In this episode of the UEG Podcast, our host Pradeep Mundre, together with IBD expert Klaartje Bel Kok, explore the latest breakthroughs in IBD presented at UEG Week 2025 in Berlin. From long-term IL-23 inhibitor data to novel drugs such as Obefazimod and Tulisokibart, the discussion covers key findings that are reshaping IBD management. Bel dives into new insights on JAK inhibitors in pregnancy, the growing role of ultrasound monitoring in IBD, and the challenge of choice overload in treatment decisions. Tune in for expert reflections on emerging research, collaboration within the IBD community, and the evolving understanding of IBD’s complex aetiology.

Join Julia Mayerle and Francisco X. Real (Paco) as they reflect on the first-ever Digestive Disease Mechanism (DDM) Summit, introduced during UEG Week 2025 in Berlin. In this special episode, they discuss how the DDM Summit brought together leading scientists and clinicians to explore the mechanisms driving GI cancers — from colorectal to pancreatic and liver cancer. Hear how cutting-edge discoveries in genomics, metabolism, and tumour microenvironment are already shaping translational research and clinical trials. Julia and Paco also share highlights from the meeting, including exciting poster sessions, emerging collaborations, and their vision for the next DDM Summit focusing on inflammation in GI disease. - 08:00 The evolution of colitis-associated colorectal cancer Trevor A. Graham (United Kingdom) - 09:45 Tumour cell plasticity and immune evasion in metastatic colorectal cancer. Eduard Batlle Gomez (Spain) - 11:45 Cutting the nerve supply to pancreatic cancer Andreas Trumpp (Germany) - 16:40 Neutrophil-driven inflammation in PDAC progression Dieter Saur (Germany) - 17:30 Exploring the therapy-associated tumour immune microenvironment across the spectrum of HCC Tom Bird (UK) - 17:45 Intermittent fasting in MASH and liver cancer Suchira Gallage (Germany) - 17:50 Metabolic drivers of cancer and obesity-related diseases Guadalupe Sabio (Spain)

In this episode, host Eglė is joined by Manmeet Matharoo (St Mark’s Hospital, London) to reflect on the highlights of UEG Week 2025 in Berlin from an endoscopy perspective. Together, they discuss the shift towards precision endoscopy, smarter patient and lesion selection, and the philosophy of “treat the patient, not the polyp.” The conversation explores how concepts such as cold-snare resection, training quality assurance, and green endoscopy are shaping modern practice. They also touch on leadership, mentorship, and the medical community’s role in tackling misinformation online — a thoughtful look at how endoscopy is evolving towards safer, more personalised care. [02:05: Rutter MD, Ranjan R, Westwood C, et al. BSG/ACPGBI guidance on the management of colorectal polyps in patients with limited life expectancy. Gut 2025; 74: 1551-1560.](https://doi.org/10.1136/gutjnl-2025-335047) [03:05: Cancer and IBD: Mitigating risk among uncertainty](https://congressplatform.ueg.eu/exhibition/dashboard#/stream/uegw2025-62b/28307) [06:45: Cold snaring for small polyps or serrated polyps: Is this the answer?](https://stream.ueg.eu/week2025/crs/cold-snaring-for-small-polyps-or-serrated-polyps-is-this-the-answer) [07:05: Cold snaring for large adenomas: Can it be an answer?](https://stream.ueg.eu/week2025/crs/cold-snaring-for-large-adenomas-can-it-be-an-answer) [09:15: NHS clinical endoscopist training programme](https://www.hee.nhs.uk/our-work/endoscopy/clinical-endoscopist-training-programme) [10:05: ESGE Academy](https://academy.esge.org/) [10:10 Gieqs](https://www.gieqs.com/) [12:40: Opening Plenary: Words of welcome](https://stream.ueg.eu/week2025/crs/words-of-welcome-18) [13:10: Lars Aabacken: UEG Lifetime Achievement Award](https://stream.ueg.eu/week2025/crs/ueg-lifetime-achievement-award-7) [14:00: How to fight fake news in medicine?](https://stream.ueg.eu/week2025/crs/how-to-fight-fake-news-in-medicine) [16:00: LONG-TERM OUTCOMES AND OPTIMAL TREATMENT STRATEGIES AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR T1 COLORECTAL CANCER: A REAL-WORLD MULTICENTER PROSPECTIVE STUDY BY THE HIROSHIMA GI ENDOSCOPY RESEARCH GROUP](https://stream.ueg.eu/week2025/crs/long-term-outcomes-and-optimal-treatment-strategies-after-endoscopic-submucosal-dissection-for-t1-colorectal-cancer-a-real-world-multicenter-prospective-study-by-the-hiroshima-gi-endoscopy-research-group)

Our hosts Egle and Pradeep take you back to UEG Week 2024 in Vienna, where they spoke with visitors from across the globe. Discover their impressions, experiences, and highlights — from career-boosting opportunities to inspiring scientific sessions and the vibrant community spirit. Tune in and get ready for what awaits at UEG Week 2025 in Berlin. Don’t miss the chance to hear why participants call UEG Week a “must” every year!

How can we ensure young patients with chronic digestive and liver diseases move safely and smoothly from paediatric to adult care? In this episode, Pradeep speaks with Professor Patrizia Burra (University of Padua, Italy; Chair of UEG Public Affairs Group) and Dr Jorge Amil Dias (Hospital Lusíadas, Porto, Portugal; ESPGHAN representative in UEG Public Affairs Committee).

In this episode of UEG Talks, host Egle and co-host Charles Murray sit down with Alexander Goldowsky, a gastroenterologist and gut microbiome expert, to explore the unique healthcare challenges faced by sexual and gender minority (SGM) groups. They discuss the stigma and discrimination that impact SGM patients, the broader implications for their health, and the urgent need for greater awareness, education, and advocacy in gastroenterology. Alexander also introduces Rainbows in Gastro, a pioneering initiative aimed at improving SGM healthcare within the field, and highlights the role of individual responsibility in driving meaningful change. https://rainbowsingastro.org/

During the summer holidays, UEG Talks re-releases older episodes: In this episode of UEG Talks, host Pradeep Mundre is joined by two experts in AI applications for endoscopy: Louis Lau from the Chinese University of Hong Kong and Alanna Ebigbo from the University Hospital in Augsburg. In the first part of the episode, they discuss the basic concepts of AI and its utility in the upper GI tract.

During the summer holidays, UEG Talks re-releases older episodes: In this episode of UEG Talks, host Pradeep Mundre is joined by two experts in AI applications for endoscopy: Louis Lau from the Chinese University of Hong Kong and Alanna Ebigbo from the University Hospital in Augsburg. In the first part of the episode, they discuss the basic concepts of AI and its utility in the upper GI tract.

In this episode, host Egle speaks with former UEG President Axel Dignass about what it takes to lead in times of crisis. Drawing on his experience during the COVID-19 pandemic, Axel reflects on the difference between being a boss and being a true leader. He shares thoughts on the value of empathy, transparency, and consistency, as well as how to build and sustain a resilient team. The conversation also touches on the challenges of going virtual, the importance of recognising team achievements, and the warning signs of toxic leadership. A must-listen for anyone looking to grow as a leader in uncertain times.

In part two of our discussion on the new MAPS 3 guidelines, the discussion spans advances in endoscopic techniques, the emerging role of AI in detection, and current best practices in managing early gastric cancer. Tune in to hear our host, Pradeep Mundre, talk to Mario Ribeiro, who shares his insights on identifying pre-malignant lesions, avoiding common surveillance pitfalls, and understanding how PPIs may influence cancer risk.

In this first part of our episode on the new MAPS 3 guidelines on gastric cancer prevention, host Pradeep Mundre is joined by Mario Dinis-Ribeiro. They explore who should be screened, how to approach surveillance, and why family history matters. Part two of this episode will be released on July 9th.

Functional gastrointestinal disorders, or disorder of gut-brain interaction, can be frightening to many GIs. How do I talk to the patient? What can I tell them if there is no improvement in their symptoms? How can I even explain to them what their diagnosis is, if I don’t even know it? To clear things up and provide clear points of action, our host Egle Dieninyte talked to Tim Vanuytsel from the University Hospital in Leuven, Belgium.

In the second part of our short two-part series on complications (not only in endoscopy, but also in doctor-patient communication), Srisha Hebbar and Pradeep Mundre sit down again to focus on the patient perspective, serious complications and the psychological aspect of complications.

Complications, not only in endoscopy but also in doctor-patient communication, are something that every experienced gastroenterologist has encountered. To talk us through this, our host Pradeep Mundre has invited Srisha Hebbar, a consultant gastroenterologist from the UK and host of the first national symposium on complications in endoscopy. The second part of this episode will be released on May 21st 2025.

Hot off the press: The BOSS (Barrett’s Oesophagus Surveillance Versus Endoscopy at Need Study) randomised control study. Is surveillance really not affecting survival in oesophageal cancer patients? To put things into perspective, we asked Massimiliano Di Pietro, UEG Talks podcast veteran and oesophageal cancer expert, to guide us through these exciting new results. Hosted by Pradeep Mundre, this bonus episode, combined with our previously released two-part series on oesophageal cancer (also with Massimiliano Di Pietro), covers everything you should know about oesophageal cancer.

The ESGE days 2025 from the 3rd to the 5th of April have ended. Interviewed at the conference, (now former) ESGE president Ian Gralnek shares his insights on the ESGE days program, the future of endoscopy, airline pilots and English & Lithuanian proverbs. *In the beginning of the episode, Egle is talking about the ESGE days, not UEG Week 2025, which is happening on October 4-7.

In this episode of UEG Talks, host Egle and co-host Charles Murray sit down with Alexander Goldowsky, a gastroenterologist and gut microbiome expert, to explore the unique healthcare challenges faced by sexual and gender minority (SGM) groups. They discuss the stigma and discrimination that impact SGM patients, the broader implications for their health, and the urgent need for greater awareness, education, and advocacy in gastroenterology. Alexander also introduces Rainbows in Gastro, a pioneering initiative aimed at improving SGM healthcare within the field, and highlights the role of individual responsibility in driving meaningful change. https://rainbowsingastro.org/

In this second part of our short two-part series on oesophageal cancer, our host, Pradeep Mundre, continues his conversation with Massimiliano Di Pietro about the risk factors of Barrett’s oesophagus, the role of proton-pump inhibitors, surveillance strategies and some future directions of oesophageal cancer research.

In the first part of this two-part series, our host, Pradeep Mundre, talks to oesophageal cancer expert Massimiliano Di Pietro about the epidemiology and treatment of oesophageal cancer, how this has changed over time and if there is potential for prevention. The second part of this episode will be released on March 5th.