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The TBPod
Actnet
44 episodes
5 months ago
Associate Professor Nicolas Alan Menzies, from the School of Global Health and Population at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, joins Dr Andrew Burke to discuss his research on the contribution of post-TB sequelae to life-years and quality-adjusted life-years lost due to TB disease in the United States. Drawing on data from both U.S. and Brazilian cohorts, he explores how a significant portion of TB’s health burden, including elevated mortality and reduced...
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Associate Professor Nicolas Alan Menzies, from the School of Global Health and Population at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, joins Dr Andrew Burke to discuss his research on the contribution of post-TB sequelae to life-years and quality-adjusted life-years lost due to TB disease in the United States. Drawing on data from both U.S. and Brazilian cohorts, he explores how a significant portion of TB’s health burden, including elevated mortality and reduced...
Show more...
Education
News,
Health & Fitness,
Medicine
Episodes (20/44)
The TBPod
Post-TB Sequelae: Life and Death After TB Treatment - In Discussion with Prof. Nicolas Menzies
Associate Professor Nicolas Alan Menzies, from the School of Global Health and Population at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, joins Dr Andrew Burke to discuss his research on the contribution of post-TB sequelae to life-years and quality-adjusted life-years lost due to TB disease in the United States. Drawing on data from both U.S. and Brazilian cohorts, he explores how a significant portion of TB’s health burden, including elevated mortality and reduced...
Show more...
5 months ago
25 minutes

The TBPod
CATAPuLT - Can we manage latent TB infection in primary care?
Dr Matthew Burman is a TB clinician and researcher from East London, Queen Mary University and the Blizzard Institute. Today he presents the data from the CATAPULT trial which randomised patients to either have their latent TB infection managed by a TB clinic in secondary care, or be managed in primary care by their GP in concert with a community pharmacist. This amazing trial re-evaluates how we think about TB preventative therapy and looks at new ways of approaching the burden of latent TB ...
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8 months ago
30 minutes

The TBPod
Unlocking GeneXpert: A Deep Dive with Dr Stijn Deborggraeve
Dr. Stijn Deborggraeve is the Diagnostics Advisor Infectious Diseases at Médecins Sans Frontières (MSF) Access Campaign. In this episode we discussed GeneXpert technology including pricing, logistics, and future developments.
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9 months ago
25 minutes

The TBPod
Fighting Childhood Tuberculosis: Expert Advice from Dr Graeme Hoddinott
Dr Graeme Hoddinott is a Senior Lecturer in Global Health at the University of Sydney. He is also an Extraordinary Associate Professor in paediatrics at Stellenbosch University. Much of his research experience is on tuberculosis, especially among children, adolescents, and their families. In this episode, we explore ground-breaking research on the preferences of children and adolescents in tuberculosis (TB) treatment and management, revealing surprising insights that could lead to bet...
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10 months ago
34 minutes

The TBPod
Understanding the Patient Tuberculosis Experience with Sarah Bernays
Associate Professor Sarah Bernays, co-director of the Masters of Global Health program at the University of Sydney, leads a social science research program focused on community engagement in infectious disease prevention, treatment, and care. Her work emphasizes understanding how individuals, households, and communities respond to health adversity, risk, and vulnerability while fostering resilience and hope. In this episode, we explored the perspectives of tuberculosis patients, the challenge...
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11 months ago
32 minutes

The TBPod
Eradication in Sight? Overcoming Tuberculosis with Guy Marks
Professor Guy Marks AO FAHMS is a distinguished respiratory and public health physician and environmental epidemiologist. Currently serving as the President and interim Executive Director of the International Union Against Tuberculosis and Lung Disease (The Union), he has led the Respiratory and Environmental Epidemiology group at the Woolcock Institute since 1997. His research primarily focuses on lung health, with particular emphasis on airway diseases, air pollution, and tuberculosis. Addi...
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1 year ago
31 minutes

The TBPod
Tuberculosis Trailblazers: Nurses Leading the Fight with Amanda Christensen
Amanda Christensen joins us in this month's edition to discuss the critical impact of nurses in the fight against tuberculosis. Amanda is the Executive Director at the Australian Respiratory Council and is deeply experienced in the field of tuberculosis care.We explored the ideal attributes of TB nurses, offering perspectives on tuberculosis both within Australia and across the Pacific. We discussed the importance of patient advocacy, examined the structure and management of TB programs withi...
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1 year ago
24 minutes

The TBPod
Advancing TB Care: The Statistical Design of Clinical Trials with Patrick Phillips
Today we had the pleasure of being joined by Associate Professor Patrick Phillips from the University of California, who is the Co-Director of the UC Tuberculosis Research Advancement Center, Clinical & Population Health Science Core. Patrick has a wealth of statistical experience and specialises in the design, implementation, and optimisation of clinical trials for new treatments for drug-sensitive and drug-resistant tuberculosis.Join us as we explore the rapidly evolving field of TB cli...
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1 year ago
36 minutes

The TBPod
The Trauma of TB Stigma - Lived Experiences with Handaa Enkh Amgalan
Handaa Enkh Amgalan is an author, TB advocate and director of QA at the International Rescue Committee in Germany who has not only recently spoken at the UN TB High Level Meeting but also written an incredible memoir of her experience being diagnosed with severe pulmonary tuberculosis as a teenager growing up in Mongolia. Handaa gives an incredible insight into what it means to be diagnosed with such a stigmatising disease as a young woman; how it affect her, her family, and her dreams. This ...
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1 year ago
29 minutes

The TBPod
Frontiers in Clinical Tuberculosis Microbiology - New TBI Diagnostics with Prof Martineau
Professor Adrian Martineau from the Queen Mary University London talks to us about the limitations of current latent TB infection diagnosis and how we can do better. his research into whether we can use fragments of TB DNA found in bone marrow cells to better predict who should be treated with Tuberculosis Preventative Treatment.REFERENCESMartineau, Adrian R., et al. "Towards a molecular microbial blood test for tuberculosis infection." International Journal of Infectious Diseases (2024...
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1 year ago
30 minutes

The TBPod
MTBVAC - one of the most promising new TB Vaccines with Dr Carlos Martín Montañés
Today we discuss the MTBVAC with Dr Montañés. MTBVAC is an attenuated vaccine from a human mycobacterial isolate which has just progressed to a phase 3 trial and shown very promising results in the phase 2 study. Dr Montañés has been involved in this project for over a decade and has an incredible insight into the development and promise of this vaccine for global TB epidemiology.ReferencesMartín, Carlos, et al. "MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG...
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1 year ago
42 minutes

The TBPod
TB Contact Tracing and Building Research in TB with Prof Philip Hill
Prof Greg Fox speaks with Prof Philip Hill about TB household contact tracing and building research capacity in TB. Prof Hill is an ID specialist and public health physician who did his PhD in TB Epidemiology. He is the current McAuley Chair in International Health as well as being Founding Direction & Co-Director of the Centre for International Health at the University of Otago.References1) Martinez, Leonardo, et al. "The risk of tuberculosis in children after close exposure: a systemati...
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1 year ago
30 minutes

The TBPod
END-TB Trial with Dr Guglielmetti
Today we speak with Dr Guglielmetti about the END-TB trial which looks at new all oral regimens for MDR-TB.REFERENCES1) https://endtb.org/2) Nyang’wa, Bern-Thomas, et al. "A 24-week, all-oral regimen for rifampin-resistant tuberculosis." New England Journal of Medicine 387.25 (2022): 2331-2343.3) Conradie, Francesca, et al. "Treatment of highly drug-resistant pulmonary tuberculosis." New England Journal of Medicine 382.10 (2020): 893-902.4) Diacon, Andreas H., et al. "Multidrug-resistant tube...
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1 year ago
46 minutes

The TBPod
Tuberculosis Diagnostics & Emerging Technologies with Dr Morten Ruhwald
Today we delve into the world of TB diagnostics and the future of leveraged TB technologies with Dr Morten Ruhwald. Dr Ruhwald is a the head of the TB programme over at FIND, an institution dedicated to accelerating equitable access to reliable diagnosis around the world. Dr Ruhwald elaborates on the current state of TB diagnostics, new clinical strategies, usability factors, and future TB perspectives.https://www.finddx.org/what-we-do/programmes/tuberculosis/https://www.actnet.org.au/
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1 year ago
24 minutes

The TBPod
Tuberculosis Nursing Challenges in Australia's Northern Territory with Dr Chris Lowbridge
Today we speak with Dr Chris Lowbridge about the amazing work of the TB teams in the Northern Territory. Chris talks about the challenges of controlling tuberculosis across 1.42 million square kilometres, more than 100 local languages, and some very isolated communities.ReferencesMeumann, Ella M., et al. "Tuberculosis in Australia's tropical north: a population-based genomic epidemiological study." The Lancet Regional Health–Western Pacific 15 (2021).Vigneswaran, Nilanthy, et al. "Factors lea...
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1 year ago
36 minutes

The TBPod
Drug Development with Dr Clifton Barry
Today we speak with Dr Clifton Barry from NIH in Bethesda, Maryland who is head of the most highly cited research group in the field of TB over the past year and has made extraordinary contributions to TB drug development. Dr Barry speaks about his involvement in the PREDICT TB study, the TB Drug Accelerator and some of the most exciting drug developments in recent years.REFERENCESGreen, Simon R., et al. "Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs." Nature commu...
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1 year ago
42 minutes

The TBPod
Where are we with TB Vaccines - with Prof Triccas
Today we get an update on where the TB Vaccine pipeline is up to, how TB vaccines work and what exciting candidates might be on the horizon. We speak with Professor Jamie Triccas from the University of Sydney about his work as the principal investigator on the Advancing Vaccine Adjuvant Research for Tuberculosis (AVAR-T) which is an NIH funded project to identify the most promising adjuvant-TB immunogenicity candidates for development.REFERENCESStewart, Erica, James A. Triccas, and Nikolai Pe...
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1 year ago
40 minutes

The TBPod
What does TB Elimination mean?
Today we have the pleasure of speaking with Professor Giovanni Migliori about TB Elimination. Professor Migliori is the director of the WHO collaborating centre for TB and lung disease and is the current chief editor for the international journal of TB and lung disease. He was formerly the secretary general of the ERS and president of the Union's European region. Today he speaks about his recent viewpoint publication regarding how different countries should be approaching TB control and elimi...
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2 years ago
40 minutes

The TBPod
Papua New Guinean Challenges of TB in Pregnancy
Today we speak with Prof Mola, Dr Welch and Dr Visiliu about their amazing work tackling TB in pregnancy in Papua New Guinea. They talk about the epidemiological, geographical and social challenges of providing maternal TB care in PNG along with some insights into treatment and control.REFERENCES:Hamada, Yohhei, et al. "The safety of isoniazid tuberculosis preventive treatment in pregnant and postpartum women: systematic review and meta-analysis." European Respiratory Journal 55.3 (2020).Gupt...
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2 years ago
34 minutes

The TBPod
How WGS is shaping the public health in Australia
Today we speak with Professor Justin Denholm about his work with the National TB Advisory Committee in Australia and the role whole genome sequencing (WGS) has in public health. Professor Denholm talks about how WGS is expanding the way we think about tuberculosis and how this WGS can bring us into a new age of TB elimination strategy.REFERENCES1. Ferdinand, Angeline S., et al. "An implementation science approach to evaluating pathogen whole genome sequencing in public health." Genome Medicin...
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2 years ago
40 minutes

The TBPod
Associate Professor Nicolas Alan Menzies, from the School of Global Health and Population at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, joins Dr Andrew Burke to discuss his research on the contribution of post-TB sequelae to life-years and quality-adjusted life-years lost due to TB disease in the United States. Drawing on data from both U.S. and Brazilian cohorts, he explores how a significant portion of TB’s health burden, including elevated mortality and reduced...