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0:00 - Introduction

1:18 - What is NAD+? Why is it Important?

8:39 - Weight Loss and NAD+

16:25 - The Dr. Sinclair Story

24:30 - Dr. Sinclair's focus on NAD+

31:50 - How have Scientists boosted NAD+?

34:09 - Do NAD+ Boosters work?

45:36 - Different types of NAD+ Boosters

49:40 - Dr. Sinclair's newest NAD+ Study (Unpublished!)

1:05:28 - Exercise and other Strategies for NAD+ Boosting

1:10:15 - NAD+ in Women

1:13:55 - Nuchido Time+ NAD+ Study in Humans

1:29:51 - Summarizing/Take Aways

1:34:08 - Taking Niacin instead of other NAD+ Boosters?

1:38:05 - Conclusion/Just Chatting

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Dave's Channel: https://youtu.be/RzG6N8WWufM?si=XNl6HTJ66vUpZ0QT 0:00 - Introduction of Study 3:47 - Introduction to Dr. Nick Norwitz and Dave Feldman 8:31 - Dr. Norwitz details the Oreo Study 31:52 - Problems with Science Communication 1:12:42 - Discussion with Dave Feldman

1:15:20 - Lipid Heart Model of Heart Disease

1:27:28 - Lean Mass Hyper-Responders

1:35:10 - Mechanisms of Action Discussion

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Timestamps

0:00 – Introduction 1:05 – Nicotinamide Mononucleotide (NMN) 17:14 – Creatine 20:25 – Collagen Peptides 25:58 – Thoughts on Meta-Analyses 29:18 – Hyaluronic Acid 34:08 – Taurine 37:42 – Thoughts on Mouse Studies 39:55 – Do Blood Markers Matter for Longevity? 42:29 – Trusting Science/Experts 44:05 – Dr. Stanfield’s Motivations for Clinical Education 53:12 – Ending Remarks

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction 5:11 - How to think about Aging 33:48 - Oxidized Blood Lipoproteins 58:34 - Study shows Age Reversal 1:15:28 - Oxalates 1:28:28 - Creatine as a Nootropic 1:35:48 - Niacin and Heart Disease 2:13:17 - Methylene Blue 2:25:25 - NMN on Health 2:38:46 - Inflammation contributing to Heart Disease 2:50:39 - Understanding Cellular Energy for Muscle Growth 3:07:08 - Subscriber Questions & Comments 3:42:05 - Housekeeping

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Table of Content

0:00 - Introduction

05:18 - Carnivore Diet

34:39 - LDL Cholesterol & Heart Disease

1:00:11 - Taurine on Longevity & Health

1:13:04 - One Meal a Day - Context Matters

1:22:27 - Fiber - Good or Bad? Mixed Reviews...

1:38:10 - Cancer is a Metabolic Disease?

2:07:10 - Fasting raises Inflammation!?

2:16:52 - Q&A

2:37:23 - Stories of Health Success

2:44:22 - My PhD Progress, Life outside of University

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WHERE ELSE IM ACTIVE:

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0:00 – Introduction.
5:30 – Toxic Acrylamides in Coffee.
18:46 – The Physionic Dream.
50:05 – Sucralose and Insulin Sensitivity.
57:00 – Insulin & Body Fat.
1:23:25 – Carbohydrate-Insulin Model of Obesity.
2:17:35 – GlyNAC for Anti-Aging.
2:29:50 – Hyaluronic Acid on Skin Aging.
2:40:45 – The Future Content.

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0:00 - Introduction.
3:00 - Dr. John Campbell, High Intensity Health.
39:40 - Nutrition Gurus.
53:00 - My Investigation on Non-Nutritive Sweeteners.
1:03:05 - Improving the 'Detailed Study Analyses'.
1:09:53 - Sweeteners break your Fast?
1:14:23 - Alternate Day Fasting.

Hi, in this episode, I cover a bunch of topics from my experience at the doctor, my own hypocrisy, some things I learned from you, and finally - the main topic of discussion: Insulin resistance and how plastics (phthalates) affect it. Oh, and if you're on Spotify or YouTube, it's now a video podcast, as well!

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Hi folks, in this episode I unintentionally discussed two topics. One, I planned on discussing, which was caffeine and it's performance effects in weight lifting and endurance. However, because I woke myself up to a nutrition documentary that I watched for 20 minutes or so before recording, I felt I had to get some things off my chest related to the second topic - nutrition documentaries. So, you have the distinct pleasure (or dismay) of listening to me ramble on both, but I hope that either way you learn something of use, especially related to caffeine.

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Video and Studies on Caffeine: https://youtu.be/9WTbwlU5yOs

In this episode, the first of a more relaxed, long form podcast style, we're going to dive into how fat relates to cancers - the mechanisms, but beyond that, the different therapies employed by pharmaceuticals, along with the use of nutrition to combat certain cancers.

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Related Videos:
Mechanisms: https://youtu.be/Ijt1lqxn2AQ
Therapies: https://youtu.be/iLdcoIIiByo

Scientific Review:
Reprogramming of Fatty Acid Metabolism in Cancer
British Journal of Cancer

I think you'd be better served if we change how we do things on the Physionic Podcast.

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In this episode, I'm going to begin the explanation as to what effects carbohydrates have on our metabolism, and one potential effect in our mitochondria.

Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs34%5D-a-high-carbohydrate-diet-lowers-the-rate-of-adipose-tissue-mitochondrial-respiration
Video: https://www.youtube.com/watch?v=7uBHNUSI6hI
Previous Video on Carbs and Metabolism: https://www.youtube.com/watch?v=xn8VJzGCK5U&t=2s

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Study:
A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration
Benjamin Bikman

In this episode, we'll discuss a potential exception to the negative results on insulin sensitivity we've been discussing with the exposure to saturated fat.

Study, Notes, & Amendments: https://www.physionic.org/examine/%5B31%5D-palmitate-acutely-induces-insulin-resistance-in-isolated-muscle-from-obese-but-not-lean-humans
Video: https://youtu.be/ldUBG4-EJDo

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Study:
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
A Brianne Thrush

Hi all, in this episode, I'm going to describe to you how your nutrition, generally, affects your mitochondria in diabetes specific cells and how long term habits in nutrition can lead to diabetes (type 2). Enjoy.

Video Version: https://youtu.be/x6EOhTzVKsE
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure

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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa

In this episode, we'll be diving into two ways your mitochondria change their "behavior" to the exposure to different nutrition situations (high vs low nutrient presence).

Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure
Video: https://www.youtube.com/watch?v=KQBmtzT4VTU

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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa

In this episode, we'll be going over a new study that wanted to find out the effects a saturated fat heavy consumption would have on insulin resistance and signaling against an unsaturated fat heavy consumption.

Video: https://youtu.be/QfII7CANt14
Study: https://www.physionic.org/examine/%5Bs30%5D-dietary-palmitate-and-oleate-differently-modulate-insulin-sensitivity-in-human-skeletal-muscle

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Sarabhai, T., Koliaki, C., Mastrototaro, L., Kahl, S., Pesta, D., Apostolopoulou, M., Wolkersdorfer, M., Bönner, A. C., Bobrov, P., Markgraf, D. F., Herder, C., & Roden, M. (2022). Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia, 65(2), 301–314. https://doi.org/10.1007/s00125-021-05596-z

In this episode, we continue our quest for understanding the effect saturated fats have on muscle insulin signaling and mitochondrial health - however, beyond that, we'll be looking at how unsaturated fats may protect against the deleterious effects of saturated fat? Let's see..

Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs28%5D-different-effects-of-oleate-vs.-palmitate-on-mitochondrial-function%2C-apoptosis%2C-and-insulin-signaling-in-l6-skeletal-muscle-cells%3A-role-of-oxidative-stress-

Video: https://youtu.be/TiO16KoH0Fs

Study Title: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Larysa Yuzefovych

In this episode, I'm kicking off a new format that's more tailored to the podcast listeners, so there's less need to head to the video versions of the podcast to understand half of what I'm talking about. In this episode, we'll be discussing saturated fat (palmitate) and it's effects in relation to insulin signaling in muscle cells, as well as mitochondrial function. What are the effects? What are the implications?


Video: https://youtu.be/zMkV91E2Bic
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249685/