GUEST: Markita Del Carpio Landry, UC BerkeleyWelcome to Episode 16 of “Dive into Imaging Science”! 🎧 Tune in for a dynamic discussion on innovative probes work, the function of dopamine in the brain, and how these new imaging tools can be used in the future to reveal new biology. This episode features a truly special guest: Markita Del Carpio Landry, the inaugural Trailblazer Plenary Lecturer at the upcoming EMIM in Ljubljana next March! "The Trailblazer Lecture celebrates a rising lead...

GUEST: Vasilis Ntziachristos🎧 Tune in for a dynamic discussion on how the interplay of light and sound is revolutionizing our understanding of disease. 🎙️ Welcome to Episode 15 of “Dive into Imaging Science”! In this edition, we’re delighted to introduce: none other than Vasilis Ntziachristos as our guest! Vasilis is a distinguished leader in the field of optical and optoacoustic imaging, renowned for his pioneering work in fluorescence molecular tomography, fluorescence-guided surgery, and o...

GUEST: Peter J.H. Scott, University Michigan (Ann Arbor)🎙️ Welcome to Episode 14 of "Dive into Imaging Science"! In this edition, we’re thrilled to welcome a very special guest: Peter Scott! Peter’s passion for radiochemistry and his dedication to translating research into clinical applications have made a lasting impact on the field of Theranostics – also the central theme of this year’s TOPIM (don’t forget to check it out!). By following Peter’s inspiring career journey, we gain valua...

GUEST: Fabian Kiessling, AachenWelcome to the Christmas edition of "Dive into imaging science"! Giannis and Tim have their festive hats on and are wearing their dodgy Christmas jumpers, ready for a cracker (!) of an episode. And we have a very special guest on the show – none other than our current past president, Fabian Kiessling, who heads up the Institute of Experimental Molecular Imaging and the Helmholtz Institute for Biomedical Engineering at Aachen University. We explore how to ‘...

GUEST: Elisa Konofagou, New YorkWe continue at full speed with back to back podcasts hosting leaders in the field of molecular imaging. In this edition we welcome Elisa Konofagou and share her passion for ultrasound imaging and its unique capabilities for visualising biology inside the human body. Her group has developed methods for estimating minute deformation as a result of physiological function, such as in the heart and vessels, and displacements induced by the ultrasound wave itself, su...

GUEST: John Ronald, London (ON, Canada)Welcome back! It has been a while but we are back with a bang, having our good friend John Ronald from The Robarts Research Institute in London, Ontario as our guest. John’s group combines advances in molecular and synthetic biology with a multimodal imaging perspective to build new tools for early detection and treatment of cancer, as well as non-invasive monitoring of cell, gene and genome therapies. One of John’s passions is gene reporter i...

GUEST: Kevin Brindle, CambridgeIn this episode we welcome the one and only Kevin Brindle from University of Cambridge.During his long and illustrious career, Kevin pioneered hyperpolarized magnetic resonance spectroscopy as a method to map metabolic flux in cancer and other diseases, with implications for treatment response monitoring.We explore how deuterium imaging and [18F]FDG PET can be used to track the metabolic changes that occur soon after stroke and during the recovery phase. We disc...

GUEST: Mikhail Shapiro, PasadenaIn this episode we welcome our famous guest Mikhail Shapiro from Caltech. Mikhail exquisitely combines ultrasound with synthetic biology for gene regulation, imaging, and therapy - and Synthetic biology is surely the common thread in this podcast edition.We discover how an engineered receptor and an intracellular signalling domain, known as ‘synNotch’ can be used to visualise cell-cell communication in vivo. And how this system can be used to identify immune-ca...

GUEST: Jason Lewis, New YorkIn this episode we discuss and learn about new PSMA-binding ligands with 161Tb, their biodistribution, dosimetry, preclinical therapy, and their comparison with conventional PSMA ligands. Our guest is one of the leading scientists in radiochemistry for cancer detection and therapy, the wonderful Jason Lewis. We talk about the importance of using 161Tb - this novel radionuclide for radioligand therapy - and its favorable decay characteristics as compared to 177...

GUEST: Annemie Van Der Linden, AntwerpIn this edition of ‘Dive into Imaging Science’ we discuss the brain and the mechanisms that it employs to clear unwanted waste material whilst we sleep with our former ESMI President and Emeritus Professor Annemie Van Der Linden - an outstanding figure and incomparable scientist.We learn how closely coupled this system - known as the glymphatics - is to blood circulation, and how physical stimulation can enhance glymphatic flow in anaesthetised but not aw...

GUEST: Elisabeth de Vries, GroningenIn this episode we talk about nectin-4 - an emerging biomarker for cancer diagnosis and therapy - with one of the most influential and distinguished scientists in medical oncology, Elisabeth de Vries. We talk about the first-in-human study of a radioligand that can target nectin-4 and learn what medical oncologists need to get out from imaging data so that these powerful tools continue to make an impact on patient outcomes. We learn about the importance and...

GUEST: Bernd Pichler, TübingenIn this episode we learn how a new lensless microscope, costing just $100 (!), can be used to evaluate radiotracer retention in cells, and discuss potential applications for this revolutionary new technology with our famous guest Bernd Pichler. We discuss how this, and other technologies, could be used to assess the heterogeneous cell populations of the tumour microenvironment and identify cell senescence using new radiotracers developed in Bernd’s lab.Selected P...

GUEST: Zaver Bhujwalla, BaltimoreIn this episode we discuss how targeting fibroblasts rather than tumour cells may be an effective strategy for both surgical guided resection and as an anti-cancer therapy with Tim’s “academic grandmother”, Zaver Bhujwalla. We discovered Zaver’s roots as a physicist and mathematician, learned about her (unpredictable) interest in cancer metabolism and how she combines tools to develop a powerful in vitro diagnostic test.Selected Publication: "Design and charac...

GUEST: Clemens C.W.G. Lowik, RotterdamIn this episode we discuss and learn about Bioluminescence Imaging and modern tools for multiplexed imaging of different colors, tackling a major challenge of the field. Our guest is one of the founding fathers of the ESMI and pioneers on multicolor BLI, the one and only Clemens Lowik. We talk about innovative approaches for unmixing multiple luciferase-luciferin pairs and quantitative analyses of bioluminescent mixtures, enabling serial tracking of...

GUEST: Simon Cherry, UC DavisIn this episode we discuss (and learn a lot about!) positronium imaging with the co-inventor of Total Body PET, the wonderful Simon Cherry, the physics behind positronium formation, and how it might provide further biological information than standard positron emission tomography imaging. We learnt about Simon’s journey that led him to change the field of clinical PET imaging and what new innovations he has up his sleeve... and if you are looking for a research ar...

GUEST: Jolanda de Vries, NijmegenIn this episode the hosts Tim and Giannis talk with the fantastic Jolanda De Vries from Nijmegen about how dendritic cell therapy got her into imaging and the latest therapeutic cell imaging methods. We touch on multimodality imaging, why imaging isn’t frequently used in the clinic for cell tracking, and why mouse models of cancer might never be good enough.Selected Publication: "In vivo imaging of nanoparticle-labeled CAR T cells" published in Proceedings of ...