Home
Categories
EXPLORE
True Crime
Comedy
Business
Society & Culture
History
Sports
Health & Fitness
About Us
Contact Us
Copyright
© 2024 PodJoint
00:00 / 00:00
Sign in

or

Don't have an account?
Sign up
Forgot password
https://is1-ssl.mzstatic.com/image/thumb/Podcasts211/v4/f1/7a/c3/f17ac3a9-a8a8-9ce1-4bd0-2db63c8ab3f9/mza_9906503684364986882.jpg/600x600bb.jpg
Rational Optimization \w Elias Schlie
Elias Schlie
69 episodes
4 days ago
Hi, I'm Elias, an AI student trying to solve aging. If you have the same goal, this podcast is for you. Here, I share what I learn on my journey, and interview people working on the same goal so they san share what they have learned. Let’s make more time. The motto is: "Live forever or die trying!" Previously, this was the Rational Optimization podcast. a philosophy podcast focused on the question "What is, all things considered, the most rational thing to do?". I don't know the answer jet, but if we solve aging we will have a lot of time to search for it :)
Show more...
Health & Fitness
RSS
All content for Rational Optimization \w Elias Schlie is the property of Elias Schlie and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Hi, I'm Elias, an AI student trying to solve aging. If you have the same goal, this podcast is for you. Here, I share what I learn on my journey, and interview people working on the same goal so they san share what they have learned. Let’s make more time. The motto is: "Live forever or die trying!" Previously, this was the Rational Optimization podcast. a philosophy podcast focused on the question "What is, all things considered, the most rational thing to do?". I don't know the answer jet, but if we solve aging we will have a lot of time to search for it :)
Show more...
Health & Fitness
Episodes (20/69)
Rational Optimization \w Elias Schlie
Personal diary - July 2025

This month, I built AI agents, I moved, I fasted, and I hiked. In this podcast, I share the stories that I experienced and the insights I found.

YouTube version

My website: eliasschlie.com


Quick Stats 📊⏱️ Total focused work: 288 hours and 46 minutes🗓️ That’s an average of 9 hours and 57 minutes every single day — weekends included!
💾 Full breakdown publicly available here: eliasschlie.com


What I spent my time on 🧠

  • 🚀 Deep dive into AI agents and language model tooling (esp. langchain + agents)

  • 🧪 Built a custom MCP server to connect LLMs with Obsidian for persistent memory scaffolding

  • 🧭 Personal reflection on direction, meaning, and intrinsic values (inspired by valuism)

  • 💬 Developing systems for better conversations and group dynamics

  • 📚 Listening to high-signal content during breaks to stay immersed in key problems


Main Achievements 🏆

✅ Built and shipped my own MCP server — clean, simple, and powerful

✅ Reached a new level of clarity on what I value and why it matters

✅ Used fasting as a powerful tool to reset and return to deep focus

✅ Refined my approach to learning through better break design and structured reflection

✅ Pushed physical + mental boundaries with a 50h fast + night hike — reminder of agency over mind and body

Show more...
3 months ago
49 minutes 30 seconds

Rational Optimization \w Elias Schlie
Personal Diary - Jun 2025

This month, I started building!

eliasschlie.com

YouTube version

Show more...
4 months ago
25 minutes 46 seconds

Rational Optimization \w Elias Schlie
Google's new AI makes scientific discoveries: AlphaEvolve (DeepMind) & Implications for Longevity Science

eliasschlie.com

Show more...
4 months ago
14 minutes 46 seconds

Rational Optimization \w Elias Schlie
Personal Diary — May 2025

eliasschlie.com

Show more...
4 months ago
11 minutes 47 seconds

Rational Optimization \w Elias Schlie
Longevity News - May 2025

















Show more...
5 months ago
1 hour 1 minute 27 seconds

Rational Optimization \w Elias Schlie
Personal Diary - April 2025

My website


Show more...
6 months ago
18 minutes 52 seconds

Rational Optimization \w Elias Schlie
Longevity News - April 2025

1) 🐁 The Rodent Aging Interventions Database (RAID)

2) 🧫 High-Throughput Yeast Aging Study

3) 🤖 Metabolic Digital Twins

4) 🏙️ How Cities Can Be Used to Learn About Aging and Exposome Influences

5) 🐷 First-ever pig-human liver transplant

Show more...
6 months ago
1 hour 19 minutes 11 seconds

Rational Optimization \w Elias Schlie
Machine Learning March

⁠⁠My Website

Show more...
7 months ago
34 minutes 19 seconds

Rational Optimization \w Elias Schlie
February 2025

⁠My Website

Show more...
8 months ago
18 minutes 26 seconds

Rational Optimization \w Elias Schlie
January 2025

My Website

Show more...
8 months ago
18 minutes 58 seconds

Rational Optimization \w Elias Schlie
2025

My website

Show more...
8 months ago
55 seconds

Rational Optimization \w Elias Schlie
#59 I was COO of a Longevity Pop-up City - This is what I learned

In this podcast, I share my experience from being in the core organizing team of Zelar.City, a Longevity Pop-up city


Links:

- ⁠Zelar.City


00:00 - Intro 00:55 - What is a Pop-up city? 04:06 - What makes Zelar.City special? 05:49 - How I came to work at Zelar 10:12 - Month leading up to Zelar 10:47 - At Zelar.city 12:41 - Daily experience at Zelar.city (Longevity pop-up City) 16:18 - Zelar.City weekend summits 19:20 - My main learning 22:49 - Future of Pop-up cities

Show more...
10 months ago
24 minutes 29 seconds

Rational Optimization \w Elias Schlie
#58 We build a Longevity Pop-up City - Zelar.city team interview with Victoria Forest, Laurence Ion, Alexey Strygin, Anatoly Karlin, & Elias Schlie

Zelar.City is a Longevity pop-up city. In this episode, the team comes together, discusses longevity, it's bottlenecks and reflects on their experience in Berlin.


Links:

- Learn about Longevity

- Sophia DAO

- Zelar.City

- Anatoly's blog

Show more...
10 months ago
1 hour 6 minutes 25 seconds

Rational Optimization \w Elias Schlie
#57 Solving Aging with Human Intelligence Enhancement - Anatoly Karlin

Links:

- ⁠Learn about Longevity⁠

- ⁠Sophia DAO⁠

- ⁠Zelar.City⁠

- ⁠Anatoly's blog

Show more...
10 months ago
1 hour 18 minutes 42 seconds

Rational Optimization \w Elias Schlie
#56 I meditated 100 hours in 10 days - Vipassana Meditation Retreat Experience report

Watch on YouTube

Vipassana website

Show more...
11 months ago
55 minutes 39 seconds

Rational Optimization \w Elias Schlie
#55 CEO of DoNotAge.org (Alan Graves) - Longevity Supplements and Tests

Summary

In this conversation, Alan Graves, CEO of DoNotAge.org, discusses the current state of the longevity supplement industry, emphasizing the importance of research and transparency. He highlights the need for consumers to be informed about the quality of supplements and the potential for aging to be reversible. Alan shares insights from his experiences in the industry, including his participation in the Reverse Longevity documentary, and offers advice for aspiring professionals in the field.


Links

- ⁠DoNotAge.org⁠

- ⁠Zelar.City⁠

- YouTube


Chapters

00:00 Introduction to DoNotAge.org and Alan Graves

03:10 Research and Development in Longevity

06:33 Challenges in the Supplement Industry

10:29 Consumer Awareness and Education

13:57 Reversibility of Aging

16:41 Personal Discoveries in Longevity

17:56 Experiences from the Reverse Longevity Documentary

19:49 Advice for Aspiring Longevity Professionals

21:54 Founding Story of DoNotAge.org

25:50 Links


Keywords

longevity, supplements, aging, health, research, DoNotAge.org, clinical trials, consumer awareness, NAD, rapamycin

Show more...
11 months ago
26 minutes 4 seconds

Rational Optimization \w Elias Schlie
#54 Longevity interview with Prof. Hans Meij

Summary

In this conversation, Professor Hans Meij discusses the importance of focusing on health span rather than just longevity. He emphasizes the need for early interventions in healthcare, the challenges posed by smoking, and the role of innovative initiatives like pop-up cities in advancing longevity research. He also highlights the significance of building networks among professionals in the field and offers advice for young individuals starting their careers in longevity. :)


Links

- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Zelar City Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠What is Zelar City?⁠⁠⁠⁠


Chapters

00:00 Who is Prof. Hans Meij

00:57 Introduction to Professor Hans Meij

02:20 The Importance of Self-Awareness in Longevity

04:13 Education and Longevity: A Global Perspective

05:54 Counterintuitive Insights on Aging

08:09 Health Span vs. Life Span: A Critical Discussion

09:23 The Future of Human Lifespan: Possibilities and Limits

13:53 Bottlenecks in Longevity Research

16:13 The Role of Pop-Up Initiatives in Longevity

19:26 Building a Global Longevity Network

24:20 Staying Updated in the Longevity Field

33:28 Advice for Young Professionals in Longevity

35:50 Reflections on Improvement in the Longevity Field

37:10 Links

Show more...
11 months ago
37 minutes 34 seconds

Rational Optimization \w Elias Schlie
#53 Doctor's view on Radical Life Extension - Rafid Fadul, MD (Cenegenics)

Charles Mattocks


Links

- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Zelar City Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠What is Zelar City?⁠⁠⁠⁠⁠

- ⁠⁠Reversed Longevity Trailer⁠⁠

- As soon as it's out, you will be able to find "Reversed Longevity" on Amazon Prime, Tubi, or Glue TV


Chapters


00:00 Introduction to Rafid Fadul and Longevity

00:41 Introduction to Rafid and His Journey

03:33 What is Cenegenics?

05:07 What is Zivian health?

07:20 How to deal with the shrinking healthcare workforce

10:00 What idea in longevity gets less attention than it deserves?

13:30 Is radical life extension the right goal?

17:57 The Importance of Fulfillment in Longevity

20:58 Ethical Considerations in Longevity Science

28:29 Ethical Implications of Radical Life Extension

30:18 Counterintuitive Insights in Longevity

35:15 Experiences from the Reverse Longevity Documentary

36:56 Evolving Perspectives in Longevity Medicine

41:29 The Role of Psychedelics in Mental Health

43:43 Advice for Aspiring Longevity Leaders

48:26 Reflections on Personal Growth and Presence

51:23 Exploring Radical Longevity and Life Extension


Summary

In this conversation, Rafid Fadul discusses his journey in the field of longevity, the importance of mental health, and the evolving landscape of healthcare. He emphasizes the need for a holistic approach to health that includes not just physical well-being but also mental and emotional fulfillment. Rafid shares insights from his experiences, including his participation in the Reverse Longevity documentary, and offers advice for future leaders in the longevity space.


Keywords

longevity, health, radical life extension, mental health, healthcare system, performance health, psychedelics, healthcare compliance, aging, wellness


Takeaways

Sanogenics has been a pioneer in hormone replacement therapy for longevity.

The US healthcare system faces significant challenges that need addressing.

Fundamentals of health such as sleep, nutrition, and exercise are crucial for longevity.

Radical life extension raises philosophical questions about the purpose of life.

Mental health plays a critical role in overall health and longevity.

Experiences from the Reverse Longevity documentary highlight the importance of collaboration in the field.

The landscape of longevity research is constantly evolving, requiring adaptability.

Psychedelics may have untapped potential in mental health treatment.

Creating accessible platforms for sharing knowledge is essential in the longevity field.

Being present and appreciating all moments can lead to a more fulfilled life.

Show more...
11 months ago
51 minutes 59 seconds

Rational Optimization \w Elias Schlie
#52 How he made a Longevity Documentary - Charles Mattocks

Summary

In this conversation, Charles discusses his latest documentary 'Reverse Longevity', exploring the concept of longevity and health interventions. He emphasizes the importance of making health information accessible to the general public and shares insights on the production process of health documentaries. Charles also reflects on the personal impact of longevity research on his life and the challenges of funding and distributing health content. He offers advice for aspiring content creators and shares his motivation for promoting longevity and health education.


Links

- ⁠⁠⁠⁠⁠⁠⁠⁠⁠Zelar City Website⁠⁠⁠⁠⁠⁠⁠⁠⁠

- ⁠⁠⁠⁠⁠⁠⁠⁠⁠What is Zelar City?⁠⁠⁠⁠

- ⁠Reversed Longevity Trailer⁠

- As soon as it's out, you will be able to find "Reversed Longevity" on Amazon Prime, Tubi, or Glue TV


Chapters

00:00 Introduction to Charles and His Journey

01:50 Charles's Longevity Documentary

06:03 What did you learn from doing this documentary?

09:24 Where is the focus? Longevity present or future?

10:58 Why Charles not host his own longevity documentary?

14:11 Choosing Costa Rica: A Unique Filming Location

15:18 Did making a Longevity Documentary change your behavior?

16:50 Funding and Producing Health Documentaries

20:32 How Charles started his Media company

22:26 Lessons from Diabetes Documentaries

24:07 How to make people open up during interviews

25:21 Crafting Compelling Narratives in Filmmaking

29:10 Advice for Aspiring Filmmakers and Advocates

31:20 The Drive for Change and Future Aspirations

36:15 Exploring Longevity and Health Documentaries

Show more...
1 year ago
36 minutes 36 seconds

Rational Optimization \w Elias Schlie
#51 Andrea Maier - Longevity advocate, speaker, and researcher

Summary

In this conversation, Andrea Maier, a prominent longevity advocate, discusses her work in the field of aging and health optimization. She emphasizes the importance of understanding organ-specific aging clocks, the need for evidence-based practices, and the significance of healthspan over lifespan. Andrea also highlights the challenges in longevity research, the role of pop-up cities in fostering innovation, and the potential of decentralized science. Throughout the discussion, she shares insights on personal approaches to longevity and the importance of mentorship for aspiring professionals in the field.


Links

- ⁠⁠⁠⁠⁠⁠⁠⁠Zelar City Website⁠⁠⁠⁠⁠⁠⁠⁠

- ⁠⁠⁠⁠⁠⁠⁠⁠What is Zelar City?⁠⁠⁠


Chapters

00:00 Introduction to Andrea Maier

01:04 Measuring Biological Age: A Missed Opportunity

01:33 Understanding Aging Clocks and Their Applications

07:52 Personal Approaches to Longevity

09:41 ls there a limit to how much we can increase lifespan?

11:13 Bottlenecks in Longevity Research

14:31 The Role of Pop-Up Cities in Longevity

16:11 Andrea Maiers opinion on Decentralized Science

17:11 How Andrea stays up to date in Longevity

18:10 Who does Andrea Maier look up to in longevity?

19:27 Counterintuitive learning

21:05 Advice for Aspiring Longevity Researchers

22:45 Outro

Show more...
1 year ago
23 minutes 5 seconds

Rational Optimization \w Elias Schlie
Hi, I'm Elias, an AI student trying to solve aging. If you have the same goal, this podcast is for you. Here, I share what I learn on my journey, and interview people working on the same goal so they san share what they have learned. Let’s make more time. The motto is: "Live forever or die trying!" Previously, this was the Rational Optimization podcast. a philosophy podcast focused on the question "What is, all things considered, the most rational thing to do?". I don't know the answer jet, but if we solve aging we will have a lot of time to search for it :)