July is Sarcoma awareness month!! A diagnosis of sarcoma can have a lasting impact on patients and families. For those who have been diagnosed and their families, there are resources and groups dedicated to educate, support and raise awareness. In this episode we highlight the MIBagents! A nonprofit organization dedicated to creating a better community and support for patients with pediatric osteosarcoma and their families. They accomplish this through many various patient programs, engaging clinicians, scientists and patients. Links https://www.mibagents.org Sarcoma strong Annual 5k - https://www.zippy-reg.com/online_reg/index.php?e=2167&rfrl=leIOZdAxZ%2BA724wBbO5ycg%3D%3D Team - UMMC Orthopaedics Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Synovial chondromatosis is a benign process that results in the formation of numerous loose bodies within a joint. This can lead to significant functional limitations as well as pain. In this episode, we discuss its pathogenesis, diagnosis and management options. Habusta SF, Mabrouk A, Tuck JA. Synovial Chondromatosis. 2023 Apr 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29262110 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Following a brief break, there is no better time for a brief review and catch up. During this episode we go over some commonly used terminology and processes along the sarcoma timeline with the new addition to our team, and host Dr. Sarah Ballatori

Artificial intelligence continues to gain popularity as society identifies its uses and benefits. AI has shown promise despite being in the early phases of implementation in sarcoma care. For this episode we discuss Artificial intelligence, its present and the future in sarcoma care. Bozzo A, Tsui JMG, Bhatnagar S, Forsberg J. Deep Learning and Multimodal Artificial Intelligence in Orthopaedic Surgery. J Am Acad Orthop Surg. 2024 Jun 1;32(11):e523-e532. Bozzo, A., Hollingsworth, A., Chatterjee, S. et al. A multimodal neural network with gradient blending improves predictions of survival and metastasis in sarcoma. npj Precis. Onc. 8, 188 (2024). sarcomaAIhub.com Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Musculoskeletal oncology (or Orthopaedic Oncology) is the field that is focused on diagnosing and treating cancers or tumors that affect bone and soft tissue. This requires a complex understanding of surgical, medical, radiologic and pathologic principles with a goal of ensuring optimal patient outcomes, and preserving function as well as quality of life. Along with the above, musculoskeletal oncologists pursue many career pathways that intersect and are woven into the fabric of providing care. In this first episode of our multi-part series, we discuss the Education Pathway, along with its challenges and successes, with an esteemed panel. This episode was held at the Musculoskeletal Tumor Society Meeting in Chicago Illinois on September 11, 2024 Contributors*** Dr. Mark Scarborough, Dr. Gregory Domson, Dr. Cara Cipriano, Dr. Tessa Balach, Dr. Lukas Nystrom, Dr. Benjamin Miller Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

There are multiple team members who all play an important role in providing coordinated multidisciplinary care for the betterment of patients with sarcomas and tumors. A pathologist is a key member of the team with an extremely important role. Pathologic analysis remains the standard for diagnosis and tumor analysis. We discuss the role of the pathologist in tumor diagnosis with Dr. Obeidin Farres. Obeidin F. What's new in bone and soft tissue pathology 2023: guidelines for molecular testing. J Pathol Transl Med. 2023 May;57(3):184-187. Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

July is Sarcoma awareness month! Sarcoma Strong remains an amazing resource and a way to be involved in the fight against Sarcoma. For the 2024 Sarcoma awareness month, we have Dr. DiCaprio, founder of Sarcoma Strong as our guest. Sarcoma Strong continues to evolve and grow providing a community and fighting sarcoma by supporting sarcoma research. We discuss the continued evolution of Sarcoma Strong, the annual 5K event and future direction. Flagship -saratoga springs > 600 ppl El paso, Boston, Cooper MD anderson NJ, UCSF, ATL Georgia, UF, Summa health, Henry ford detroit me=ic Links http://www.sarcomastrong.com https://www.zippy-reg.com/online_reg/?e=1956 ::after Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Giant cell tumor of tendon sheath as well as tenosynovial giant cell tumors are similar appearing tumors on imaging and pathology that occur in different parts of the body. TGCT occurs within joints particularly the knee and the tendon sheath variant occurs along the tendons of the hands and feet. Treatment options vary depending on the location and presentation, in this episode we discuss the two diagnoses, management and treatment. Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F. Tenosynovial giant cell tumor. Folia Med Cracov. 2022;62(2):93-107 van der Heijden L, Spierenburg G, Kendal JK, Bernthal NM, van de Sande MAJ. Multimodal management of tenosynovial giant cell tumors (TGCT) in the landscape of new druggable targets. J Surg Oncol. 2023 Sep;128(3):478-488 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Giant Cell Tumors of bone are common bone tumors. They can cause pain and present with a mass. They can be isolated to one bone or affect multiple bones. They can also metastasize to the lungs. Treatment for Giant Cell Tumor of Bone can be Surgical or Medical. We discuss the presentation, clinical findings and options for intervention. Hartmann W, Harder D, Baumhoer D. Giant Cell-Rich Tumors of Bone. Surg Pathol Clin. 2021 Dec;14(4):695-706. Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

A continuation of our series featuring Sarcoma stories with Janet Panoch. Janet's Daughter was diagnosed with osteosarcoma at the age of 12 and going through the process with her daughter inspired Janet to do more for sarcoma patients. She obtained a PhD and has worked since then to help and educate other families going through a sarcoma diagnosis. We discuss her amazing journey from diagnosis to present. https://osteosarcomadecisionaid.com/ https://www.linkedin.com/in/janetpanoch/ Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Chordomas are malignant tumors that affect the spine. They can be large, locally invasive and aggressive. In this episode we discuss The diagnosis, treatment and management *** Daniel M. Sciubba, Jennifer J. Cheng, Rory J. Petteys, Kristy L. Weber, Deborah A. Frassica, Ziya L. Gokaslan. Chordoma of the Sacrum and Vertebral Bodies. 708 -717 Journal of the American Academy of Orthopaedic Surgeons. Nov 2009, Vol 17. Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Tumors of the spine can be difficult to identify, diagnose and treat. These tumors are defined as primary or secondary(malignant). In this episode we will discuss the secondary or malignant spine tumors. Dr. Aoude shares his diagnostic as well as treatment algorithms for patients with metastatic spine tumors. Ciftdemir M, Kaya M, Selcuk E, Yalniz E. Tumors of the spine. World J Orthop. 2016 Feb 18;7(2):109-16 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Tumors of the spine can be difficult to identify, diagnose and treat. These tumors are defined as primary or secondary(malignant). In this episode we will discuss with Spine oncologist, Dr. Ahmed Aoude regarding the primary spine tumors. Primary as well as malignant, their evaluation, diagnosis and treatment. Ciftdemir M, Kaya M, Selcuk E, Yalniz E. Tumors of the spine. World J Orthop. 2016 Feb 18;7(2):109-16 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Peripheral Nerves are vital to the function of the human body. Nerves and the sheath that lines them can become neoplastic leading to the formation of tumors. In the previous episode we discussed the benign tumors that arise from peripheral nerves, this episode will focus on the malignant peripheral nerve sheath tumors (MPNST). These tumors are associated with a high local recurrence rate and can be problematic to treat. We discuss the diagnosis, management and treatment of MPNST. Cai, Z., Tang, X., Liang, H. et al. Prognosis and risk factors for malignant peripheral nerve sheath tumor: a systematic review and meta-analysis. World J Surg Onc 18, 257 (2020) Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Peripheral Nerves are vital to the function of the human body. Nerves and the sheath that lines them can become neoplastic leading to the formation of tumors. This episode will focus on the common benign nerve sheath tumors, Schwannomas and Neurofibromas. WE discuss their diagnosis, treatment and management Rodriguez, F.J., Folpe, A.L., Giannini, C. et al. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol 123, 295–319 (2012). Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

The rarity and uniqueness of each individuals case make research in orthopaedic oncology and sarcoma challenging. The Musculoskeletal Tumor Registry (MsTR) is taking this on, led by Dr. Benjamin Miller and program manager Atusa Moreno. The MsTr is an orthopaedic oncological diagnosis-based registry developed in partnership with the Musculoskeletal Tumor Society (MSTS). The goal of the registry is to capture data on orthopaedic oncology, specifically bone and soft tissue tumor procedures, in a structured and scalable way. On this episode we discuss sarcoma research and the future of the registry Links https://www.aaos.org/registries/registry-program/musculoskeletal-tumor-registry/ Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Happy New Year from the Sarcoma Insight Family! Episode recorded: 11/13/2022 Metastatic bone disease are a big cause of pain, morbidity and mortality for patients. The tumor is able to hijack normal bone metabolism and weaken the bone. In this episode we discuss the mechanisms of metastatic disease, diagnosis, management and treatment with Dr. Cory Couch of the Mayo clinic Links Rougraff BT, Kneisl JS, Simon MA. Skeletal metastases of unknown origin. A prospective study of a diagnostic strategy. J Bone Joint Surg Am. 1993 Sep;75(9):1276-81. Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Myxofibrosarcomas are often high grade malignant tumors that can be problematic to treat. They are locally aggressive and associated with a high risk of recurrence. In this episode we discuss the diagnostic and treatment dilemmas as well as the management for patients with myxofibrosarcoma. Links Castronovo C, Arrese JE, Quatresooz P, Nikkels AF. Myxofibrosarcoma: a diagnostic pitfall. Rare Tumors. 2013 May 31;5(2):60-1. doi: 10.4081/rt.2013.e15. PMID: 23888215; PMCID: PMC3719110 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Myxomas are benign soft tissue tumors filled with gelatinous material. They can be painful and occur in many different parts of the body. In this episode we discuss the common presentation, treatment, management and follow up after a diagnosis with Myxoma. We also discuss the differential diagnosis for myxoma which includes malignant tumors that should be ruled out when making the diagnosis. Akshay D. Baheti, Sree Harsha Tirumani Michael H. Rosenthal Stephanie A. Howard Atul B. Shinagare Nikhil H. Ramaiya Jyothi P. Jagannathan. Myxoid Soft-Tissue Neoplasms: Comprehensive Update of the Taxonomy and MRI Features. AJR:204, February 2015 Links Subramanian S, Kemp AK, Viswanathan VK. Bone Cyst. [Updated 2022 Jan 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539849 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Tune in for the second installment of our series, featuring Sarcoma patients/ survivors and their stories: with Brandi Benson. An Ewing sarcoma survivor, Entrepreneur, veteran, author and much more. We discuss her amazing journey from diagnosis to present. We have Brandi's mother with us for the episode and discuss the role and effect of the Sarcoma diagnosis on members of the family. https://brandilbenson.com/ Sarcomaalliance.org sarcomastrong.com Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/