What happens when AI meets the earth’s natural heat? Join us as we explore how Fervo and global partners are harnessing AI to unlock geothermal energy’s potential—delivering clean, flexible power around the clock. From Houston to the Middle East, we examine the science, policy, and investment trends driving the energy transition, and how geothermal could help power the AI revolution itself. Guests include: Fahad Alajlan, President at King Abdullah Petroleum Studies and Research Center (KAPSARC) Josh Posamentier, Co-Founder and Managing Partner of Congruent Ventures Tim Latimer, Co-Founder and CEO of Fervo Energy Tom Mitchell, Partner at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Discover how AI is breaking down barriers to education and tailoring learning experiences for students everywhere. From Duolingo’s global reach to the innovative use of AI in real classrooms at Miss Porter’s School in Connecticut, this episode explores how technology is expanding access, enhancing engagement, and equipping the next generation with essential skills—while ensuring integrity and safety remain at the forefront. Guests include: Luis von Ahn, CEO and Co-Founder of Duolingo Henry Ellenbogen, Chief Investment Officer at Durable Capital Partners Maureen Lamb, Latin teacher and the Language Department Chair at Miss Porter's School Dean Dimizas, Partner and Managing Director at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Get ready—Season 6 of Unseen Upside launches October 21. This season, we’re taking you behind the scenes to explore how AI is transforming our world. From labs and classrooms to clinics and fields, we’ll follow the capital and uncover how AI is driving the next chapter of human progress. Tune in for episode one on your favorite podcast platform, Tuesday, October 21.

Once numbering in the tens of millions, the American bison was nearly driven to extinction by the early 1900s. But a coalition of conservationists, Native American communities, and private partners were determined to save the species. Join us for this mini episode of Unseen Upside: Investments Beyond Their Returns, as we share the remarkable story of the bison’s restoration alongside John Calvelli, Executive Vice President of Public Affairs at Wildlife Conservation Society. Stay tuned for Season 6 which explores the transformative impact of AI across industries—launching Tuesday, October 21. In the meantime, catch up on past episodes in our podcast feed! Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Summer isn't over just yet--Unseen Upside is bringing you Part 2 of our summer reading list! Tune in as we share more book recommendations from investors and entrepreneurs on the leading edge of healthcare. Check the show notes for links to all the recommendations, and catch up on past episodes in our podcast feed. Stay tuned for Season 6—launching soon. Featured Recommendations: The Frozen River: A GMA Book Club Pick by Ariel Lawhon The Hard Thing About Hard Things: Building a Business When There Are No Easy Answers by by Ben Horowitz Zero to One: Notes on Startups, or How to Build the Future by Peter Thiel  Clayton M. Christensen’s Books Fifty Miles from Tomorrow by William L. Iggiagruk Hensley A Fortunate Man: The Story of a Country Doctor by John Berger  Guests Include: Theresa Hajer, Head of US Venture Capital Research at Cambridge Associates Alyssa Jaffe, Partner at Seven Wire Ventures Lucas Trout, Lecturer on Global Health and Social Medicine at Harvard Medical School Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

As summer heats up, Unseen Upside brings you a special two-part mini-episode packed with inspiration for your reading and listening list. From thought-provoking explorations of social justice and capitalism to the latest in women’s sports and business innovation, this short episode is your guide to what’s fueling the minds and spirits of those driving change in healthcare, housing, and beyond. Whether you’re looking for your next great read, a podcast to spark new ideas, or just want to know what’s on the radar of industry leaders, this episode has you covered. Check the show notes for links to all the recommendations, and stay tuned for part 2 of our guests' summer picks soon! Featured Recommendations: Weathering: The Extraordinary Stress of Ordinary Life in an Unjust Society by Dr. Arline T. Geronimus James (Pulitzer Prize Winner) by Percival Everett Outliers: The Story of Success by Malcolm Gladwell Just Mercy: A Story of Justice and Redemption by Bryan Stevenson A Brief History of Seven Killings (Booker Prize Winner): A Novel by Marlon James  Queens of the Court (The Women’s Hoops Show Podcast) Americana: A 400-Year History of American Capitalism by Bhu Srinivasan Acquired: Novo Nordisk (Ozempic), Season 14, Episode 1 Unseen Upside: Appetite for Change: The Obesity Epidemic Meets Biotech Guests Include: Chavon Sutton, Managing Director, Sustainable & Impact Investing at Cambridge Associates Lynne Chou O’Keefe, Founder and Managing Partner at Define Ventures Tim Ortez, Chief Financial Officer of the Weingart Foundation Margaret Anadu, Senior Partner at The Vistria Group Jasmine Richards, Head of Diverse Manager Research at Cambridge Associates Gunnar Esiason, Head of Patient Engagement at RAVen (RA Ventures) Dean Dimizas, Partner in the Private Client Practice at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

There’s a maternal health crisis in the United States, with high rates of maternal mortality, especially among marginalized communities. But what is being done to improve it?  Through conversations with those on the front lines, we uncover the stark health inequities that exist in maternal healthcare and the developments created to tackle them. We also hear from mothers who have firsthand experience with Preeclampsia—a serious pregnancy complication and one of the many causes of maternal mortality— and one company on a quest to cure it.   Guests include: Scott Gottlieb, MD, Partner at New Enterprise Associates and Former FDA Commissioner Scott Johnson, MD, Chief Executive Officer and Co-Founder at Comanche Biopharma Jennell Lynch, Chief Executive Officer and Founder at Executive Doula Agency  Theresa Hajer, Head of US Venture Capital Research at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

How will evolving digital technologies impact healthcare delivery, patient experience, and access to care? According to new venture-backed companies, they can advance health equity, democratize access, and empower individuals to take control of their health journey. Alongside industry pioneers and investors, we explore digital health advancements such as telemedicine, remote monitoring, and data-driven diagnostics that are all working to improve healthcare efficiencies. Join us as we uncover the potential of these technologies to improve healthcare outcomes for all. Guests include: Lynne Chou O'Keefe, Founder & Managing Partner at Define Ventures Siva Namasivayam, CEO & Co-Founder at Cohere Health Chavon Sutton, Senior Investment Director in the Sustainable & Impact Investing Research Group at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Join us in Kotzebue, Alaska to explore the issue of rural healthcare and the inequities faced by these communities. We shine a light on innovative solutions aimed at improving rural healthcare delivery, like a program called Siamit that’s connecting cutting-edge medicine from Massachusetts General Hospital (MGH) and Harvard Medical School to the tribal regions of Alaska. We also look at the role of venture capital in driving advancements that promote access to healthcare for those living in rural parts of the country. Guests include: Lucas Trout, Lecturer on Global Health and Social Medicine at Harvard Medical School Susan Rawlings Molina, Co-Founder and CEO at GroundGame Health Alyssa Jaffee, Partner at 7wireVentures Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Prescription drug prices in the United States are 2.78 times higher than in other developed countries, but why? We untangle the barriers surrounding drug affordability and find out why accessing life-saving medications is costly to so many. Joined by experts, advocates, and one Cystic Fibrosis patient relying on expensive medication to live, we examine the complex factors contributing to the high costs of drugs, from research and development to pricing strategies and supply chain dynamics. We also investigate potential solutions to improve access and affordability without compromising on drug innovation. Guests include: Peter Kolchinsky, Founder and Managing Partner at RA Capital Gunnar Esiason, Head of Patient Engagement at RAVen (RA Ventures) Dean Dimizas, Partner in the Private Client Practice at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Join us as we head to the Bronx to examine the critical intersection of housing and health and the innovative solutions that are aiming to address the affordable housing crisis in major cities like New York and LA. Through conversations with non-profit leaders and impact investors, we dive into how affordable housing impacts public health and health equity, highlighting the investment strategies and community partnerships that are moving the needle. We also discuss the challenges of housing insecurity and the disproportionate effects on marginalized communities, recognizing affordable housing is a critical determinant of community health.  Guests include: Margaret Anadu, Senior Partner at The Vistria Group Tim Ortez, Vice President & Chief Financial Officer at Weingart Foundation Jasmine Richards, Head of Diverse Manager Research at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

How does venture capital contribute to advancing health equity and public health? Find out on season five of Unseen Upside, premiering Tuesday, October 8. This season, we dive into how today's investment decisions are shaping tomorrow's innovations in critical areas such as affordable housing, maternal health, drug pricing, and more. Join us for engaging conversations with investors and entrepreneurs as we uncover the profound impact of venture capital on our lives on a grand scale. Powered by the global network of Cambridge Associates, join us to explore healthcare investments beyond their returns. Listen now to Unseen Upside. 

While we’re busy pulling together stories for the fifth season of Unseen Upside, we thought you might be curious about what it is that Cambridge Associates actually does. In a nutshell, we have the privilege of partnering with some of the world’s top institutional investors—like nonprofits, universities, hospitals, pension plans, and even private families—and we try to help them reach their investment goals. Recently, we had a conversation with four of our non-profit clients from institutions with assets ranging from $200 million to $850 million to understand why they chose to outsource day-to-day portfolio decisions so they could focus on bigger picture strategy for their organizations. Their stories offer insight into how we collaborate with clients so they can do even more for the communities they serve.  Don’t forget to check back this fall for the latest season of Unseen Upside: Investments Beyond Their Returns. Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Artificial intelligence is transforming healthcare, unleashing new investment opportunities. From cancer screening to drug discovery, AI promises to augment clinical decision-making and improve care.  We’ll explore the surging ecosystem of medical AI innovations, from the emerging tech landscape to practical deployment. But what are the challenges facing real-world implementation? Which applications show the most promise?  Join us as we investigate how artificial intelligence can change healthcare for the better while examining what it will take to do it well.  Guests include: Bob Nelsen, Co-Founder and Managing Director at Arch Venture Partners Daphne Koller, Founder and CEO at insitro David Baker, Ph.D., 2024 Nobel Prize in Chemistry Laureate, Director at the Institute for Protein Design and Professor of Biochemistry at University of Washington Theresa Hajer, Partner and Managing Director of Venture Capital Research at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Autoimmune diseases like lupus impact over 5 million patients globally, but treatment options remain limited. Now, decoding the once mysterious "dark genome" could bring new therapies. Over 90% of our DNA was once considered "junk"—but we’ve learned this dark matter regulates gene expression and human disease. This episode takes you to the pioneers who are unlocking the dark genome's potential to correct root causes of complex conditions like lupus. We'll chat with those illuminating this uncharted territory and developing novel approaches.  Guests include: Rosana Kapeller, M.D., Ph.D., Co-Founder, President, & CEO at Rome Therapeutics Steve Kafka, General Partner at S32 Keri Mastrogiacomo, mother of a Lupus patient Katherine Cavanagh, Associate Investment Director at Cambridge Associates  This episode has named a Winner by the International Women’s Podcast Awards for their “A Moment of Visionary Leadership” category. Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Obesity is a global health crisis, with over 650 million adults affected worldwide. This drives massive economic and disease burdens. Yet new treatment options like GLP-1 drugs offer hope. This episode analyzes the investment landscape and future of obesity therapeutics, focusing on transformational GLP-1 drugs like Ozempic that curb appetite. Join us as we investigate the promise and challenges of emerging anti-obesity drugs, learn about one patient’s journey taking them, and discover what the future of weight loss medicine could look like. You'll hear from leaders in the space as well as a current patient taking these medications. Guests include: Rod Wong, Founder, Managing Partner, and Chief Investment Officer at RTW Investments Raymond Stevens, Ph.D., Chief Executive Officer at Structure Therapeutics Dean Dimizas, Partner and Managing Director at Cambridge Associates Kathleen Mikaelian, Patient Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Precision oncology represents an exciting shift in cancer treatment from a one-size-fits-all approach to personalized care based on each patient's unique cancer and molecular makeup. In this episode, we'll explore how precision oncology is transforming the landscape of cancer care and improving outcomes at leading hospitals like St. Jude Children’s Research Hospital. We'll discuss the latest precision diagnostic technologies enabling doctors to analyze a tumor's molecular profile and match targeted therapies to save lives. Join us as we investigate the promise of precision medicine to make cancer treatment more effective and more equitable. Guests include: Rick Shadyac, President and CEO at ALSAC, the fundraising and awareness organization for St. Jude Children’s Research Hospital, a Cambridge Associates client Matt Gevaert, Co-Founder and Board Member at Kiyatec Jason Robart, Co-Founder & Managing Partner at Seae Ventures Jeff Blazek, Partner and Head of the Northeast & Midwest Endowment & Foundation Practice at Cambridge Associates, who works with ALSAC/St. Jude as one of his clients, in partnership with Anurag Pandit, CIO of ALSAC/SJCRH, and the Investment Department. Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

Thanks to medical advances, we're living longer lives but with that comes rising rates of Alzheimer's disease. Currently 6 million Americans have Alzheimer's, and that could triple by 2050. This episode explores emerging innovations offering hope against neurodegenerative diseases. We'll discuss promising new drugs that could slow cognitive decline and the strides scientists are making towards understanding causes and developing therapies—and how these breakthroughs are giving hope to one family fighting to save their mom.  Episode two explores the history of Alzheimer’s, its current challenges, and the promising therapies made possible by innovation and investment. You’ll hear from: Dr. Asa Abeliovich, Neurologist, Molecular Geneticist, and Founder and CEO at Leal Therapeutics Carl Gordon, Managing Partner and Head of Global Private Equity at OrbiMed Ham Lee, Co-Head of the Healthcare Practice at Cambridge Associates Randi Casciano, Director of Global Public Relations at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

The mental health crisis is growing, especially among Gen Z (91% report anxiety or depression). This episode explores innovations in mental healthcare access, new therapeutic approaches for young people and families, and how hospitals are striking creative partnerships to tackle this emergency. Tune in to learn what’s working and showing promise in mental healthcare, glimpses of what the future could look like, and where persistent gaps remain. Hear from leaders Melody Dickerson (VHC Health); Emily Melton (Threshold Ventures); Naomi Allen (Brightline); and Bridget Sproles (Cambridge Associates).

The future of healthcare is here. Get an an inside look at the innovations transforming lives on season four of Unseen Upside, premiering Tuesday, February 6. This season, we pull back the curtain on cutting-edge advancements at the intersection of technology and medicine, learn how AI is revolutionizing diagnostics and treatment, discover the potential of GLP-1s to combat obesity, and how breakthrough Alzheimer's therapies are offering hope to millions. We'll also uncover creative approaches to solving the mental health crisis. Powered by the global network of Cambridge Associates, join us to explore healthcare investments beyond their returns.