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The Health Edge: translating the science of self-care
Mark Pettus MD and John Bagnulo PhD, MPH
48 episodes
2 weeks ago
Send us a text Curious why coconut oil can raise LDL for some people yet still show up in diets that improve metabolic health, cognition, and body composition? We get clear on what coconut oil actually is—a family of saturated fats with a rare abundance of medium-chain triglycerides—and why MCTs create ketones that the brain and mitochondria can use even without fasting. Instead of stopping at cholesterol, we look at the fuller picture: insulin resistance, inflammation, triglycerides, and rea...
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Medicine
Health & Fitness,
Alternative Health,
Nutrition
RSS
All content for The Health Edge: translating the science of self-care is the property of Mark Pettus MD and John Bagnulo PhD, MPH and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Send us a text Curious why coconut oil can raise LDL for some people yet still show up in diets that improve metabolic health, cognition, and body composition? We get clear on what coconut oil actually is—a family of saturated fats with a rare abundance of medium-chain triglycerides—and why MCTs create ketones that the brain and mitochondria can use even without fasting. Instead of stopping at cholesterol, we look at the fuller picture: insulin resistance, inflammation, triglycerides, and rea...
Show more...
Medicine
Health & Fitness,
Alternative Health,
Nutrition
Episodes (20/48)
The Health Edge: translating the science of self-care
Is Coconut Oil A Villain Or Just Misunderstood? Spoiler: It’s Complicated
Send us a text Curious why coconut oil can raise LDL for some people yet still show up in diets that improve metabolic health, cognition, and body composition? We get clear on what coconut oil actually is—a family of saturated fats with a rare abundance of medium-chain triglycerides—and why MCTs create ketones that the brain and mitochondria can use even without fasting. Instead of stopping at cholesterol, we look at the fuller picture: insulin resistance, inflammation, triglycerides, and rea...
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2 weeks ago
42 minutes

The Health Edge: translating the science of self-care
Your gut can turn ellagic acid into urolithin A—and that shift may protect muscle, brain, and metabolism
Send us a text If pomegranates, raspberries, and walnuts could whisper a secret to your cells, it might be this: the right microbes can turn plant defense into human resilience. We dive into the journey from ellagic acid to urolithin A, mapping how polyphenols meet the microbiome to support mitochondrial function, muscle strength, and brain health. Along the way, we unpack the science of mitophagy, inflammation control, and metabolic signaling that ties colorful foods to better performance an...
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3 weeks ago
39 minutes

The Health Edge: translating the science of self-care
Four Days to Metabolic Flexibility: What a Danish Crossover Trial Reveals About Carbs, Fat, and Fatty Liver
Send us a text A 35% drop in liver fat in under a week sounds impossible—until you see how a simple macro shift can redirect your metabolism. We dive into a Danish crossover study where calories stayed equal, protein held steady, and the only real change was carbohydrates versus fat. The result: rapid reductions in hepatic fat, lower triglycerides, improved insulin sensitivity, and clear signs of metabolic flexibility, all in four to five days. We unpack what that means for everyday eating, h...
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1 month ago
30 minutes

The Health Edge: translating the science of self-care
Childhood Night Light Exposure and the Hidden Cost of “Junk Light”
Send us a text The clock isn’t just on your wall—it’s in your cells. As autumn settles in and daylight wanes, we dig into how light acts as information for your biology, shaping sleep depth, hormone timing, and metabolic health. A standout 15-year cohort of 200,000+ children links persistent artificial light at night to higher obesity risk, and it pairs with wearable data from tens of thousands of people that reveals how little real sunlight most of us get—even at the height of summer. We br...
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1 month ago
37 minutes

The Health Edge: translating the science of self-care
Forest Bathing: Nature Heals Our Disconnect
Send us a text Nature deficit syndrome is silently affecting millions as we spend over 95% of our lives indoors beneath artificial lighting that disrupts our biology at the most fundamental level. Dr. Mark Pettus delivers a compelling exploration of this modern disconnection, introducing the powerful concept that our current "junk light" epidemic may soon be viewed with the same concern we now direct toward processed foods. Drawing from both scientific research and ancient wisdom traditions,...
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6 months ago
24 minutes

The Health Edge: translating the science of self-care
Nourishing the Mind: Food, Light, and Lifestyle for Better Mood
Send us a text At a time when anxiety and depression rates are soaring across all age groups, Dr. Mark Pettus cuts through the noise with revelatory insights into how our daily choices shape our mental landscape. This compelling exploration connects the dots between what's on your plate, how you move through your day, and the remarkable resilience of your brain. Dr. Pettus introduces the concept of allostatic load—how our bodies interpret and respond to environmental stressors—and reveals wh...
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6 months ago
32 minutes

The Health Edge: translating the science of self-care
Light as Medicine: How Natural Light Cycles Impact Health and Longevity
Send us a text The rhythms of nature have orchestrated human biology for millennia, but our modern lifestyle has disconnected us from these essential patterns. Dr. Mark Pettus takes us on a fascinating journey through the science of circadian rhythms, revealing how light serves as crucial information that synchronizes every cell in our bodies with the natural day-night cycle. From ancient Hippocrates to Nobel Prize-winning research, the evidence is clear: our bodies respond profoundly to lig...
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6 months ago
33 minutes

The Health Edge: translating the science of self-care
Beyond Ozempic: The Natural Pathways to Enhanced GLP-1 Production
Send us a text Curious about natural alternatives to expensive GLP-1 medications like Ozempic? Dr. Mark Pettus unveils powerful nutritional strategies to boost your body's own GLP-1 production for improved metabolic health and sustainable weight management. This eye-opening presentation dives into the fascinating relationship between your diet, gut microbiome, and GLP-1 production. Dr. Pettus, a kidney and integrative medicine specialist with 40 years of medical experience, explains how qual...
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7 months ago
41 minutes

The Health Edge: translating the science of self-care
Playing with Fire: How Modern Lifestyle Fuels Inflammation
Send us a text Chronic inflammation has emerged as one of the most significant drivers behind virtually all modern health challenges. In this thought-provoking exploration, Dr. Mark Pettus reveals why researchers now refer to inflammation as "the cause of everything" and introduces the concept of "inflammaging" – how chronic inflammation accelerates biological aging and compromises quality of life. Dr. Pettus takes us beyond conventional medical thinking to understand that while inflammation...
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7 months ago
39 minutes

The Health Edge: translating the science of self-care
Epigenetics: How well do you fit into your genes?
Send us a text Prepare to have your understanding of genetics completely transformed. The revolutionary science of epigenetics reveals that you're not simply a prisoner of your DNA – you're actively participating in how your genes express themselves through every choice you make. Dr. Mark Pettus takes us on a fascinating journey through this emerging field that bridges the gap between fate and free will. Drawing on cutting-edge research and decades of clinical experience, he explains how our...
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7 months ago
37 minutes

The Health Edge: translating the science of self-care
Creatine: The Underrated Powerhouse for Muscle and Brain Health
Send us a text Creatine might be the most underappreciated nutritional powerhouse in our health toolkit. While many associate it exclusively with weightlifters and athletes, the science reveals a molecule with profound benefits reaching far beyond the gym. Mark Pettus MD and John Bagnulo PhD,MPH dive into creatine's fundamental role in human physiology as part of our body's most immediate energy production system – the ATP-PCR pathway. They unpack how this simple compound supports not just m...
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7 months ago
31 minutes

The Health Edge: translating the science of self-care
Unlocking the Power of Protein: Transform Your Health with Optimal Intake and Lean Body Mass Maintenance
Unlock the secrets to a healthier, longer life by mastering the science behind protein intake. Discover the critical role of animal protein in maintaining lean body mass, boosting metabolic health, and combating age-related muscle loss. We challenge traditional views and outdated guidelines, bringing you insights from recent research and experts in the field to help you reassess the power of protein in your diet.With less than 10% of Americans achieving optimal metabolic health, it's time to ...
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9 months ago
40 minutes

The Health Edge: translating the science of self-care
Does Eating More Eggs Reduce Alzheimer's Disease Risk?
In this first Health Edge podcast of 2025, Mark Pettus MD and John Bagnulo PhD, MPH review a 2024 study published in The Journal of Nutrition.https://www.sciencedirect.com/science/article/abs/pii/S002231662400289X?via%3Dihubhttps://www.thehealthedgepodcast.com
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9 months ago
29 minutes

The Health Edge: translating the science of self-care
Insulin Resistance: The Primary Driver of Modern Disease
In this Health Edge recording, Mark describes a model of integrative health-lifestyle medicine that is distinctly different from current allopathic disease-based models. He examines the metabolic perfect storm of insulin resistance and inflammation as passports to accelerated aging, chronic complex disease risk and poor quality of life or healthspan. His slides can be downloaded at www.thehealthedgepodcast.com
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1 year ago
53 minutes

The Health Edge: translating the science of self-care
Statin Use, LDL Reduction and the Magnitude of Cardiovascular Benefit
In this episode of the Health Edge I review a recent meta-analysis examining the magnitude of cardiovascular benefit from taking statins for elevated LDL in both primary and secondary prevention.JAMA Intern Med. 2022;182(5):474-481. doi:10.1001/jamainternmed.2022.0134 Published online March 14, 2022. https://pubmed.ncbi.nlm.nih.gov/35285...
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1 year ago
30 minutes

The Health Edge: translating the science of self-care
Exploring the Health Benefits of Saturated Fats and Full-Fat Dairy
Do you ever feel like everything you've been told about healthy eating seems to be teetering on the edge of being overturned? Welcome to a mind-bending exploration where we question the status quo, particularly the demonization of full fat dairy and saturated fats. I'm diving deep into a groundbreaking study suggesting that pentadecanoic acid, a saturated fat found in full-fat dairy could actually promote health and contribute to our longevity. We challenge the shortcomings in the tradi...
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1 year ago
41 minutes

The Health Edge: translating the science of self-care
Red Meat and Diabetes: More than Meets the Eye
In a world where health advice is abundant, it can be challenging to sift through conflicting data and headlines. One such contentious issue is the connection between red meat and type 2 diabetes. On this episode of The Health Edge, we take a critical look at this connection and aim to provide a balanced perspective on this often polarizing topic.The episode focuses on a recent study from the Harvard School of Public Health that has purportedly found a connection between red meat consumption ...
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1 year ago
14 minutes

The Health Edge: translating the science of self-care
Body Mass Index (BMI): Is it time to abandon this surrogate marker of metabolic health and mortality risk?
Ready to have your understanding of BMI flipped on its head? We're diving into an intriguing study that suggests a BMI lower than 25 might be linked with decreased mortality. That's right, what you've been told about the ideal BMI could be all wrong. We also tackle the waist to hip ratio, showing you how to measure it and why it might be a better health marker than BMI. So, grab a tape measure and prepare for a health knowledge overhaul.
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2 years ago
14 minutes

The Health Edge: translating the science of self-care
Understanding the Complex World of Proteins, Essential Amino Acids, and the Role of IGF-1 in Brain Health
Are you ready to unlock the mysteries of protein and its pivotal role in our dietary intake? Strap in as we guide you through the complex world of essential amino acids, and the significant part they play in our bodies. We discuss the importance of achieving a balance in your protein consumption, focusing on the dietary reference intakes, and the potential risks of under-consuming protein. Discover why 25 grams of protein per meal can be beneficial for you, and the distinctions between plant ...
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2 years ago
43 minutes

The Health Edge: translating the science of self-care
Powerful Lifestyle Medicine Interventions
In this podcast Mark reviews the current paradigm linking environmental inputs-lifestyle with epigenetics and the human microbiome. He translates these connections ibto effective lifestyle medicine interventions. The PowerPoint below goes with the audio recording. You Tube recording can be found below. PowerPoint slides can be downloaded at www.thehealthedgepodcast.com Enjoy!
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2 years ago
1 hour 7 minutes

The Health Edge: translating the science of self-care
Send us a text Curious why coconut oil can raise LDL for some people yet still show up in diets that improve metabolic health, cognition, and body composition? We get clear on what coconut oil actually is—a family of saturated fats with a rare abundance of medium-chain triglycerides—and why MCTs create ketones that the brain and mitochondria can use even without fasting. Instead of stopping at cholesterol, we look at the fuller picture: insulin resistance, inflammation, triglycerides, and rea...