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Longevity by Design

Gil Blander PhD

95 episodes

1 week ago

Aging is more than disease—it’s the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives. Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a...

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Health & Fitness,

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Aging is more than disease—it’s the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives. Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a...

Show more...

Health & Fitness,

Episodes (20/95)

Longevity by Design

Dr. Peter Fedichev: Why Aging Is Functional Decline, Not Just Disease

Aging is more than disease—it’s the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives. Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a...

4 days ago

1 hour 7 minutes

Longevity by Design

Dr. Eric Verdin on the Effects of Therapeutic Plasma Exchange on Longevity

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks. Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept insp...

2 weeks ago

52 minutes

Longevity by Design

What Happens to Your Body When You Sit All Day, with Dr. Keith Diaz

In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Keith Diaz, Associate Professor of Behavioral Medicine at Columbia University Irving Medical Center, to unpack the hidden health risks of prolonged sitting. Keith explains why even daily exercise isn't enough to counteract the effects of sedentary behavior. Drawing on his lab's findings, he shares a simple but powerful prescription: five minutes of light walking every hour. That small change can lower blood pressure, ...

1 month ago

1 hour 5 minutes

Longevity by Design

Acetylation Insights: Unlocking Longevity Secrets with Dr. Haim Cohen

In this episode, Dr. Gil Blander welcomes Dr. Haim Cohen to Longevity by Design to explore his revolutionary approach to understanding aging. Haim's team analyzed acetylation sites across 107 mammalian species, creating its most extensive comparative study. This computational approach revealed specific post-translational modifications that evolved exclusively in long-lived animals. The research identifies critical pathways where evolution engineered longevity solutions. These acetylation cha...

1 month ago

55 minutes

Longevity by Design

Karl Pfleger Explains the Aging Biotech Explosion

On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Karl Pfleger, aging biotechnology investor and creator of AgingBiotech.info, to dissect the rapidly evolving field of aging therapeutics. Karl breaks down the sector into two main categories: interventions that slow aging rates versus rejuvenation strategies that repair accumulated damage. Karl highlights the most promising areas in his investment portfolio, including senolytics for clearing senescent cells and epigen...

2 months ago

1 hour 18 minutes

Longevity by Design

How to Extend Your Healthspan with Dr. Eric Topol

Gil and Eric discuss Eric’s book, Super Agers, and the inspiration behind it: a 98-year-old patient who exemplified healthy aging. They explore the five dimensions of healthspan optimization: lifestyle, omics, the immune system, and the role of data and AI in personalized medicine. Eric highlights how AI can analyze multi-layered data to provide personalized recommendations for preventing age-related diseases. The conversation also explores the importance of exercise, sleep, and social conne...

2 months ago

1 hour 13 minutes

Longevity by Design

The Science of Muscle, Protein, and Longevity: Insights from Dr. Layne Norton

In this episode of Longevity By Design, Dr. Layne Norton, Founder of BioLayne and Carbon app, joins Gil Blander to discuss optimizing nutrition and fitness for a longer, healthier life. Layne emphasizes the importance of prioritizing scientific evidence over popular narratives, highlighting how easily isolated studies can be misinterpreted. He stresses the power of personalized approaches to nutrition and fitness, advocating for a critical approach to information consumption. Layne dives int...

3 months ago

1 hour 19 minutes

Longevity by Design

Beyond Sick Care: Evelyne Bischof on the Rise of Longevity Medicine

On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Evelyne Bischof, President of the Healthy Longevity Medicine Society. Evelyne discusses her background in internal medicine and oncology and how her work puzzling together patient diagnoses led her to the field of longevity medicine. She highlights the importance of optimizing health span, not just lifespan, and how healthy longevity medicine benefits not only individuals, but population health and the world econ...

3 months ago

56 minutes

Longevity by Design

Precision Habits: How Wearables and AI Are Powering Personalized Longevity

In this episode of Longevity by Design, our host, Dr. Gil Blander talks with Dr. Renee Deehan and Paul Fabian about Inside Tracker's new Healthspan Habits Score feature. This innovative tool analyzes data from wearable devices and daily journal entries to identify the most impactful habit to improve each week for better health span and longevity. The guests explain how the algorithm processes up to 15 different variables, including sleep quality, step count, and lifestyle factors to create a ...

4 months ago

51 minutes

Longevity by Design

Scanning the Future: How Whole-Body MRI is Transforming Longevity with Dr. Daniel Durand

Dr. Gil Blander welcomes Dr. Daniel Durand, Chief Medical Officer at Prenuvo, to Longevity by Design for a deep dive into the future of preventative healthcare. Dr. Durand shares how full-body MRI is redefining early detection by making advanced imaging accessible, non-invasive, and radiation-free. He explains why MRI, as a soft tissue imaging modality, offers unmatched insight into early-stage cancers and chronic conditions. The conversation unpacks misconceptions around overdiagnosis and f...

4 months ago

1 hour 22 minutes

Longevity by Design

AI, LLMs & The Future of Longevity: Unlocking Healthspan Innovations with Dr. Eran Segal

In this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Eran Segal, Professor at the Weizmann Institute of Science, to explore the intersection of artificial intelligence (AI) and personalized health. The conversation dives into how AI and machine learning are transforming our understanding of nutrition, disease prediction, and overall longevity. Eran provides a clear overview of AI, machine learning, and deep learning, explaining how these technologies can be applied to var...

5 months ago

1 hour 1 minute

Longevity by Design

GLP-1, Wearables & Longevity: What You Need to Know – AMA with Gil & Ashley

Dr. Gil Blander and Ashley Reaver dive into the science behind GLP-1 agonists, a class of drugs originally developed for type 2 diabetes but now widely used for weight management and longevity. They explore how these medications work, their effects on appetite, metabolism, and inflammation, and why they might be a game-changer for cardiovascular health, brain function, and fertility. While promising, they emphasize the importance of long-term research and consulting with medical professionals...

5 months ago

49 minutes

Longevity by Design

Muscle, Longevity, and the Power of Protein with Dr. Gabrielle Lyon

In this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Gabrielle Lyon, a board-certified family physician and New York Times bestselling author of Forever Strong. Gabrielle discusses the growing epidemic of sarcopenia, the loss of muscle mass and strength, accelerated by the use of GLP-1 medications. She emphasizes the importance of muscle health for overall longevity and introduces the concept of "muscle span." Gil and Gabrielle explore the critical role of skeletal muscl...

6 months ago

1 hour 18 minutes

Longevity by Design

The Science, Evolution, and Future of Lifespan and Healthspan with Dr. Michael Ringel

On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens. Michael highlights the challenges and breakthroughs in lon...

6 months ago

1 hour 12 minutes

Longevity by Design

How Long Can Humans Live? Insights from Dr. Jay Olshansky

In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Jay Olshansky, a leading professor at the University of Illinois Chicago and a renowned expert in aging and biodemography. Together, they delve into the science of longevity, exploring how public health advancements in the 20th century revolutionized life expectancy and what lies ahead in the quest to extend both lifespan and healthspan. Dr. Olshansky unpacks the biological limits of human longevity, shedding light on...

7 months ago

1 hour 10 minutes

Longevity by Design

Precision Longevity Medicine with Dr. David Barzilai

Can personalized medicine unlock the secrets to living longer and healthier lives? In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Barzilai, a renowned longevity physician and founder of Barzilai Longevity Consulting, to explore the science of extending healthspan through precision and innovation. Dr. Barzilai shares his journey into biogerontology and longevity science, unpacking key concepts like the hallmarks of aging, the potential of lifestyle inter...

7 months ago

1 hour 51 minutes

Longevity by Design

How Can a Nutrition AI Platform Help Us Live Healthier and Longer Lives with Dr. Dmitriy Richard Starson

On this episode of Longevity by Design, Dr. Gil Blander hosts Dr. Dmitriy Richard Starson, Founder and CEO of Passio, an AI-powered nutrition coaching platform. Dmitriy discusses his career path from astrophysics to the world of nutrition tracking. He explains how his company seeks to make healthy eating more accessible. Passio aims to achieve this through user-friendly technology like food scanning, voice logging, and personalized AI coaching.Dmitriy believes this technology will revolutioni...

8 months ago

56 minutes

Longevity by Design

The Path to a 1,000-Year Lifespan with Dr. Aubrey de Grey

In this episode of Longevity by Design, our host Dr. Gil Blander welcomes Dr. Aubrey de Grey, a biomedical gerontologist, to explore the frontiers of aging research and lifespan extension. Dr. de Grey shares his work identifying and addressing the seven major categories of aging-related diseases. He discusses how targeted damage repair offers a promising alternative to traditional methods to slow aging, providing a path to longer, healthier lives. The conversation delves into the hallmarks o...

8 months ago

53 minutes

Longevity by Design

Dietary Changes to Reduce the Risk of Prostate Cancer with Dr. John Erdman

On this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. John Erdman to discuss prostate cancer and the impact of diet on disease progression. John shares his personal connection to this disease and why he’s dedicated his research to understanding dietary interventions. John explains that prostate cancer is often slow-growing, with most men experiencing decades between early mutations and noticeable tumor growth. He stresses the importance of early detection through regular checku...

9 months ago

37 minutes

Longevity by Design

Unlocking Longevity: Dr. Jens Juul Holst on GLP-1’s Life-Changing Impact on Metabolic Health

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have ...

9 months ago

1 hour 23 minutes