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The Big Experiment
Mark Davison
26 episodes
3 weeks ago
What if the solution to chronic wound healing has been floating in our oceans for 600 million years? Jellyfish collagen isn't just different from the cow and pig-derived materials used in medicine today. It's actually better at healing human tissue. I sit down with Dr Andrew Mearns-Spragg, Founder and Chief Scientific Officer at Jellagen, who's proving this remarkable claim with hard data. His research shows jellyfish collagen outperforms traditional materials in vocal fold repair, triggers f...
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Entrepreneurship
Business,
Science,
Life Sciences
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What if the solution to chronic wound healing has been floating in our oceans for 600 million years? Jellyfish collagen isn't just different from the cow and pig-derived materials used in medicine today. It's actually better at healing human tissue. I sit down with Dr Andrew Mearns-Spragg, Founder and Chief Scientific Officer at Jellagen, who's proving this remarkable claim with hard data. His research shows jellyfish collagen outperforms traditional materials in vocal fold repair, triggers f...
Show more...
Entrepreneurship
Business,
Science,
Life Sciences
Episodes (20/26)
The Big Experiment
From Jellyfish to Wound Healing with Dr Andrew Mearns-Spragg
What if the solution to chronic wound healing has been floating in our oceans for 600 million years? Jellyfish collagen isn't just different from the cow and pig-derived materials used in medicine today. It's actually better at healing human tissue. I sit down with Dr Andrew Mearns-Spragg, Founder and Chief Scientific Officer at Jellagen, who's proving this remarkable claim with hard data. His research shows jellyfish collagen outperforms traditional materials in vocal fold repair, triggers f...
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3 weeks ago
37 minutes

The Big Experiment
Jenny Barnett: New tests and drugs for schizophrenia
Can neuroscience finally catch up with the complexity of mental illness? Society faces a huge and growing burden from mental illness and impairment. Schizophrenia, for example, is a bigger socioeconomic burden than all cancers put together. We have medicines for some of these conditions, but typically they work well for some, not at all for many, and cause side-effects for others. One of medicine's greatest challenges has been identifying exactly which patients will benefit from a treatment b...
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3 months ago
38 minutes

The Big Experiment
Paul Beastall: Fuelling our future planet with a zero-carbon biofuel
Forget drilling—what if diesel could be grown instead? In this episode we head into the world of engineered biology with Paul Beastall, CEO of HutanBio. He explains how his team is cultivating an oil-rich microalgae, previously unknown to science, that thrives in desert heat, tolerates high salinity, and could transform the future of sustainable fuel. From modular algae farms that resemble vineyards more than refineries, to carbon-negative bio-oil ready for aviation, shipping, and long-haul t...
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3 months ago
34 minutes

The Big Experiment
Brain-on-a chip? Neurons as future biocomputers with Dr. Ewelina Kurtys
What if the future of computing isn’t silicon... but neurons? In this episode, we explore a radical new frontier where biology and technology come together — programming living neurons as processors. I am joined by Dr. Ewelina Kurtys of FinalSpark, a pioneering scientist bridging neuroscience and AI. We unpack the astonishing potential of bioprocessors—miniaturised clusters of human neurons that can process and store data while consuming a fraction of the energy traditional systems demand. Ev...
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4 months ago
33 minutes

The Big Experiment
A Brain-Based Revolution in Women's Health: The Nettle Device with Emilė Radytė
Three-quarters of women report that menstrual symptoms impact their daily performance, yet until recently, no one had looked at the brain's role in these symptoms. In this eye-opening episode I am joined by Emilė Radytė, PhD—Harvard and Oxford-trained neuroscientist, Forbes 30 Under 30 honoree, and co-founder/CEO of Samphire Neuroscience. Emilė reveals how a woman's brain during PMS can actually resemble that of someone with depression—with measurable neurological changes that affect mood, de...
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6 months ago
33 minutes

The Big Experiment
Therapeutic brain-computer-interfaces for glioblastoma, with Dr Elise Jenkins
Electrical monitoring and stimulation could revolutionise diagnosis and treatment for some of the most aggressive brain cancers and intractable neurological diseases. In glioblastoma, a particularly aggressive brain tumour that is hard to treat and almost invariably fatal, the impacts of an effective treatment would be huge. My guest in this episode, Dr Elise Jenkins, is working with a new class of therapeutic brain-computer-interface (BCI) that can measure and disrupt neural signalling withi...
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9 months ago
37 minutes

The Big Experiment
Che Connon. Lab-grown tissues in medicine, food and fashion
Imagine that we could make tissues indistinguishable from those produced by humans or animals, at will, and at comparable cost to the natural products. With the rate of progress being made, it won’t be imaginary much longer.If we don’t need to kill animals for food, leather, or other products, then we reduce animal suffering. We increase biodiversity because we don’t need to devote huge land areas to feed farm animals. And we help climate change - the meat industry is a huge contributor to gr...
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10 months ago
42 minutes

The Big Experiment
On the Road! A Quick Tour of Synthetic Biology
In this episode of The Big Experiment, we are live, recording from the Synthetic Biology UK 2024 conference hosted by the Biochemical Society, at Hinxton Hall near Cambridge, home of the famous Genome Campus.Synthetic biology is the practice of manipulating biology to achieve outcomes that don’t occur naturally or in some cases are not naturally possible. Common examples include producing new proteins for therapeutic use, but there are many other applications of lab-derived augmentation of li...
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10 months ago
30 minutes

The Big Experiment
Transforming Cancer Care: The Fight Against Cachexia with Robin Bhattacherjee
Weight loss drugs are in the spotlight. Obesity is a huge and potentially profitable problem, attracting lots of scientific and medical resources.But there are circumstances where avoiding weight loss is crucial and where it is beneficial to put weight on. Cachexia is a serious condition affecting cancer patients, which is characterised by significant weight loss and muscle wasting. Appetite is often suppressed, but just eating more doesn’t work anyway.The resulting frailty and weakening of t...
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11 months ago
39 minutes

The Big Experiment
Revolutionising Heart Surgery with Francis White
Heart valve surgery is one of the most complex procedures in medicine.Francis White and his company Heart Biotech Ltd are trying to change all of that, by making heart valves in a totally new way. This will make surgery simpler and more accessible globally.Building on the pioneering work of Professor Magdi Yacoub and colleagues, Heart Biotech are innovating the field by creating living tissue heart valves on a dissolving scaffold using the body's healing mechanisms. We explore the methods bei...
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11 months ago
34 minutes

The Big Experiment
Ovaries, Menopause, and Genomics with Dr Stasa Stankovic
This episode went live on World Menopause Day.Menopause is an inevitable aspect of life for half of the global population, but one that requires far more study. New genomic insights could empower women with better reproductive choices and insights into likely future health.In this episode, I talk with Dr Stasa Stankovic. She has a PhD in Genomic Medicine from Cambridge University, and is on a mission to reshape the future of women's health by developing, and eventually commercialising, predic...
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1 year ago
45 minutes

The Big Experiment
Hazel Jones: Enhancing Drug Discovery with 3D Genomics
What role does 3D genomics have in drug discovery?In this episode I am joined by Hazel Jones, CEO of Enhanc3d Genomics, to find out more about this cutting-edge technology.Hazel is a dynamic and flexible senior leader with experience of oncology research, both in pharma/biotech and an academic/charity setting. Making her insights into the workings of not for profit and big pharma invaluable.We discuss her work at Enhanc3d Genomics and the role of 3D genomics in uncovering the regulatory eleme...
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1 year ago
42 minutes

The Big Experiment
How Medicines are Developed: Mark's Quick Guide
What does it take to get a new drug to market?I have been involved in the drug industry for 35 years. I’ve worked for big pharma like GlaxoSmithkline, contract research organisations (CROs) like Charles River and IQVIA, and for several biotech and “virtual” drug companies. I’ve consulted for many more. I now run a laboratory instruments company that supplies crucial equipment used by thousands of labs in the biomedical research industry. In my career, there have been many changes due to ...
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1 year ago
32 minutes

The Big Experiment
Zoe Kourtzi: Artificial intelligence and predicting dementia
1 in 2 of us will be affected by dementia in our lives.Something so prevalent without a cure requires novel approaches for diagnosis.In this episode I am joined by Professor Zoe Kourtzi, from the University of Cambridge. Zoe is an expert in Cognitive Computational Neuroscience and a pioneer in translating Artificial intelligence to brain and mental health.We discuss new approaches to diagnosing people at an earlier stage of dementia. She explains how her research combines brain sciences and c...
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1 year ago
41 minutes

The Big Experiment
Lily Elsner - Breaking the Taboo: Men's Fertility Testing
Men’s fertility is falling and fast.In the last 50 years sperm counts are down by 60%. Yet this is still a topic that no one is really talking about.My guest in this episode, Lily Elsner, is the co-founder and CEO of Jack Fertility. They are trying to break the taboo with thier product, the world’s first postable sperm test kit.Lily discusses the importance of addressing male fertility and the lack of research in this area. We cover the gender imbalance in fertility support and the misconcept...
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1 year ago
48 minutes

The Big Experiment
The Ignite Program at the University of Cambridge Judge Business School
This edition of The Big Experiment is a little bit different to the usual format.I'm on the road visiting the famous University of Cambridge Judge Business School to talk to people at the Ignite program. It’s an intensive weeklong boot camp for early-stage founders, generally in tech and sometimes in biotech, but can be all sorts of different tech themes.Ignite is about business and risk, which are the core themes of the podcast. But it's a slightly different flavour to usual. Science is...
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1 year ago
48 minutes

The Big Experiment
Mike Teiler – Innovating Type 1 Diabetes Treatment
My son was diagnosed with type 1 diabetes at the age of 13.Which is why this episode is very close to my heart. There are big life-altering challenges for the patient and their family in managing type 1 diabetes. With limitations to the current insulin therapies that make the work of my guest in the episode, Mike Teiler, all the more important.Mike is the Chief Pharmaceutical Officer at LeviCure, a startup focused on new approaches to type 1 diabetes. In this episode we discuss the difference...
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1 year ago
50 minutes

The Big Experiment
Dr. Kärt Tomberg - Making Better Protein Drugs
The challenges of scientific entrepreneurship don’t end when you get funding.In fact, a whole new set of challenges arise, from finding labs, to building your team and more.In this episode I talk to Dr. Kärt Tomberg, CEO and co-founder of ExpressionEdits. She is now at that exact moment, where she has just secured £10 million of funding. So, who better to talk us through the pitching process and how to be successful at it. Kärt discusses her journey into science from Estonia to Cambridge...
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1 year ago
43 minutes

The Big Experiment
Ruchi Sharma - Innovation in Stem Cells
Would you have the guts to pitch directly to the customer to sell your idea?You need to be prepared to hear no a lot, and learn from the experience to adapt for the next time, to get the yes you need.This was the reality faced by my guest in this episode, Ruchi Sharma, CEO & Founder of Stemnovate Limited. She used that customer-first approach and eventually got the funding needed to start her company that focuses on stem cell research.Ruchi’s work at Stemonovate creates a unique platform ...
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1 year ago
43 minutes

The Big Experiment
Joel Eichmann: Making cell biology efficient and sustainable
It is a guilty secret that the pharma and biotech industry has a big carbon footprint. Single-use plastics are a huge problem. Sensitive experiments need clean, sterile labware. This has often meant using virgin plastic with little or no recycling or reuse. Innovative approaches are needed to reduce plastic consumption in the lab.How bad is bad? On average, cell biologists produce several kg of plastic waste, each, per day. These include pipettes, plastic trays for cell growth, various ...
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1 year ago
39 minutes

The Big Experiment
What if the solution to chronic wound healing has been floating in our oceans for 600 million years? Jellyfish collagen isn't just different from the cow and pig-derived materials used in medicine today. It's actually better at healing human tissue. I sit down with Dr Andrew Mearns-Spragg, Founder and Chief Scientific Officer at Jellagen, who's proving this remarkable claim with hard data. His research shows jellyfish collagen outperforms traditional materials in vocal fold repair, triggers f...