patients and HCPs to make better decisions, consolidate fragmented care

The first Alloutcoach episode of 2025 is a powerful and honest conversation from an unforgettable Expert Panel at the 2024 Medical Affairs Innovation Olympics about a much needed modern view of leadership in Medical Affairs, pharma, healthcare and beyond. The thought-provoking discussion will certainly challenge you and offer practical solutions. It features some of the most dynamic, accomplished leaders who provide intriguing, candid, and diverse perspectives across pharma and biotech, Medical Affairs, ESG, finance, technology, and life sciences backgrounds. Speakers: Melissa Norcross, AVP, Corporate Strategy and ESG, Hyland SoftwareChristopher Piedmonte, Managing Director, NeoTerra Capital, Tech Executive, Angel Investor Natasha Hansjee, Integrated Medical Enabling Catalyst, Roche

Topics

1. Leadership & Talent: What are the current gaps in innovative Medical Affairs leadership approaches from a talent management perspective – how do we maximize the power of medical decisions from a skillset and mindset perspective (AI savviness, critical thinking, innovative, digital HCP engagement)?

2. Measuring and Improving Impact on Patients: How can Medical Affairs continue to reinvent itself with emerging challenges, technology, or competitive sources of information that drive clinical decisions to instead utilize them appropriately yet demonstrate its independent value and impact in the future?

3. Decision-Driven Analytics – what case studies or best practices can we learn from in decision-driven analytics and excellence in internal decision-making and strategy across the different life cycles of products, devices, etc.4. How do we stimulate problem solving and adaptive performance, not only tactical performance to drive innovation in Medical Affairs?

0:11 Episode Highlights

8:20 Introduction of Panel

9:50 Moderator's Introduction - What Gaps are there in Medical Leadership?

What does it mean to lead well? Provide not only skillsets but toolsets.

Celebrate and stimulate failure.

Emphasize customer experience

15:46 Gaps in Clarity of vision, Access to Resources

18:35 Setting the right foundation of trust and mindset as LeadersLeader's job is to help team members to avoid trouble, resolve problems and not assign blame.

21:59 Empowerment comes through accountability, which is missingPerformance Feedback is critical

23:57 Unlocking Innovation and Critical ThinkingPsychological safety is effective only when combined with AccountabilityTeaching others how to think in order to maximize performance

25:20Leaders Drive Business PerformanceTrust and accountability fall along a spectrum, and are not opposites

27:26 How do the greatest leaders drive more effective innovation?

31:44 Innovation through accidental discovery accelerated by Generative AIIn many ways AI stands for artificial intern vs artificial intelligenceHow critical collaboration is as well as competition

33:45 At the edge of performance, athletes learn from other competitors who have superior skills.

34:45 Case Studies of Utilizing Analytics to Drive Better Decisions

36:45 Get diverse perspectives, from relevant and large groupsBeware of making assumptions based on data

39:31 Take data you have available, match the quality of the data to make best decision. It is never perfect. Do more with less resources - innovation.

43:14 Last Call to Action to Lead differently tomorrow in Medical AffairsClarity - Objectives, Timelines, Resources, Performance metricsVoice of Customer + Voice of Employee

46:53 Find Someone to Compensate for your Blind Spots

This last Alloutcoach podcast episode of 2024 is the most personal and revealing to date. I openly reflect on my own performance and journey through successes and failures in my career in pharma and biotech. The discussion directly addresses the most critical external and internal factors that are driving the new reality of competition in healthcare and life sciences, pointing out key differences in our perceptions of external/internal competition in the world of sports versus pharma. Finally, the episode is centered on the most memorable examples of athletes or teams and their performances or disappointments at the 2024 Paris Olympics to provide 5 critical business lessons for individuals or organizations in the healthcare industry and beyond for a stronger, transformative 2025 year ahead.

0:00 Episode Intro Music

0:07 Highlight #1 – Three Times I was fired / laid off

2:45 Highlight #2 – Noah Lyles’ loss of gold medal at his best event – 200-meter sprint

3:35 Highilght #3 – Recipe for Consistency of High Performance

6:13 Episode Introduction – Summary of the 2024 Medical Affairs Innovation Olympics Opening Remarks  

7:52 Detailed Episode Outline

8:49 Current State of Competition in Medical Affairs and Healthcare Industry

External and Internal Pressures of Competition and their Consequences.

Major Layoffs due to changing workflows and inaccurate forecasting.

Need of Medical Affairs to discover new power in medical decisions to stay competitive.

2024 Medical Affairs Innovation Spectrum – collaborating with tech to describe, predict, and prescribe best personalized treatments.

12:20 Our Perceptions of Competition vs Reality in Sports vs Pharma / Biotech

Life Compass with only two directions – Progress and Success

14:03 Why I have always gone to work as if it were a sport I liked to master

15:07 Case Study – Leading Medical to grow a Pharma Startup by $40 million through a head-to-head study analysis

18:07 Personal Reflection and Analysis – Why I was fired / reorganized / laid off three times

23:14 Paris 2024 Olympics Lesson #1 – Respect Your Competition

Noah Lyles’ claims of superiority in an event he dominated and disappointing bronze medal.

Recent personal observation and outcome of a child celebrating another’s failure and waiting for him to fail.

Gary Hall Jr, 5-time Olympic Gold Medalist – won his first Olympic gold only after he began to respect his arch rival.

27:58 Paris 2024 Olympics Lesson #2 – It is the Final Lean that Counts

Noah Lyles’ closest margin of gold medal victory in the 100-meter sprint.

Dominant Italian national teams in volleyball and water polo at the opening group stage missed the podium and could not medal.

29:51 Paris 2024 Olympics Lesson #3 - Recipe of Consistency is Proportions not Ingredients Alone

Carl Lewis’ remarkable consistency of winning 4 consecutive Olympic gold medals in the long jump.

Greek Long Jumper Miltiadis Tentoglou and Women’s South Korean Archery Team’s Consistency of defending their gold medals at the Paris Olympics.

Personal application of mastering cooking pasta professionally to mixing highest quality talent on a team with the right proportion and size of equipment and environment.

33:20 Paris 2024 Olympics Lesson #4 – Never Bypass the Basics to Stay in Competition

US Men’s 4 x 100 Sprint Relay Team’s Inefficient Baton Pass

Marquis Dendy, US veteran, best current long jumper’s

Damian Warner, Canadian decathlete Olympic gold medalist’s failure to post a jump at the opening height in the pole vault to miss the podium.

35:13 Paris 2024 Olympics Lesson #5 – Adapt to New Rules and Formats

The judge or new competition format led to an unpredictable result with a favorite team not able to adapt in Paris.

Celebrate Competition in Medical Affairs to stay competitive and relevant

Clinical research is undergoing a revolution in light of new demands for speed and opportunities from a technological standpoint. These trends have given rise to a debate about the quality and clinical meaning of traditional methods of investigations versus modern types of clinical studies to collect real world evidence. This debate at the 3rd annual Medical Affairs Innovation Olympics #MAIO2024 in a unique and exciting format with a live poll at the conclusion, features an animated discussion from three speakers: Rashad Massoud, MD, MPH, CEO of Rashad Massoud Associates, LLC., globally recognized healthcare quality expert, physician, formerly visiting faculty at the T.H. Chan School of Public Health; Suzanne Pavon (moderator), Doctor of Pharmacy, Board Member at Iethico, former Vice President of Pharmacovigilance and Quality at Argenx; and Sana Syed, Senior Medical Director - Clinical Lead at Sanofi and public health expert formerly at T.H. Chang School of Public Health.

Debate Objectives: ● To discuss the utility of RCTs in research and learning ● To discuss the challenges in translating RCT findings into the real-world environment ● To review the utility of the RCT approach to facilitate real world implementation ● To review the impact of the RCT approach for impact and limitations ● To discuss alternative research methods for research and learning ● To conclude with the research approaches that fit best for clinical trials and the real world; indicating a need for an adaptive, dual approach. 0:00 Alloutcoach Intro Music

0:09 Episode Highlight

3:09 Innovation Olympics Introduction

4:44 Debate Rules & Introduction

6:30 RCTs are the Gold Standard for Research and Learning - For the Motion - Sana Syed 8:12 The Scientific Method - Standard RCT Design 9:46 Rare Disease Case Study 11:38 Translating Biology vs Translating Real World Factors 14:34 Diversity of patients critical for data to represent populations 18:50 RCTs are NOT the Gold Standard for Research: Against the Motion - Rashad Massoud 20:27 Properties of an RCT 21:19 Other Research Questions to Eliminate Other Factors that may influence the results 24:13 Access Questions and Outcomes of Interest - Discovery and Delivery

24:48 Agency for Healthcare Research and Quality (AHRQ) - ~17 yrs to translate data into real world 26:33 Efficacy vs. Effectiveness Research 31:02 Concluding Remarks - case study in which RCT designs are not beneficial 35:30 Question: Health Avatar and AI to create real and virtual control arm Using virtual control arm using real world databases using Bayesian statistical methods 39:23 Case study to emphasize Harnessing Tacit knowledge 42:02 Comment: Weaknesses in generating data we can translate into populations 43:44 Question: Are we creating RCTs from virtual patients or classical RCT design? 47:34 Final Comments - For the Motion, Sana Syed Clinical Studies and Scientific Method - adjustments in diverse patient recruitment tactics

49:31 Final Comments - Against the Motion, Rashad Massoud

53:14 Live Voting Results

In this special episode you will have an opportunity to learn about the key factors to not only living longer but better and higher quality lives from a global expert and pioneer researcher in longevity medicine, Dr. David Barzilai. David provided an update of the landscape in this field as a keynote speaker at the 3rd annual Medical Affairs Innovation Olympics held in October. David is CEO and founder of Healthspan Coaching, LLC., and agingdoc.com, providing longevity medicine and lifestyle consulting. Dr. Barzilai is a Diplomate at the American Board of Lifestyle. He is board-certified in dermatology, with a PhD focused on evidence-based medicine, and also holds an MBA.

In his keynote presentation, Dr. Barzilai critically addresses the gaps in treating only one disease at a time and provides alternative methods that target root, underlying causes of disease that can prevent multiple chronic diseases and lengthen the human Healthspan. David challenges the healthcare community and Medical Affairs function in pharma and biotech with a call to action to prioritize efforts to improve healthspan and transform medicine.

0:00 Timeline

0:09 Episode Highlight + Call to Action

1:30 Host Introduction of the Episode

4:17 Keynote Speaker's Presentation Overview

5:04 Dramatic Increase in Global Aging Population

6:10 Gray Tsunami Economic Impact - Rising Health Expenditures 7:07 Healthspan must accompany lifespan increase - Holy Grail of Longevity 7:41 Targeting the Bioscience of Aging: The Geroscience Hypothesis 8:21 12 Hallmarks of Aging 9:29 Problem with Current Approach of Targeting 1 Disease at a Time 10:26 Aging can be manipulated across different species Rapamycin increased lifespan even after being injected in middle aged humans 12:22 Growing Frontier in Longevity Biotech Number of biotech companies have grown from 20 to 50 since 2020 13:57 Lifestyle Medicine as Longevity Foundation 15:12 Global Strategy for Healthy Longevity Global Roadmap to Healthy Longevity National Academy of Medicine - Goal to Increase Lifespan by 6 years by 2030 15:47 Hevolution Foundation - $1 billion investment to accelerate in aging research 16:31 Bridging the gap between biotech and public health initiatives Immediate reforms in healthcare are needed such as compression of morbidity 17:13 Tackle Urgent Challenges of Aging where health is not just preserved but extended Call to Action Integrate Biotech and Public Health Strategies Invest in Aging BIology Train Physician Workforce Promise of Geroscience 19:09 Q & A

20:10 Questions: Roles of 1) Neuralink + 2) Telehealth on Longevity

21:07 Role of Telehealth - know your target audience/sub-specialization is a key factor

22:24 Neuralink comments - exponential increase of dementia

Bob Beamon is a multi-talented champion that has followed the path of his own inspiration to generate excitement and purpose throughout life. In order to succeed and leave a legacy on others, he had to make the decisive steps to make the right jumps in sports to break longest-standing world and Olympic records as well as in life to follow his many dreams and succeed. At the 3rd annual Medical Affairs Innovation Olympics, I sat down with Bob Beamon to learn how his sports career and multiple inspirations (basketball) influenced the decisions he has made in his personal life and success in continuing to reinvent himself as a champion in music. We explored explore what makes the long jump one of the most classic and difficult events in track and field and possibly sports, the individual components and mechanics of the jump, how his talent, circumstances, and training led to his success. In addition, he discusses his personal theories on competition, approaches to edging out competitors in sports, and transition into how he defines competition in life and what impact his environment, character, and personal inspiration have played on the kinds of jumps he has had to make in his personal life to follow multiple different and challenging paths yet succeed. In this absolutely inspirational and candid discussion, Bob speaks about his own health, how healthcare professionals throughout his career and life have helped him make personal decisions, the role his coaches and training have had on his health after retiring from sports, and what types of innovation inspire him currently or those he hopes to see in healthcare in particular.

0:00 Episode Intro 2:17 Keynote Speaker Welcome

4:20 First Jump in Bob's Life that shaped his career afterwards.

Bob's tough childhood and background 8:42 Basketball and Track Field in Police Athletic League Activities Bob wanted to find a sport in which he could simply win. 10:07 First long jump at age of 10 was 19 feet 10:43 Bob's personal approach and philosophy on competition His motivation was to be "somebody special" and "proving to people" he was going to be a "shining star" in his community. 12:23 Daily discipline of practice His goal was not only Athletic but Personal and Social Achievement 13:04 First time he competed in the Junior Olympics 14:29 Bob had no coach or supporter at the Junior Olympics He jumped 24 feet 1 inch and newspapers mentioned him as a "future Olympian" 15:18 Dean of Students became Bob's coach and "saving graces" Larry Ellis 16:47 What part of his success was due to his God-given talent vs training? Bob had the foundation - basics of jumping. He was always open to Learning and to making himself feel good about what he was doing. His drive was rooted deep inside. 19:19 How Bob put the world-record performance together in Mexico City He trained with the fastest sprinters in the world which 21:07 What makes the long jump one of the most difficult disciplines? His strong inner spirit helped him. He knew deep inside he would one day be successful. He had lost so often that he felt even 23:23 How becoming a champion influenced Bob's career and life? Many athletes are lost and do not know how to transition after ending their sports career. We need to coach athletes and prepare them for life after sports. 26:53 Bob's problem with blood pressure and kidneys 29:10 Message on healthcare innovation to the medical community Bob educated people on hypertension through opportunities opened by pharma companies. He developed kidney problems and diabetes. He dealt with health problems like a sports athlete, like an intelligent athlete. I am going to continue to be a winner. 33:33 How Bob has reinvented himself recently as a musician, drummer 38:25 Bob's experience as a percussionist and favorite instruments 42:20 How do you teach someone to find the fire inside them" Open up - How you really feel about yourself helps you open yourself to win, achieve, and find opportunities.

Bob Beamon is a multi-talented Olympic champion that has followed the "beat" of his own inspiration to make the right jumps in sports and throughout his life. In order to succeed and leave a legacy on others, he had to make the decisive steps in sports to break the longest-standing world and Olympic records as well as in life to follow and achieve his many dreams. On this episode of the @Alloutcoach podcast where sportsmanship meets the scientific method, I sat down with Bob Beamon to learn how his sports career and multiple inspirations (basketball) influenced the decisions he has made in his personal life and success in continuing to reinvent himself as a champion in music. In this conversation leading to his keynote presentation at the 3rd annual Medical Affairs Innovation Olympics event (see follow up episode - stay tuned), Bob presents a very personal, detailed account of how his particular talent, challenging circumstances, approaches to training as well as facing adversity led to his success. In addition, he demonstrates the role his life inspiration and sports competitor's character played on reinventing himself throughout his career across his life transitions including the latest one in retirement as a musician. 0:00 Episode Highlight

1:04 Episode Intro

3:08 What inspired Bob to become a sports athlete

Growing up in South Jamaica, New York, rough childhood. Bob's involvement in the Police Athletic League thanks to which he started to compete in track and field.

6:04 Bob did not stop competing because he lost consistently

8:02 Transition from sprint to long jump

8:46 First long jump competition - 19 feet at 10 years of age

10:32 Bob's family background and early loss of his mother

12:38 Junior Olympics in New York - Turning Point at age 14

15:09 What makes the long jump special and difficult

Bob's background in the triple jump. He had jumped 25 feet 6 inches in high school. The event requires consistency in training, coaching, and inner drive.

20:48 Bob's coach Larry Ellis did not force Bob to change his peculiar form of jumping

Bob's technique - jump over a hurdle during training to maintain a height. He perfected an "unorthodox" form of jumping.

24:43 Reliving Bob's 1968 World Record Jump in Mexico City

26:38 Advantage of working out with best sprinters in the world

Bob's adjustments to the long jump the day before the final only qualifying on the last attempt.

30:12 Bob's Attitude & Mindset on the morning of his World Record

32:16 Specific Goal of Winning Olympic Gold vs. World Record

34:26 The emotions of breaking a world record

38:46 Nothing compares to the Intensity of the Olympics

41:02 How Bob reinvented himself as a musician at age 77

43:48 Welcoming the new challenge of becoming a drummer

Bob played with a Grammy-award winning band, opened the Track and Field competition at the Paris 2024 Olympics with a musical performance

This is a special Episode Edition on the @Alloutcoach Podcast. Tune into this memorable highlight from the 2023 Medical Affairs Innovation Olympics event Opening Ceremony full of real-world practical case studies, striking new statistics, and critical commentary - an expert panel discussion about the details necessary to make both short-term and long-term marks on improving healthcare quality from both the perspective of a globally recognized healthcare quality expert physician and public health speaker, Dr. Rashad Massoud (Visiting Faculty T.H. Chan School of Public Health), and of an innovative pharma industry executive recognized for his leadership and dedication to patient advocacy groups, holding senior leadership roles in Commercial, Marketing, Market Access and most recently in Medical Affairs, Rob Adamoski (Vice President, Corcept Therapeutics).

0:00 Intro Music

0:22 Episode Highlight

Cushing Syndrome Case Study - Perception Gap on Treatment Quality between Patients vs their Healthcare Providers. 1:58 Speaker Introductions

4:11 Panel Discussion Outline

4:38 Global Healthcare Quality Improvement Case Study USAID Applying Chronic Care Model to Improve Coverage, Retention, and Clinical Outcomes: Uganda

16:46 Role Medical Affairs in Pharma can Play on Health Quality

17:56 Connection to Disease - Stimulating Purpose in Medical Affairs

19:29 Value of Recent and Relevant Clinical Experience in Medical Affairs

20:21 Aiming for Diversity of Experience across entire Care Continuum

22:07 Finding the Right Balance on Your Medical Affairs Team

22:58 Case Study: Personalized Medical Liaison led Executive Staff training

25:01 Critical Gaps in Training in Medical Affairs Team - benchmarking data

Larger Organizations offer more training opportunities vs mid-sized and smaller pharma or biotech companies in Medical Affairs. Only 42% of Medical Affairs organizations provide any training and only 23% of small pharma companies (Medical Affairs Professional Society)

27:01 Why Most of Us in Medical Affairs believe Metrics are not Meaningful 28:57 Power of a Graded Data Science based KPI Feedback Loop

30:12 2023 Medical Affairs Metrics Global Benchmarking Gap in Analysis70% of Medical Affairs companies do not systematically analyze how their activities lead to outcomes

30:41 The Motive to Measure Performance in Medical Affairs with KPIs

31:24 Medical Productivity Index (MPI) Model to Increase Performance

32:25 Integrating Health Systems Approaches to Metrics in PharmaAll-Mobile Hypertension Clinics that improved quality and bridges health equity gaps - India Case Study

42:38 Medical Affairs Improving Healthcare Decisions - Patient Advocacy

47:00 How Healthcare Cost relates to Quality - latest trends

49:44 How can we make Healthcare Jobs Desirable again? 52:40 Improving Quality w/ 1) Accountability & 2) Transparent Data Culture

This latest episode is centered around discussing how mentorship directly impacts our bottom line in business and personal career based on real-world examples and decades of research. I speak about this topic with a returning guest on the show, co-author of a new book and practical step by step guide just published called "Financial Times Guide to Mentoring", Dr. Ruth Gotian, Chief Learning Officer at Weill Cornell Medicine in New York.

Dr. Gotian is a globally recognized mentorship expert by Nature, Wall Street Journal and Columbia University who named her a top 20 mentor worldwide, a mentorship thought leader ranked by Thinkers50 as the #1 emerging management thinker in the world in 2021, award-winning book author of "The Success Factor" previously featured on Alloutcoach, and prolific contributor to Harvard Business Review, Forbes, and Psychology Today having interviewed Nobel Prize winners, astronauts, Olympic champions, leading physicians and scientists of our time, among others.

0:00 Episode Highlight

0:44 Episode and Guest Introduction

3:08 Advantages and disadvantages of formal versus informal mentorship programs

61% of mentorship is informal. Formal mentorship programs can however be a launching pad for those uncomfortable to seek out mentors or mentees

5:23 Why is it crucial to find mentors outside of your direct line of management?

It is important to diversify mentors in case they leave or you decide to leave.

7:14 Shared experiences in mentorship and how to identify informal mentors

Steve Kerr, NBA champion and coach's example of his lesson from a football coach and mentor: Mentorship is more than technical coaching or shared experiences. It is about shared values and the kind of culture you create in a relationship.

9:13 How mentors make impact business bottom line and job satisfaction

Those who have a mentor earn more, are happier at work, and stay longer. 89% of employees with mentors feel their contributions are valued by others.

11:28 Most common barriers and misconceptions in mentorship

15:36 How do you continue to learn informally despite higher titles or roles?

18:29 What proportion of mentorship should be informal vs. formal or experiential?

22:40 Should minorities, women, etc seek mentors with the same background?

24:41 What surprised Dr. Gotian during the writing process of her latest book?

25:45 How Dr. Gotian and her co-author Andy Lopata complement each other?

27:52 How do you tell when mentorship is successful?

29:38 Biggest achievement with "Financial Times Guide to Mentoring"

31:11 How Dr. Gotian is stretching herself and lifting others in her next projects

On the latest episode of Alloutcoach, I spoke to Neel Doshi whose research on human motivation and performance has inspired me over the years.

Watch this video podcast to understand why I consider him one of the brightest minds in organizational change research who has created forward-thinking solutions that can transform your business. Neel Doshi is Co-founder and CEO of Vega Factor and Factor.AI https://www.factor.ai, NY Times and Wall Street Journal best-selling author of "Primed to Perform", multiple award-winning founder of various tech startups, MIT graduate in engineering and Wharton Business School MBA.

0:00 Intro 0:08 Episode Highlight 1:52 Neel Doshi Introduction 3:30 Why Neel decided to study human performance at work His journey from first job as software engineer at major bank and personal frustration from lack fulfillment and mediocre attempt at starting a company to researching the root causes and drivers of human motivation at work for the next 15 years 7:56 Various types of industries Neel Doshi has researched 8:58 Distinguishing and Ranking Tactical vs. Adaptive Types of Performance at work Tactical Performance refers to alignment to roles, objectives, and goals while adaptive performance refers to innovation, problem-solving, and improvisation. 13:23 Measuring Motivation to produce both Tactical and Adaptive Performance at Factor.AI Research indicates 6 motivational factors along a spectrum of stimulating or inhibiting performance: 1) play 2) purpose 3) potential (3 positive factors that stimulate adaptive performance), followed by 4) emotional pressure, 5) economic pressure, and 6) inertia (3 negative / inhibiting factors) in descending order 21:42 Tesla Model 3 Mass Market Case Study Real-world example confirming that relying completely on Tactical Performance alone through technology is insufficient and detrimental, and Adaptive Performance via human capacity to think critically is central to driving growth in business. Elon Musk's 2009 Tweet: "Excessive automation at Tesla was a mistake. To be precise, my mistake. Humans are underrated". 24:50 How do you measure performance through profitability vs social impact? Majority of the motivation of performance is local to the employee not global to the company. This is why social impact is not a driver of motivation or performance. 29:20 How to both perform and collaborate today when the pace of competition is rising so rapidly. Companies do not have to turn increasing external competition and global pressures into coersion and blame. They can make competition fun. Competition can make work more purposeful because an employee can feel like he/she matters more in the presence of an adversary. Companies turn competition into pressure rather than play and purpose. Play and purpose, our highest performance motivators are not bound by a limit and do not represent a zero-sum game unlike emotional or economic pressure, for example. So if companies are using emotional or economic pressure or indirect motives to drive performance they are fracturing collaboration by design. Collaboration suffers, and so does problem-solving and adaptive performance. When I do not have companies I work with that have internal competition, I create competitions. 35:13 What are some examples of new ways of working to drive higher motivation at work? Hierarchies and distinct roles are important to communicate diverse vantage points and perspectives. Metrics make work more fun because they provide a scoreboard to a game and can drive stronger performance as long as they are not weaponized by leaders. Similarly, performance reviews should be used not to blame and shame people but should involve teams to evaluate team performance together rather than use individual reviews to measure teams. 45:10 How Neel is currently stretching himself and lifting others Engineering stronger performance has become a science and there are specific solutions we have now built that are available for you.

In this Part 2 of the Alloutcoach podcast episode focused on phage therapy to fight infections and antimicrobial resistance, I spoke to the Chief Physician at the globally leading center of excellence of an alternative, effective treatment approach to antibiotics, Dr. Dea Nizharadze at the Eliava Phage Therapy Center (EPTC) based in Tbilisi, Georgia. She explains the basic principles of phage treatments, its unique qualities, advantages and real-world clinical examples of methods and types of patients and infections this personalized therapy specifically targets.

0:00 Episode Introduction

1:42 Why the Republic of Georgia is a global leader in phage therapy

2:39 How phage therapy works in bacterial infections?Eliava Phage Therapy Center (EPTC) was founded in 1923 by Professor George Eliava who had collaborated with Felix D'Herelle, who had discovered phages, and while most other countries turned to antibiotics only, it is the only institution in the world that has continued to research bacteriophages without a pause of even one day since its inception and therefore collected the greatest research and real-world clinical experience with phages.

5:34 How do phages work to eradicate or stop further growth of bacteria?

Phages are biological "weapons" against bacteria, namely viruses that target specific microbes only, without destroying the "good" bacteria or microbiota. They are naturally occurring substances and have no safety concerns. In some patients with antimicrobial resistance phage therapy enables improvement in sensitivity.

10:42 Synergistic effect of phage combination therapy with antibiotics

11:58 Phage Therapy Doisng and Success Factors

15:14 Length of phage treatmentIn chronic infections phage therapy may divided into 3 stages and last 15-20 days, and varies by nature and severity of disease. Patient treatment includes days off therapy, or holidays, however, bacterial analysis is continued and patient condition is monitored throughout the entire course of treatment. Success of therapy is indicated when bacterial titers and virulence decrease or bacteria are eradicated. Patient's objective and subjective signs and symptoms often vary throughout response to therapy. 16:42 Phage Product Variability and Market Availability

How do we ensure educating patients to access the correct, most appropriate therapy for their infections

17:35 Multi-disciplinary personalized team care and telemedicine

19:53 Steps for patients outside of Georgia to access phage therapy via telemedicine?

24:04 Affordability and access to phage treatments

25:23 How to contact Eliava Phage Therapy Center

In this special episode I spoke with an international guest from my native country, Republic of Georgia, and global ambassador of a critical alternative solution against tough chronic infections and antimicrobial resistance on behalf of a global center of excellence in bacteriophage therapy, discovered over 100 years ago. My guest, Davit Sturua, Doctor of Business Administration, Public Health and Medical Tourism expert, is the director of the Eliava Phage Therapy Center, a global leader in real-world, clinical, research, and commercial experience with naturally occurring bacteriophage treatments. He discusses the Georgian center's 100-year old history and evolution, its extensive experience treating patients across 84 countries, explains the current global public health problem, and provides an update along with rationale on the recent growth in clinical studies investigating phage therapy across the globe in this part 1 of 2 episodes on this topic. Watch this episode with English subtitles to learn about how you, your friends, family, healthcare payers and experts, healthcare providers, patients and their loved ones can consider alternative options via telemedicine or in person to treat chronic, tough bacterial infections or prevent antimicrobial resistance. Stay tuned for the next episode (part 2) on this topic with my guest Dr. Dea Nizharadze, Chief Physician at the Eliava Phage Therapy Center, who delves deeper into the typical course of treatment, patient journey, and various scientific attributes of phage treatments.

0:00 Introduction

0:08 Introduction in English

2:19 Special Guest Mr. Davit Sturua, Director of Eliava Phage Therapy Center Introduction in English

4:34 Episode Introduction in Georgian (English subtitles)

4:53 Overview of Part 1: Overview of 100-year history of Eliava Phage Therapy Center, its advances, growth, current goals and Part 2: Scientific Rationale for phage treatment, appropriate patients, typical course of treatment, and access to care for patients worldwide

5:54 Davit's personal inspiration and history at the Eliava Center

10:27 How is EPTC raising awareness about phage therapy outside of Georgia? The center has treated patients from 84 different countries in 2023 alone. The majority of patients internationally who obtain care from EPTC suffer from various antibiotic-resistant or chronic infections.

12:20 5 million patients die from antimicrobial resistantce every year - underestimation, with tens of millions of deaths projected by 2050

13:04 Future Scientific and Commercial goals of Eliava Center to expand globally, standardize phage production to meet GMP standards, conduct randomized clinical studies and secure access for patients worldwide

15:23 Challenges in scaling phage production and quality standardization.

Georgia is currently a global leader in commercial production of bacterial phage treatments. While only a few years ago there were only a handful of clinical studies conducted globally, currently there are over 50 clinical studies in 2023-2024 alone over the past year being conducted in the United States alone. Similarly, other European countries, particularly Great Britain are also actively pursuing and advancing clinical research in bacteriophage therapies. Government and research funding in phage treatment is therefore continuing to grow rapidly.

18:33 Final Greetings - Conclusion of Part 1. Invitation to partner across Europe and the U.S. with the Eliava Phage Therapy Center

Patients with obesity are at the forefront of latest developments in medicine once again, with new options but many new questions still to be solved, including a public health emergency and shortage despite the latest advances. In this latest interview Angela Fitch MD, FACP, FOMA, Dipl. ABOM critically reviews the advances, public health emergency, and problems with patient access to obesity treatments with an important call to action to the entire healthcare community. She offers a scientific overview of latest obesity treatments, incredibly practical solutions as well as valuable tips for treatments of obesity you do not want to miss!

Angela Fitch, MD, FACP, FOMA is a leader in the field of obesity medicine, immediate past president of the Obesity Medicine Association, Assistant Professor of Medicine at Harvard University, and former co-director of the Massachusetts General Hospital Weight Center. She is a dedicated clinician, as well as an activist for obesity medicine, board member of the Obesity Action Coalition, and a founding member of the Massachusetts Coalition for Action on Obesity. 0:00 Episode Highlights - Public Health Emergency: only 5-10% of 140 million patients w/ access to obesity care

1:36 Episode + Guest Introduction

3:31 Inspiration behind Dr. Angela Fitch's activism + specialization in Obesity

3:56 Background in engineering, primary care with GLP1 agonists

5:16 Obesity is a heterogeneous chronic disease

7:26 How far we have advanced in obesity treatments from phentermine and topiramate to semaglutide (Wegovy)or tirzepatide (Zepbound) and their relative probability in losing 20% bodyweight

8:49 Surgery vs newer GLP1 and other obesity treatments and new investigational drug retatrutide

10:03 Triple mechanism of experimental new obesity drug retatrutide

10:16 Comparison of Tirzpatide - double agonist (GLP1 / GIP): Semaglutide - single mechanism (GLP1) agonist, and retatrutide - triple agonist (GLP1, GIP, and glucagon)

11:18 Success Factors in Obesity Treatments

13:01 Why lifestyle and diet are not effective in many patients

13:41 Personal case study of diet and weight loss with associated GERD

14:24 Dr. Fitch's lifestyle tips: 5P's: planned portions, plants + protein, power, pillow, pause

15:48 Our society does not promote healthy nutrition

18:38 Lifestyle effective in only 5% of patients with obesity

19:02 Weight loss and maintenance - two different biologic phenomena

21:00 How to gain a Metabolic Advantage

23:28 Weight loss maintenance post surgery vs medications

25:32 How patients can access drugs despite obesity medicine shortage

26:06 Public Health Emergency - Obesity Medicine is not a Standard health insurance benefit in the U.S.

28:33 140 million Americans qualify for treatment, but only 5-10% receive it

29:26 Why we are awaiting new drug approvals - why patients are turning to non-FDA approved options

31:00 Reality - alternative ways patients are accessing obesity treatments

31:36 Dr. Fitch's solutions - declare public health emergency, consider vial formulations, coordinate comprehensive care

34:42 Call to Action and Challenge to Healthcare Community

39:23 Dr. Fitch's Current and Future Focus

39:57 Expansion of Dr. Fitch's knownwell patient centered medical home & collaborative practice across new locations in the U.S., 75% telemedicine

If you have an interest in digital health or digital therapeutics and want to know the latest analyses, trends, and tangible lessons, my latest guest on Alloutcoach, Giorgia Pezzotta is the person I strongly recommend that you follow. Giorgia is a health and innovation engineer, emerging leader, and entrepreneur recognized among 100 under 35 young talents by Financial Times to innovate the "future of Italian entrepreneurship worldwide". She is personally committed to driving change, creating strategic innovation, and promoting social impact.

Her purpose is to ensure that innovation and technology improve people's health and healthcare management, and deliver a better future for our society.
She works as Key Account Project Manager at a French unicorn digital health company Doctolib, and an instrumental part of the Italian launch team of hospitals. Doctolib is the first digital health service in Europe and one of the fastest-growing healthcare tech companies. Giorgia previously served as a healthcare consultant at KPMG Advisory S.p.A.
0:00 Highlight from Episode - Advantages of continuous monitoring of root causes of chronic disease with remote patient monitoring, digital wearables and telemedicine to reach more patients in rural areas

1:45 Episode + Guest Introduction

3:44 Giorgia's Journey to her Passion for Health Innovation

7:58 Unique Learning Motive behind Digital Health Content Strategy

8:48 What are the latest health innovations with biggest impact on patients?

13:57 Where are the biggest investments focused on health innovation?

16:14 What are some quality metrics and standards among different Digital Health products?

19:08 Are there any plans to accelerate regulation and approval of digital therapeutics globally?

22:11 How should patients choose which digital health app to use?

25:36 Lessons for Entrepreneurs in Digital Health

28:47 Final Message: Importance of finding someone who believes in you