This episode breaks down a classic PYQ on apoptosis vs necrosis — a must-know concept for NEET PG, FMGE, and INICET aspirants. Learn the differences, avoid common traps, and understand the clinical relevance in under 10 minutes. Designed by a medico, for medicos.
Apoptosis vs Necrosis — PYQ Breakdown
🧪 PYQ Question
Which of the following is a feature of apoptosis but not necrosis?
A. Cell swelling
B. Inflammatory response
C. DNA fragmentation
D. Loss of membrane integrity
✅ Correct Answer: C. DNA fragmentation
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🧠 Concept Breakdown
- Apoptosis is a programmed, energy-dependent cell death — clean and non-inflammatory.
- Necrosis is accidental, uncontrolled cell death — messy and inflammatory.
- Key differences:
- Apoptosis: Cell shrinkage, chromatin condensation, DNA fragmentation, intact membrane.
- Necrosis: Cell swelling, membrane rupture, inflammation.
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⚠️ Caution for Students
- Don’t confuse cell swelling (necrosis) with cell shrinkage (apoptosis).
- Inflammation is absent in apoptosis — a common MCQ trap.
- DNA laddering is a lab clue for apoptosis.
- Image-based questions often show apoptotic bodies — small, round fragments.
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🩺 Clinical Relevance
- Apoptosis: Seen in embryogenesis, immune regulation, cancer therapy.
- Necrosis: Seen in ischemia, infections, toxins — e.g., myocardial infarction.
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