In this episode, we review recommendations 51 to 56 from the 2025 American Thyroid Association guidelines on long term management of differentiated thyroid cancer. Key topics include:

• The role of ongoing (dynamic) risk stratification in individualized patient management

• Decision making for reoperative neck surgery and alternative local therapies such as ethanol and RFA

• Indications for additional RAI therapy for cervical lymph node metastases

• The role of EBRT in unresectable locoregional recurrences

• Radioactive iodine dosing strategies and preparation methods, including dosimetry and TSH stimulation

• Management of metastatic disease with RAI, including treatment of pulmonary micrometastases and macronodular metastases