In our first episode, Dr George Gaitanos explores fasting, calorie restriction, intermittent fasting and the Fasting Mimicking Diet, with Professor Kostas Tsintzas (University of Nottingham). The discussion clarifies how short, structured periods of energy restriction can activate autophagy, increase fat oxidation and ketosis, and support favourable shifts in cardiometabolic markers. The episode reviews a randomised clinical study that compared a classic low-protein FMD with a higher-protein, plant-based variant. About the study: https://www.chenot.com/about-chenot/world-best-detox-programme/