I am delighted to reconnect with Dr. Stephen Hussey today. He is a Chiropractor and Functional Medicine practitioner who guides his clients back to health using the latest research and health-attaining strategies.  In our conversation, we explore the challenge of chronic pain, discussing how it is assessed, experienced, and managed. We unpack the concepts of coherence and heart rate variability, highlighting the value of optimizing circadian rhythm for managing hormonal changes and pain in perimenopause. Dr. Hussey also shares his perspective on chiropractic care, the nervous system, fascia, and the role of trauma, metabolic health, and environmental factors in healing. Join us as we explore how to navigate chronic pain, support natural healing, and restore balance from the inside out. IN THIS EPISODE, YOU WILL LEARN: Why is pain so difficult to treat? How the Flexner Report influenced medical education and contributed to pharmaceutical-based care The breadth and scope of the opioid crisis, and why people become addicted How our bodies perceive pain  Why the fascia is so important, and its role in our physiological processes What is structured water? The link between cellular hydration, metabolic health, and the pain response How obesity and diabetes are directly associated with artificial light exposure How trauma rewires the brain and contributes to chronic pain Dr. Hussey explains the concept of coherence and its importance How pain changes during perimenopause and menopause  Bio: Stephen Hussey Dr. Stephen Hussey, MS, DC, is a Chiropractor and Functional Medicine practitioner. His story of personally healing heart disease using light and environmental health strategies has become an inspiration to many and a calling for change in healthcare. In addition to Chiropractic clinical practice, Dr. Hussey is a health consultant, speaker, and the author of three books on health: The Health Evolution, Understanding the Heart, and Pain Sense. Dr. Hussey guides clients from around the world back to health by using the latest research and health-attaining strategies. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Stephen Hussey On his website Social media:@drstephenhussey

I am delighted to have Jessie Inchauspé, the Glucose Goddess, joining me on the podcast today! Metabolic health is my passion! It is a huge area of focus in my work, and Jessie is truly a gift in the space! She is a rising star author and biochemist with a clear and accessible way of explaining the science behind glucose metabolism.  Jessie joins me today to discuss the impact of glucose metabolism and spikes. We dive into her background and how an accident created her pain-to-purpose story. We discuss the role of continuous glucose monitors and how glucose spikes impact our mitochondria, inflammation, and oxidative stress. We get into glycation and aging, how weight gain is a protective aspect of glucose spikes- or hyperglycemia, and the role of vinegar, movement, and fiber. We also talk about Jessie’s new book, her opinions on fasting, and so much more.  I loved interviewing Jessie! Her enthusiasm is contagious, and it is easy to understand why she is such a beloved author in the health and wellness space! IN THIS EPISODE YOU WILL LEARN: Jessie shares how an accident led her to where she is today. Wearing a continuous glucose monitor (CGM) changed everything for Jessie How Jessie developed her simple principles to stabilize glucose levels What is the purpose of glucose in the body? Glucose spikes and our mitochondria Vinegar hack for reducing side effects and symptoms of glucose spikes Being metabolically unhealthy impacts the aging process Benefits of having savory breakfasts and eating vegetables first with every meal Jessie’s book, The Glucose Goddess Method How gaining weight protects our bodies from the impact of glucose spikes Walking or moving after meals to balance blood sugar levels Why blood sugar so important Connect with Cynthia Thurlow Follow on X Instagram LinkedIn Check out Cynthia’s website Connect with Jessie Inchauspé On her website   Instagram Link for Jessie’s new book: Buy a copy of Jessie’s book, The Glucose Goddess Method.

Today, I am thrilled to be joined by Dr. Sarah Hill, an award-winning researcher, professor, and leading voice in the field of women’s hormones and brain health. She wrote This Is Your Brain on Birth Control and has also authored The Period Brain, which is due to be released this fall. In our conversation, Dr. Hill dispels the myths surrounding bioidentical hormones and shares her view on how women are not biologically disordered, but just ignored by science. We dive into research on how oral contraceptives affect the brain and how the pill creates a dysregulated stress response, particularly in women with histories of adverse childhood experiences. We also explore progesterone through the lens of an evolutionary biologist and neuro-endocrinologist, highlighting its role in supporting GABAergic tone, the key differences between synthetic progestins and natural progesterone, and research on PMS and PMDD, including practical ways to manage those issues. This helpful discussion with Dr. Sarah Hill is a must-listen for women at every stage of life. IN THIS EPISODE, YOU WILL LEARN: Why has science ignored women? How oral contraceptives affect the way women perceive the world How early-life trauma impacts the ability to manage stress in adulthood Often-overlooked benefits of progesterone The different ways estrogen and progesterone impact women’s ability to build muscle mass from resistance training The positive effects of the GABAergic system in the brain The problem with combined hormone therapy How progesterone gets ignored and villainized, even though it can help women experience better lives How the protective and anti-inflammatory properties of progesterone support brain health and enhance neuroplasticity What the research suggests for women experiencing severe PMS or PMDD Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Sarah Hill On her website Instagram Pre-order a copy of Dr. Hill’s new book, The Period Brain: The New Science of Why We PMS and How to Fix It, which will be on sale at the end of September. 

Today, I am thrilled to reconnect with my friend and colleague, Dave Asprey, for our third podcast together.  Dave is the founder of Bulletproof Coffee, the Bulletproof Diet, and the biohacking movement. He is a four-time New York Times best-selling author, and his latest book, Heavily Meditated, is a USA Today best-seller. As a leader in the longevity movement, Dave collaborates with medical professionals, researchers, and innovators to develop groundbreaking techniques and products that enhance mental and physical performance. In our discussion today, we explore what it means to be triggered, covering the five Fs, the role of ego and altered states, and the impact of social media, credentialism, and health bullying. We also discuss the importance of intuition, especially for women in perimenopause and menopause, highlighting that the ovaries contain the greatest concentration of mitochondria in the female body, the value of forgiveness, and the importance of finding peace in our lives. Dave also shares his breathwork “buckets bicep” practice and explains its effects on the dopamine receptors. I thoroughly enjoyed this inspiring conversation with Dave, and every woman navigating midlife transitions will benefit from the insights he shares in this episode. IN THIS EPISODE, YOU WILL LEARN: What it means to be triggered Dave explains the biological and neurological aspects of triggers The difference between managing triggers and turning them off at the source How fear, food, and reproduction drive automatic behavior The benefits of meditation  How criticism often triggers a deep-seated fear response  How credentialism and health bullying prevent people from trusting their intuition and personal experiences  The power of forgiveness to free energy and reduce emotional triggers. The value of intentional discomfort practices during perimenopause for recalibrating dopamine receptors The potential link between mitochondrial activity and the intuitive ability of women Bio:  Dave Asprey is the founder of Bulletproof Coffee, The Bulletproof Diet, and the biohacking movement. He is a four-time NYT bestselling author, the author of the recent USA Today Best-Seller, Heavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace, the CEO of Upgrade Labs, and hosts "The Human Upgrade" podcast. Dave pioneered online sales in the 1990s, co-founded an early data center company, and later transformed his own health by losing over 100 pounds and improving his cognitive function. This journey led him to create The Bulletproof Diet and coin "biohacking." Dave runs the 40 Years of Zen neurofeedback program, the Biohacking Conference, and a regenerative agriculture farm while investing in biohacking startups. As a leader in the longevity movement, Dave collaborates with medical professionals, researchers, and innovators to develop groundbreaking techniques and products that enhance mental and physical performance. Using science-backed methods, his mission is to help people upgrade their minds to a happier, more conscious state and optimize their bodies one cell at a time. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dave Asprey On his website Danger Coffee The Human Upgrade podcast Heavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace is available on Amazon.

Today, I am delighted to reconnect with two previous guests, Dr. Darren Candow. Dr. Candow is a distinguished professor and an internationally renowned researcher on creatine monohydrate, nutrition, and physical activity, whom I had the pleasure of speaking with on Episode 301, where we discussed creatine.  We are doing an AMA session today, delving into various themes surrounding creatine, from debunking outdated RDA recommendations to exploring the synergies between strength training and creatine efficacy. We examine the cognitive benefits of creatine, investigating its interactions with caffeine and its implications for bone health, hydration, anabolic resistance, and metabolic health.  You will find today's AMA session as enlightening and enriching as I did while recording it. IN THIS EPISODE YOU WILL LEARN: The safety and efficacy of creatine as a supplement How creatine increases muscle mass and reduces protein catabolism The benefits of combining creatine with protein  Is it better to take creatine before or after a workout? How creatine supplementation may improve brain performance and mental clarity Why exercise is essential for those who want to experience the benefits of creatine for maintaining their bone health The benefits of resistance-band workouts for post-menopausal women Are there any age-related limits for creatine supplementation? Bio: Dr. Darren Candow Dr. Darren Candow, PhD, CSEP-CEP, is Professor and Director of the Aging Muscle and Bone Health Laboratory in the Faculty of Kinesiology and Health Studies at the University of Regina, Canada. The overall objectives of Dr. Candow’s research program are to develop effective lifestyle interventions that incorporate nutrition (primarily creatine monohydrate) and physical activity (resistance training), with practical and clinical relevance for improving musculoskeletal aging and reducing the risk of falls and fractures. Dr. Candow has published over 120 peer-refereed journal manuscripts, supervised over 20 MSc and PhD students, and received research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, the National Institute of Health, and the Nutricia Research Foundation. In addition, Dr. Candow serves on the editorial review boards for the Journal of the International Society of Sports Nutrition, Nutrients, and Frontiers. Connect with Cynthia Thurlow Follow on X ⁠Instagram⁠ ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Connect with Dr. Darren Candow On⁠ Instagram⁠ and X  Previous Episode Mentioned: ⁠Ep. 301 Creatine: The Best Supplement for Better Bones & Brain Health with Darren Candow, PhD, CSEP-CEP⁠

Today, I am honored to connect with Rachel Frankenthal, a board-certified physician assistant with a master's degree in public health, specializing in gynecologic oncology. Rachel is on the staff at UCLA Health, where she treats women with gynecologic cancers and women at high risk for uterine or ovarian cancer due to genetic mutations or a strong family history.  In our discussion, we unpack GYN oncology, covering the five GYN cancers, why ovarian cancer is the silent killer, and the labs and ultrasounds to help screen for ovarian cancer. We dive into genetics, including BRCA mutations and Lynch syndrome, appropriate genetic counseling, and what Rachel considers when dealing with younger patients still at peak fertility versus older patients. We explore the importance of HRT utilization for cancer previvors, the effects of pelvic radiation, vaginal and sexual health, and what thriving looks like after cancer. Rachel shares her stepwise approach to hot flashes, and we also discuss the importance of lifestyle, bone health, and specific research on the benefits of GLP-1s for women with ovarian and endometrial cancer.  This conversation is especially relevant as we are in GYN and Ovarian Cancer Awareness Month. I look forward to having Rachel back again, hopefully later this fall, to discuss the use of hormone replacement therapy with GYN oncology survivors. IN THIS EPISODE, YOU WILL LEARN: How the lack of effective screening makes ovarian cancer hard to detect due to  How BRCA and Lynch syndrome influence cancer risk and treatment choices The benefits of HRT for cancer previvors Risks that arise from surgical menopause without sufficient or properly dosed HRT Why less than 50% of eligible women actually receive hormone therapy How pelvic radiation impacts menopause, vaginal tissue, bladder, and GI health The support that is crucial for cancer survivors after pelvic radiation Lifestyle factors to improve cancer treatment outcomes   Rachel shares her stepwise approach to managing hot flashes  What GLP-1 research reveals about reducing ovarian cancer mortality and endometrial cancer risk Bio: Rachel Frankenthal Rachel Frankenthal is a board-certified and licensed Physician Associate and Menopause Society Certified Practitioner with a Master's in Public Health. She specializes in gynecologic oncology, treating women with gynecologic cancers as well as women at high risk for uterine or ovarian cancer due to genetic mutations. Rachel has a special passion for menopause and midlife women's healthcare. She developed the menopause clinic for gynecologic cancer survivors and previvors at UCLA and has played an integral role in developing the GYN cancer survivorship program, where she teaches the weekly yoga and meditation class. Rachel lectures at UCLA and across the country on the importance of comprehensive menopause care in cancer survivorship and has created a course on hormone therapy for gynecologic cancer survivors through the Heather Hirsch Academy. In addition to being a medical practitioner, Rachel is a certified yoga and Pilates instructor, a prior Broadway performer, and an advocate for integrative, holistic health. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Rachel Frankenthal On Instagram

Today, we have the first episode of a series of AMAs with McCall McPherson. McCall McPherson is the visionary behind Modern Thyroid Clinic, a thyroid-centered functional medicine practice in Austin, Texas. McCall is a physician assistant and thyroid expert. She is a recent TEDx speaker, a frequent guest on podcasts and summits, and the owner, host, and Chief Thyroid Hope Giver of the Thyroid Nations podcast.  Today, McCall joins me to dive into a range of listener questions, covering whether intermittent fasting damages the thyroid, the role of GLP-1s, constipation, split-dosing medication, adrenal health, ADHD, phentermine versus Glucophage versus GLP-1s, and how HRT affects thyroid medication. We also explore the impact of lipids on thyroid health and the role of nutrition, and we share our opinions on the Dutch test.  This invaluable AMA was made even more special by the flood of questions submitted by listeners. IN THIS EPISODE, YOU WILL LEARN: The benefits of adopting a nuanced approach to intermittent fasting  How Graves' disease and Hashimoto's differ in terms of fasting Why fasting is not advisable when taking GLP-1s Do thyroid medications cause constipation? Strategies for overcoming constipation and improving gut health McCall shares her rationale for splitting thyroid medication doses Will progesterone increase free T4 levels? The importance of rechecking thyroid labs after starting or adjusting HRT Foods to avoid and include in your diet for thyroid health Is the Dutch test worth using? Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with McCall McPherson Modern Thyroid Clinic  Modern Weight Loss On Instagram and TikTok Modern Thyroid and Wellness Podcast

Today, we have the next episode in our series of sponsored podcasts with highly vetted companies.  I am delighted to connect with Sarah Kennedy, the founder and CEO of Calocurb, a revolutionary product for weight management that became commercialized after 15 years and $30 million of research from the New Zealand government. Calocurb currently sells in five international markets and continues to grow rapidly through channels and geographies.  Sarah is a veterinarian by training and has held several senior executive positions in the agribusiness and food industries. In our conversation today, we explore the science behind Calocurb, the evolutionary mechanisms of satiety, and how Calocurb reduces caloric intake by 18%. We discuss endogenous GLP-1 drugs, highlighting how Calocurb’s mechanism of action differs, and examining current research on gender differences in GLP-1 secretion, including their impact on the menstrual cycle and intermittent fasting. Sarah also covers the four core tenets of Calocurb, shares upcoming research that excites her, and explains the key differences between Calocurb and other supplements, like berberine and chromium. This conversation is truly invaluable, so it's worth revisiting. I am excited about Calocurb’s potential to support a variety of needs, helping those looking to improve their hunger and satiety mechanisms, and assisting those taking GLP-1 medications who want to reduce their dosage and transition off GLP-1 medications without compromising the long-term results. IN THIS EPISODE, YOU WILL LEARN: How Calocurb began How Calocurb supports those on GLP-1s looking to lower their doses or taper off (in conjunction with their healthcare team) Sarah explains why Calocurb is very safe, and its four to six-hour mode of action.  The three primary use cases for Calocurb, and how it helps to reduce the side effects and costs associated with GLP-1 injections The importance of making lifestyle changes when transitioning off GLP-1 medications How Calocurb stimulates natural GLP-1 receptors, making it easier to manage food cravings during intermittent fasting Sarah shares how Calocurb helped her manage her love-hate relationship with food. How to take Calocurb for optimal effectiveness Sarah outlines Calocurb’s four core values.  How Calocurb differs from other supplements Foods that help to reinforce the satiety mechanism You can use code CYNTHIA10 for 10% off an order on ⁠calocurb.com⁠. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Sarah Kennedy You can use code CYNTHIA10 for 10% off an order on ⁠⁠calocurb.com⁠⁠. Research Articles: Gastrointestinal delivery of bitter hop extract reduces appetite and food cravings in healthy adult women undergoing acute fasting  New Zealand Bitter Hops Extract Reduces Hunger During a 24h Water  Only Fast Body weight reduction in women treated with tirzepatide by reproductive stage: a post hoc analysis from the SURMOUNT program   

Today, I am thrilled to reconnect with Dr. Kelly Caspersen, a urologist who empowers women to live their best love lives. She is a two-time author, with her latest being The Menopause Moment. In our conversation, we cover a wide range of topics, from navigating UTI purgatory and understanding the vaginal microbiome to how vaginal estrogen can dramatically reduce the risk of sepsis and death in the ICU. We unpack the evolving language of hormones- specifically progesterone, estrogen, and testosterone and we examine censorship and bias on social media, and the differences between prescribers and non-prescribers. We explore the effects of SSRIs on bone and brain health, changes in self-perception in middle age, and the effects of the baby boomer generation and the Women’s Health Initiative, exposing the medical gaslighting behind the use it or lose it narrative. We also offer practical options for women who cannot take hormones, and Dr. Kelly shares her go-to supplements and those she avoids. This conversation is one of my recent favorites. Dr. Kelly’s enthusiasm is contagious, and her straightforward approach makes complex topics clear, practical, and unforgettable. IN THIS EPISODE, YOU WILL LEARN: Why recurrent UTIs can feel like UTI purgatory How hormone terminology is evolving, and what that means for women in midlife The value of vaginal estrogen, and the potential it holds for saving women’s lives How the approaches of prescribers and non-prescribers differ How SSRIs can raise the risk of bone fractures  The brain health and self-perception shifts that often occur in midlife  Why the use it or lose it belief is misleading, and how it veers into medical gaslighting How the baby boomer generation and the Women’s Health Initiative still influence women’s healthcare today Some alternative options for women who cannot take hormones Dr. Kelly shares her preferred supplements and those she avoids Bio:  Dr. Kelly Casperson, MD Urologist • Author • Podcaster • Women's Health Thought Leader Dr. Kelly Casperson is a board-certified urologist, best-selling author, and top-ranked international podcaster empowering women to take control of their health, hormones, and sexuality. Known for blending science with storytelling, she transforms complex medical topics into relatable and actionable insights that help women live fully and fearlessly—especially in midlife. With her signature candor and evidence-based clarity, Dr. Casperson dismantles long-held myths around sex, menopause, and desire. Her acclaimed podcast, You Are Not Broken, has become a go-to resource for hundreds of thousands of women seeking real answers about their bodies and brains. Her groundbreaking work integrates urology, neuroscience, and mindset coaching to drive lasting change in intimacy, confidence, and overall well-being. As a keynote speaker and educator, Dr. Casperson challenges outdated norms in medicine while offering bold, science-backed solutions. She’s on a mission to build a world where women are educated, empowered, and no longer afraid of their own bodies. Whether she’s on stage, in a clinic, or behind the mic, Dr. Casperson is leading a health revolution—one smart, honest conversation at a time. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Kelly Casperson On her website On Instagram You Are Not Broken (Podcast) The Menopause Moment is available on Amazon and Barnes and Noble.

I am delighted to connect with Shanna Pearson today. She is the Founder and President of Expert ADHD Coaching, which is the most extensive ADHD coaching program of its kind in the world, providing one-on-one, action-based coaching for adults who are easily distracted and seeking personal, professional, and financial success. Shanna is also the author of Invisible ADHD.  In our discussion, we take a clear and practical look at what ADHD really is. We unpack the chemical changes that occur in the brain, highlighting the gender differences, and exploring why women have become the lost generation and why so many people get misdiagnosed. We also discuss common conditions that often accompany ADHD, the challenges of social conditioning, and share practical tools for addressing ADHD. Whether you have ADHD or you struggle with overwhelm, this discussion offers helpful insights and strategies that are sure to make a real difference. IN THIS EPISODE, YOU WILL LEARN: What ADHD truly is The brain biochemistry of those with ADHD How ADHD differs in men and women Why Shanna refers to women whose ADHD is undiagnosed until perimenopause or menopause as a lost generation    How ADHD in women often gets misdiagnosed How hormonal changes during perimenopause and menopause impact ADHD symptoms How societal expectations tend to exacerbate ADHD symptoms in women Strategies for managing ADHD Lifestyle factors that are essential for managing ADHD symptoms How her book, Invisible ADHD, can help anyone struggling with ADHD or overwhelm Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Shanna Pearson Expert ADHD Coaching   Purchase your copy of Invisible ADHD here, or on Amazon

I am thrilled to connect with my friend and colleague, Dr. Anthony Youn, today.  Dr. Youn is a nationally recognized board-certified plastic surgeon and the author of many best-selling books. He has a massive social media presence and hosts the widely acclaimed podcast The Holistic Plastic Surgery Show. In our conversation today, we dive into Dr. Youn’s new book, Younger for Life, and he offers valuable insights on skin health and overall well-being. We explore the aging process and address oxidative-free radical damage, chronic inflammation, autophagy, and the impact of processed foods. We also explore helpful supplements for skin support, examine the concept of greenwashing, and discuss sunscreen, exfoliation, in-office treatments, breast implant illness, and the impact of lifestyle choices. Stay tuned for more! IN THIS EPISODE YOU WILL LEARN: How to avoid aging too quickly through nutrition and lifestyle changes How sugar and seed oils impact skin aging The benefits of collagen supplements for healthier skin  Hormonal changes that affect the metabolism and skin health after menopause The importance of screening the ingredients in skincare products How chemical sunscreens differ from physical sunblocks Using Retinol for anti-aging and skin health Non-invasive fat reduction treatments and their potential risks Dr. Youn discusses breast implant illness What you need to look out for when using Botox Connect with Cynthia Thurlow Follow on X ⁠Instagram⁠ ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Connect with Dr. Anthony Youn On his ⁠website⁠ ⁠Youn Beauty⁠   ⁠Instagram⁠ ⁠YouTube

Today, I am delighted to connect with Dr. Heather Quaile. She is a double board-certified women's health nurse practitioner and advanced forensic nurse with specialty training in female sexual medicine. Her training focused on integrative gynecology. Today, we dive into trauma-informed care, defining big and little T trauma, examining how adverse childhood events impact gynecologic care, and clarifying how chronic stress and trauma affect ovarian aging. We discuss the role of recalibration of the nervous and autonomic nervous systems during perimenopause and menopause, and explore the importance of estrogen in supporting serotonin, dopamine, and adrenal health in middle age. We cover GLP-1s, reframing packaging around vaginal estrogen, FDA approval for testosterone, the new terminology of PET, and holistic management of low libido, and we also tackle the genitourinary syndrome of menopause, new terminology, barriers, self-advocacy, and the significance of pelvic floor Health.  This conversation with Dr. Quaile is truly invaluable. She is a most helpful resource on everything related to integrative gynecology, sexual medicine, and self-advocacy. IN THIS EPISODE, YOU WILL LEARN: How big and little T trauma differ What trauma-informed care is, and why it is particularly relevant for women in perimenopause and menopause Symptoms and behaviors that indicate trauma in women How the interrelationship between estradiol and serotonin affects our worldview, self-perception, sleep, and relationships  The benefits of addressing any hormonal imbalances before using GLP-1s for weight loss The pros and cons of gaining FDA approval for testosterone and commercializing it   Factors that could cause decreased libido in middle-aged women The genitourinary changes that occur in different life phases of women, or with cancer, or when going through gender reassignment How PET (progesterone, estrogen, and testosterone) terminology is evolving to include women outside of perimenopause and menopause  The five questions Dr. Quaile has in her DSDS (decreased sexual desire screener) for clinicians, to get to the root cause of hypoactive sexual desire disorder in patients The importance of women being comfortable about advocating for themselves Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Heather Quaile On her website  Instagram

We have the next episode in our series of thyroid-focused podcasts today. In this episode, Dr. Shawn Tassone, Dr. Alan Christianson, and Dr. Amie Hornaman join me to dive into medications, treatment options, personal preferences, and the fear that often drives medical decision-making. We discuss the current prevalence of thyroid-related conditions and why iodine remains a controversial topic in thyroid physiology. We also cover the role of micronutrients and the impact and symptoms of hypothyroidism, clarifying the concept of thyroid pause, and the specific lab tests required for evaluation, in addition to sharing some practical strategies.  Dr. Shawn Tassone advocates for a personalized approach to thyroid treatment, often preferring desiccated or compounded medications over standard synthetics, depending on patient response, insurance coverage, and symptom relief. He also addresses the ongoing resistance within conventional endocrinology to T3-based therapies, despite clear clinical improvements in patients using them. Dr. Alan Christianson explains that the dramatic rise in thyroid disorders over recent decades is due to increased iodine exposure, particularly from processed foods, dairy, supplements, and cosmetics. While iodine is essential for thyroid function, even small excesses can overwhelm the system, triggering autoimmune responses. However, reducing iodine intake can significantly improve or even reverse thyroid dysfunction in many people. Dr. Amie Hornaman explains that optimal thyroid function is essential for overall health, and the active thyroid hormone, T3, is needed by every cell in the body. She highlights the importance of comprehensive thyroid testing to detect dysfunction often missed by standard TSH tests, particularly in women over 40 or those experiencing symptoms linked to perimenopause, menopause, or Hashimoto’s. This enlightening conversation, with three leading thyroid authorities, is packed with valuable insights, so you should revisit it more than once. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Shawn Tassone On his website Instagram (Appointments: drshawntassone) Call Dr. Tassone’s office: 512 956029 Facebook Connect with Dr. Alan Christianson On his website Facebook, Instagram, Pinterest, and YouTube Connect with Dr. Amie Hornaman On her website Facebook and Instagram YouTube The Thyroid Fixer Podcast Ep 243 Balancing your hormones and thyroid health with Dr. Shawn Tassone Ep. 154 Thyroid & Intermittent Fasting Reset: How to Normalize Your Thyroid Function with Dr. Alan Christianson Ep. 426 Thyroid Health Masterclass: Labs, Diets & Autoimmune Insights with Dr. Amie Hornaman (DCN)

I am happy to connect with Coach Bronson Dant today. He has spent over a decade guiding and training people in health and fitness. He discovered the benefits of a whole-food, animal-based ketogenic diet for optimizing metabolic health and performance, and wrote The Ultimate Ketogenic Fitness Book. In our discussion today, we dive into the powerful story of Coach Bronson’s pain-to-purpose journey. We explore the value of mindset and examine how age-related changes impact muscle, inflammation, and metabolic flexibility. He shares his three pillars of muscle health related to nutrient density, bioavailability, and satiety, and we examine the importance of sleep, the impact of extremes in exercise, and the value of stress management. We also unravel the complexities of weight loss resistance, and Coach Bronson discusses his research from the Journal of Nutrition Metabolism and Health Science, sharing his perspective on macros and functional movement in menopausal women. IN THIS EPISODE YOU WILL LEARN: Coach Bronson shares his three pillars for nutrition The limitations of basing nutrition on calories alone How the hormone piece impacts effective weight management How to avoid physical deterioration through fitness and nutrition Why Coach Bronson advocates for living life to the fullest and dying quickly How does muscle mass impact metabolic health? The importance of taking a balanced approach to weight loss How sleep aids muscle recovery and growth  Stress management, nutrition, and fitness for overall well-being How alcohol affects our health and fitness The benefits of combining functional movement training and proper nutrition for older adults  Connect with Cynthia Thurlow Follow on X, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to support@cynthiathurlow.com Connect with Bronson Dant On his ⁠website⁠  ⁠YouTube⁠ and ⁠Instagram⁠ ⁠The Ultimate Ketogenic Fitness Bundle⁠

Today, I am thrilled to connect with Dr. Austin Perlmutter, a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, podcaster, and entrepreneur. He is on a mission to help people get their brains unstuck for better mental and cognitive health.  In our conversation today, we explore brain inflammation and its connection to longevity, the differences between acute and chronic inflammation, the influence of environmental factors, and how exposure to negative news and biases can elevate stress and affect our brain health. We examine how consumer culture promotes stress and disconnection, and we unpack the immune-metabolic effects of estrogen and its impact on neuroplasticity and our ability to learn. We also focus on the role of nutrition and nutraceuticals, and we discuss the relationship between the brain, gut, and the vagus nerve. This discussion with Dr. Austin Perlmutter is rich and insightful, and I look forward to welcoming him back for further exploration into the science and research. IN THIS EPISODE, YOU WILL LEARN: Why brain inflammation becomes an issue for many women as they navigate middle age and beyond How inflammation leads to constant changes in our cognitive and mental state Various environmental factors and other inputs that could influence brain inflammation Some easy ways to positively impact your brain health and cognition How chronic stress affects the brain How the gut microbiome and the gut immune system influence cognitive and mental health The long-term health benefits of avoiding processed foods and following a Mediterranean diet  The importance of being conscientious and purposeful about the quality of the foods you eat Dr. Perlmutter shares easy and cost-effective ways to improve your cognitive, mental, and overall health Bio: Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, published researcher, and a leading expert on how lifestyle and environmental factors impact mental health. His mission is to help people reclaim their mental and physical health by addressing the biological basis of “stuckness” that disrupts brain function and emotional balance. He is a co-producer of the Alzheimer’s: The Science of Prevention series and the host of the Better Brain Blueprint series, where he provides actionable strategies to support brain resilience. Dr. Perlmutter currently serves as the Managing Director at Big Bold Health, a food-as-medicine company focused on helping people rejuvenate health through better immune function, where he has published a pioneering study exploring the effects of plant nutrients on human aging through epigenetics. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Austin Perlmutter On his website On social media: @draustinperlmutter Find out more about the research on immuno-metabolism pathways  Big Bold Health on social media: @bigboldhealth

We have the second episode in a series of conversations with Dr. Thomas Dayspring today.  The esteemed Dr. Dayspring is an expert on internal medicine and clinical lipidology. In this episode, we continue with our last conversation, diving into Lp(a) and the influences of gender, race, and menopause. We explain how estrogen is a PCSK9 inhibitor and explore the significance of brain health and risks for dementia. We tackle cholesterol synthesis and discuss the side effects of statins, clarifying who is most susceptible to their impact on the brain. We also examine the significance of the desmosterol biomarker, highlighting the level to aim for, especially when making decisions regarding cholesterol medications, and we answer one question from a listener.  You may want to listen to this insightful conversation with the renowned Dr. Dayspring more than once. He has graciously agreed to return and film additional episodes, where we will dive into more questions from listeners.  IN THIS EPISODE, YOU WILL LEARN: Why Lp(a) is like a wolf in sheep's clothing for many individuals How Lp(a) levels are higher in African Americans and women, especially after menopause  Dr. Dayspring highlights that Lp(a) particles are even more pro-inflammatory than LDL particles How PCSK9 inhibitors are the only drugs that significantly reduce Lp(a) Why do women have a higher risk of dementia than men? Dr. Dayspring explains ApoE as the key lipoprotein for brain cholesterol transport. How statins cross the blood-brain barrier to lower brain cholesterol Why desmosterol levels matter New therapies that can lower ApoB and Lp(a) Why imaging is essential for menopausal women with elevated ApoB and Lp(a) Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Thomas Dayspring On X (@Drlipid) On LinkedIn Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations  Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?

We have another episode in our series of sponsored podcasts today, with brands I like, know, and trust. I am delighted to reconnect with Angelo Keely, the founder and CEO of Kion, a supplement company that focuses on helping people look good, feel young, and be strong. In our discussion today, Angelo explains essential aminos, highlighting their importance and clarifying how to differentiate between various protein powders and other forms of protein. We explore the significance of bioavailability, anabolic resistance, and changes in body composition, discussing how protein needs increase with age and how dieting and caloric restriction can augment our protein requirements. We also cover the results of intermittent fasting, examining how sleep, stress, and lifestyle requirements can change with menopause. I regularly take Kion essential amino acids. They have generously offered a discount for our community. Use the link in the show notes to get 20% off your next Kion purchase. IN THIS EPISODE, YOU WILL LEARN: The importance of eating sufficient protein as you age How various protein sources, such as animal protein, plant protein, whey protein, and essential amino acids, differ Strategies to buffer your protein intake and support your body as you navigate middle age and beyond Why Leucine is vital for muscle protein synthesis Why you should only source your amino acid supplements from trusted brands that follow the science How much protein do you need to maintain your body composition as you age? Why sleep is crucial for muscle protein synthesis How supplementing with essential amino acids helps you maintain your muscle mass throughout your life   The benefits of body scans for a better understanding of your body composition Connect with Cynthia Thurlow   Follow on X Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Angelo Keely Get a 20% discount on Kion products

I am deeply honored to reconnect with Dr. Thomas Dayspring, who joined me in 2024 for an immensely popular five-part series. Dr. Dayspring is certified in internal medicine and clinical lipidology. He is a distinguished fellow of both the American College of Physicians and the National Lipid Association.  Today, we have the first episode in a new series of conversations with Dr. Dayspring, in which he will share more of his perspective and answer more questions from listeners. In our discussion, we review the basics about cholesterol, triglycerides, and lipoproteins, exploring the factors that contribute to the development of cardiovascular disease, the significance of ApoB and Lp(a), and the risk factors for younger women. We also dive into the limitations of traditional allopathic medicines, and Dr. Dayspring shares his views on lipids, lipid changes in menopause, specific ways to address ApoB, some of the challenges associated with statin therapy, and more.  Dr. Dayspring brings a wealth of experience and expertise to this discussion, and you are sure to find this series as invaluable as the last. IN THIS EPISODE, YOU WILL LEARN: Dr. Dayspring revisits the differences between cholesterol, triglycerides, and lipoproteins What atherosclerosis is, and why it is concerning Dr. Dayspring explains the structure and function of lipoproteins The role of ApoB in lipoprotein particles and its significance in atherosclerosis Some of the risk factors for lipid abnormalities in younger women Lipid changes that occur as women transition from perimenopause to menopause  Dr. Dayspring shares his take on statin therapy Ways to address high ApoB Dr. Dayspring’s suggested goals for ApoB therapy Connect with Cynthia Thurlow   Follow on ⁠X⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Connect with Dr. Thomas Dayspring On⁠ X⁠ (@Drlipid) On⁠ LinkedIn⁠ ⁠Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations⁠  ⁠Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?⁠  

I am honored to connect with Mike Sapiro today. He is an ordained Zen Buddhist monk, poet, clinical psychologist, psychedelic psychotherapist, author, meditation teacher, and researcher, in addition to being a transformational coach for world-class musicians, athletes, veterans, scientists, authors, and playwrights. In our conversation, Mike talks about truth medicine and explains how trauma is a disconnection from the present moment, clarifying how the nervous system responds to chronic stress or trauma, and how midlife transitions can reactivate unhealed wounds. We explore how culture, ancestry, parenting, and epigenetics shape conditioning, and examine the roles of ego, psychedelics, and surrender in the healing process. We also discuss what it means to lead with the heart, integrity, and humility, and tackle the emotional weight of regret, remorse, and shame. Mike also recommends some simple yet powerful daily practices to help us heal. This conversation with Mike Sapiro is truly invaluable. I loved his book, Truth Medicine, and I know the wisdom in both the book and this episode will resonate deeply with many of you. IN THIS EPISODE, YOU WILL LEARN: The healing benefits of framing trauma as a disconnection from the present moment Understanding and addressing the causes of undesirable behaviors, and addressing the hurt and conditioning that drive them How chronic stress and trauma impact the nervous system How societal pressures and constant connectivity contribute to stress and a sense of disconnection The value of psychedelics for accessing new perspectives and insights How midlife transitions can reactivate unhealed wounds The benefit of involving the heart, psyche, and cosmos in the therapeutic process Why trusting, letting go, and surrendering are essential for psychedelic therapy  How integrity and humility can lead to profound healing and transformation within the therapeutic process Mike shares some small, consistent actions that can help build trust and self-care  Bio: Michael Ryoshin Sapiro, PsyD, is an ordained Zen Buddhist monk and poet, clinical psychologist, psychedelic psychotherapist, author, meditation teacher, and researcher. He is also a transformational coach for world-class musicians, athletes, former special operations veterans, scientists, CEOs, authors, and playwrights.  Over the last two decades, he has served and reached thousands of people in a variety of settings: therapy, workshops, international retreats, hosting a nationally syndicated radio show called Radio Awakened, keynote addresses, and being featured on podcasts. In the last several years, his work has been featured on over 20 well-known podcasts, and he is a co-host for global mental health summits put on by Wisdom for Life, landing in over 70 countries and reaching hundreds of thousands of people. He is featured in a documentary by Brandow Kapelow called “An Act of Service” on ketamine treatment for first responders that was featured by The New York Times. He currently works extensively with first responders in therapy, offering ketamine-assisted psychotherapy, leading retreats, and running calls with them. He believes that unconditional love, speaking one’s truth, and authenticity are the medicines for good health and a thriving life. His work is dedicated to personal awakening for the sake of collective transformation.  Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Michael Sapiro On his website On Instagram Purchase a copy of Truth Medicine

I am delighted to have the privilege of reconnecting with Dr. Deb Matthew today. She joined me once before in Episode 259. She is a distinguished best-selling author, international speaker, and dedicated educator known as the Happy Hormone Doctor.  Cardiovascular disease is the number one killer of women in the United States, causing one of every 3.2 deaths among women annually. In our conversation today, Dr. Matthew and I delve into the realm of cardiovascular disease, exploring the benefits of hormone replacement therapy, essential laboratory testing, medications, and the neurocognitive changes that occur during perimenopause and menopause. We also focus on lifestyle, gut testing, and the all-time favorite topic of weight loss resistance.  Stay tuned for today’s engaging, enriching, and enlightening discussion with Dr. Deb Matthew. IN THIS EPISODE YOU WILL LEARN: How HRT reduces the risk of cardiovascular disease  How long-term use of estrogen can reduce the risk of heart disease over time Why should you do a hormone panel before starting HRT? How cortisol levels impact cardiovascular health How the coronary calcium score helps to predict heart attack risk Cholesterol markers and their significance in cardiovascular risk assessment Managing cholesterol levels in perimenopausal women The importance of addressing underlying hormonal imbalances in women to mitigate cognitive decline and lipid disorders The connection between gut health and brain fog How women’s testosterone levels impact their cognition and motivation Hormone imbalance and weight loss resistance in women  Connect with Cynthia Thurlow Follow on ⁠Twitter⁠ ⁠Instagram⁠ ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠. Submit your questions to ⁠support@cynthiathurlow.com⁠. Connect with Dr. Deb Matthew On her ⁠website⁠ ⁠Facebook⁠ ⁠Instagram⁠ Dr. Deb Mathew’s book ⁠This is Not Normal on Amazon⁠ or ⁠download the ebook⁠  Previous Episode featuring Dr. Matthew ⁠Ep. 295: HRT’s Impact on Women’s Health Through Time with Dr. Deb Matthew