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Mind & Matter
Nick Jikomes
249 episodes
19 hours ago
Send us a text The appendix's hidden role and how "good" parasites like helminths shape immune health. Episode Summary: Dr. William Parker discusses gut anatomy, the appendix's role in harboring beneficial bacterial biofilms and immune tissue, and how modern hygiene depletes helminths (intestinal worms), causing immune overreactions like allergies, autoimmunity, and psychiatric conditions. He explores helminth self-therapy for treating relapsing MS, depression, and allergies; challenges in cl...
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All content for Mind & Matter is the property of Nick Jikomes and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Send us a text The appendix's hidden role and how "good" parasites like helminths shape immune health. Episode Summary: Dr. William Parker discusses gut anatomy, the appendix's role in harboring beneficial bacterial biofilms and immune tissue, and how modern hygiene depletes helminths (intestinal worms), causing immune overreactions like allergies, autoimmunity, and psychiatric conditions. He explores helminth self-therapy for treating relapsing MS, depression, and allergies; challenges in cl...
Show more...
Science
Education,
Society & Culture
Episodes (20/249)
Mind & Matter
Appendix, Gut Worms, Allergies & Autoimmunity | William Parker | 246
Send us a text The appendix's hidden role and how "good" parasites like helminths shape immune health. Episode Summary: Dr. William Parker discusses gut anatomy, the appendix's role in harboring beneficial bacterial biofilms and immune tissue, and how modern hygiene depletes helminths (intestinal worms), causing immune overreactions like allergies, autoimmunity, and psychiatric conditions. He explores helminth self-therapy for treating relapsing MS, depression, and allergies; challenges in cl...
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3 days ago
1 hour 19 minutes

Mind & Matter
Cannabinoid System: Metabolism, Evolution & Energy Storage | Giovanni Marsicano | 245
Send us a text What is the core evolved function of the endocannabinoid system? Episode Summary: Dr. Giovanni Marsicano is a neuroscientist based in Bordeaux, France, where he leads a research group at INSERM focusing on the endocannabinoid system. About the guest: Giovanni Marsicano, PhD discusses the endocannabinoid system, starting with its core components like CB1 receptors and lipid-based molecules derived from omega-6 fatty acids; its cellular signaling, evolutionary role in energy stor...
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1 week ago
1 hour 44 minutes

Mind & Matter
Seed Oils & Heart Disease: Oxidized LDL, Cholesterol, Fat & Cardiology | Tucker Goodrich | 244
Send us a text Overview and alternative interpretation to the mainstream view on how dietary fat and cholesterol relate to cardiovascular disease. Episode Summary: Tucker Goodrich is an engineer by training who has become a prominent independent researcher and blogger on nutrition and metabolic health, focusing on the harms of seed oils and polyunsaturated fats. About the guest: Nick Jikomes and Tucker Goodrich explore atherosclerosis and heart disease, critiquing the standard model that blam...
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2 weeks ago
1 hour 39 minutes

Mind & Matter
Evolution & Variation in Human Diet, Energy Expenditure & Metabolism | Herman Pontzer | 243
Send us a text Human metabolism, primate evolution, and modern health challenges with evolutionary anthropologist Herman Pontzer. Episode Summary: Anthropologist Dr. Herman Pontzer discusses human evolution and metabolism, comparing humans to primates like chimps and gorillas to explain our higher energy use, bigger brains, and longer lives despite trade-offs in reproduction and activity; they discuss dietary shifts from plant-based to hunting-gathering, metabolic adaptations, and modern issu...
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2 weeks ago
1 hour 49 minutes

Mind & Matter
Sunlight: Cosmology, Energy Metabolism & the Physics of Life | Robert Fosbury | 242
Send us a text The deep connection between sunlight and life, from the scale of the cosmos to the quantum. Episode Summary: Astrophysicist Dr. Robert Fosbury discusses the sun's characteristics as a star, its analogies to living systems via entropy and complexity, and Erwin Schrödinger's insights on life as order-maintaining entities; he explores how near-infrared (NIR) light from the sun penetrates bodies to enhance mitochondrial function and metabolism, critiques modern artificial lighting'...
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3 weeks ago
2 hours 13 minutes

Mind & Matter
Synapse Energetics & Fat Metabolism in the Brain | Timothy Ryan | 241
Send us a text How brain synapses work and fuel themselves with fat. Episode Summary: Dr. Timothy Ryan talks about the high energy costs of synapses, the role of mitochondria and glycolysis, and challenge the long-held view that the brain relies solely on glucose by discussing new evidence that neurons burn fats from lipid droplets for fuel, especially during activity. The talk touches on metabolic flexibility, links to epilepsy treatments like ketogenic diets, neurodegenerative diseases, and...
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4 weeks ago
1 hour 25 minutes

Mind & Matter
Microbiome as a Modifiable Organ System | Eugene Chang | 240
Send us a text Episode Summary: Dr. Eugene Chang talks about the microbiome’s role as a vital organ, the impacts of antibiotics and Western diets on microbial health, and strategies for restoring a damaged microbiome through diet and fecal microbial transplants. They delve into microbiome dysbiosis, its links to modern diseases, and Chang’s research on personalized microbiome interventions. About the guest: Eugene Chang, MD is a physician-scientist and Professor of Medicine at the University ...
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1 month ago
1 hour 28 minutes

Mind & Matter
Sleep Duration, Sleep Timing & Short-Sleepers | Ying-Hui Fu | 239
Send us a text The genetics of sleep duration and sleep timing. Episode Summary: Dr. Ying-Hui Fu discusses her research on the genetics of sleep, focusing on natural short sleepers who thrive on 4-6 hours of sleep and the heritability of sleep traits like duration and timing. She explores how sleep efficiency, rather than just duration, may explain why some need less sleep without health deficits, and delves into the molecular and circadian mechanisms regulating sleep. About the guest: ...
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1 month ago
54 minutes

Mind & Matter
Hormones, Endocrine Disruptors & the Fate of Modern Liberal Society | Charles Cornish-Dale | 238
Send us a text A blend of biology, philosophy, and history exploring how hormones and endocrine disruptors affect social behavior and society. Episode Summary: Dr. Charles Cornish-Dale discusses the decline of masculinity in modern society, linking it to falling testosterone levels, environmental endocrine disruptors, and the limitations of liberal democracy. Drawing on Francis Fukuyama’s “End of History & the Last Men” and historical perspectives, Cornish-Dale argues that biological and ...
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1 month ago
1 hour 33 minutes

Mind & Matter
Circadian Biology: Genetics, Behavior, Metabolism, Light, Oxygen & Melatonin | Joseph Takahashi | M&M 237
Send us a text How our biological clocks shape biology from the molecular to behavioral level. Episode Summary: Dr. Joseph Takahashi discusses circadian rhythms, exploring their biological basis, from molecular mechanisms to their impact on metabolism and health; the discovery of circadian clock genes; role of the suprachiasmatic nucleus, and how light, feeding, and oxygen influence these rhythms. The conversation highlights practical implications, such as the effects of artificial light and ...
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1 month ago
1 hour 52 minutes

Mind & Matter
Cell Biology: Cytoskeleton, Self-Assembly & Self-Organization, Wound Healing | Bill Bement | 236
Send us a text Cellular self-organization, cytoskeleton dynamics, and membrane wound healing. Episode Summary: Cell Biologist Dr. Bill Bement explains the dynamic world of the cell cortex, discussing how actin filaments and microtubules drive processes like cell division and wound healing through self-assembly and self-organization; energy dynamics of these processes; the role of rho GTPases in patterning; the implications for diseases such as cancer and muscular dystrophy, using vivid analog...
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1 month ago
1 hour 31 minutes

Mind & Matter
Computational Neuroscience, Machine Learning vs. Biological Learning, Large Language Models | Marius Pachitariu | 235
Send us a text How brains compute and learn, blending neuroscience with AI insights. Episode Summary: Dr. Marius Pachitariu discusses how the brain computes information across scales, from single neurons to complex networks, using mice to study visual learning. He explains the differences between supervised and unsupervised learning, the brain’s high-dimensional processing, and how it compares to artificial neural networks like large language models. The conversation also covers experimental ...
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1 month ago
1 hour 50 minutes

Mind & Matter
Brain Fat: Dietary PUFAs, Cannabinoids, Fatty Acid Binding Proteins, Anxiety & Mood | Steven Laviolette | 234
Send us a text How dietary fats and cannabinoids shape brain function and mental well-being. Episode Summary: Dr. Steven Laviolette discusses the role of lipids, particularly endocannabinoids and fatty acids, in brain signaling and mental health, discussing how dietary omega-3 and omega-6 imbalances, prenatal THC exposure, and fatty acid binding proteins (FABPs) impact mood, anxiety, and neuroinflammation, while highlighting potential dietary interventions to mitigate these effects. About the...
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2 months ago
1 hour 12 minutes

Mind & Matter
Feel the Burn: Seed Oils, Memes & Oxidative Stress | Brian Kerley | 233
Send us a text Are seed oils really driving chronic disease (and sunburns), or is it hype? Episode Summary: Dr. Brian Kerley talks about the health impacts of seed oils, their high omega-6 fatty acid content, and their role in chronic diseases through mechanisms like lipid peroxidation and oxidative stress. They explore how these industrially processed oils may contribute to conditions like heart disease and obesity, discuss the challenges of studying their long-term effects, and highlight th...
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2 months ago
2 hours 10 minutes

Mind & Matter
SSRIs, Sexual Dysfunction, Suicide & Mass Shootings, How FDA Works | David Healy | 232
Send us a text A critique of SSRIs and pharma’s influence on medicine, including SSRI-induced sexual dysfunction, suicidality, and violence. Long Summary: Dr. David Healy critiques modern medicine, focusing on SSRIs and psychiatric medicine, including: how pharmaceutical companies manipulate clinical trial data, ghostwrite studies, and influence medical practice, often ignoring patient experiences; highlighting issues like post-SSRI sexual dysfunction (PSSD), the immediate sensory effec...
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2 months ago
2 hours 10 minutes

Mind & Matter
Psychedelic Chemistry, Magic Mushrooms, Kratom, Gray Market Research Chemicals, Vape Shops | Andrew Chadeayne | 231
Send us a text Episode Summary: Dr. Andrew Chadeayne discusses the chemistry of psilocybin and other psychedelics, their potential therapeutic applications, and the challenges of commercializing them in a shifting biotech market. The conversation delves into the complexities of magic mushroom composition, debunking myths like "lemon tekking," and uncovers the booming, unregulated alternative products industry, including kratom and synthetic psilocybin analogs sold in vape shops. About the gue...
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2 months ago
1 hour 38 minutes

Mind & Matter
Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication | Michael Wheeler | 230
Send us a text Episode Summary: Dr. Michael Wheeler talks about neuroimmune interactions, exploring how the immune system and brain communicate, particularly through the blood-brain barrier and meninges; how chronic stress and inflammation can alter brain circuits, contributing to mood disorders like depression; how drugs like psilocybin and MDMA may reduce inflammation by modulating immune cells in the meninges, offering potential therapeutic benefits. About the guest: Michael Wheeler, PhD i...
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3 months ago
1 hour 9 minutes

Mind & Matter
Linoleic Acid, Seed Oils, mTOR & Breast Cancer | Nikos Koundouros & John Blenis | 229
Send us a text Episode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth; role of the FABP5 protein in enhancing cancer cells’ sensitivity to omega-6 fats; differences between breast cancer subtypes; broader implications of dietary balance for health. About the guest: John Blenis, PhD is a Professor of Pharmacology at the Meyer Cancer...
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3 months ago
1 hour 47 minutes

Mind & Matter
Rhythms, Memory, Time, Place, Representation & the Brain | György Buzsáki | 228
Send us a text Episode Summary: Dr. Gyorgy Buzsaki discusses the hippocampus’s role beyond memory and spatial navigation, delving into its broader functions in cognition, action planning, and brain-body interactions; how hippocampal rhythms, like sharp wave ripples, influence memory consolidation, glucose regulation, and metabolic health, challenging conventional neuroscience assumptions; the interplay of brain rhythms, sleep, and preconfigured neural dynamics; the history and conceptual foun...
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3 months ago
1 hour 48 minutes

Mind & Matter
Biophysics of Life: Biophotons, Light, Quantum Biology, Regeneration & Cancer | Nirosha Murugan | 227
Send us a text The biophysics of life, exploring how light & energy shape biology, with biophysicist Dr. Nirosha Murugan. Episode Summary: Dr. Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how microtubules may act as biological fiber optics, the impact of modern light environments on health; her work inducing limb regeneration in frogs usi...
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3 months ago
1 hour 39 minutes

Mind & Matter
Send us a text The appendix's hidden role and how "good" parasites like helminths shape immune health. Episode Summary: Dr. William Parker discusses gut anatomy, the appendix's role in harboring beneficial bacterial biofilms and immune tissue, and how modern hygiene depletes helminths (intestinal worms), causing immune overreactions like allergies, autoimmunity, and psychiatric conditions. He explores helminth self-therapy for treating relapsing MS, depression, and allergies; challenges in cl...