🎙️ Podcast Segment: Amyloidosis — PYQ Breakdown & Concept Mastery
❓ PYQ Example
Question: Which stain is used to identify amyloid deposits in tissue sections?
A. PAS
B. Congo red
C. Hematoxylin
D. Ziehl-Neelsen
✅ Correct Answer: B. Congo red
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🧠 Concept Breakdown
- Amyloidosis is a condition where misfolded proteins deposit extracellularly in tissues.
- These proteins form β-pleated sheets, giving them unique staining and birefringence properties.
- Types of Amyloid:
- AL (light chain) — seen in multiple myeloma
- AA (acute phase reactant) — seen in chronic inflammation
- Aβ — seen in Alzheimer’s disease
- Staining: Congo red stain shows apple-green birefringence under polarized light — a classic PYQ clue.
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⚠️ Caution for Students
- Don’t confuse PAS stain (used for glycogen) with Congo red for amyloid.
- Know the clinical associations — e.g., nephrotic syndrome, restrictive cardiomyopathy, macroglossia.
- Amyloid deposits are extracellular, not intracellular — a common MCQ trap.
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🩺 Clinical Relevance
- Systemic amyloidosis affects kidneys, heart, liver, and nerves.
- Localized amyloidosis includes Alzheimer’s and medullary thyroid carcinoma.
- Diagnosis involves biopsy + Congo red staining + clinical correlation.
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🎙️ Title
"Amyloidosis Uncovered: PYQ Mastery for NEET PG & FMGE"
📝 Description
This episode tackles one of the most conceptually tricky and frequently asked topics in NEET PG/FMGE/INICET — Amyloidosis. Learn the types, staining techniques, clinical relevance, and how to avoid common traps in under 10 minutes. Designed by a medico, for medicos.
NEETPG #FMGEprep #INICET #Amyloidosis #PathologyPYQ #MedicoPodcast #RapidReview #MedicalStudents #ExamPrep #MBBS #HighYieldPathology #SpotifyPodcast
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