In this episode you’ll get to hear two extended excerpts from a long conversation that myself and several of my Cannabis science colleagues had about Cannabis quality, chemistry, and beyond at the end of the American Chemical Society Spring Conference on March 27th, 2025.



The conversation was recorded at Abstrax Headquarters in Irvine, CA with Evan Friedmann, Kyle Boyar, TJ Martin, and Iain Oswald.



Catch the rest of the conversation on The Noid Knowledge podcast with Evan Friedman and be on the lookout for the full extended edit whenever we find the time to put it together!

How closely have you examined your deeply held beliefs? How confident are you that your beliefs are true? What are the reasons you have that give you your level of confidence in your belief?



In this throwback episode we take a critical look at beliefs. Beliefs of all kinds. Belief in God, karma, the law of attraction, ghosts, spirits – anything. In this episode of Isn’t Life Curious? I had the chance to sit down for a conversation with Anthony Magnabosco – a leader in a movement that seeks to critically examine and question deeply held beliefs through repeated non-confrontational questioning known as Street Epistemology. Anthony has spent the past eight years or so engaging strangers in short respectful conversations that challenge the participant to pick a deeply held belief and explain why they believe what they believe is true. In Socratic fashion, Street Epistemology relies on repeated questioning to peel away the “baggage” that is stacked on top of a belief so that the core ideas at the center of the belief can be exposed and examined.



Anthony has had several hundred chats (many of them on camera and uploaded to his YouTube channel) on a variety of claims including Gods, ghosts, karma, law of attraction, and a variety of social and political topics. He is a Founder and the current Executive Director of the new nonprofit organization Street Epistemology International. Anthony has given dozens of talks and workshops on Street Epistemology at conferences and events domestically and internationally in an attempt to spread practice of this method far and wide in hopes that it will help lead to a more reasonable and thoughtful society.​Learn more about Street Epistemology at http://www.streetepistemology.com

In this throw back episode from the very beginning of the Isn’t Life Curious? series we join farmer and permaculturist Mark Shepard to discuss practical solutions to surviving and thriving on planet Earth. Mark is the CEO of Forest Agriculture Enterprises LLC, founder of Restoration Agriculture Development LLC and award-winning author of the book, Restoration Agriculture: Real-World Permaculture for Farmers. Mark has also been a farmer member of the Organic Valley cooperative, the worlds largest Organic Farmer’s marketing co-op, since 1995. He is most widely known as the founder of New Forest Farm, the 106-acre perennial agricultural savanna considered by many to be one of the most ambitious sustainable agriculture projects in the United States.



Throughout our conversation we talk about Mark’s journey to build New Forest Farm, lessons he has learned along the way, practical challenges to implementing permaculture and restorative agriculture techniques at scale, his experience studying permaculture under Bill Mollison, what modern permaculturists often misunderstand about permaculture, and much more!



You can learn more about New Forest Farm here: https://newforestfarm.us/You can learn about Forest Agriculture Enterprises here: https://www.forestag.com/You can learn about Restoration Agriculture Development here: http://www.restorationag.com/

Is life really all that special? Or is it just a happy accident that we are here?



Neil Manson, PhD is a philosopher and professor of philosophy specialized in tackling these very questions. An expert on philosophy of science and philosophy of religion, Dr. Manson and I dive down a metaphysical wormhole to explore the ways humans have tried to wrestle with our place in the universe. If there is a multiverse, what does that mean for our traditional concepts of God? If we live in a simulation, then what ethical obligations do I have to you or anyone else?



Take a deep breath and let’s have an existential crisis together on this episode of Isn’t Life Curious?!



Enjoy! Stay curious, and take it easy!

Do we even test for the right things?



Now that medical and adult-use cannabis programs have been around for some time, and with them mandated lab testing of products – we have a lot of data that we can begin to review in order to assess how well we are managing the quality of cannabis in the market.



In this episode we are joined by microbiologist and analytical technologist Kyle Boyar to confront the idea that there may be some things that regulators require testing for that will almost never show up in a sample, while there are certain toxins that show up more often than we might expect which are NEVER required for testing in any state in the country.



What’s going on? Let’s dive in and find out!

Continuing our series on the issues facing the Cannabis testing industry, we sit down with Josh Swider of Infinite Chemical Analysis Labs to discuss the ways that he and his lab have felt the effects of potency inflation and lab shopping over the past several years. One by one Josh has watched clients disappear after complaints that his THC potency numbers were not high enough compared to his competitors. This is a story all too familiar to most labs that have ever operated in the space. Eventually the requests to boost THC results became much more direct as clients started offering bribes including outright briefcases full of cash. When he denied these advances, he began receiving death threats.



In an effort to understand just how bad the problem was, Josh and his team began collecting products off the shelf and testing them in the lab to see how the results compared to the original test results on record for the product. The results were alarming. Not only did he find evidence of potency fraud, but he also ended up finding evidence of various contaminants in products that somehow originally tested “clean.”



In this episode Josh and I take time to discuss his journey, how the industry has gotten into the situation it is in, and some potential solutions for moving the industry in a positive direction.



Learn more about iCAL: https://infinitecal.com/

In this extended 2+ hour episode, Josh Smith of Therapeutic Health Choice, an analytical lab based out of Michigan, takes us on a deep dive into his experiences of Cannabis testing fraud as we explore some potential ways to fix issues like lab shopping and bring scientific integrity back to the cannabis industry.



About Josh:



Josh Smith is a seasoned biotech executive with a graduate degree in Clinical Microbiology and over 24 years of experience in biotechnology, molecular biology, and pharmaceutical R&D. He has played a key role in pioneering various projects, including founding Premium CBD Labs and later Vardera Inc., where he built a nationally recognized laboratory network from the ground up. His work has led to several molecular biology patents, and he has served as an expert witness in legal cases across Wisconsin, Illinois, and Michigan.



Josh is actively involved in shaping industry standards through his participation in international method committees like AOAC and ASTM. He has also lobbied in Wisconsin, advocating for improved policies in the lab testing industry. In late 2023, he was part of the team that successfully overturned the compliance testing requirement for Aspergillus spp. in the state of Oregon.



Beyond his corporate roles, Josh is passionate about advancing scientific knowledge and innovation. He serves on the Curriculum Advisory Board for the graduate-level Cannabis Applied Science Program at Fanshawe College (London, ON), is a member of the Cannabis Science and Research Organization (Oregon), and is an editor for the Cannabis and Psychedelic Science Journal.

This is the first of a series of conversations with lab owners and industry experts revolving around the topic of fraud, mismanagement, and poor regulations facing Cannabis testing labs. With issues ranging from THC potency inflation, under-reporting of contaminants, perverse incentive structures promoted by regulations, market manipulation, and more – this series dives deep into a very controversial issue to try to understand the problem at its foundation and find meaningful and practical solutions forward to restore trust and bring greater transparency to the Cannabis industry.



Yasha Kahn is one of the co-founders of MCR Labs and spends much of his time diving into data. Over the past several years, Yasha has been on a mission to collect publicly available Cannabis testing data and make it accessible to the industry in hopes of promoting fruitful research, discussion, and regulatory changes to positively impact the industry. In this episode we dive into some of the data that Yasha has gathered and start to unpack the story that it tells.



Link to the raw data: https://drive.google.com/drive/folders/1IIlgudS3b1rvxbupeMaR_BdeUQmz3pOZ?usp=drive_link

There is no doubt that when it comes to aroma, the Cannabis plant is LOUD. Depending on the variety, a host of smells can be found in Cannabis ranging from the sweet and floral to the funky, gassy, savory, and beyond. Chemist Twinkle Paryani has been trying to understand the chemistry behind the spectrum of aromas found in Cannabis and recently unearthed some interesting findings.



Abstrax Tech: https://abstraxtech.com/



Twinkle’s publication “Nonterpenoid Chemical Diversity of Cannabis Phenotypes Predicts Differentiated Aroma Characteristics“: https://pubs.acs.org/doi/full/10.1021/acsomega.4c03225

In this episode of Isn’t Life Curious? we join comedian and social media sensation Rodney Norman to talk about the meaning of life and what exactly he finds so funny about it all. Throughout the conversation we are joined by some of Rodney’s friends including Leonard, the World’s Worst Motivational Speaker, to unpack some of their most profound insights about what it means to be alive.



Get ready to discover all the answers you have ever sought about life and the universe! It’s all packaged up for you in this single hour long conversation – available to you for free! (plus shipping and handling)



You can learn more about Rodney and find tour dates, merch and more at www.rodneynorman.com



“Have a super freakin’ awesome day!”



Stay curious, and take it easy!

Session Time Stamps



2:17 – Extraction Basics, Hydrocarbon Safety (2019)



1:35:18 – Remediation, CRC, Chromatography (2021)



3:17:16 – State of Industry in 2022, Medusa Stones, Gas Quality



5:40:33 – Lecture: Extraction Fundamentals (2021)



7:38:06 – Lecture: “Liquid Diamonds” and Product Terminology (2024)



Turn a long drive or your lab’s downtime into a masterclass in extraction and lab safety with extraction technologist and natural products formulator Murphy Murry in this special 9-hour mega-compilation!



CAC Sessions present compilations of conversations with guests through the years of the CAC podcast. The Murphy Murri Sessions presents 9 hours of conversations and lectures featuring extraction technologist and natural products formulator Murphy Murri. This mega-compilation starts with Murphy’s first appearance on the podcast in 2019 where we discuss extraction basics, hydrocarbon safety, and lab quality. This is followed by several additional podcast appearances where we dive into extract remediation, medusa stones, CRC, chromatography, and more. The Sessions are then capped with two previously unreleased lectures focusing on extraction fundamentals and product terminology.

​To kick off the new show, I wanted to re-release my conversation with Dr. Steven Novella, most famously known as the producer and host of The Skeptic’s Guide to the Universe Podcast and author of The Skeptic’s Guide to the Universe book. Dr. Novella is a neurologist and professor at Yale School of Medicine and an advocate of the skepticism movement. In our conversation we talk about the concept of reality vs perception and how to evaluate whether we are in touch with reality or are lost in our own fictions and hallucinations that our brains produce for us so easily. We discuss some of the cognitive biases that we wrestle with every day, common misconceptions about skepticism, the failings of public education in promoting critical thinking skills in kids, the severe consequences that may be in store if humans can’t learn to think better, and much more!



Learn more about The Skeptic’s Guide to the Universe at https://www.theskepticsguide.org/



Stay curious!

The Curious About Cannabis Podcast is now a show on the Isn’t Life Curious? network. Isn’t Life Curious? continues the curious quest of biologist and science educator Jason Wilson, MS as he delves into the complexities and wonders of life on Earth through engaging conversations with a diverse range of guests, including critical thinkers, philosophers, comedians, and everyday people. Each episode offers listeners a chance to explore profound questions about our human experience, making it a perfect listen for those who love to ponder the curious nature of life.

How does CBD affect the CB1 receptor, really?



Rob Laprairie is a cannabinoid researcher out of the University of Saskatchewan who was involved in the discovery of CBD’s allosteric binding activity on the CB1 receptor – leading to a host of speculative theories about how CBD influences the activity of THC. In this conversation, continuing our Train with Mary Jane series, we sit down with Rob and discuss his work studying the CB1 receptor to better understand how CBD and “minor” cannabinoids from Cannabis affect the body. Rob helps break down common misunderstandings about CBD’s effects, explains how our understanding of chemical receptors is evolving, and what the future of cannabinoid research may look like.



“Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors”: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14440

In this episode we sit down with Integrated Pest Management (IPM) specialist Matthew Gates to delve into the often-overlooked world of cannabis viruses and viroids. In this episode, Matthew brings his extensive expertise to the table, shedding light on the insidious pathogens that can silently wreak havoc on cannabis crops.



As the cannabis industry continues to grow and evolve, understanding the hidden threats posed by viruses and viroids becomes paramount. Matthew explains the various types of viruses and viroids that can affect cannabis plants, their symptoms, and the potential economic impact on growers. He also shares insights into the latest research and diagnostic techniques that can help detect these pathogens early, enabling proactive management and prevention.



But it’s not all doom and gloom. Matthew provides practical, actionable advice on how to implement effective IPM strategies to mitigate the risks. From cultural practices to biological controls and cutting-edge technologies, he covers a comprehensive range of tools and methods that can help protect your cannabis crop and ensure its health and productivity.



Whether you’re a seasoned cultivator, a novice grower, or simply interested in the science behind cannabis cultivation, this episode is packed with valuable information that you won’t want to miss. Tune in to gain a deeper understanding of the challenges posed by cannabis viruses and viroids and learn how to safeguard your plants against these unseen adversaries.



Learn more about Matthew at www.zenthanol.com

Dive into a journey of discovery with our latest episode of the ‘Train With Mary Jane’ mini-series, where we delve deep into the pioneering research funded by the NFL on Cannabis and its potential to revolutionize the treatment of traumatic brain injuries (TBIs) in athletes. This episode welcomes the return of clinical physiologist Liz Thompson and introduces a new, distinguished guest, Dr. Patrick Neary, PhD – a researcher in the realm of kinesiology from the University of Regina, Canada, with a passion for unraveling the mysteries of concussions and TBIs.



Join us as we embark on an exploration of Dr. Neary’s experience in concussion research, unlocking the intricate science behind concussions, the profound long-term effects of TBIs, and the promising intersection of TBI treatment with the endocannabinoid system. Discover the potential of cannabinoids in altering the landscape of TBI therapy and much more!



For those eager to learn more about the ‘Train with Mary Jane’ initiative and the NFL’s foray into cannabis research for athlete care, visit Mary Jane Athletics or Train with Mary Jane. Don’t miss this captivating episode that bridges the worlds of sports, science, and hope through the lens of cannabis research.

After our initial episode concluded with Liz Thompson, we decided we had more to talk about so we hit record! Enjoy this bonus conversation where we explore how Canada handles insurance coverage for Cannabis expenses and what the future of health insurance coverage for Cannabis could look like in Canada and the US.

Elizabeth Thompson is a researcher at the University of Saskatchewan currently working on a project that has started to get international attention – the National Football League’s (NFL) million dollar research project to understand how cannabinoids could impact the health and safety of athletes. In this behind-the-scenes conversation we hear Liz’s story about her personal connection to professional sports, her journey to understand molecular mechanisms of the body, links between the endocannabinoid system and sports injury recovery, and how a moment of inspiration snowballed into the clinical trial now titled “Cannabinoids for Pain Management and Neuroprotection From Concussion” (ClinicalTrials.gov ID: NCT06204003).



If you are an athlete, athletic trainer or sports healthcare worker, you have an opportunity to contribute to the NFL research project! Visit www.maryjaneathletics.com to complete a survey so that your experience and voice can be represented in this groundbreaking project!



Learn more at:



https://www.maryjaneathletics.com/



https://clinicaltrials.gov/study/NCT06204003



https://www.nfl.com/playerhealthandsafety/health-and-wellness/pain-management/nfl-awards-1-million-to-study-impact-of-cannabis-and-cbd-on-pain-management

You may have noticed that your local gas station has started selling products marketed like Cannabis products with promises that they are legal ways to get you high without THC. No, we haven’t gone back in time. This isn’t 1999 and no, you’re not reading one of those “legal bud” ads in the back of the High Times magazine. This is 2024 and we are seeing a re-emergence of synthetic cannabinoids, particularly THC analogues, now presumably legal under the guise of the 2018 Farm Bill.



Colorado Chromatography is one of the leading labs responsible for producing and studying these new cannabinoids on the block, like HHC, H4CBD, THCP, and others. In this conversation we sit down with the Chief Science Officer of and co-founder of Colorado Chromatography, Westley Cruces, to talk about their journey learning about these molecules, the results from preliminary safety studies on HHC, evidence of fraud in delta-8 and THCP products, and more!



Learn more about Colorado Chromatography: https://coloradochromatography.com/

We kick off 2024 catching up with Dr. Jeff Raber of The Werc Shop to talk about Cannabis quality, Cannabis potency testing fraud, THC inflation, acetone showing up in Cannabis extracts, preparing young scientists for working in the Cannabis industry, the launch of The Werc Shop’s ENTOUR brand and more!



How do we fix the lab testing fraud issue in the Cannabis industry?



Why is acetone showing up in terpene-rich Cannabis samples?



How can young scientists prepare for the brutal realities of working for a startup Cannabis company?



We explore these questions and more in this episode of The Curious About Cannabis Podcast!







Learn more about ENTOUR at www.entourbrand.com



Learn more about The Werc Shop at www.thewercshop.com