This episode of The Human Upgrade reveals how to naturally activate your body’s stem cells to regenerate tissue, reverse aging, and supercharge recovery using cutting-edge biohacks like fasting, PEMF, and targeted supplements.

This episode reveals the emotional formula that makes fasting easier and more effective by rewiring your subconscious patterns for healing, self-control, and longevity.

Host Dave Asprey and environmental health attorney Alan Bell expose the hidden poisons in everyday environments, reveal the top toxic chemicals destroying longevity and human performance, and share biohacking and functional medicine strategies to reduce your toxic burden and reclaim your health.

Jim Kwik joins Host Dave Asprey to reveal the exact nootropics, brain hacks, and biohacking routines he used to recover from traumatic brain injuries and unlock peak cognitive performance.

Dave Asprey joins Jay Campbell and Hunter Williams to explore cutting-edge peptides, hormone protocols, and bioregulators that enhance metabolism, optimize hormones, and reverse aging.

Dave Asprey and Lucas Aoun reveal the most advanced, underrated compounds for hacking dopamine, hormones, and mitochondria to radically upgrade motivation, focus, and resilience.

This episode of The Human Upgrade with Host Dave Asprey and Dr. Gabrielle Lyon reveals why eating 50 grams of high-quality animal protein per meal is the most overlooked biohacking strategy for reversing muscle loss, boosting metabolism, and extending longevity.

This episode explores how the U.S. Air Force and elite performers are using personalized sound frequencies to rewire brainwaves, enhance neuroplasticity, and accelerate human performance—featuring Rev. Michael Beckwith and SOAAK founder Henry Penix.

This episode reveals how to rewire your brain in 63 seconds using Dr. Caroline Leaf’s science-backed method for habit change, trauma healing, and mental self-regulation.

What is Herbal Ecstasy—and why does it matter? This might be one of the most insane episodes we’ve ever recorded, and we had to bring it back because the story is too wild, too relevant, and too packed with real lessons in biohacking, brain optimization, and supplement hacking to miss.  Host Dave Asprey sits down with Shaahin Cheyene, the renegade teenage entrepreneur who built a billion-dollar supplement empire before he could legally drink. As the creator of Herbal Ecstasy, Shaahin hacked natural compounds into high-performance nootropics that boosted energy, neuroplasticity, and metabolism—long before biohacking was a movement. He faced seven federal investigations, never spent a day in jail, and went on to pioneer the vaporizer industry and dominate Amazon with advanced supplement marketing.   This episode explores how Shaahin reverse-engineered functional medicine principles, used ancient plant medicine to upgrade human performance, and scaled a controversial brand using raw hustle and hacking tactics. You’ll hear how Herbal Ecstasy worked, why it was banned, and what it teaches us about supplements, mitochondrial function, dopamine regulation, and the dark politics behind wellness innovation.   You’ll learn:  • Why Herbal Ecstasy became a billion-dollar underground supplement  • How Shaahin used nootropics and adaptogens to hack energy, focus, and neuroplasticity  • What his clash with the FDA reveals about supplement regulation and functional medicine  • How dopamine, mitochondria, and metabolism drive human performance  • The difference between hacking systems vs conforming to broken ones  • How storytelling, podcasting, and controversial supplements build legacy brands  Whether you’re optimizing your sleep, hacking your brain, experimenting with ketosis or fasting, or upgrading your stack with supplements that actually work—this channel delivers strategies, cautionary tales, and insight you won’t find anywhere else. lt is essential listening for anyone serious about biohacking, brain optimization, supplements, mitochondria, metabolism, functional medicine, nootropics, longevity, dopamine, cold therapy, sleep optimization, emotional regulation, neuroplasticity, fasting, podcasting, RFK-era health freedom, ketosis, entrepreneurship, and building influence smarter not harder—with or without Danger Coffee.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.  Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.  Thank you to our sponsors!   Resources:   • Shaahin’s Website: https://www.shaahincheyenne.com/  • Dave Asprey’s Website: https://daveasprey.com  • Danger Coffee: https://dangercoffee.com/DAVE15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com  Timestamps:  • 0:00 — Trailer  • 0:45 — Intro and guest setup  • 4:39 — Escaping Iran and early hustle  • 8:26 — Birth of Herbal Ecstasy  • 14:21 — Explosive growth and legal heat  • 25:06 — Lessons on money and business  • 31:17 — Inventing the digital vaporizer  • 40:03 — Hacking success on Amazon  • 41:59 — Nootropics and the Limitless pill  • 46:38 — Martial arts and mental resilience  • 55:44 — Podcasting, media, and influence  • 1:07:09 — Where to find Shaahin and closing thoughts  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode reveals how your cultural programming shapes brain function, perception, and performance—and how decoding it can unlock next-level biohacking and longevity.

This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body.  Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with inventor and tech entrepreneur Tom Benson, founder of Mitrix. After launching three successful Silicon Valley companies, Benson shifted focus to one of the most promising frontiers in science: mitochondrial bioreactors designed to regrow your own autologous mitochondria. This isn’t theory—it’s a near-future anti-aging technology poised to transform functional medicine, personalized medicine, and the global conversation around aging reversal.  They explore how mitochondrial DNA mismatches affect aging, why mitochondria act like cellular AI cores, and how dysfunction in these ancient organelles contributes to neurodegenerative disease, metabolic decline, and cognitive disorders. You’ll learn how restoring mitochondria could enhance everything from stem cell therapy and nootropics to ketosis, fasting, cold therapy, and even sleep optimization.   You’ll Learn:  • Why mitochondria may be the real control centers of human biology  • How mitochondrial transfusion could revolutionize longevity and functional medicine  • The connection between mitochondrial dysfunction and Parkinson’s, autism, and ALS  • Why brain optimization and neuroplasticity depend on cellular energy  • How stem cell-derived mitochondria compare to nootropics and NAD  • What happens when mitochondrial DNA and nuclear DNA are mismatched  • Why early aging might start with your egg cells’ mitochondrial computing  • How mitochondrial health influences metabolism, ketosis, and fat storage  • Why stress, toxins, and pharmaceuticals like statins wreck mitochondrial function  • What it takes to scale mitochondrial bioreactors for widespread human use  • How mitochondrial hacking could improve immune function, sleep, and resilience  • Why the future of biohacking might begin with testing and upgrading your mitochondria  This episode is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.  Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.  Thank you to our sponsors!   -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.   -Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order.    Resources:   • Mitrix Website: https://www.mitrix.bio/  • Dave Asprey’s Website: https://daveasprey.com  • Danger Coffee: https://dangercoffee.com/DAVE15  • Dave Asprey’s BEYOND Conference: https://beyondconference.com  • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Upgrade Collective: https://www.ourupgradecollective.com  • Upgrade Labs: https://upgradelabs.com  • 40 Years of Zen: https://40yearsofzen.com  Timestamps:  • 00:00 Trailer  • 01:42 Intro  • 04:33 Mitochondrial DNA & Performance  • 08:49 Challenges in Mitochondrial Therapy  • 13:31 Future Applications  • 19:07 Mitochondria & Longevity  • 20:19 Traditional Medicine  • 28:50 Space Exploration  • 29:35 Human Fragility  • 30:19 Aging Revisited  • 32:52 Experimental Research  • 36:04 Ethics & Risks  • 41:24 Mental Health Links  • 46:28 Treatment Breakthroughs  • 51:01 Personal Longevity Hacks  • 54:30 Wrap-Up & Contact  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Host Dave Asprey uncovers how a groundbreaking topical glutathione spray bypasses IVs and pills to deliver rapid cellular upgrades for brain health, emotional resilience, and longevity.

Host Dave Asprey joins nitric oxide expert Dr. Nathan Bryan to reveal how this overlooked molecule controls blood flow, metabolism, brain function, and sexual performance—and how to restore it for peak human performance and longevity.

A powerful conversation on how just 15 minutes of oxygen therapy can supercharge your mitochondria, reduce inflammation, and transform energy, brain function, and recovery.

Dave Asprey uncovers the real causes of wrinkles, the hidden risks of breast implants, and how stem cells, fat transfers, and advanced cosmetic procedures can regenerate your skin and optimize your biology.

Host Dave Asprey and Soren Gordhamer explore how to stay emotionally and biologically resilient as AI, superintelligence, and transhumanism reshape human health and connection.

Creatine is one of the most powerful, science-backed supplements for brain optimization, mitochondria, and longevity—and in this episode, Dave Asprey reveals how to use it smarter for total human performance.

Dave Asprey and Dr. Stephen Cave explore the philosophy, science, and ethical edge of longevity, revealing why the quest to live longer is as much about meaning and identity as it is about biohacking and technology.

This episode uncovers the hidden causes of joint pain and premature aging—like insulin resistance, leaky gut, and mitochondrial dysfunction—and reveals how to restore mobility and longevity using smarter biohacking strategies and breakthrough supplements.