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This episode features a conversation with Senior Investigator Michael DeBaun, Professor of Pediatrics and Medicine at Vanderbilt University Medical Center, who has had a long career investigating the causes of and treatments for sickle cell anemia, and advocating for children and adults with this condition across the globe.
You can access his Vanderbilt page here: Michael R. DeBaun, MD, MPH | Department of Pediatrics
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In this episode, Geoff Marsh speaks to Dr. Stephanie Ford about our Collection on Fetal Alcohol Spectrum Disorder.
Read the collection here: https://www.nature.com/collections/fccidiefbi
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This month features a conversation with Senior Investigator, Professor Richard Jackson, who’s had an extensive career in Public Health. Now Professor Emeritus at the Fielding School of Public Health at the University of California, Los Angeles, Richard has served in many leadership positions including nine years as Director of the CDC's National Centre for Environmental Health.
Our conversation covered a wide range of topics affecting children's health, from pesticides to urban planning to gun violence, testament to his rich and varied career.
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In this episode, listen to our editorial apprentice, Dr. Eric Peeples describe the scope and importance of our collection on neonatal encephalopathy and hypoxic-ischemic encephalopathy.
Visit the collection here: Neonatal Encephalopathy and Hypoxic Ischemic Encephalopathy (nature.com)
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Pediatric researchers Cynthia Bearer and Eleanor Molloy join podcast host Geoff Marsh to give an update on plans for the podcast and to offer some sage advice for Early Career Investigators.
Find more Pediapod episodes here: https://www.nature.com/collections/fcbjjbchaa
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The United Nations recently stated that “climate change is the defining issue of our time, and we are at a defining moment” (https://www.un.org/en/global-issues/climate-change). This statement ended the political debate about the role of human activities in climate change. Global climate change is happening and it will have a profound effect on our children.
Listen and learn from Dr. Kari Nadeau the Chair of Environmental Health from Harvard School of Public Health and one of the guest editors of Pediatric Research's special issue on climate change.
Read Dr. Nadeau's editorial here: Global climate change: the defining issue of our time for our children’s health | Pediatric Research (nature.com)
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Illness severity scores are commonly used for mortality prediction and risk stratification in pediatric critical care research. However, as mortality has steadily declined in the pediatric intensive care unit there has been increasing attention given to evaluating non-mortality outcomes in survivors.
In this episode we meet Early Career Investigator Elizabeth Killien from Seattle Children's Hospital. In order to evaluate the ability of two commonly used illness severity scores to predict morbidity outcomes, she performed a secondary analysis of the Life After Pediatric Sepsis Evaluation (LAPSE) multicenter longitudinal cohort study of functional and health-related quality of life outcomes among survivors of septic shock.
Read the full article here: Predicting functional and quality-of-life outcomes following pediatric sepsis: performance of PRISM-III and PELOD-2 | Pediatric Research (nature.com)
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This episode, along with a few more to come, involves a conversation with a senior investigator who has had a large and lasting effect in the world of pediatric research. The Early Career Investigator episodes will still be coming once a month, but hopefully this will add a bit of variety to the Pediapod feed and shine a light on some of the pioneers who have helped shape the face of modern Pediatrics. This episode features Dr. Max Vento.
Read Max Vento's biocommentary here: www.nature.com/documents/Max_Vento_Biocommentary.pdf
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Hypoxic Ischaemic Encephalopathy (HIE), a subset of neonatal encephalopathy, is the most common neurological condition in term born infants. It is known that a range of acute and chronic placental pathologies are more common in infants with HIE. However little is known about how differences in utero-placental function might contribute to varied outcomes in these infants.
In this episode of Pediapod, we speak to Early Career Investigator Dr. Jeffrey Russ from Duke University Medical Center, who retrospectively analyzed whether acute versus chronic placental pathology were differentially associated with outcomes in patients with presumed HIE.
Read the full study here: The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy | Pediatric Research (nature.com)
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The development of children born very preterm is most often evaluated using the Bayley Scales of Infant Development. These single assessments are routinely used as outcome measures for neonatal interventions or as a means of prognosis. However, early Bayley scores may not accurately predict later outcomes.
In this episode of Pediapod, we speak to Dr. Mary Lauren Neel from Emory University who, along with her team, set up a study to determine whether Bayley-III score trajectories measured at multiple timepoints in children born very preterm, predicted school readiness at age 5, better than a single assessment.
Read the full study here: Bayley trajectories predict school readiness better than single assessments in formerly very preterm preschoolers | Pediatric Research (nature.com)
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The temporal facilitates many complex neurological processes. Alterations to these processes are known to correlate with specific functional deficits commonly found in preterm-born children at and beyond school age. However, as yet there is not an objective, validated method to assess the temporal lobe structure or size in very preterm infants.
In this episode of Pediapod, I speak to neonatologist and this month's highlighted Early Career Investigator, Katherine Bell, from the Brigham and Women's hospital, Boston who developed a new method for quantifying temporal lobe size in very preterm infants at term equivalent age using simple metrics performed on brain MRI.
Read the full study here: Novel metrics to characterize temporal lobe of very preterm infants on term-equivalent brain MRI | Pediatric Research (nature.com)
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The COVID-19 pandemic severely affected health and healthcare systems worldwide and could have resulted in changes in fetal and neonatal outcomes.
In this episode, we speak to Early Career Investigator, Vivek Shukla from the University of Alabama at Birmingham. Using machine learning techniques, he performed a population-based study to identify changes in fetal and neonatal outcomes during the initial and delta COVID-19 pandemic period as compared to the baseline period.
Listen to the full study here: Trends in fetal and neonatal outcomes during the COVID-19 pandemic in Alabama | Pediatric Research (nature.com)
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Before the COVID-19 pandemic, the use of telemedicine was limited in pediatric primary care. Then, in 2020 it increased exponentially. However, early COVID-19 reports described inequities in telemedicine use across multiple specialties.
In this episode, we meet Early Career Investigator, Kelsey Schweiberger from the University of Pittsburgh. In a recent paper, she describes the factors associated with scheduling and attendance of telemedicine appointments for pediatric primary care throughout the first year of the COVID-19 pandemic to identify priorities for enhanced equity in access.
Read the full paper here: https://www.nature.com/articles/s41390-023-02481-w
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