In today’s episode, I sit down with Dr. Shahzadi Harper, a leading voice in women’s midlife health and founder of The Harper Clinic in London. Known as “The Perimenopause Doctor,” Dr. Harper is a medical doctor and hormonal health expert who blends conventional and lifestyle medicine to help women thrive through perimenopause and beyond.
This conversation is all about weight—specifically, the frustrating, stubborn weight gain so many women experience in perimenopause and the science behind why it happens. We cover the hottest topics in midlife wellness right now: intermittent fasting, insulin resistance, and GLP-1s like Ozempic and Mounjaro. Dr. Harper breaks down what actually works, what’s hype, and how to approach weight loss in this season of life with clarity and confidence.
We dive into how shifting hormones impact metabolism, how cortisol and stress affect blood sugar and fat storage, and why so many women feel like nothing is working—even when they’re doing everything “right.” You’ll also hear Dr. Harper’s take on microdosing GLP-1s—starting low and slow rather than jumping to a full dose—and how that can lead to better results with fewer side effects.
Whether you're feeling stuck, frustrated, or just trying to make sense of the chaos happening in your body—this one is for you.
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